YBR226C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR226C / YBR226C

Click on Significant Values for Screen Details ID:SGTC_136|Compound:0097-0015|FD-Score:3.70|P-value:9.23E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:4.21|P-value:1.99E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.47|P-value:8.51E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.87|P-value:5.23E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:4.15|P-value:2.37E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:4.13|P-value:2.56E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.10|P-value:2.83E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-4.37|P-value:1.08E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.69|P-value:8.81E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.82|P-value:5.95E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.80|P-value:6.92E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.51|P-value:2.05E-8 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.72|P-value:8.69E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:-3.98|P-value:3.74E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:5.40|P-value:2.68E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.94|P-value:4.64E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.83|P-value:5.77E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.80|P-value:6.89E-4 ID:SGTC_1835|Compound:st008666|FD-Score:6.55|P-value:1.74E-8 ID:SGTC_1837|Compound:st055472|FD-Score:6.05|P-value:1.69E-7 ID:SGTC_1910|Compound:st062352|FD-Score:-4.15|P-value:2.21E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-4.59|P-value:5.06E-5 ID:SGTC_2003|Compound:4023581|FD-Score:5.15|P-value:7.35E-6 ID:SGTC_2010|Compound:4012422|FD-Score:-4.66|P-value:3.91E-5 ID:SGTC_2012|Compound:4023501|FD-Score:4.23|P-value:1.88E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-4.26|P-value:1.54E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-3.78|P-value:6.65E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-4.34|P-value:1.18E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.86|P-value:2.13E-5 ID:SGTC_2286|Compound:7945697|FD-Score:5.75|P-value:6.44E-7 ID:SGTC_2323|Compound:6148992|FD-Score:4.86|P-value:2.16E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-3.89|P-value:4.88E-4 ID:SGTC_2416|Compound:tofa|FD-Score:5.58|P-value:1.29E-6 ID:SGTC_2426|Compound:5582046|FD-Score:-5.24|P-value:4.48E-6 ID:SGTC_2427|Compound:5545055|FD-Score:-4.15|P-value:2.18E-4 ID:SGTC_2428|Compound:5615643|FD-Score:5.17|P-value:6.64E-6 ID:SGTC_2466|Compound:5983409|FD-Score:3.84|P-value:6.15E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.92|P-value:4.93E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:5.29|P-value:4.17E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.77|P-value:7.61E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-3.93|P-value:4.34E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:4.20|P-value:2.06E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.19|P-value:2.12E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-3.99|P-value:3.59E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.17|P-value:2.01E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.69|P-value:9.49E-4 ID:SGTC_3112|Compound:9123419|FD-Score:4.02|P-value:3.57E-4 ID:SGTC_3135|Compound:9127742|FD-Score:4.86|P-value:2.16E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.70|P-value:9.23E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:4.21|P-value:1.99E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.47|P-value:8.51E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.87|P-value:5.23E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:4.15|P-value:2.37E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:4.13|P-value:2.56E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.10|P-value:2.83E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-4.37|P-value:1.08E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.69|P-value:8.81E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.82|P-value:5.95E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.80|P-value:6.92E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.51|P-value:2.05E-8 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.72|P-value:8.69E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:-3.98|P-value:3.74E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:5.40|P-value:2.68E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.94|P-value:4.64E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.83|P-value:5.77E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.80|P-value:6.89E-4 ID:SGTC_1835|Compound:st008666|FD-Score:6.55|P-value:1.74E-8 ID:SGTC_1837|Compound:st055472|FD-Score:6.05|P-value:1.69E-7 ID:SGTC_1910|Compound:st062352|FD-Score:-4.15|P-value:2.21E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-4.59|P-value:5.06E-5 ID:SGTC_2003|Compound:4023581|FD-Score:5.15|P-value:7.35E-6 ID:SGTC_2010|Compound:4012422|FD-Score:-4.66|P-value:3.91E-5 ID:SGTC_2012|Compound:4023501|FD-Score:4.23|P-value:1.88E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-4.26|P-value:1.54E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-3.78|P-value:6.65E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-4.34|P-value:1.18E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.86|P-value:2.13E-5 ID:SGTC_2286|Compound:7945697|FD-Score:5.75|P-value:6.44E-7 ID:SGTC_2323|Compound:6148992|FD-Score:4.86|P-value:2.16E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-3.89|P-value:4.88E-4 ID:SGTC_2416|Compound:tofa|FD-Score:5.58|P-value:1.29E-6 ID:SGTC_2426|Compound:5582046|FD-Score:-5.24|P-value:4.48E-6 ID:SGTC_2427|Compound:5545055|FD-Score:-4.15|P-value:2.18E-4 ID:SGTC_2428|Compound:5615643|FD-Score:5.17|P-value:6.64E-6 ID:SGTC_2466|Compound:5983409|FD-Score:3.84|P-value:6.15E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.92|P-value:4.93E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:5.29|P-value:4.17E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.77|P-value:7.61E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-3.93|P-value:4.34E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:4.20|P-value:2.06E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.19|P-value:2.12E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-3.99|P-value:3.59E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.17|P-value:2.01E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.69|P-value:9.49E-4 ID:SGTC_3112|Compound:9123419|FD-Score:4.02|P-value:3.57E-4 ID:SGTC_3135|Compound:9127742|FD-Score:4.86|P-value:2.16E-5

Top fitness defect scores for YBR226C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1835 st008666 6.55 49.2 µM 1.74E-8 6 2.96E-11
2 SGTC_1161 k007-0610 6.51 110.0 µM 2.05E-8 ERAD & cell cycle 50 3.74E-11
3 SGTC_1837 st055472 6.05 66.5 µM 1.69E-7 6 7.05E-10
4 SGTC_2286 7945697 5.75 125.0 µM 6.44E-7 17 4.52E-9
5 SGTC_2416 tofa 5.58 880.0 nM 1.29E-6 sphingolipid biosynthesis & PDR1 25 1.19E-8
6 SGTC_1237 0330-0133 5.40 46.1 µM 2.68E-6 ergosterol biosynthesis 8 3.28E-8
7 SGTC_2557 derrustone 5.29 83.8 µM 4.17E-6 10 6.07E-8
8 SGTC_2428 5615643 5.17 7.8 µM 6.64E-6 17 1.16E-7
9 SGTC_2003 4023581 5.15 200.0 µM 7.35E-6 cell wall signaling 20 1.33E-7
10 SGTC_2283 7944793 4.86 200.0 µM 2.13E-5 19 5.84E-7
11 SGTC_2323 6148992 4.86 148.3 µM 2.16E-5 16 5.93E-7
12 SGTC_3135 9127742 4.86 49.5 µM 2.16E-5 7 5.97E-7
13 SGTC_481 bay k-8644 4.47 50.0 µM 8.51E-5 19 3.98E-6
14 SGTC_2012 4023501 4.23 200.0 µM 1.88E-4 22 1.19E-5
15 SGTC_478 N-arachidonylglycine 4.21 10.0 µM 1.99E-4 2 1.28E-5
16 SGTC_2760 etidronate 4.20 98.0 µM 2.06E-4 20 1.35E-5
17 SGTC_2785 7756463 4.19 72.7 µM 2.12E-4 23 1.41E-5
18 SGTC_683 panaxydol 4.15 45.0 µM 2.37E-4 sphingolipid biosynthesis & PDR1 33 1.64E-5
19 SGTC_816 0325-0417 4.13 81.3 µM 2.56E-4 9 1.82E-5
20 SGTC_945 3381-0768 4.10 11.3 µM 2.83E-4 endomembrane recycling 31 2.09E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.10E-9 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.082 1.97E-6 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.079 4.14E-6 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.079 4.20E-6 YKL013C ARC19 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.079 4.55E-6 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.077 9.11E-6 YMR013C SEC59 het Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
0.075 1.30E-5 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.075 1.43E-5 YML105C SEC65 het Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
0.075 1.44E-5 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.075 1.50E-5 YCR031C RPS14A hom Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication
0.074 1.93E-5 YPL198W RPL7B hom Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication
0.071 3.44E-5 YCL047C POF1 hom ATPase involved in the protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; also interacts with Ubc7p
0.070 5.05E-5 YEL062W NPR2 hom Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline
0.068 7.17E-5 YOR308C SNU66 hom Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1
0.067 9.56E-5 YDL212W SHR3 het Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface