YBR237W / PRP5

RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR237W / PRP5

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:-3.50|P-value:5.10E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.06|P-value:3.70E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.58|P-value:3.96E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:4.18|P-value:2.06E-6 ID:SGTC_235|Compound:0330-0087|FD-Score:3.59|P-value:3.83E-5 ID:SGTC_251|Compound:melphalan|FD-Score:2.95|P-value:5.77E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:2.84|P-value:8.79E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.15|P-value:6.44E-9 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.34|P-value:1.05E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-4.58|P-value:1.92E-7 ID:SGTC_288|Compound:1315-0019|FD-Score:2.94|P-value:5.99E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:4.01|P-value:4.99E-6 ID:SGTC_347|Compound:4534-1311|FD-Score:5.20|P-value:4.81E-9 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.02|P-value:3.89E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-4.92|P-value:2.42E-8 ID:SGTC_407|Compound:eburnamonine|FD-Score:2.96|P-value:5.67E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.43|P-value:7.86E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:3.43|P-value:7.96E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.16|P-value:2.53E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.35|P-value:9.74E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:4.51|P-value:3.34E-7 ID:SGTC_968|Compound:1309-0633|FD-Score:3.61|P-value:3.46E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.02|P-value:4.34E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.96|P-value:6.18E-6 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.95|P-value:2.29E-8 ID:SGTC_1416|Compound:3966-0321|FD-Score:-3.76|P-value:1.50E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.81|P-value:1.36E-5 ID:SGTC_1606|Compound:st000094|FD-Score:2.99|P-value:4.93E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.21|P-value:2.04E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.90|P-value:3.13E-8 ID:SGTC_1726|Compound:st035556|FD-Score:-2.93|P-value:5.71E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.07|P-value:3.56E-4 ID:SGTC_1771|Compound:st048882|FD-Score:2.84|P-value:8.88E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.89|P-value:8.79E-6 ID:SGTC_1982|Compound:st072467|FD-Score:3.86|P-value:1.04E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.03|P-value:4.23E-4 ID:SGTC_2070|Compound:5230947|FD-Score:2.89|P-value:7.22E-4 ID:SGTC_2084|Compound:5306078|FD-Score:4.01|P-value:4.87E-6 ID:SGTC_2204|Compound:7233102|FD-Score:3.47|P-value:6.40E-5 ID:SGTC_2238|Compound:6671620|FD-Score:3.17|P-value:2.40E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.01|P-value:4.65E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.89|P-value:9.16E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.03|P-value:3.77E-4 ID:SGTC_2473|Compound:5854593|FD-Score:2.88|P-value:7.49E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.10|P-value:2.90E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.43|P-value:7.67E-5 ID:SGTC_3001|Compound:9076041|FD-Score:3.67|P-value:2.64E-5 ID:SGTC_3010|Compound:9080089|FD-Score:2.88|P-value:7.50E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.57|P-value:4.21E-5 ID:SGTC_3054|Compound:9094397|FD-Score:3.16|P-value:2.45E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.80|P-value:1.42E-5 ID:SGTC_3207|Compound:9114163|FD-Score:4.13|P-value:2.57E-6 ID:SGTC_3209|Compound:9113616|FD-Score:-3.89|P-value:7.89E-6 ID:SGTC_3319|Compound:9138450|FD-Score:3.17|P-value:2.41E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.50|P-value:5.10E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.06|P-value:3.70E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.58|P-value:3.96E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:4.18|P-value:2.06E-6 ID:SGTC_235|Compound:0330-0087|FD-Score:3.59|P-value:3.83E-5 ID:SGTC_251|Compound:melphalan|FD-Score:2.95|P-value:5.77E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:2.84|P-value:8.79E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.15|P-value:6.44E-9 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.34|P-value:1.05E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-4.58|P-value:1.92E-7 ID:SGTC_288|Compound:1315-0019|FD-Score:2.94|P-value:5.99E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:4.01|P-value:4.99E-6 ID:SGTC_347|Compound:4534-1311|FD-Score:5.20|P-value:4.81E-9 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.02|P-value:3.89E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-4.92|P-value:2.42E-8 ID:SGTC_407|Compound:eburnamonine|FD-Score:2.96|P-value:5.67E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.43|P-value:7.86E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:3.43|P-value:7.96E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.16|P-value:2.53E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.35|P-value:9.74E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:4.51|P-value:3.34E-7 ID:SGTC_968|Compound:1309-0633|FD-Score:3.61|P-value:3.46E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.02|P-value:4.34E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.96|P-value:6.18E-6 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.95|P-value:2.29E-8 ID:SGTC_1416|Compound:3966-0321|FD-Score:-3.76|P-value:1.50E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.81|P-value:1.36E-5 ID:SGTC_1606|Compound:st000094|FD-Score:2.99|P-value:4.93E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.21|P-value:2.04E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.90|P-value:3.13E-8 ID:SGTC_1726|Compound:st035556|FD-Score:-2.93|P-value:5.71E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.07|P-value:3.56E-4 ID:SGTC_1771|Compound:st048882|FD-Score:2.84|P-value:8.88E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.89|P-value:8.79E-6 ID:SGTC_1982|Compound:st072467|FD-Score:3.86|P-value:1.04E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.03|P-value:4.23E-4 ID:SGTC_2070|Compound:5230947|FD-Score:2.89|P-value:7.22E-4 ID:SGTC_2084|Compound:5306078|FD-Score:4.01|P-value:4.87E-6 ID:SGTC_2204|Compound:7233102|FD-Score:3.47|P-value:6.40E-5 ID:SGTC_2238|Compound:6671620|FD-Score:3.17|P-value:2.40E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.01|P-value:4.65E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.89|P-value:9.16E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.03|P-value:3.77E-4 ID:SGTC_2473|Compound:5854593|FD-Score:2.88|P-value:7.49E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.10|P-value:2.90E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.43|P-value:7.67E-5 ID:SGTC_3001|Compound:9076041|FD-Score:3.67|P-value:2.64E-5 ID:SGTC_3010|Compound:9080089|FD-Score:2.88|P-value:7.50E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.57|P-value:4.21E-5 ID:SGTC_3054|Compound:9094397|FD-Score:3.16|P-value:2.45E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.80|P-value:1.42E-5 ID:SGTC_3207|Compound:9114163|FD-Score:4.13|P-value:2.57E-6 ID:SGTC_3209|Compound:9113616|FD-Score:-3.89|P-value:7.89E-6 ID:SGTC_3319|Compound:9138450|FD-Score:3.17|P-value:2.41E-4

Top fitness defect scores for YBR237W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_347 4534-1311 5.20 26.2 µM 4.81E-9 RPP1 & pyrimidine depletion 2 1.00E-7 1.23
2 SGTC_273 hydroxyurea 5.15 18.1 mM 6.44E-9 heme biosynthesis & mitochondrial translocase 10 1.28E-7 0.00
3 SGTC_1409 3909-8004 4.95 61.9 µM 2.29E-8 3 3.62E-7 1.24
4 SGTC_1717 st033143 4.90 58.0 µM 3.13E-8 3 4.70E-7 0.56
5 SGTC_960 1222-0186 4.51 7.7 µM 3.34E-7 6 3.31E-6 0.14
6 SGTC_151 3013-0144 4.18 2.3 µM 2.06E-6 iron homeostasis 7 1.49E-5 0.14
7 SGTC_3207 9114163 4.13 49.5 µM 2.57E-6 9 1.79E-5 0.08
8 SGTC_2084 5306078 4.01 60.6 µM 4.87E-6 2 3.03E-5 0.16
9 SGTC_307 1501-1223 4.01 22.3 µM 4.99E-6 5 3.09E-5 0.17
10 SGTC_1272 0839-0021 3.96 27.0 µM 6.18E-6 8 3.69E-5 0.17
11 SGTC_1980 st071811 3.89 45.7 µM 8.79E-6 RPP1 & pyrimidine depletion 4 4.94E-5 0.26
12 SGTC_2331 7980721 3.89 200.0 µM 9.16E-6 13 5.11E-5 0.12
13 SGTC_1982 st072467 3.86 71.9 µM 1.04E-5 8 5.67E-5 0.25
14 SGTC_1511 0906-3109 3.81 28.5 µM 1.36E-5 excess fatty acid 14 7.07E-5 0.23
15 SGTC_3117 9124945 3.80 49.5 µM 1.42E-5 1 7.32E-5 0.30
16 SGTC_3001 9076041 3.67 71.4 µM 2.64E-5 3 1.23E-4 0.04
17 SGTC_968 1309-0633 3.61 340.0 µM 3.46E-5 7 1.54E-4 0.26
18 SGTC_235 0330-0087 3.59 5.0 mM 3.83E-5 TSC3-RPN4 7 1.67E-4 0.06
19 SGTC_105 0111-0055 3.58 734.8 µM 3.96E-5 3 1.72E-4 0.05
20 SGTC_3029 9088683 3.57 49.5 µM 4.21E-5 5 1.81E-4 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.180 7.88E-26 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.135 4.70E-15 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.117 1.24E-11 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.096 2.63E-8 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.082 1.74E-6 YER011W TIR1 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
0.076 1.00E-5 YAL012W CYS3 hom Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress
0.072 3.00E-5 YOR230W WTM1 hom Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
0.072 3.25E-5 YPL007C TFC8 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90
0.070 4.42E-5 YDR423C CAD1 hom AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication
0.069 6.47E-5 YOR250C CLP1 het Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation
0.069 6.55E-5 YDL064W UBC9 het SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
0.068 8.96E-5 YDL237W AIM6 hom Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene
0.067 9.74E-5 YNL099C OCA1 hom Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA
0.066 1.28E-4 YCR082W AHC2 hom Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex
0.065 1.65E-4 YLR440C SEC39 het Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope