YBR234C / ARC40

Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR234C / ARC40

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-4.70|P-value:4.97E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:4.39|P-value:2.79E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:4.93|P-value:1.64E-7 ID:SGTC_364|Compound:0083-0097|FD-Score:4.11|P-value:1.05E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.32|P-value:3.04E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.76|P-value:4.98E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:3.87|P-value:3.11E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.66|P-value:7.77E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:-5.29|P-value:1.92E-8 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.48|P-value:1.45E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.52|P-value:1.25E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.81|P-value:3.59E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:3.58|P-value:1.08E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:-4.08|P-value:1.07E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:5.01|P-value:1.06E-7 ID:SGTC_881|Compound:0833-0569|FD-Score:4.44|P-value:2.15E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:4.35|P-value:3.43E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:3.29|P-value:3.30E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.50|P-value:1.50E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:4.10|P-value:1.09E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.05|P-value:7.30E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.48|P-value:1.45E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.23|P-value:3.78E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.52|P-value:1.48E-6 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.17|P-value:5.32E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.47|P-value:1.84E-6 ID:SGTC_1219|Compound:1469-0211|FD-Score:5.33|P-value:1.72E-8 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.79|P-value:3.59E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.14|P-value:5.85E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.23|P-value:3.86E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.27|P-value:3.24E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-4.09|P-value:1.04E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.03|P-value:8.66E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.23|P-value:4.26E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.27|P-value:3.31E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.48|P-value:1.62E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.03|P-value:1.55E-5 ID:SGTC_1633|Compound:st005664|FD-Score:3.35|P-value:2.71E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.27|P-value:2.43E-8 ID:SGTC_1693|Compound:xanthone|FD-Score:3.49|P-value:1.54E-4 ID:SGTC_1761|Compound:st044296|FD-Score:3.39|P-value:2.25E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-4.11|P-value:9.30E-6 ID:SGTC_2058|Compound:5236698|FD-Score:3.12|P-value:6.34E-4 ID:SGTC_2198|Compound:6589944|FD-Score:-3.39|P-value:2.09E-4 ID:SGTC_2229|Compound:7354935|FD-Score:3.68|P-value:6.90E-5 ID:SGTC_2254|Compound:7938975|FD-Score:4.12|P-value:9.98E-6 ID:SGTC_2289|Compound:7946404|FD-Score:3.44|P-value:1.88E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.19|P-value:7.12E-6 ID:SGTC_2364|Compound:9055074|FD-Score:3.27|P-value:3.67E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.00|P-value:9.65E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.16|P-value:5.49E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.26|P-value:3.74E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.89|P-value:2.61E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.45|P-value:1.62E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.08|P-value:6.61E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.46|P-value:1.74E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.15|P-value:5.63E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.83|P-value:3.68E-5 ID:SGTC_2885|Compound:9057732|FD-Score:-3.78|P-value:4.15E-5 ID:SGTC_3050|Compound:9093513|FD-Score:-3.10|P-value:6.20E-4 ID:SGTC_3051|Compound:9093778|FD-Score:-3.26|P-value:3.36E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-3.30|P-value:2.98E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.41|P-value:2.10E-4 ID:SGTC_3327|Compound:9140648|FD-Score:4.53|P-value:1.38E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.70|P-value:4.97E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:4.39|P-value:2.79E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:4.93|P-value:1.64E-7 ID:SGTC_364|Compound:0083-0097|FD-Score:4.11|P-value:1.05E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.32|P-value:3.04E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.76|P-value:4.98E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:3.87|P-value:3.11E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.66|P-value:7.77E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:-5.29|P-value:1.92E-8 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.48|P-value:1.45E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.52|P-value:1.25E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.81|P-value:3.59E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:3.58|P-value:1.08E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:-4.08|P-value:1.07E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:5.01|P-value:1.06E-7 ID:SGTC_881|Compound:0833-0569|FD-Score:4.44|P-value:2.15E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:4.35|P-value:3.43E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:3.29|P-value:3.30E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.50|P-value:1.50E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:4.10|P-value:1.09E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.05|P-value:7.30E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.48|P-value:1.45E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.23|P-value:3.78E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.52|P-value:1.48E-6 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.17|P-value:5.32E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.47|P-value:1.84E-6 ID:SGTC_1219|Compound:1469-0211|FD-Score:5.33|P-value:1.72E-8 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.79|P-value:3.59E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.14|P-value:5.85E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.23|P-value:3.86E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.27|P-value:3.24E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-4.09|P-value:1.04E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.03|P-value:8.66E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.23|P-value:4.26E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.27|P-value:3.31E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.48|P-value:1.62E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.03|P-value:1.55E-5 ID:SGTC_1633|Compound:st005664|FD-Score:3.35|P-value:2.71E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.27|P-value:2.43E-8 ID:SGTC_1693|Compound:xanthone|FD-Score:3.49|P-value:1.54E-4 ID:SGTC_1761|Compound:st044296|FD-Score:3.39|P-value:2.25E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-4.11|P-value:9.30E-6 ID:SGTC_2058|Compound:5236698|FD-Score:3.12|P-value:6.34E-4 ID:SGTC_2198|Compound:6589944|FD-Score:-3.39|P-value:2.09E-4 ID:SGTC_2229|Compound:7354935|FD-Score:3.68|P-value:6.90E-5 ID:SGTC_2254|Compound:7938975|FD-Score:4.12|P-value:9.98E-6 ID:SGTC_2289|Compound:7946404|FD-Score:3.44|P-value:1.88E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.19|P-value:7.12E-6 ID:SGTC_2364|Compound:9055074|FD-Score:3.27|P-value:3.67E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.00|P-value:9.65E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.16|P-value:5.49E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.26|P-value:3.74E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.89|P-value:2.61E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.45|P-value:1.62E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.08|P-value:6.61E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.46|P-value:1.74E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.15|P-value:5.63E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.83|P-value:3.68E-5 ID:SGTC_2885|Compound:9057732|FD-Score:-3.78|P-value:4.15E-5 ID:SGTC_3050|Compound:9093513|FD-Score:-3.10|P-value:6.20E-4 ID:SGTC_3051|Compound:9093778|FD-Score:-3.26|P-value:3.36E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-3.30|P-value:2.98E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.41|P-value:2.10E-4 ID:SGTC_3327|Compound:9140648|FD-Score:4.53|P-value:1.38E-6

Top fitness defect scores for YBR234C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1219 1469-0211 5.33 33.1 µM 1.72E-8 1 4.96E-8 0.85
2 SGTC_1635 st007035 5.27 42.4 µM 2.43E-8 11 6.84E-8 0.40
3 SGTC_866 0495-0101 5.01 262.0 µM 1.06E-7 60S ribosome export 4 2.70E-7 0.42
4 SGTC_360 0957-0399 4.93 1.0 µM 1.64E-7 cell wall 4 4.05E-7 0.08
5 SGTC_1239 0337-0584 4.79 35.4 µM 3.59E-7 unfolded protein response 22 8.43E-7 0.03
6 SGTC_3327 9140648 4.53 26.9 µM 1.38E-6 8 2.96E-6 0.28
7 SGTC_1113 artemisinin 4.52 1.2 µM 1.48E-6 heme biosynthesis & mitochondrial translocase 29 3.16E-6 0.14
8 SGTC_1129 3453-1384 4.47 223.0 µM 1.84E-6 12 3.87E-6 0.05
9 SGTC_881 0833-0569 4.44 170.0 µM 2.15E-6 1 4.49E-6 0.28
10 SGTC_158 k038-0087 4.39 26.4 µM 2.79E-6 ubiquinone biosynthesis & proteasome 28 5.70E-6 0.03
11 SGTC_922 1866-0035 4.35 480.0 µM 3.43E-6 excess fatty acid 9 6.93E-6 0.17
12 SGTC_2344 7990960 4.19 77.0 µM 7.12E-6 34 1.37E-5 0.02
13 SGTC_2254 7938975 4.12 95.2 µM 9.98E-6 7 1.88E-5 0.17
14 SGTC_364 0083-0097 4.11 67.7 µM 1.05E-5 6 1.97E-5 0.01
15 SGTC_989 1501-0895 4.10 10.3 µM 1.09E-5 2 2.03E-5 0.23
16 SGTC_1567 st069303 4.03 68.4 µM 1.55E-5 mitochondrial processes 12 2.83E-5 0.16
17 SGTC_571 k831-0106 3.87 44.2 µM 3.11E-5 5 5.43E-5 0.08
18 SGTC_2820 7989630 3.83 71.4 µM 3.68E-5 ERG2 5 6.35E-5 0.23
19 SGTC_464 bw-b 70c 3.76 158.0 µM 4.98E-5 9 8.43E-5 0.06
20 SGTC_2229 7354935 3.68 190.0 µM 6.90E-5 RSC complex & mRNA processing 21 1.14E-4 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 1.09E-27 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.137 1.74E-15 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.133 1.15E-14 YGL184C STR3 hom Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p
0.124 4.53E-13 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.121 2.34E-12 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.119 5.07E-12 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.118 6.17E-12 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.116 1.94E-11 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.110 1.80E-10 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.108 3.57E-10 YOL027C MDM38 hom Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
0.107 4.28E-10 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.105 9.45E-10 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.104 1.44E-9 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.098 1.11E-8 YDR427W RPN9 het Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress
0.098 1.43E-8 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p