YBR230C / OM14

Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR230C / OM14

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:-3.94|P-value:8.71E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.79|P-value:1.62E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.89|P-value:1.11E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-5.03|P-value:8.22E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.57|P-value:7.20E-6 ID:SGTC_430|Compound:0958-0115|FD-Score:3.48|P-value:4.76E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.61|P-value:3.07E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.32|P-value:8.15E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.46|P-value:4.81E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.37|P-value:6.88E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.77|P-value:1.74E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.42|P-value:5.97E-4 ID:SGTC_917|Compound:harmaline|FD-Score:4.31|P-value:2.16E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:4.83|P-value:2.33E-6 ID:SGTC_980|Compound:1473-0395|FD-Score:5.55|P-value:6.88E-8 ID:SGTC_993|Compound:3909-8757|FD-Score:3.46|P-value:5.15E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:5.71|P-value:3.04E-8 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.77|P-value:1.74E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:4.39|P-value:1.58E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.03|P-value:6.63E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.98|P-value:7.97E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.81|P-value:1.39E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.70|P-value:4.10E-6 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.55|P-value:3.84E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.77|P-value:1.77E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.41|P-value:5.68E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.75|P-value:1.77E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.71|P-value:2.01E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.27|P-value:9.19E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.45|P-value:5.33E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-3.93|P-value:9.04E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.36|P-value:6.75E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.15|P-value:4.13E-5 ID:SGTC_1948|Compound:st076329|FD-Score:3.94|P-value:9.37E-5 ID:SGTC_1952|Compound:st077036|FD-Score:-3.27|P-value:8.99E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-4.94|P-value:1.28E-6 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.98|P-value:7.52E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-5.36|P-value:1.64E-7 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-7.07|P-value:8.39E-12 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-8.20|P-value:2.93E-15 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.45|P-value:4.96E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.42|P-value:1.34E-7 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.76|P-value:3.12E-6 ID:SGTC_2716|Compound:st080858|FD-Score:3.30|P-value:8.77E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.27|P-value:9.26E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.86|P-value:1.25E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-5.12|P-value:5.33E-7 ID:SGTC_2841|Compound:9004761|FD-Score:-3.29|P-value:8.48E-4 ID:SGTC_2848|Compound:9016370|FD-Score:8.05|P-value:1.01E-14 ID:SGTC_2865|Compound:9030313|FD-Score:3.55|P-value:3.84E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.40|P-value:6.37E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.66|P-value:2.43E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-3.32|P-value:7.79E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-4.18|P-value:3.37E-5 ID:SGTC_2952|Compound:9073731|FD-Score:-3.84|P-value:1.25E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.41|P-value:6.03E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.35|P-value:7.55E-4 ID:SGTC_3189|Compound:9110682|FD-Score:-3.30|P-value:8.38E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.73|P-value:2.02E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.94|P-value:8.71E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.79|P-value:1.62E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.89|P-value:1.11E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-5.03|P-value:8.22E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.57|P-value:7.20E-6 ID:SGTC_430|Compound:0958-0115|FD-Score:3.48|P-value:4.76E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.61|P-value:3.07E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.32|P-value:8.15E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.46|P-value:4.81E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.37|P-value:6.88E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.77|P-value:1.74E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.42|P-value:5.97E-4 ID:SGTC_917|Compound:harmaline|FD-Score:4.31|P-value:2.16E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:4.83|P-value:2.33E-6 ID:SGTC_980|Compound:1473-0395|FD-Score:5.55|P-value:6.88E-8 ID:SGTC_993|Compound:3909-8757|FD-Score:3.46|P-value:5.15E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:5.71|P-value:3.04E-8 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.77|P-value:1.74E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:4.39|P-value:1.58E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.03|P-value:6.63E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.98|P-value:7.97E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.81|P-value:1.39E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.70|P-value:4.10E-6 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.55|P-value:3.84E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.77|P-value:1.77E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.41|P-value:5.68E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.75|P-value:1.77E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.71|P-value:2.01E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.27|P-value:9.19E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.45|P-value:5.33E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-3.93|P-value:9.04E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.36|P-value:6.75E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.15|P-value:4.13E-5 ID:SGTC_1948|Compound:st076329|FD-Score:3.94|P-value:9.37E-5 ID:SGTC_1952|Compound:st077036|FD-Score:-3.27|P-value:8.99E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-4.94|P-value:1.28E-6 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.98|P-value:7.52E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-5.36|P-value:1.64E-7 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-7.07|P-value:8.39E-12 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-8.20|P-value:2.93E-15 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.45|P-value:4.96E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.42|P-value:1.34E-7 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.76|P-value:3.12E-6 ID:SGTC_2716|Compound:st080858|FD-Score:3.30|P-value:8.77E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.27|P-value:9.26E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.86|P-value:1.25E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-5.12|P-value:5.33E-7 ID:SGTC_2841|Compound:9004761|FD-Score:-3.29|P-value:8.48E-4 ID:SGTC_2848|Compound:9016370|FD-Score:8.05|P-value:1.01E-14 ID:SGTC_2865|Compound:9030313|FD-Score:3.55|P-value:3.84E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.40|P-value:6.37E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.66|P-value:2.43E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-3.32|P-value:7.79E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-4.18|P-value:3.37E-5 ID:SGTC_2952|Compound:9073731|FD-Score:-3.84|P-value:1.25E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.41|P-value:6.03E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.35|P-value:7.55E-4 ID:SGTC_3189|Compound:9110682|FD-Score:-3.30|P-value:8.38E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.73|P-value:2.02E-4

Top fitness defect scores for YBR230C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2848 9016370 8.05 26.0 µM 1.01E-14 1 4.01E-16
2 SGTC_1008 4106-0037 5.71 6.0 µM 3.04E-8 PDR1 6 5.80E-9
3 SGTC_980 1473-0395 5.55 201.0 µM 6.88E-8 1 1.43E-8
4 SGTC_2633 5,7-dihydroxyisoflavone 5.42 100.0 µM 1.34E-7 11 2.97E-8
5 SGTC_977 1348-1378 4.83 135.0 µM 2.33E-6 12 6.98E-7
6 SGTC_2636 apigenin dimethyl ether 4.76 100.0 µM 3.12E-6 20 9.65E-7
7 SGTC_1257 0669-0121 4.70 16.0 µM 4.10E-6 13 1.30E-6
8 SGTC_402 epigallocatechin gallate 4.57 10.0 µM 7.20E-6 11 2.43E-6
9 SGTC_1023 4482-3888 4.39 16.0 µM 1.58E-5 TSC3-RPN4 6 5.79E-6
10 SGTC_917 harmaline 4.31 728.1 nM 2.16E-5 ergosterol biosynthesis 19 8.16E-6
11 SGTC_1941 st076221 4.15 61.8 µM 4.13E-5 sphingolipid biosynthesis & PDR1 69 1.67E-5
12 SGTC_1114 scopoletin 4.03 1.7 µM 6.63E-5 20 2.81E-5
13 SGTC_1165 k072-0275 3.98 30.3 µM 7.97E-5 42 3.44E-5
14 SGTC_1948 st076329 3.94 66.6 µM 9.37E-5 29 4.11E-5
15 SGTC_305 1682-2595 3.89 20.8 µM 1.11E-4 RNA processing & uracil transport 23 4.98E-5
16 SGTC_2766 oltipraz 3.86 83.9 µM 1.25E-4 heme requiring 26 5.64E-5
17 SGTC_213 1246-0773 3.79 967.0 nM 1.62E-4 24 7.53E-5
18 SGTC_882 0843-0131 3.77 351.0 µM 1.74E-4 19 8.13E-5
19 SGTC_1022 4477-0945 3.77 21.3 µM 1.74E-4 31 8.16E-5
20 SGTC_1283 0922-0125 3.77 16.4 µM 1.77E-4 28 8.32E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.52E-11 YDR233C RTN1 hom Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication
0.111 1.25E-10 YGR023W MTL1 hom Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p
0.098 1.49E-8 YER092W IES5 hom Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
0.083 1.37E-6 YBR180W DTR1 hom Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation
0.080 3.11E-6 YEL017W GTT3 hom Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
0.079 4.01E-6 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.078 6.08E-6 YJL157C FAR1 hom Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.078 6.14E-6 YBR115C LYS2 hom Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
0.076 9.68E-6 YOL055C THI20 hom Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p
0.076 1.03E-5 YNL172W APC1 het Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress
0.076 1.09E-5 YDR183W PLP1 hom Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators
0.075 1.49E-5 YDL012C YDL012C hom Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication
0.074 1.90E-5 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.074 1.99E-5 YCL074W YCL074W hom Pseudogene: encodes fragment of Ty Pol protein
0.072 3.19E-5 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress