YBR247C / ENP1

Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR247C / ENP1

Click on Significant Values for Screen Details ID:SGTC_75|Compound:0159-0059|FD-Score:3.94|P-value:4.77E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:3.30|P-value:5.46E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.07|P-value:2.71E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.44|P-value:5.29E-6 ID:SGTC_476|Compound:mead acid|FD-Score:3.29|P-value:5.66E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.68|P-value:1.34E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:5.17|P-value:1.49E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:3.83|P-value:7.24E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.58|P-value:1.93E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.49|P-value:2.70E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.21|P-value:1.53E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.18|P-value:7.30E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.55|P-value:2.16E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.78|P-value:9.09E-5 ID:SGTC_1769|Compound:st044406|FD-Score:4.10|P-value:2.39E-5 ID:SGTC_1821|Compound:st053465|FD-Score:3.29|P-value:5.54E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.32|P-value:4.98E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.22|P-value:7.12E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.02|P-value:3.42E-5 ID:SGTC_1939|Compound:st074455|FD-Score:4.31|P-value:9.54E-6 ID:SGTC_2070|Compound:5230947|FD-Score:3.45|P-value:3.23E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.40|P-value:3.86E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-4.28|P-value:9.68E-6 ID:SGTC_2282|Compound:7944268|FD-Score:-3.25|P-value:5.69E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.20|P-value:7.79E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.32|P-value:4.47E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-5.50|P-value:2.00E-8 ID:SGTC_2415|Compound:st077333|FD-Score:-3.37|P-value:3.77E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-4.18|P-value:1.48E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.61|P-value:2.44E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.23|P-value:1.36E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.25|P-value:1.10E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.23|P-value:6.95E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.67|P-value:1.37E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.65|P-value:2.03E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.67|P-value:1.83E-6 ID:SGTC_2849|Compound:9019321|FD-Score:-3.85|P-value:6.06E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.52|P-value:2.46E-4 ID:SGTC_2906|Compound:7926292|FD-Score:4.25|P-value:1.24E-5 ID:SGTC_2985|Compound:9022375|FD-Score:-3.35|P-value:4.06E-4 ID:SGTC_3140|Compound:9094243|FD-Score:4.16|P-value:1.91E-5 ID:SGTC_3170|Compound:9103054|FD-Score:-3.95|P-value:3.87E-5 ID:SGTC_3180|Compound:9109287|FD-Score:3.42|P-value:3.50E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.21|P-value:7.43E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.96|P-value:4.40E-7 ID:SGTC_75|Compound:0159-0059|FD-Score:3.94|P-value:4.77E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:3.30|P-value:5.46E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.07|P-value:2.71E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.44|P-value:5.29E-6 ID:SGTC_476|Compound:mead acid|FD-Score:3.29|P-value:5.66E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.68|P-value:1.34E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:5.17|P-value:1.49E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:3.83|P-value:7.24E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.58|P-value:1.93E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.49|P-value:2.70E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.21|P-value:1.53E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.18|P-value:7.30E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.55|P-value:2.16E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.78|P-value:9.09E-5 ID:SGTC_1769|Compound:st044406|FD-Score:4.10|P-value:2.39E-5 ID:SGTC_1821|Compound:st053465|FD-Score:3.29|P-value:5.54E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.32|P-value:4.98E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.22|P-value:7.12E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.02|P-value:3.42E-5 ID:SGTC_1939|Compound:st074455|FD-Score:4.31|P-value:9.54E-6 ID:SGTC_2070|Compound:5230947|FD-Score:3.45|P-value:3.23E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.40|P-value:3.86E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-4.28|P-value:9.68E-6 ID:SGTC_2282|Compound:7944268|FD-Score:-3.25|P-value:5.69E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.20|P-value:7.79E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.32|P-value:4.47E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-5.50|P-value:2.00E-8 ID:SGTC_2415|Compound:st077333|FD-Score:-3.37|P-value:3.77E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-4.18|P-value:1.48E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.61|P-value:2.44E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.23|P-value:1.36E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.25|P-value:1.10E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.23|P-value:6.95E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.67|P-value:1.37E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.65|P-value:2.03E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.67|P-value:1.83E-6 ID:SGTC_2849|Compound:9019321|FD-Score:-3.85|P-value:6.06E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.52|P-value:2.46E-4 ID:SGTC_2906|Compound:7926292|FD-Score:4.25|P-value:1.24E-5 ID:SGTC_2985|Compound:9022375|FD-Score:-3.35|P-value:4.06E-4 ID:SGTC_3140|Compound:9094243|FD-Score:4.16|P-value:1.91E-5 ID:SGTC_3170|Compound:9103054|FD-Score:-3.95|P-value:3.87E-5 ID:SGTC_3180|Compound:9109287|FD-Score:3.42|P-value:3.50E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.21|P-value:7.43E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.96|P-value:4.40E-7

Top fitness defect scores for YBR247C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_571 k831-0106 5.17 44.2 µM 1.49E-7 1 1.19E-7 0.96
2 SGTC_3323 9138564 4.96 53.9 µM 4.40E-7 3 3.58E-7 0.24
3 SGTC_2725 haloperidol 4.67 53.2 µM 1.83E-6 plasma membrane duress 12 1.51E-6 0.16
4 SGTC_2688 kanamycin b 4.65 96.7 µM 2.03E-6 calcium & mitochondrial duress 11 1.68E-6 0.07
5 SGTC_2496 diffractaic acid 4.61 79.8 µM 2.44E-6 2 2.03E-6 0.32
6 SGTC_392 N-ethylmaleimide 4.44 8.3 µM 5.29E-6 RNA pol III & RNase P/MRP 9 4.43E-6 0.10
7 SGTC_1939 st074455 4.31 53.6 µM 9.54E-6 4 8.06E-6 0.13
8 SGTC_2906 7926292 4.25 26.4 µM 1.24E-5 3 1.05E-5 0.27
9 SGTC_2553 4-methylesculetin 4.23 85.1 µM 1.36E-5 2 1.16E-5 0.21
10 SGTC_1013 4112-3890 4.21 241.0 µM 1.53E-5 TSC3-RPN4 5 1.30E-5 0.12
11 SGTC_3140 9094243 4.16 49.5 µM 1.91E-5 3 1.62E-5 0.15
12 SGTC_1769 st044406 4.10 64.4 µM 2.39E-5 10 2.05E-5 0.23
13 SGTC_391 gliotoxin 4.07 8.3 µM 2.71E-5 3 2.32E-5 0.08
14 SGTC_1871 st057448 4.02 67.3 µM 3.42E-5 6 2.93E-5 0.02
15 SGTC_75 0159-0059 3.94 199.0 µM 4.77E-5 fatty acid desaturase (OLE1) 10 4.11E-5 0.04
16 SGTC_800 3448-7362 3.83 155.0 µM 7.24E-5 translation 50 6.28E-5 0.01
17 SGTC_1700 st030840 3.78 7.9 µM 9.09E-5 PDR1 8 7.90E-5 0.08
18 SGTC_560 2332-1943 3.68 155.0 µM 1.34E-4 4 1.17E-4 0.02
19 SGTC_2687 chenodiol 3.67 100.0 µM 1.37E-4 6 1.20E-4 0.07
20 SGTC_3181 9108277 3.63 49.5 µM 1.62E-4 iron homeostasis 15 1.42E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.64E-18 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.112 6.56E-11 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.112 8.02E-11 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.109 2.75E-10 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.108 3.12E-10 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.107 4.29E-10 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.107 5.08E-10 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.102 2.63E-9 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.102 3.79E-9 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.101 4.54E-9 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.101 5.22E-9 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.094 5.12E-8 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.092 8.38E-8 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090 2.03E-7 YER073W ALD5 hom Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
0.089 2.51E-7 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;