YBR232C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR232C / YBR232C

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:-3.68|P-value:8.24E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.17|P-value:5.74E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:3.69|P-value:7.75E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:3.11|P-value:7.25E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.39|P-value:2.59E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.17|P-value:5.77E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-4.13|P-value:1.15E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:3.04|P-value:9.32E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.23|P-value:4.77E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.17|P-value:5.80E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.38|P-value:2.65E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.17|P-value:5.88E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:7.26|P-value:5.03E-14 ID:SGTC_852|Compound:0418-0143|FD-Score:3.32|P-value:3.36E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.61|P-value:1.09E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.04|P-value:9.21E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.55|P-value:1.59E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.28|P-value:3.94E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.88|P-value:3.58E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.16|P-value:1.02E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.71|P-value:7.15E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.48|P-value:1.80E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.07|P-value:8.17E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.20|P-value:5.23E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.84|P-value:4.23E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.25|P-value:4.32E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.36|P-value:2.91E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.08|P-value:8.13E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.30|P-value:5.32E-6 ID:SGTC_1634|Compound:st006576|FD-Score:3.97|P-value:2.34E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.03|P-value:9.41E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.49|P-value:1.72E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.50|P-value:1.70E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.03|P-value:9.68E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.76|P-value:5.92E-5 ID:SGTC_2097|Compound:5376186|FD-Score:3.98|P-value:2.23E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.12|P-value:6.93E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.50|P-value:1.70E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.48|P-value:2.23E-6 ID:SGTC_2180|Compound:6301957|FD-Score:3.03|P-value:9.59E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.54|P-value:1.44E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.07|P-value:1.52E-5 ID:SGTC_2481|Compound:5478948|FD-Score:7.07|P-value:2.12E-13 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.27|P-value:6.22E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.80|P-value:5.10E-5 ID:SGTC_2691|Compound:st077356|FD-Score:3.44|P-value:2.14E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.65|P-value:9.26E-5 ID:SGTC_2887|Compound:9044784|FD-Score:3.71|P-value:7.24E-5 ID:SGTC_2922|Compound:7999257|FD-Score:3.67|P-value:8.56E-5 ID:SGTC_2947|Compound:9072639|FD-Score:-4.48|P-value:2.24E-6 ID:SGTC_2994|Compound:9053520|FD-Score:-3.08|P-value:7.95E-4 ID:SGTC_3110|Compound:9122132|FD-Score:4.37|P-value:3.70E-6 ID:SGTC_3193|Compound:9111931|FD-Score:4.27|P-value:5.99E-6 ID:SGTC_14|Compound:0354-0009|FD-Score:-3.68|P-value:8.24E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.17|P-value:5.74E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:3.69|P-value:7.75E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:3.11|P-value:7.25E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.39|P-value:2.59E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.17|P-value:5.77E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-4.13|P-value:1.15E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:3.04|P-value:9.32E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.23|P-value:4.77E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.17|P-value:5.80E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.38|P-value:2.65E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.17|P-value:5.88E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:7.26|P-value:5.03E-14 ID:SGTC_852|Compound:0418-0143|FD-Score:3.32|P-value:3.36E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.61|P-value:1.09E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.04|P-value:9.21E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.55|P-value:1.59E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.28|P-value:3.94E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.88|P-value:3.58E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.16|P-value:1.02E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.71|P-value:7.15E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.48|P-value:1.80E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.07|P-value:8.17E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.20|P-value:5.23E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.84|P-value:4.23E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.25|P-value:4.32E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.36|P-value:2.91E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.08|P-value:8.13E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.30|P-value:5.32E-6 ID:SGTC_1634|Compound:st006576|FD-Score:3.97|P-value:2.34E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.03|P-value:9.41E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.49|P-value:1.72E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.50|P-value:1.70E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.03|P-value:9.68E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.76|P-value:5.92E-5 ID:SGTC_2097|Compound:5376186|FD-Score:3.98|P-value:2.23E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.12|P-value:6.93E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.50|P-value:1.70E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.48|P-value:2.23E-6 ID:SGTC_2180|Compound:6301957|FD-Score:3.03|P-value:9.59E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.54|P-value:1.44E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.07|P-value:1.52E-5 ID:SGTC_2481|Compound:5478948|FD-Score:7.07|P-value:2.12E-13 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.27|P-value:6.22E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.80|P-value:5.10E-5 ID:SGTC_2691|Compound:st077356|FD-Score:3.44|P-value:2.14E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.65|P-value:9.26E-5 ID:SGTC_2887|Compound:9044784|FD-Score:3.71|P-value:7.24E-5 ID:SGTC_2922|Compound:7999257|FD-Score:3.67|P-value:8.56E-5 ID:SGTC_2947|Compound:9072639|FD-Score:-4.48|P-value:2.24E-6 ID:SGTC_2994|Compound:9053520|FD-Score:-3.08|P-value:7.95E-4 ID:SGTC_3110|Compound:9122132|FD-Score:4.37|P-value:3.70E-6 ID:SGTC_3193|Compound:9111931|FD-Score:4.27|P-value:5.99E-6

Top fitness defect scores for YBR232C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_834 0312-0008 7.26 75.7 µM 5.03E-14 NEO1 11 1.90E-13
2 SGTC_2481 5478948 7.07 45.2 µM 2.12E-13 PDR1 5 7.48E-13
3 SGTC_964 1287-0107 4.55 19.4 µM 1.59E-6 cell wall 24 2.73E-6
4 SGTC_2178 5812956 4.48 200.0 µM 2.23E-6 7 3.76E-6
5 SGTC_3110 9122132 4.37 49.5 µM 3.70E-6 redox potentiating 16 6.08E-6
6 SGTC_1630 st005209 4.30 31.3 µM 5.32E-6 17 8.61E-6
7 SGTC_3193 9111931 4.27 49.5 µM 5.99E-6 19 9.64E-6
8 SGTC_2536 dehydroabietamide 4.27 32.0 µM 6.22E-6 27 9.99E-6
9 SGTC_1035 k081-0041 4.16 55.2 µM 1.02E-5 Golgi 16 1.61E-5
10 SGTC_2420 aureobasidin a 4.07 50.0 nM 1.52E-5 37 2.35E-5
11 SGTC_2097 5376186 3.98 200.0 µM 2.23E-5 16 3.38E-5
12 SGTC_1634 st006576 3.97 41.0 µM 2.34E-5 TSC3-RPN4 18 3.54E-5
13 SGTC_1172 0370-0043 3.84 85.0 µM 4.23E-5 26 6.24E-5
14 SGTC_2088 5278280 3.76 127.4 µM 5.92E-5 28 8.60E-5
15 SGTC_1036 k216-0215 3.71 33.5 µM 7.15E-5 mitochondrial response to ROS 61 1.03E-4
16 SGTC_2887 9044784 3.71 58.4 µM 7.24E-5 fatty acid desaturase (OLE1) 36 1.04E-4
17 SGTC_347 4534-1311 3.69 26.2 µM 7.75E-5 RPP1 & pyrimidine depletion 18 1.11E-4
18 SGTC_2922 7999257 3.67 32.5 µM 8.56E-5 14 1.22E-4
19 SGTC_2854 9024559 3.65 71.4 µM 9.26E-5 34 1.32E-4
20 SGTC_2155 5570423 3.50 76.0 µM 1.70E-4 ergosterol biosynthesis 17 2.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.22E-12 YNR053C NOG2 het Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
0.111 1.01E-10 YBR062C_p YBR062C_p hom Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.
0.100 7.13E-9 YBR152W SPP381 het mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p
0.090 1.53E-7 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.089 2.60E-7 YLR307W CDA1 hom Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
0.085 9.00E-7 YBR159W IFA38 hom Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
0.082 2.24E-6 YIL104C SHQ1 het Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones
0.079 5.11E-6 YIL087C AIM19 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth
0.078 5.84E-6 YGR052W_p FMP48_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.078 6.83E-6 YGR198W YPP1 het Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
0.077 7.30E-6 YAL038W CDC19 het Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
0.077 8.56E-6 YBL014C RRN6 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.076 9.36E-6 YBR241C_p YBR241C_p hom Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
0.076 1.12E-5 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.074 1.63E-5 YFL007W BLM10 hom Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200