YBR231C / SWC5

Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR231C / SWC5

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:-3.99|P-value:8.29E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.19|P-value:3.66E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.99|P-value:2.97E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:8.36|P-value:1.02E-11 ID:SGTC_108|Compound:0509-0257|FD-Score:3.86|P-value:9.16E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:13.20|P-value:1.76E-26 ID:SGTC_138|Compound:0850-0259|FD-Score:5.41|P-value:6.62E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:11.70|P-value:4.62E-21 ID:SGTC_149|Compound:3970-0822|FD-Score:5.36|P-value:8.19E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:13.30|P-value:7.75E-27 ID:SGTC_165|Compound:k038-0023|FD-Score:4.66|P-value:8.73E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:5.64|P-value:2.86E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:9.16|P-value:1.02E-13 ID:SGTC_207|Compound:4185-0010|FD-Score:7.29|P-value:2.48E-9 ID:SGTC_210|Compound:3551-0445|FD-Score:10.20|P-value:1.68E-16 ID:SGTC_212|Compound:3807-4682|FD-Score:10.50|P-value:2.70E-17 ID:SGTC_214|Compound:4373-3496|FD-Score:4.95|P-value:3.41E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:4.65|P-value:8.88E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:12.10|P-value:1.48E-22 ID:SGTC_227|Compound:fluconazole|FD-Score:3.84|P-value:9.71E-4 ID:SGTC_229|Compound:benomyl|FD-Score:12.60|P-value:2.72E-24 ID:SGTC_286|Compound:k060-0067|FD-Score:3.95|P-value:7.20E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:5.44|P-value:6.04E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.55|P-value:5.70E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:4.85|P-value:4.62E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:5.94|P-value:9.06E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:4.87|P-value:4.33E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.60|P-value:1.43E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-5.55|P-value:5.74E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:8.88|P-value:5.26E-13 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.17|P-value:5.00E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.86|P-value:4.61E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:4.49|P-value:1.46E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:4.52|P-value:1.34E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:14.60|P-value:8.86E-32 ID:SGTC_701|Compound:4424-0219|FD-Score:-4.25|P-value:3.99E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:6.09|P-value:4.97E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:11.10|P-value:2.91E-19 ID:SGTC_796|Compound:1234-0020|FD-Score:4.70|P-value:7.60E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:4.27|P-value:2.88E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.88|P-value:1.65E-8 ID:SGTC_809|Compound:3998-0021|FD-Score:-5.33|P-value:1.25E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:5.95|P-value:8.79E-7 ID:SGTC_837|Compound:0091-0265|FD-Score:4.28|P-value:2.77E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:6.12|P-value:4.32E-7 ID:SGTC_846|Compound:0335-0850|FD-Score:4.55|P-value:1.24E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:7.06|P-value:7.29E-9 ID:SGTC_902|Compound:1120-0002|FD-Score:3.99|P-value:6.34E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:5.54|P-value:4.17E-6 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.42|P-value:1.86E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.91|P-value:3.84E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:6.72|P-value:3.44E-8 ID:SGTC_1226|Compound:3909-7979|FD-Score:5.09|P-value:2.09E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:5.99|P-value:7.26E-7 ID:SGTC_1263|Compound:0774-1208|FD-Score:6.34|P-value:1.77E-7 ID:SGTC_1326|Compound:1431-2094|FD-Score:7.17|P-value:4.38E-9 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.32|P-value:9.25E-6 ID:SGTC_1626|Compound:st003712|FD-Score:5.03|P-value:2.58E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.96|P-value:3.21E-5 ID:SGTC_1643|Compound:st009866|FD-Score:9.21|P-value:7.65E-14 ID:SGTC_1723|Compound:st034307|FD-Score:8.54|P-value:3.67E-12 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.99|P-value:6.37E-4 ID:SGTC_1803|Compound:st050068|FD-Score:6.35|P-value:1.68E-7 ID:SGTC_1812|Compound:st052057|FD-Score:3.83|P-value:9.99E-4 ID:SGTC_1851|Compound:st056236|FD-Score:4.05|P-value:5.37E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.98|P-value:6.60E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:15.60|P-value:5.25E-36 ID:SGTC_1930|Compound:st074634|FD-Score:4.02|P-value:5.88E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-4.36|P-value:2.89E-4 ID:SGTC_2090|Compound:5301565|FD-Score:4.36|P-value:2.20E-4 ID:SGTC_2125|Compound:5246583|FD-Score:8.03|P-value:6.02E-11 ID:SGTC_2141|Compound:5621638|FD-Score:4.41|P-value:1.86E-4 ID:SGTC_2174|Compound:5790901|FD-Score:15.00|P-value:1.10E-33 ID:SGTC_2186|Compound:6124449|FD-Score:5.30|P-value:9.98E-6 ID:SGTC_2200|Compound:6600604|FD-Score:8.89|P-value:5.22E-13 ID:SGTC_2266|Compound:7929956|FD-Score:4.00|P-value:6.16E-4 ID:SGTC_2269|Compound:7935389|FD-Score:5.73|P-value:2.06E-6 ID:SGTC_2279|Compound:7948423|FD-Score:-4.76|P-value:8.63E-5 ID:SGTC_2289|Compound:7946404|FD-Score:3.98|P-value:6.51E-4 ID:SGTC_2319|Compound:6033012|FD-Score:8.69|P-value:1.61E-12 ID:SGTC_2352|Compound:9027995|FD-Score:6.86|P-value:1.79E-8 ID:SGTC_2469|Compound:5655019|FD-Score:5.51|P-value:4.59E-6 ID:SGTC_2479|Compound:5617353|FD-Score:4.36|P-value:2.19E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.38|P-value:2.05E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.07|P-value:5.10E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.49|P-value:9.30E-10 ID:SGTC_2584|Compound:androsterone|FD-Score:7.27|P-value:2.65E-9 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.24|P-value:3.10E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.06|P-value:5.25E-4 ID:SGTC_2793|Compound:7325131|FD-Score:4.24|P-value:3.13E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.34|P-value:2.31E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.03|P-value:5.66E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-5.34|P-value:1.23E-5 ID:SGTC_2997|Compound:9067075|FD-Score:6.34|P-value:1.78E-7 ID:SGTC_3008|Compound:9078912|FD-Score:-4.09|P-value:6.31E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.17|P-value:3.89E-4 ID:SGTC_3221|Compound:9128209|FD-Score:4.93|P-value:3.64E-5 ID:SGTC_3321|Compound:9137793|FD-Score:4.63|P-value:9.61E-5 ID:SGTC_3331|Compound:9141060|FD-Score:5.30|P-value:9.99E-6 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.99|P-value:8.29E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.19|P-value:3.66E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.99|P-value:2.97E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:8.36|P-value:1.02E-11 ID:SGTC_108|Compound:0509-0257|FD-Score:3.86|P-value:9.16E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:13.20|P-value:1.76E-26 ID:SGTC_138|Compound:0850-0259|FD-Score:5.41|P-value:6.62E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:11.70|P-value:4.62E-21 ID:SGTC_149|Compound:3970-0822|FD-Score:5.36|P-value:8.19E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:13.30|P-value:7.75E-27 ID:SGTC_165|Compound:k038-0023|FD-Score:4.66|P-value:8.73E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:5.64|P-value:2.86E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:9.16|P-value:1.02E-13 ID:SGTC_207|Compound:4185-0010|FD-Score:7.29|P-value:2.48E-9 ID:SGTC_210|Compound:3551-0445|FD-Score:10.20|P-value:1.68E-16 ID:SGTC_212|Compound:3807-4682|FD-Score:10.50|P-value:2.70E-17 ID:SGTC_214|Compound:4373-3496|FD-Score:4.95|P-value:3.41E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:4.65|P-value:8.88E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:12.10|P-value:1.48E-22 ID:SGTC_227|Compound:fluconazole|FD-Score:3.84|P-value:9.71E-4 ID:SGTC_229|Compound:benomyl|FD-Score:12.60|P-value:2.72E-24 ID:SGTC_286|Compound:k060-0067|FD-Score:3.95|P-value:7.20E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:5.44|P-value:6.04E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.55|P-value:5.70E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:4.85|P-value:4.62E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:5.94|P-value:9.06E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:4.87|P-value:4.33E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.60|P-value:1.43E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-5.55|P-value:5.74E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:8.88|P-value:5.26E-13 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.17|P-value:5.00E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.86|P-value:4.61E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:4.49|P-value:1.46E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:4.52|P-value:1.34E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:14.60|P-value:8.86E-32 ID:SGTC_701|Compound:4424-0219|FD-Score:-4.25|P-value:3.99E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:6.09|P-value:4.97E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:11.10|P-value:2.91E-19 ID:SGTC_796|Compound:1234-0020|FD-Score:4.70|P-value:7.60E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:4.27|P-value:2.88E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.88|P-value:1.65E-8 ID:SGTC_809|Compound:3998-0021|FD-Score:-5.33|P-value:1.25E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:5.95|P-value:8.79E-7 ID:SGTC_837|Compound:0091-0265|FD-Score:4.28|P-value:2.77E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:6.12|P-value:4.32E-7 ID:SGTC_846|Compound:0335-0850|FD-Score:4.55|P-value:1.24E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:7.06|P-value:7.29E-9 ID:SGTC_902|Compound:1120-0002|FD-Score:3.99|P-value:6.34E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:5.54|P-value:4.17E-6 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.42|P-value:1.86E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.91|P-value:3.84E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:6.72|P-value:3.44E-8 ID:SGTC_1226|Compound:3909-7979|FD-Score:5.09|P-value:2.09E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:5.99|P-value:7.26E-7 ID:SGTC_1263|Compound:0774-1208|FD-Score:6.34|P-value:1.77E-7 ID:SGTC_1326|Compound:1431-2094|FD-Score:7.17|P-value:4.38E-9 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.32|P-value:9.25E-6 ID:SGTC_1626|Compound:st003712|FD-Score:5.03|P-value:2.58E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.96|P-value:3.21E-5 ID:SGTC_1643|Compound:st009866|FD-Score:9.21|P-value:7.65E-14 ID:SGTC_1723|Compound:st034307|FD-Score:8.54|P-value:3.67E-12 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.99|P-value:6.37E-4 ID:SGTC_1803|Compound:st050068|FD-Score:6.35|P-value:1.68E-7 ID:SGTC_1812|Compound:st052057|FD-Score:3.83|P-value:9.99E-4 ID:SGTC_1851|Compound:st056236|FD-Score:4.05|P-value:5.37E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.98|P-value:6.60E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:15.60|P-value:5.25E-36 ID:SGTC_1930|Compound:st074634|FD-Score:4.02|P-value:5.88E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-4.36|P-value:2.89E-4 ID:SGTC_2090|Compound:5301565|FD-Score:4.36|P-value:2.20E-4 ID:SGTC_2125|Compound:5246583|FD-Score:8.03|P-value:6.02E-11 ID:SGTC_2141|Compound:5621638|FD-Score:4.41|P-value:1.86E-4 ID:SGTC_2174|Compound:5790901|FD-Score:15.00|P-value:1.10E-33 ID:SGTC_2186|Compound:6124449|FD-Score:5.30|P-value:9.98E-6 ID:SGTC_2200|Compound:6600604|FD-Score:8.89|P-value:5.22E-13 ID:SGTC_2266|Compound:7929956|FD-Score:4.00|P-value:6.16E-4 ID:SGTC_2269|Compound:7935389|FD-Score:5.73|P-value:2.06E-6 ID:SGTC_2279|Compound:7948423|FD-Score:-4.76|P-value:8.63E-5 ID:SGTC_2289|Compound:7946404|FD-Score:3.98|P-value:6.51E-4 ID:SGTC_2319|Compound:6033012|FD-Score:8.69|P-value:1.61E-12 ID:SGTC_2352|Compound:9027995|FD-Score:6.86|P-value:1.79E-8 ID:SGTC_2469|Compound:5655019|FD-Score:5.51|P-value:4.59E-6 ID:SGTC_2479|Compound:5617353|FD-Score:4.36|P-value:2.19E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.38|P-value:2.05E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.07|P-value:5.10E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.49|P-value:9.30E-10 ID:SGTC_2584|Compound:androsterone|FD-Score:7.27|P-value:2.65E-9 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.24|P-value:3.10E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.06|P-value:5.25E-4 ID:SGTC_2793|Compound:7325131|FD-Score:4.24|P-value:3.13E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.34|P-value:2.31E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.03|P-value:5.66E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-5.34|P-value:1.23E-5 ID:SGTC_2997|Compound:9067075|FD-Score:6.34|P-value:1.78E-7 ID:SGTC_3008|Compound:9078912|FD-Score:-4.09|P-value:6.31E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.17|P-value:3.89E-4 ID:SGTC_3221|Compound:9128209|FD-Score:4.93|P-value:3.64E-5 ID:SGTC_3321|Compound:9137793|FD-Score:4.63|P-value:9.61E-5 ID:SGTC_3331|Compound:9141060|FD-Score:5.30|P-value:9.99E-6

Top fitness defect scores for YBR231C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1875 nocodazole 15.60 6.0 µM 5.25E-36 tubulin folding & SWR complex 6 4.08E-55
2 SGTC_2174 5790901 15.00 200.0 µM 1.10E-33 tubulin folding & SWR complex 4 1.73E-51
3 SGTC_673 1082-0474 14.60 110.0 µM 8.86E-32 RSC complex & mRNA processing 3 1.66E-48
4 SGTC_158 k038-0087 13.30 26.4 µM 7.75E-27 ubiquinone biosynthesis & proteasome 16 8.76E-41
5 SGTC_137 0438-0332 13.20 85.4 µM 1.76E-26 ubiquinone biosynthesis & proteasome 18 3.14E-40
6 SGTC_229 benomyl 12.60 22.9 µM 2.72E-24 tubulin folding & SWR complex 8 8.27E-37
7 SGTC_221 trifluoperazine 12.10 10.3 µM 1.48E-22 NEO1-PIK1 37 4.25E-34
8 SGTC_142 0335-0849 11.70 62.7 µM 4.62E-21 ubiquinone biosynthesis & proteasome 23 9.09E-32
9 SGTC_794 k038-0031 11.10 316.0 µM 2.91E-19 ubiquinone biosynthesis & proteasome 11 5.80E-29
10 SGTC_212 3807-4682 10.50 38.8 µM 2.70E-17 tubulin folding & SWR complex 6 6.75E-26
11 SGTC_210 3551-0445 10.20 56.8 µM 1.68E-16 15 1.17E-24
12 SGTC_1643 st009866 9.21 20.2 µM 7.65E-14 11 1.60E-20
13 SGTC_200 k038-0079 9.16 37.5 µM 1.02E-13 ubiquinone biosynthesis & proteasome 11 2.51E-20
14 SGTC_2200 6600604 8.89 21.9 µM 5.22E-13 tubulin folding & SWR complex 13 3.16E-19
15 SGTC_514 4466-0038 8.88 2.6 nM 5.26E-13 cell wall 29 3.20E-19
16 SGTC_2319 6033012 8.69 152.6 µM 1.61E-12 tubulin folding & SWR complex 9 1.82E-18
17 SGTC_1723 st034307 8.54 2.5 µM 3.67E-12 mitochondrial processes 1 6.54E-18
18 SGTC_86 0417-1630 8.36 471.9 µM 1.02E-11 ubiquinone biosynthesis & proteasome 56 3.21E-17
19 SGTC_2125 5246583 8.03 200.0 µM 6.02E-11 tubulin folding & SWR complex 8 5.02E-16
20 SGTC_2582 agaric acid 7.49 100.0 µM 9.30E-10 redox potentiating 114 3.49E-14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.592 3.56E-316 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.567 3.33E-285 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.564 7.68E-281 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.559 2.35E-275 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.528 2.61E-240 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.421 4.86E-144 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.387 1.86E-120 YOL012C HTZ1 hom Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
0.367 2.77E-107 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.342 1.96E-92 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.334 5.41E-88 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.307 3.56E-74 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.307 4.24E-74 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.297 3.80E-69 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.289 1.54E-65 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.286 4.24E-64 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2