YBR233W / PBP2

RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR233W / PBP2

Click on Significant Values for Screen Details ID:SGTC_92|Compound:0063-0024|FD-Score:3.37|P-value:4.03E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.53|P-value:2.20E-4 ID:SGTC_406|Compound:estrone|FD-Score:-3.18|P-value:6.26E-4 ID:SGTC_480|Compound:am 92016|FD-Score:-3.35|P-value:3.45E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.46|P-value:2.81E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.79|P-value:6.11E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.25|P-value:6.05E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.37|P-value:3.10E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:4.46|P-value:4.31E-6 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.23|P-value:5.16E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.21|P-value:7.14E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.11|P-value:2.09E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:-5.10|P-value:1.25E-7 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.57|P-value:1.88E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.87|P-value:4.37E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.52|P-value:2.30E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:5.05|P-value:2.33E-7 ID:SGTC_1467|Compound:k284-1082|FD-Score:5.64|P-value:8.96E-9 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.80|P-value:7.69E-5 ID:SGTC_1784|Compound:st039334|FD-Score:-3.47|P-value:2.18E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.08|P-value:8.79E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.37|P-value:4.03E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.98|P-value:3.69E-5 ID:SGTC_2240|Compound:6690706|FD-Score:4.52|P-value:3.30E-6 ID:SGTC_2256|Compound:7954252|FD-Score:3.20|P-value:7.38E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.09|P-value:8.61E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.71|P-value:8.39E-5 ID:SGTC_2434|Compound:5670830|FD-Score:4.43|P-value:4.87E-6 ID:SGTC_2482|Compound:5981709|FD-Score:5.48|P-value:2.20E-8 ID:SGTC_2483|Compound:5729050|FD-Score:-3.13|P-value:7.57E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.71|P-value:1.27E-6 ID:SGTC_2842|Compound:9000675|FD-Score:4.68|P-value:1.51E-6 ID:SGTC_3181|Compound:9108277|FD-Score:3.85|P-value:6.37E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:3.37|P-value:4.03E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.53|P-value:2.20E-4 ID:SGTC_406|Compound:estrone|FD-Score:-3.18|P-value:6.26E-4 ID:SGTC_480|Compound:am 92016|FD-Score:-3.35|P-value:3.45E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.46|P-value:2.81E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.79|P-value:6.11E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.25|P-value:6.05E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.37|P-value:3.10E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:4.46|P-value:4.31E-6 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.23|P-value:5.16E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.21|P-value:7.14E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.11|P-value:2.09E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:-5.10|P-value:1.25E-7 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.57|P-value:1.88E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.87|P-value:4.37E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.52|P-value:2.30E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:5.05|P-value:2.33E-7 ID:SGTC_1467|Compound:k284-1082|FD-Score:5.64|P-value:8.96E-9 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.80|P-value:7.69E-5 ID:SGTC_1784|Compound:st039334|FD-Score:-3.47|P-value:2.18E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.08|P-value:8.79E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.37|P-value:4.03E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.98|P-value:3.69E-5 ID:SGTC_2240|Compound:6690706|FD-Score:4.52|P-value:3.30E-6 ID:SGTC_2256|Compound:7954252|FD-Score:3.20|P-value:7.38E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.09|P-value:8.61E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.71|P-value:8.39E-5 ID:SGTC_2434|Compound:5670830|FD-Score:4.43|P-value:4.87E-6 ID:SGTC_2482|Compound:5981709|FD-Score:5.48|P-value:2.20E-8 ID:SGTC_2483|Compound:5729050|FD-Score:-3.13|P-value:7.57E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.71|P-value:1.27E-6 ID:SGTC_2842|Compound:9000675|FD-Score:4.68|P-value:1.51E-6 ID:SGTC_3181|Compound:9108277|FD-Score:3.85|P-value:6.37E-5

Top fitness defect scores for YBR233W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1467 k284-1082 5.64 293.0 µM 8.96E-9 4 8.69E-9
2 SGTC_2482 5981709 5.48 142.7 µM 2.20E-8 PDR1 14 2.13E-8
3 SGTC_1289 0976-0073 5.05 69.1 µM 2.33E-7 4 2.23E-7
4 SGTC_2567 aureobasidin a 4.71 60.0 nM 1.27E-6 64 1.21E-6
5 SGTC_2842 9000675 4.68 19.5 µM 1.51E-6 10 1.44E-6
6 SGTC_2240 6690706 4.52 185.9 µM 3.30E-6 10 3.14E-6
7 SGTC_747 3448-8087 4.46 38.7 µM 4.31E-6 15 4.10E-6
8 SGTC_2434 5670830 4.43 169.9 µM 4.87E-6 16 4.63E-6
9 SGTC_916 4466-0038 4.11 42.0 nM 2.09E-5 cell wall 63 1.98E-5
10 SGTC_2050 5263056 3.98 171.0 µM 3.69E-5 fatty acid desaturase (OLE1) 41 3.49E-5
11 SGTC_3181 9108277 3.85 49.5 µM 6.37E-5 iron homeostasis 19 6.02E-5
12 SGTC_1541 2',3',6-trimethoxyflavone 3.80 64.0 µM 7.69E-5 17 7.27E-5
13 SGTC_1027 k015-0025 3.57 8.7 µM 1.88E-4 36 1.77E-4
14 SGTC_151 3013-0144 3.53 2.3 µM 2.20E-4 iron homeostasis 44 2.08E-4
15 SGTC_1285 0929-0069 3.52 65.5 µM 2.30E-4 34 2.17E-4
16 SGTC_560 2332-1943 3.46 155.0 µM 2.81E-4 21 2.66E-4
17 SGTC_1969 st069479 3.37 40.1 µM 4.03E-4 23 3.80E-4
18 SGTC_92 0063-0024 3.37 660.9 µM 4.03E-4 25 3.81E-4
19 SGTC_684 1140-0066 3.25 328.0 µM 6.05E-4 Golgi 65 5.71E-4
20 SGTC_903 1134-0042 3.21 114.0 µM 7.14E-4 54 6.73E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 9.13E-29 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.121 1.84E-12 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.109 2.52E-10 YER114C BOI2 hom Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication
0.099 9.10E-9 YOR367W SCP1 hom Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin
0.097 1.89E-8 YDR118W APC4 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
0.094 5.28E-8 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.093 6.74E-8 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.092 8.54E-8 YCL009C ILV6 hom Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
0.090 1.77E-7 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.089 2.51E-7 YGL169W SUA5 het Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family
0.088 3.24E-7 YGR042W YGR042W hom Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress
0.087 4.13E-7 YHR107C CDC12 het Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells
0.085 8.06E-7 YLR318W EST2 hom Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia
0.085 9.62E-7 YEL033W_p MTC7_p hom Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
0.083 1.39E-6 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis