YBR240C / THI2

Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR240C / THI2

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:-3.54|P-value:4.26E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.42|P-value:7.50E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.49|P-value:1.54E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:4.41|P-value:2.08E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:3.41|P-value:7.85E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-4.07|P-value:6.54E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:4.03|P-value:9.13E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:4.16|P-value:5.59E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-4.42|P-value:1.60E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:4.20|P-value:4.79E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:-3.41|P-value:6.53E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:-3.48|P-value:5.24E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.78|P-value:1.86E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.53|P-value:5.32E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-3.33|P-value:8.55E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.48|P-value:6.17E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.78|P-value:2.26E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:-3.32|P-value:8.73E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:-4.15|P-value:4.80E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.43|P-value:7.45E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.30|P-value:9.41E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:4.76|P-value:4.94E-6 ID:SGTC_1351|Compound:1496-0003|FD-Score:5.78|P-value:3.77E-8 ID:SGTC_1363|Compound:1636-0063|FD-Score:5.48|P-value:1.71E-7 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.98|P-value:1.09E-4 ID:SGTC_1832|Compound:st054113|FD-Score:-4.25|P-value:3.18E-5 ID:SGTC_1839|Compound:st053978|FD-Score:3.90|P-value:1.46E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.67|P-value:3.38E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.90|P-value:1.47E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-4.07|P-value:6.45E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.52|P-value:5.55E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.84|P-value:1.82E-4 ID:SGTC_2241|Compound:6772625|FD-Score:4.47|P-value:1.63E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-3.87|P-value:1.37E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-3.83|P-value:1.58E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.58|P-value:1.04E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.82|P-value:1.96E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.82|P-value:1.96E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.11|P-value:6.72E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-3.99|P-value:8.82E-5 ID:SGTC_2841|Compound:9004761|FD-Score:3.92|P-value:1.36E-4 ID:SGTC_2902|Compound:5787006|FD-Score:4.12|P-value:6.49E-5 ID:SGTC_2903|Compound:5923464|FD-Score:3.80|P-value:2.10E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-5.13|P-value:7.32E-7 ID:SGTC_3231|Compound:9132313|FD-Score:4.27|P-value:3.73E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.54|P-value:4.26E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.42|P-value:7.50E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.49|P-value:1.54E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:4.41|P-value:2.08E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:3.41|P-value:7.85E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-4.07|P-value:6.54E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:4.03|P-value:9.13E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:4.16|P-value:5.59E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-4.42|P-value:1.60E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:4.20|P-value:4.79E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:-3.41|P-value:6.53E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:-3.48|P-value:5.24E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.78|P-value:1.86E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.53|P-value:5.32E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-3.33|P-value:8.55E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.48|P-value:6.17E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.78|P-value:2.26E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:-3.32|P-value:8.73E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:-4.15|P-value:4.80E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.43|P-value:7.45E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.30|P-value:9.41E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:4.76|P-value:4.94E-6 ID:SGTC_1351|Compound:1496-0003|FD-Score:5.78|P-value:3.77E-8 ID:SGTC_1363|Compound:1636-0063|FD-Score:5.48|P-value:1.71E-7 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.98|P-value:1.09E-4 ID:SGTC_1832|Compound:st054113|FD-Score:-4.25|P-value:3.18E-5 ID:SGTC_1839|Compound:st053978|FD-Score:3.90|P-value:1.46E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.67|P-value:3.38E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.90|P-value:1.47E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-4.07|P-value:6.45E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.52|P-value:5.55E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.84|P-value:1.82E-4 ID:SGTC_2241|Compound:6772625|FD-Score:4.47|P-value:1.63E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-3.87|P-value:1.37E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-3.83|P-value:1.58E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.58|P-value:1.04E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.82|P-value:1.96E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.82|P-value:1.96E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.11|P-value:6.72E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-3.99|P-value:8.82E-5 ID:SGTC_2841|Compound:9004761|FD-Score:3.92|P-value:1.36E-4 ID:SGTC_2902|Compound:5787006|FD-Score:4.12|P-value:6.49E-5 ID:SGTC_2903|Compound:5923464|FD-Score:3.80|P-value:2.10E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-5.13|P-value:7.32E-7 ID:SGTC_3231|Compound:9132313|FD-Score:4.27|P-value:3.73E-5

Top fitness defect scores for YBR240C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1351 1496-0003 5.78 46.5 µM 3.77E-8 4 3.67E-9
2 SGTC_1363 1636-0063 5.48 10.4 µM 1.71E-7 Golgi 8 2.07E-8
3 SGTC_1345 1488-0192 4.76 31.4 µM 4.94E-6 7 9.81E-7
4 SGTC_2587 piperic acid 4.58 92.2 µM 1.04E-5 11 2.30E-6
5 SGTC_94 0334-0113 4.49 514.8 µM 1.54E-5 12 3.60E-6
6 SGTC_2241 6772625 4.47 37.8 µM 1.63E-5 17 3.84E-6
7 SGTC_163 1327-0036 4.41 7.5 µM 2.08E-5 86 5.09E-6
8 SGTC_3231 9132313 4.27 49.5 µM 3.73E-5 4 9.92E-6
9 SGTC_855 0428-0020 4.20 25.0 µM 4.79E-5 Golgi 20 1.32E-5
10 SGTC_840 0245-0196 4.16 390.0 µM 5.59E-5 8 1.58E-5
11 SGTC_2902 5787006 4.12 60.5 µM 6.49E-5 Golgi 24 1.87E-5
12 SGTC_2776 terbinafine 4.11 19.9 µM 6.72E-5 cell wall signaling 51 1.95E-5
13 SGTC_838 0109-0203 4.03 71.4 µM 9.13E-5 12 2.77E-5
14 SGTC_1457 k015-0032 3.98 57.3 µM 1.09E-4 34 3.40E-5
15 SGTC_2841 9004761 3.92 39.0 µM 1.36E-4 amide catabolism 30 4.35E-5
16 SGTC_1839 st053978 3.90 48.0 µM 1.46E-4 15 4.73E-5
17 SGTC_1907 st060210 3.90 83.7 µM 1.47E-4 23 4.78E-5
18 SGTC_2236 dapsone 3.84 200.0 µM 1.82E-4 14 6.10E-5
19 SGTC_2730 imipramine 3.82 71.3 µM 1.96E-4 29 6.64E-5
20 SGTC_2713 st079149 3.82 53.4 µM 1.96E-4 26 6.65E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.090 2.01E-7 YBL099W ATP1 hom Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.087 4.54E-7 YLL031C GPI13 het ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein
0.082 2.09E-6 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.081 3.02E-6 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.076 9.87E-6 YDR075W PPH3 hom Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
0.075 1.34E-5 YGR184C UBR1 hom E3 ubiquitin ligase (N-recognin); forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; plays a major role in targeting cytosolic misfolded proteins for degradation; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)
0.074 1.63E-5 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.072 3.12E-5 YGR175C ERG1 het Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
0.072 3.28E-5 YOR379C_d YOR379C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W
0.070 5.47E-5 YKL143W LTV1 hom Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
0.069 6.72E-5 YER106W MAM1 hom Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle
0.068 7.40E-5 YHR031C RRM3 hom DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
0.068 7.47E-5 YPL209C IPL1 het Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest
0.068 8.94E-5 YBR049C REB1 het RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication
0.068 9.10E-5 YJR005W APL1 hom Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex