YBR222C / PCS60

Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR222C / PCS60

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.83|P-value:8.85E-6 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.06|P-value:3.14E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.23|P-value:1.48E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.29|P-value:6.00E-7 ID:SGTC_393|Compound:acivicin|FD-Score:-3.14|P-value:2.25E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:2.74|P-value:9.53E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.10|P-value:2.66E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.04|P-value:2.81E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.33|P-value:7.95E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:3.15|P-value:1.76E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-4.05|P-value:2.83E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:5.28|P-value:1.19E-9 ID:SGTC_591|Compound:4299-0174|FD-Score:-2.85|P-value:7.18E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-2.82|P-value:8.15E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.11|P-value:2.12E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.15|P-value:2.14E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.11|P-value:2.12E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.02|P-value:3.71E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-2.99|P-value:4.17E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.09|P-value:2.32E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.01|P-value:3.28E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.12|P-value:2.04E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.55|P-value:2.91E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.22|P-value:1.32E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-2.77|P-value:9.63E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.55|P-value:2.89E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-3.21|P-value:1.66E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.01|P-value:3.28E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.18|P-value:1.56E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.27|P-value:1.07E-4 ID:SGTC_1847|Compound:st056231|FD-Score:2.92|P-value:4.60E-4 ID:SGTC_1911|Compound:st060208|FD-Score:2.98|P-value:3.63E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.85|P-value:6.63E-6 ID:SGTC_2004|Compound:4023728|FD-Score:2.89|P-value:5.29E-4 ID:SGTC_2163|Compound:5671233|FD-Score:2.76|P-value:8.76E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-3.21|P-value:1.63E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:6.92|P-value:2.68E-15 ID:SGTC_2464|Compound:5717415|FD-Score:4.32|P-value:5.03E-7 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.02|P-value:3.14E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:2.97|P-value:3.78E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.68|P-value:1.51E-5 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.21|P-value:1.61E-4 ID:SGTC_2847|Compound:9005661|FD-Score:3.25|P-value:1.15E-4 ID:SGTC_2905|Compound:7799065|FD-Score:2.84|P-value:6.51E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.97|P-value:3.51E-6 ID:SGTC_3026|Compound:9090633|FD-Score:-2.83|P-value:7.69E-4 ID:SGTC_3042|Compound:9091578|FD-Score:2.85|P-value:6.07E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.83|P-value:8.85E-6 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.06|P-value:3.14E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.23|P-value:1.48E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.29|P-value:6.00E-7 ID:SGTC_393|Compound:acivicin|FD-Score:-3.14|P-value:2.25E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:2.74|P-value:9.53E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.10|P-value:2.66E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.04|P-value:2.81E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.33|P-value:7.95E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:3.15|P-value:1.76E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-4.05|P-value:2.83E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:5.28|P-value:1.19E-9 ID:SGTC_591|Compound:4299-0174|FD-Score:-2.85|P-value:7.18E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-2.82|P-value:8.15E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.11|P-value:2.12E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.15|P-value:2.14E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.11|P-value:2.12E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.02|P-value:3.71E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-2.99|P-value:4.17E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.09|P-value:2.32E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.01|P-value:3.28E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.12|P-value:2.04E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.55|P-value:2.91E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.22|P-value:1.32E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-2.77|P-value:9.63E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.55|P-value:2.89E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-3.21|P-value:1.66E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.01|P-value:3.28E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.18|P-value:1.56E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.27|P-value:1.07E-4 ID:SGTC_1847|Compound:st056231|FD-Score:2.92|P-value:4.60E-4 ID:SGTC_1911|Compound:st060208|FD-Score:2.98|P-value:3.63E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.85|P-value:6.63E-6 ID:SGTC_2004|Compound:4023728|FD-Score:2.89|P-value:5.29E-4 ID:SGTC_2163|Compound:5671233|FD-Score:2.76|P-value:8.76E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-3.21|P-value:1.63E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:6.92|P-value:2.68E-15 ID:SGTC_2464|Compound:5717415|FD-Score:4.32|P-value:5.03E-7 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.02|P-value:3.14E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:2.97|P-value:3.78E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.68|P-value:1.51E-5 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.21|P-value:1.61E-4 ID:SGTC_2847|Compound:9005661|FD-Score:3.25|P-value:1.15E-4 ID:SGTC_2905|Compound:7799065|FD-Score:2.84|P-value:6.51E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.97|P-value:3.51E-6 ID:SGTC_3026|Compound:9090633|FD-Score:-2.83|P-value:7.69E-4 ID:SGTC_3042|Compound:9091578|FD-Score:2.85|P-value:6.07E-4

Top fitness defect scores for YBR222C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2410 aloe-emodin-8-o-glycoside 6.92 46.3 µM 2.68E-15 mitochondrial processes 2 2.21E-12
2 SGTC_557 1315-0110 5.28 16.2 µM 1.19E-9 Golgi 2 6.41E-8
3 SGTC_2464 5717415 4.32 7.7 µM 5.03E-7 10 7.69E-6
4 SGTC_388 3',4'-dichloroisocoumarin 4.29 16.7 µM 6.00E-7 9 8.85E-6
5 SGTC_2930 9013230 3.97 14.9 µM 3.51E-6 heme biosynthesis & mitochondrial translocase 36 3.59E-5
6 SGTC_1969 st069479 3.85 40.1 µM 6.63E-6 14 5.95E-5
7 SGTC_2722 naftopidil 3.68 47.2 µM 1.51E-5 11 1.14E-4
8 SGTC_1433 4060-0023 3.55 7.6 µM 2.89E-5 tubulin folding & SWR complex 28 1.91E-4
9 SGTC_1198 1612-1005 3.55 86.7 µM 2.91E-5 22 1.93E-4
10 SGTC_491 tetrandrine 3.33 80.3 µM 7.95E-5 22 4.28E-4
11 SGTC_1830 st055982 3.27 50.3 µM 1.07E-4 49 5.40E-4
12 SGTC_2847 9005661 3.25 71.4 µM 1.15E-4 17 5.75E-4
13 SGTC_1245 0418-0076 3.22 17.2 µM 1.32E-4 ERG2 58 6.40E-4
14 SGTC_1821 st053465 3.18 65.6 µM 1.56E-4 25 7.33E-4
15 SGTC_531 3788-1495 3.15 174.0 µM 1.76E-4 unfolded protein response 51 8.04E-4
16 SGTC_1072 oxiconazole 3.12 14.9 nM 2.04E-4 ergosterol depletion effects on membrane 86 9.06E-4
17 SGTC_624 k048-0052 3.11 28.0 µM 2.12E-4 Golgi 47 9.34E-4
18 SGTC_799 1310-0557 3.11 151.0 µM 2.12E-4 superoxide 63 9.34E-4
19 SGTC_1065 prochlorperazine maleate 3.09 2.5 µM 2.32E-4 44 0.00100
20 SGTC_481 bay k-8644 3.04 50.0 µM 2.81E-4 67 0.00117

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.04E-15 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.117 1.19E-11 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.112 6.97E-11 YJL035C TAD2 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
0.111 1.29E-10 YDL053C PBP4 hom Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress
0.099 1.00E-8 YGL262W_p YGL262W_p hom Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene
0.096 2.97E-8 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.095 3.63E-8 YML086C ALO1 hom D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress
0.093 6.24E-8 YGL053W PRM8 hom Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
0.091 1.30E-7 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.088 3.01E-7 YFR017C IGD1 hom Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication
0.088 3.12E-7 YLR267W_p BOP2_p hom Protein of unknown function
0.088 3.65E-7 YPL203W TPK2 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase
0.086 5.26E-7 YNL071W LAT1 hom Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.085 7.41E-7 YGR249W MGA1 hom Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
0.081 2.28E-6 YFL020C PAU5 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme