YBR238C

Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR238C / YBR238C

Click on Significant Values for Screen Details ID:SGTC_106|Compound:0092-0003|FD-Score:-3.64|P-value:8.41E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:5.42|P-value:1.93E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:9.33|P-value:7.92E-16 ID:SGTC_146|Compound:3448-8650|FD-Score:3.98|P-value:3.51E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:4.28|P-value:1.32E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:4.12|P-value:2.26E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.65|P-value:9.46E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.64|P-value:3.79E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.74|P-value:7.25E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.53|P-value:5.62E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:6.35|P-value:3.04E-8 ID:SGTC_799|Compound:1310-0557|FD-Score:4.28|P-value:1.33E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.90|P-value:4.50E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-6.24|P-value:3.98E-8 ID:SGTC_958|Compound:1222-0007|FD-Score:3.89|P-value:4.62E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.82|P-value:5.71E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.19|P-value:1.78E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:5.23|P-value:4.14E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.85|P-value:5.23E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.93|P-value:1.33E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:-3.72|P-value:6.66E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:4.04|P-value:2.89E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.20|P-value:1.71E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.97|P-value:3.65E-4 ID:SGTC_1729|Compound:st035615|FD-Score:6.45|P-value:1.84E-8 ID:SGTC_1759|Compound:st043059|FD-Score:4.28|P-value:1.34E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.87|P-value:4.98E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-4.15|P-value:1.71E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-4.78|P-value:1.88E-5 ID:SGTC_2148|Compound:5546263|FD-Score:4.13|P-value:2.18E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-4.44|P-value:6.44E-5 ID:SGTC_2266|Compound:7929956|FD-Score:-4.89|P-value:1.24E-5 ID:SGTC_2343|Compound:7990716|FD-Score:-4.50|P-value:5.18E-5 ID:SGTC_2702|Compound:st077768|FD-Score:-3.92|P-value:3.63E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-3.70|P-value:7.09E-4 ID:SGTC_2706|Compound:st078239|FD-Score:4.02|P-value:3.09E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.69|P-value:7.15E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.67|P-value:7.67E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-5.15|P-value:4.55E-6 ID:SGTC_2980|Compound:9014342|FD-Score:4.12|P-value:2.27E-4 ID:SGTC_3140|Compound:9094243|FD-Score:4.61|P-value:4.32E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.94|P-value:3.41E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.76|P-value:5.84E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.64|P-value:8.41E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:5.42|P-value:1.93E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:9.33|P-value:7.92E-16 ID:SGTC_146|Compound:3448-8650|FD-Score:3.98|P-value:3.51E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:4.28|P-value:1.32E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:4.12|P-value:2.26E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.65|P-value:9.46E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.64|P-value:3.79E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.74|P-value:7.25E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.53|P-value:5.62E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:6.35|P-value:3.04E-8 ID:SGTC_799|Compound:1310-0557|FD-Score:4.28|P-value:1.33E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.90|P-value:4.50E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-6.24|P-value:3.98E-8 ID:SGTC_958|Compound:1222-0007|FD-Score:3.89|P-value:4.62E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.82|P-value:5.71E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.19|P-value:1.78E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:5.23|P-value:4.14E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.85|P-value:5.23E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.93|P-value:1.33E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:-3.72|P-value:6.66E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:4.04|P-value:2.89E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.20|P-value:1.71E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.97|P-value:3.65E-4 ID:SGTC_1729|Compound:st035615|FD-Score:6.45|P-value:1.84E-8 ID:SGTC_1759|Compound:st043059|FD-Score:4.28|P-value:1.34E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.87|P-value:4.98E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-4.15|P-value:1.71E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-4.78|P-value:1.88E-5 ID:SGTC_2148|Compound:5546263|FD-Score:4.13|P-value:2.18E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-4.44|P-value:6.44E-5 ID:SGTC_2266|Compound:7929956|FD-Score:-4.89|P-value:1.24E-5 ID:SGTC_2343|Compound:7990716|FD-Score:-4.50|P-value:5.18E-5 ID:SGTC_2702|Compound:st077768|FD-Score:-3.92|P-value:3.63E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-3.70|P-value:7.09E-4 ID:SGTC_2706|Compound:st078239|FD-Score:4.02|P-value:3.09E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.69|P-value:7.15E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.67|P-value:7.67E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-5.15|P-value:4.55E-6 ID:SGTC_2980|Compound:9014342|FD-Score:4.12|P-value:2.27E-4 ID:SGTC_3140|Compound:9094243|FD-Score:4.61|P-value:4.32E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.94|P-value:3.41E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.76|P-value:5.84E-4

Top fitness defect scores for YBR238C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_117 lucigenin 9.33 22.1 µM 7.92E-16 redox potentiating 9 5.47E-21
2 SGTC_1729 st035615 6.45 46.0 µM 1.84E-8 7 5.56E-11
3 SGTC_795 0685-0265 6.35 78.0 µM 3.04E-8 excess fatty acid 6 1.10E-10
4 SGTC_115 0527-0192 5.42 112.0 µM 1.93E-6 20 3.04E-8
5 SGTC_1123 mangostin 5.23 811.3 nM 4.14E-6 mitochondrial response to ROS 14 8.56E-8
6 SGTC_1255 0566-0045 4.93 221.0 µM 1.33E-5 excess fatty acid 11 4.14E-7
7 SGTC_674 0498-0004 4.64 451.0 µM 3.79E-5 heme requiring 11 1.71E-6
8 SGTC_3140 9094243 4.61 49.5 µM 4.32E-5 19 2.04E-6
9 SGTC_769 0302-0231 4.53 76.0 µM 5.62E-5 25 2.91E-6
10 SGTC_178 4092-0806 4.28 87.5 µM 1.32E-4 ergosterol depletion effects on membrane 80 9.21E-6
11 SGTC_799 1310-0557 4.28 151.0 µM 1.33E-4 superoxide 15 9.28E-6
12 SGTC_1759 st043059 4.28 70.0 µM 1.34E-4 amide catabolism 14 9.43E-6
13 SGTC_1533 dihydroergotamine mesylate 4.20 29.4 µM 1.71E-4 DNA intercalators 11 1.31E-5
14 SGTC_1017 4239-0030 4.19 168.0 µM 1.78E-4 21 1.38E-5
15 SGTC_2148 5546263 4.13 113.6 µM 2.18E-4 16 1.81E-5
16 SGTC_194 1486-1323 4.12 56.9 µM 2.26E-4 17 1.90E-5
17 SGTC_2980 9014342 4.12 25.3 µM 2.27E-4 23 1.91E-5
18 SGTC_1397 3532-0190 4.04 20.1 µM 2.89E-4 5 2.65E-5
19 SGTC_2706 st078239 4.02 82.5 µM 3.09E-4 9 2.89E-5
20 SGTC_146 3448-8650 3.98 53.1 µM 3.51E-4 NEO1-PIK1 136 3.44E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 2.56E-25 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.172 1.21E-23 YLR324W PEX30 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.155 1.45E-19 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.105 1.02E-9 YJL062W LAS21 hom Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity
0.095 3.16E-8 YBL032W HEK2 hom RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
0.095 3.37E-8 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.095 4.01E-8 YLR325C RPL38 hom Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog
0.094 4.72E-8 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.088 3.71E-7 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.087 4.12E-7 YHL020C OPI1 hom Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance
0.086 5.91E-7 YDR409W SIZ1 hom SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
0.083 1.67E-6 YOR197W MCA1 hom Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization
0.081 2.72E-6 YBR224W_d YBR224W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
0.080 3.35E-6 YDL095W PMT1 hom Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen
0.079 4.49E-6 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA