YBR224W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR224W / YBR224W

Click on Significant Values for Screen Details ID:SGTC_96|Compound:0929-0093|FD-Score:3.43|P-value:1.20E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.65|P-value:4.54E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:-2.94|P-value:7.97E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.25|P-value:2.55E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.40|P-value:1.35E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.75|P-value:2.96E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:3.57|P-value:6.57E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-2.90|P-value:9.16E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.33|P-value:1.76E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.23|P-value:2.73E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.10|P-value:4.43E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:-2.94|P-value:7.86E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.53|P-value:7.61E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.62|P-value:4.97E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:3.12|P-value:4.07E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.45|P-value:1.10E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:-3.13|P-value:3.87E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.90|P-value:9.59E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.03|P-value:5.73E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.22|P-value:2.74E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.11|P-value:4.34E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.43|P-value:1.19E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.62|P-value:5.31E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:3.16|P-value:3.59E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.22|P-value:2.98E-6 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.07|P-value:4.90E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.66|P-value:4.32E-5 ID:SGTC_1707|Compound:st032323|FD-Score:6.92|P-value:5.92E-14 ID:SGTC_1713|Compound:st033146|FD-Score:-2.90|P-value:9.14E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.16|P-value:3.50E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.17|P-value:3.34E-4 ID:SGTC_1909|Compound:st060837|FD-Score:2.91|P-value:9.13E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.81|P-value:2.21E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-3.85|P-value:1.76E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.52|P-value:8.11E-5 ID:SGTC_2350|Compound:9023895|FD-Score:3.04|P-value:5.56E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-2.88|P-value:9.90E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.77|P-value:2.71E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.02|P-value:6.10E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.81|P-value:2.31E-10 ID:SGTC_2716|Compound:st080858|FD-Score:-4.05|P-value:6.65E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.19|P-value:3.11E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.71|P-value:3.51E-5 ID:SGTC_2917|Compound:7979103|FD-Score:-5.65|P-value:6.56E-10 ID:SGTC_2921|Compound:7974240|FD-Score:3.24|P-value:2.58E-4 ID:SGTC_2923|Compound:7992654|FD-Score:4.62|P-value:3.70E-7 ID:SGTC_2924|Compound:9010168|FD-Score:4.80|P-value:1.31E-7 ID:SGTC_2928|Compound:9011484|FD-Score:5.02|P-value:3.72E-8 ID:SGTC_2956|Compound:9076196|FD-Score:3.79|P-value:2.46E-5 ID:SGTC_2962|Compound:9082311|FD-Score:4.06|P-value:6.58E-6 ID:SGTC_3073|Compound:9114972|FD-Score:-3.12|P-value:4.06E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.30|P-value:1.97E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.09|P-value:4.67E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.45|P-value:1.08E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.43|P-value:1.20E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.65|P-value:4.54E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:-2.94|P-value:7.97E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.25|P-value:2.55E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.40|P-value:1.35E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.75|P-value:2.96E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:3.57|P-value:6.57E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-2.90|P-value:9.16E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.33|P-value:1.76E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.23|P-value:2.73E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.10|P-value:4.43E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:-2.94|P-value:7.86E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.53|P-value:7.61E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.62|P-value:4.97E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:3.12|P-value:4.07E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.45|P-value:1.10E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:-3.13|P-value:3.87E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.90|P-value:9.59E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.03|P-value:5.73E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.22|P-value:2.74E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.11|P-value:4.34E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.43|P-value:1.19E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.62|P-value:5.31E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:3.16|P-value:3.59E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.22|P-value:2.98E-6 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.07|P-value:4.90E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.66|P-value:4.32E-5 ID:SGTC_1707|Compound:st032323|FD-Score:6.92|P-value:5.92E-14 ID:SGTC_1713|Compound:st033146|FD-Score:-2.90|P-value:9.14E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.16|P-value:3.50E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.17|P-value:3.34E-4 ID:SGTC_1909|Compound:st060837|FD-Score:2.91|P-value:9.13E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.81|P-value:2.21E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-3.85|P-value:1.76E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.52|P-value:8.11E-5 ID:SGTC_2350|Compound:9023895|FD-Score:3.04|P-value:5.56E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-2.88|P-value:9.90E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.77|P-value:2.71E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.02|P-value:6.10E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.81|P-value:2.31E-10 ID:SGTC_2716|Compound:st080858|FD-Score:-4.05|P-value:6.65E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.19|P-value:3.11E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.71|P-value:3.51E-5 ID:SGTC_2917|Compound:7979103|FD-Score:-5.65|P-value:6.56E-10 ID:SGTC_2921|Compound:7974240|FD-Score:3.24|P-value:2.58E-4 ID:SGTC_2923|Compound:7992654|FD-Score:4.62|P-value:3.70E-7 ID:SGTC_2924|Compound:9010168|FD-Score:4.80|P-value:1.31E-7 ID:SGTC_2928|Compound:9011484|FD-Score:5.02|P-value:3.72E-8 ID:SGTC_2956|Compound:9076196|FD-Score:3.79|P-value:2.46E-5 ID:SGTC_2962|Compound:9082311|FD-Score:4.06|P-value:6.58E-6 ID:SGTC_3073|Compound:9114972|FD-Score:-3.12|P-value:4.06E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.30|P-value:1.97E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.09|P-value:4.67E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.45|P-value:1.08E-4

Top fitness defect scores for YBR224W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1707 st032323 6.92 6.3 µM 5.92E-14 DNA damage response 16 2.31E-12
2 SGTC_2582 agaric acid 5.81 100.0 µM 2.31E-10 redox potentiating 168 3.11E-9
3 SGTC_2928 9011484 5.02 9.8 µM 3.72E-8 heme biosynthesis & mitochondrial translocase 16 2.62E-7
4 SGTC_2924 9010168 4.80 62.8 µM 1.31E-7 cell wall signaling 21 7.87E-7
5 SGTC_2923 7992654 4.62 58.1 µM 3.70E-7 Golgi 14 1.94E-6
6 SGTC_117 lucigenin 4.25 22.1 µM 2.55E-6 redox potentiating 74 1.05E-5
7 SGTC_2962 9082311 4.06 13.2 µM 6.58E-6 19 2.41E-5
8 SGTC_1910 st062352 3.81 60.4 µM 2.21E-5 42 6.96E-5
9 SGTC_2956 9076196 3.79 2.5 µM 2.46E-5 23 7.63E-5
10 SGTC_2436 5633522 3.77 8.1 µM 2.71E-5 20 8.31E-5
11 SGTC_453 enantio-paf c16 3.75 10.0 µM 2.96E-5 160 8.97E-5
12 SGTC_2849 9019321 3.71 13.0 µM 3.51E-5 37 1.04E-4
13 SGTC_1638 st008370 3.66 60.6 µM 4.32E-5 ergosterol biosynthesis 38 1.25E-4
14 SGTC_98 0074-0023 3.65 107.7 µM 4.54E-5 Golgi 50 1.31E-4
15 SGTC_1584 6-fluoro-dl-tryptophan 3.62 90.0 µM 5.31E-5 mitochondrial processes 23 1.50E-4
16 SGTC_455 paf C-16 3.57 10.0 µM 6.57E-5 42 1.80E-4
17 SGTC_769 0302-0231 3.53 76.0 µM 7.61E-5 64 2.05E-4
18 SGTC_2165 5727197 3.52 32.1 µM 8.11E-5 49 2.17E-4
19 SGTC_3348 9149464 3.45 3.5 µM 1.08E-4 30 2.79E-4
20 SGTC_889 0919-1524 3.45 82.7 µM 1.10E-4 28 2.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.200 1.26E-31 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.181 3.60E-26 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.166 3.09E-22 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.150 1.93E-18 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.143 1.04E-16 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.141 2.30E-16 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.139 6.26E-16 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.137 1.41E-15 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.136 2.15E-15 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.134 6.43E-15 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.133 1.14E-14 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.131 3.25E-14 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.129 5.30E-14 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.129 5.69E-14 YIL153W RRD1 hom Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.128 8.27E-14 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress