RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YBR237W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.180 | 7.88E-26 | YJL027C_p | YJL027C_p | hom | Putative protein of unknown function |
0.135 | 4.70E-15 | YLR401C | DUS3 | hom | Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress |
0.117 | 1.24E-11 | YMR195W | ICY1 | hom | Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation |
0.096 | 2.63E-8 | YDR047W | HEM12 | het | Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda |
0.082 | 1.74E-6 | YER011W | TIR1 | hom | Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking |
0.076 | 1.00E-5 | YAL012W | CYS3 | hom | Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress |
0.072 | 3.00E-5 | YOR230W | WTM1 | hom | Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats |
0.072 | 3.25E-5 | YPL007C | TFC8 | het | One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 |
0.070 | 4.42E-5 | YDR423C | CAD1 | hom | AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication |
0.069 | 6.47E-5 | YOR250C | CLP1 | het | Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation |
0.069 | 6.55E-5 | YDL064W | UBC9 | het | SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC) |
0.068 | 8.96E-5 | YDL237W | AIM6 | hom | Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene |
0.067 | 9.74E-5 | YNL099C | OCA1 | hom | Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA |
0.066 | 1.28E-4 | YCR082W | AHC2 | hom | Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex |
0.065 | 1.65E-4 | YLR440C | SEC39 | het | Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope |