YBR227C / MCX1

Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR227C / MCX1

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-3.29|P-value:7.28E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:11.70|P-value:6.05E-30 ID:SGTC_171|Compound:k064-0041|FD-Score:5.54|P-value:4.31E-8 ID:SGTC_198|Compound:3454-2873|FD-Score:3.74|P-value:1.50E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.32|P-value:6.85E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.60|P-value:2.56E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.27|P-value:8.10E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.98|P-value:6.06E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.37|P-value:5.75E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:4.09|P-value:3.96E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.61|P-value:2.41E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.65|P-value:2.15E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.26|P-value:8.15E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.37|P-value:5.61E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:5.03|P-value:5.90E-7 ID:SGTC_584|Compound:0986-0246|FD-Score:3.62|P-value:2.33E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:5.01|P-value:6.55E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:4.58|P-value:4.89E-6 ID:SGTC_959|Compound:1222-0044|FD-Score:3.81|P-value:1.19E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:4.61|P-value:4.29E-6 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.53|P-value:3.20E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.51|P-value:3.47E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.48|P-value:3.83E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.31|P-value:6.91E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.54|P-value:3.06E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.57|P-value:2.79E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.27|P-value:7.90E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.31|P-value:7.01E-4 ID:SGTC_1660|Compound:st012960|FD-Score:6.07|P-value:2.24E-9 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.37|P-value:5.51E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.41|P-value:4.79E-4 ID:SGTC_1794|Compound:st048918|FD-Score:4.28|P-value:1.79E-5 ID:SGTC_1797|Compound:st048695|FD-Score:-3.71|P-value:1.64E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-4.06|P-value:4.27E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.69|P-value:1.85E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.26|P-value:8.02E-4 ID:SGTC_2103|Compound:5378138|FD-Score:-3.22|P-value:9.29E-4 ID:SGTC_2212|Compound:7123476|FD-Score:3.70|P-value:1.77E-4 ID:SGTC_2219|Compound:9098279|FD-Score:-3.85|P-value:9.68E-5 ID:SGTC_2311|Compound:7694451|FD-Score:4.76|P-value:2.15E-6 ID:SGTC_2325|Compound:6158266|FD-Score:-3.64|P-value:2.16E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.32|P-value:6.84E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.20|P-value:2.46E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.45|P-value:8.58E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:4.05|P-value:4.53E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.62|P-value:3.87E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.65|P-value:2.09E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.72|P-value:1.64E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.35|P-value:6.01E-4 ID:SGTC_2713|Compound:st079149|FD-Score:4.76|P-value:2.17E-6 ID:SGTC_2742|Compound:clothiapine|FD-Score:4.41|P-value:1.04E-5 ID:SGTC_2884|Compound:9058502|FD-Score:-3.35|P-value:5.95E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.42|P-value:4.73E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.77|P-value:2.03E-6 ID:SGTC_2965|Compound:9082772|FD-Score:3.50|P-value:3.67E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.54|P-value:3.16E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.26|P-value:7.94E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.62|P-value:2.35E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.65|P-value:2.15E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-3.29|P-value:7.28E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:11.70|P-value:6.05E-30 ID:SGTC_171|Compound:k064-0041|FD-Score:5.54|P-value:4.31E-8 ID:SGTC_198|Compound:3454-2873|FD-Score:3.74|P-value:1.50E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.32|P-value:6.85E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.60|P-value:2.56E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.27|P-value:8.10E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.98|P-value:6.06E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.37|P-value:5.75E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:4.09|P-value:3.96E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.61|P-value:2.41E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.65|P-value:2.15E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.26|P-value:8.15E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.37|P-value:5.61E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:5.03|P-value:5.90E-7 ID:SGTC_584|Compound:0986-0246|FD-Score:3.62|P-value:2.33E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:5.01|P-value:6.55E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:4.58|P-value:4.89E-6 ID:SGTC_959|Compound:1222-0044|FD-Score:3.81|P-value:1.19E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:4.61|P-value:4.29E-6 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.53|P-value:3.20E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.51|P-value:3.47E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.48|P-value:3.83E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.31|P-value:6.91E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.54|P-value:3.06E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.57|P-value:2.79E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.27|P-value:7.90E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.31|P-value:7.01E-4 ID:SGTC_1660|Compound:st012960|FD-Score:6.07|P-value:2.24E-9 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.37|P-value:5.51E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.41|P-value:4.79E-4 ID:SGTC_1794|Compound:st048918|FD-Score:4.28|P-value:1.79E-5 ID:SGTC_1797|Compound:st048695|FD-Score:-3.71|P-value:1.64E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-4.06|P-value:4.27E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.69|P-value:1.85E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.26|P-value:8.02E-4 ID:SGTC_2103|Compound:5378138|FD-Score:-3.22|P-value:9.29E-4 ID:SGTC_2212|Compound:7123476|FD-Score:3.70|P-value:1.77E-4 ID:SGTC_2219|Compound:9098279|FD-Score:-3.85|P-value:9.68E-5 ID:SGTC_2311|Compound:7694451|FD-Score:4.76|P-value:2.15E-6 ID:SGTC_2325|Compound:6158266|FD-Score:-3.64|P-value:2.16E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.32|P-value:6.84E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.20|P-value:2.46E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.45|P-value:8.58E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:4.05|P-value:4.53E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.62|P-value:3.87E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.65|P-value:2.09E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.72|P-value:1.64E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.35|P-value:6.01E-4 ID:SGTC_2713|Compound:st079149|FD-Score:4.76|P-value:2.17E-6 ID:SGTC_2742|Compound:clothiapine|FD-Score:4.41|P-value:1.04E-5 ID:SGTC_2884|Compound:9058502|FD-Score:-3.35|P-value:5.95E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.42|P-value:4.73E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.77|P-value:2.03E-6 ID:SGTC_2965|Compound:9082772|FD-Score:3.50|P-value:3.67E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.54|P-value:3.16E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.26|P-value:7.94E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.62|P-value:2.35E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.65|P-value:2.15E-4

Top fitness defect scores for YBR227C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_73 0327-0325 11.70 16.2 µM 6.05E-30 DNA damage response 4 6.11E-32
2 SGTC_1660 st012960 6.07 28.1 µM 2.24E-9 iron homeostasis 6 6.30E-10
3 SGTC_171 k064-0041 5.54 9.7 µM 4.31E-8 heme requiring 9 1.49E-8
4 SGTC_580 1123-0028 5.03 41.0 µM 5.90E-7 DNA damage response 12 2.44E-7
5 SGTC_785 1270-0111 5.01 65.3 µM 6.55E-7 9 2.73E-7
6 SGTC_2928 9011484 4.77 9.8 µM 2.03E-6 heme biosynthesis & mitochondrial translocase 21 9.14E-7
7 SGTC_2311 7694451 4.76 200.0 µM 2.15E-6 8 9.70E-7
8 SGTC_2713 st079149 4.76 53.4 µM 2.17E-6 10 9.80E-7
9 SGTC_963 1269-2853 4.61 151.0 µM 4.29E-6 18 2.03E-6
10 SGTC_955 1216-0110 4.58 33.0 µM 4.89E-6 sphingolipid biosynthesis & PDR1 48 2.34E-6
11 SGTC_2575 plumbagin 4.45 510.0 nM 8.58E-6 superoxide 29 4.26E-6
12 SGTC_2742 clothiapine 4.41 36.3 µM 1.04E-5 NEO1 4 5.21E-6
13 SGTC_1794 st048918 4.28 76.9 µM 1.79E-5 9 9.32E-6
14 SGTC_2567 aureobasidin a 4.20 60.0 nM 2.46E-5 83 1.32E-5
15 SGTC_521 r062-0005 4.09 13.8 µM 3.96E-5 14 2.18E-5
16 SGTC_2586 curcumin 4.05 80.0 µM 4.53E-5 iron homeostasis 47 2.52E-5
17 SGTC_288 1315-0019 3.98 35.1 µM 6.06E-5 RSC & ERG11 24 3.44E-5
18 SGTC_959 1222-0044 3.81 107.0 µM 1.19E-4 24 7.07E-5
19 SGTC_198 3454-2873 3.74 16.2 µM 1.50E-4 60S ribosome export 15 9.06E-5
20 SGTC_2658 polymyxin b sulfate 3.72 77.0 µM 1.64E-4 NEO1 49 9.95E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.193 1.95E-29 YBR035C PDX3 hom Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
0.164 1.30E-21 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.138 1.07E-15 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.120 2.51E-12 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.118 5.84E-12 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.113 5.57E-11 YDL119C_p YDL119C_p hom Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
0.107 5.27E-10 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.106 6.65E-10 YMR105C PGM2 hom Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress
0.102 2.62E-9 YJL158C CIS3 hom Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
0.097 1.89E-8 YMR144W_p YMR144W_p hom Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
0.096 2.32E-8 YLR346C_p YLR346C_p hom Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
0.095 3.08E-8 YNR027W BUD17 hom Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)
0.094 4.99E-8 YPR002W PDH1 hom Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
0.094 5.62E-8 YJL077C ICS3 hom Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2
0.087 5.19E-7 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene