YBR242W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR242W / YBR242W

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:-3.50|P-value:7.62E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.91|P-value:2.95E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:5.55|P-value:5.01E-7 ID:SGTC_123|Compound:0083-0120|FD-Score:4.51|P-value:3.64E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:4.65|P-value:2.10E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:7.26|P-value:6.88E-11 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.00|P-value:1.47E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.13|P-value:1.44E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.31|P-value:7.66E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.66|P-value:2.01E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.55|P-value:9.26E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.85|P-value:3.60E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.90|P-value:3.12E-4 ID:SGTC_1676|Compound:st018489|FD-Score:5.32|P-value:1.38E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.69|P-value:1.84E-5 ID:SGTC_1793|Compound:st048256|FD-Score:-3.82|P-value:2.70E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.57|P-value:2.89E-5 ID:SGTC_2018|Compound:5133068|FD-Score:4.07|P-value:1.73E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.92|P-value:1.96E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.73|P-value:5.30E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.81|P-value:1.13E-5 ID:SGTC_2268|Compound:7933382|FD-Score:6.34|P-value:1.05E-8 ID:SGTC_2270|Compound:7924575|FD-Score:-3.56|P-value:6.24E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.12|P-value:1.49E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.75|P-value:5.04E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.96|P-value:1.69E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.49|P-value:3.89E-5 ID:SGTC_2805|Compound:7950783|FD-Score:4.74|P-value:1.52E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.70|P-value:5.80E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.83|P-value:2.65E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.19|P-value:1.14E-4 ID:SGTC_3295|Compound:9122362|FD-Score:4.82|P-value:1.11E-5 ID:SGTC_3297|Compound:9117502|FD-Score:-6.51|P-value:2.30E-9 ID:SGTC_3313|Compound:9133968|FD-Score:-3.72|P-value:3.75E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.50|P-value:7.62E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.91|P-value:2.95E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:5.55|P-value:5.01E-7 ID:SGTC_123|Compound:0083-0120|FD-Score:4.51|P-value:3.64E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:4.65|P-value:2.10E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:7.26|P-value:6.88E-11 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.00|P-value:1.47E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.13|P-value:1.44E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.31|P-value:7.66E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.66|P-value:2.01E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.55|P-value:9.26E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.85|P-value:3.60E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.90|P-value:3.12E-4 ID:SGTC_1676|Compound:st018489|FD-Score:5.32|P-value:1.38E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.69|P-value:1.84E-5 ID:SGTC_1793|Compound:st048256|FD-Score:-3.82|P-value:2.70E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.57|P-value:2.89E-5 ID:SGTC_2018|Compound:5133068|FD-Score:4.07|P-value:1.73E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.92|P-value:1.96E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.73|P-value:5.30E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.81|P-value:1.13E-5 ID:SGTC_2268|Compound:7933382|FD-Score:6.34|P-value:1.05E-8 ID:SGTC_2270|Compound:7924575|FD-Score:-3.56|P-value:6.24E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.12|P-value:1.49E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.75|P-value:5.04E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.96|P-value:1.69E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.49|P-value:3.89E-5 ID:SGTC_2805|Compound:7950783|FD-Score:4.74|P-value:1.52E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.70|P-value:5.80E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.83|P-value:2.65E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.19|P-value:1.14E-4 ID:SGTC_3295|Compound:9122362|FD-Score:4.82|P-value:1.11E-5 ID:SGTC_3297|Compound:9117502|FD-Score:-6.51|P-value:2.30E-9 ID:SGTC_3313|Compound:9133968|FD-Score:-3.72|P-value:3.75E-4

Top fitness defect scores for YBR242W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_255 tunicamycin 7.26 200.5 nM 6.88E-11 unfolded protein response 21 1.97E-13
2 SGTC_2268 7933382 6.34 153.8 µM 1.05E-8 6 1.12E-10
3 SGTC_122 0236-0016 5.55 402.4 µM 5.01E-7 RNA processing & uracil transport 10 1.47E-8
4 SGTC_1676 st018489 5.32 23.4 µM 1.38E-6 60S ribosome export 9 5.27E-8
5 SGTC_3295 9122362 4.82 53.6 µM 1.11E-5 6 7.30E-7
6 SGTC_2238 6671620 4.81 73.2 µM 1.13E-5 12 7.45E-7
7 SGTC_2805 7950783 4.74 58.4 µM 1.52E-5 13 1.09E-6
8 SGTC_1789 tunicamycin 4.69 25.0 nM 1.84E-5 unfolded protein response 32 1.38E-6
9 SGTC_1045 1348-1485 4.66 165.0 µM 2.01E-5 12 1.54E-6
10 SGTC_178 4092-0806 4.65 87.5 µM 2.10E-5 ergosterol depletion effects on membrane 64 1.63E-6
11 SGTC_2016 5121758 4.57 140.0 µM 2.89E-5 redox potentiating 27 2.44E-6
12 SGTC_123 0083-0120 4.51 66.7 µM 3.64E-5 33 3.27E-6
13 SGTC_2570 licareol 4.49 100.0 µM 3.89E-5 18 3.55E-6
14 SGTC_1030 k029-0042 4.31 36.7 µM 7.66E-5 TSC3-RPN4 16 8.34E-6
15 SGTC_3293 9120939 4.19 62.0 µM 1.14E-4 15 1.38E-5
16 SGTC_639 0833-0042 4.13 114.0 µM 1.44E-4 41 1.84E-5
17 SGTC_2274 7947094 4.12 46.1 µM 1.49E-4 32 1.93E-5
18 SGTC_2018 5133068 4.07 143.0 µM 1.73E-4 19 2.32E-5
19 SGTC_119 0121-0043 3.91 24.8 µM 2.95E-4 mitochondrial stress 118 4.55E-5
20 SGTC_1209 2323-2347 3.90 50.3 µM 3.12E-4 17 4.90E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.232 2.63E-42 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.122 1.21E-12 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.121 2.10E-12 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.112 7.64E-11 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.104 1.49E-9 YDR489W SLD5 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.102 3.04E-9 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.100 7.69E-9 YKR035W-A DID2 hom Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors
0.098 1.11E-8 YNL334C SNO2 hom Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin
0.091 1.30E-7 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
0.090 1.78E-7 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.083 1.59E-6 YKR080W MTD1 hom NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
0.080 3.70E-6 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.080 3.79E-6 YJL191W RPS14B hom Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication
0.080 3.89E-6 YNL286W CUS2 hom Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)
0.078 6.48E-6 YOR259C RPT4 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization