YBR248C / HIS7

Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR248C / HIS7

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.38|P-value:2.06E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:5.20|P-value:2.87E-8 ID:SGTC_12|Compound:0849-0099|FD-Score:3.02|P-value:8.08E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:3.45|P-value:1.59E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.82|P-value:3.52E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.96|P-value:1.88E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.77|P-value:4.39E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:6.51|P-value:5.75E-12 ID:SGTC_198|Compound:3454-2873|FD-Score:3.03|P-value:7.91E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.52|P-value:1.19E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.46|P-value:1.63E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.01|P-value:8.32E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.79|P-value:3.85E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.21|P-value:3.97E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.20|P-value:4.35E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:2.99|P-value:9.06E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.61|P-value:8.74E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.09|P-value:6.57E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.49|P-value:1.33E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.50|P-value:1.31E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:5.30|P-value:1.64E-8 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.87|P-value:2.67E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.17|P-value:4.73E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.34|P-value:2.46E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.02|P-value:8.20E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.70|P-value:5.68E-5 ID:SGTC_1762|Compound:st045503|FD-Score:3.22|P-value:3.82E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.07|P-value:6.84E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.26|P-value:3.27E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.82|P-value:3.57E-5 ID:SGTC_2007|Compound:4011539|FD-Score:-3.49|P-value:1.41E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.50|P-value:1.28E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.60|P-value:8.69E-5 ID:SGTC_2010|Compound:4012422|FD-Score:4.18|P-value:6.35E-6 ID:SGTC_2300|Compound:7976697|FD-Score:-4.06|P-value:1.22E-5 ID:SGTC_2301|Compound:7769476|FD-Score:-5.66|P-value:1.96E-9 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-2.99|P-value:9.57E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.95|P-value:1.85E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:7.35|P-value:9.12E-15 ID:SGTC_2586|Compound:curcumin|FD-Score:6.57|P-value:3.69E-12 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.44|P-value:1.78E-6 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.40|P-value:1.92E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.85|P-value:2.94E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.33|P-value:2.53E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.96|P-value:1.78E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-3.49|P-value:1.41E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.93|P-value:2.18E-5 ID:SGTC_3007|Compound:9078383|FD-Score:2.99|P-value:8.96E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-3.21|P-value:4.26E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.54|P-value:1.11E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-5.19|P-value:3.28E-8 ID:SGTC_3193|Compound:9111931|FD-Score:-6.01|P-value:2.08E-10 ID:SGTC_3195|Compound:9113082|FD-Score:-3.34|P-value:2.61E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.33|P-value:2.70E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.38|P-value:2.06E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:5.20|P-value:2.87E-8 ID:SGTC_12|Compound:0849-0099|FD-Score:3.02|P-value:8.08E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:3.45|P-value:1.59E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.82|P-value:3.52E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.96|P-value:1.88E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.77|P-value:4.39E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:6.51|P-value:5.75E-12 ID:SGTC_198|Compound:3454-2873|FD-Score:3.03|P-value:7.91E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.52|P-value:1.19E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.46|P-value:1.63E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.01|P-value:8.32E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.79|P-value:3.85E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.21|P-value:3.97E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.20|P-value:4.35E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:2.99|P-value:9.06E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.61|P-value:8.74E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.09|P-value:6.57E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.49|P-value:1.33E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.50|P-value:1.31E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:5.30|P-value:1.64E-8 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.87|P-value:2.67E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.17|P-value:4.73E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.34|P-value:2.46E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.02|P-value:8.20E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.70|P-value:5.68E-5 ID:SGTC_1762|Compound:st045503|FD-Score:3.22|P-value:3.82E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.07|P-value:6.84E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.26|P-value:3.27E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.82|P-value:3.57E-5 ID:SGTC_2007|Compound:4011539|FD-Score:-3.49|P-value:1.41E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.50|P-value:1.28E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.60|P-value:8.69E-5 ID:SGTC_2010|Compound:4012422|FD-Score:4.18|P-value:6.35E-6 ID:SGTC_2300|Compound:7976697|FD-Score:-4.06|P-value:1.22E-5 ID:SGTC_2301|Compound:7769476|FD-Score:-5.66|P-value:1.96E-9 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-2.99|P-value:9.57E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.95|P-value:1.85E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:7.35|P-value:9.12E-15 ID:SGTC_2586|Compound:curcumin|FD-Score:6.57|P-value:3.69E-12 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.44|P-value:1.78E-6 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.40|P-value:1.92E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.85|P-value:2.94E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.33|P-value:2.53E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.96|P-value:1.78E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-3.49|P-value:1.41E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.93|P-value:2.18E-5 ID:SGTC_3007|Compound:9078383|FD-Score:2.99|P-value:8.96E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-3.21|P-value:4.26E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.54|P-value:1.11E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-5.19|P-value:3.28E-8 ID:SGTC_3193|Compound:9111931|FD-Score:-6.01|P-value:2.08E-10 ID:SGTC_3195|Compound:9113082|FD-Score:-3.34|P-value:2.61E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.33|P-value:2.70E-4

Top fitness defect scores for YBR248C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2584 androsterone 7.35 48.7 µM 9.12E-15 cell wall 30 1.01E-13
2 SGTC_2586 curcumin 6.57 80.0 µM 3.69E-12 iron homeostasis 8 2.55E-11
3 SGTC_163 1327-0036 6.51 7.5 µM 5.75E-12 39 3.83E-11
4 SGTC_1360 1598-0022 5.30 39.8 µM 1.64E-8 ERG2 10 5.88E-8
5 SGTC_8 0354-0001 5.20 70.0 µM 2.87E-8 38 9.86E-8
6 SGTC_2658 polymyxin b sulfate 4.44 77.0 µM 1.78E-6 NEO1 31 4.45E-6
7 SGTC_2010 4012422 4.18 159.0 µM 6.35E-6 18 1.44E-5
8 SGTC_2920 7982904 3.96 15.8 µM 1.78E-5 24 3.73E-5
9 SGTC_2476 5806916 3.95 10.5 µM 1.85E-5 15 3.87E-5
10 SGTC_1473 k844-0725 3.87 134.0 µM 2.67E-5 13 5.43E-5
11 SGTC_2782 7736369 3.85 71.4 µM 2.94E-5 45 5.92E-5
12 SGTC_769 0302-0231 3.79 76.0 µM 3.85E-5 47 7.60E-5
13 SGTC_1732 st034308 3.70 51.8 µM 5.68E-5 30 1.09E-4
14 SGTC_2009 4012297 3.60 12.1 µM 8.69E-5 cell wall signaling 78 1.61E-4
15 SGTC_3127 9126946 3.54 49.5 µM 1.11E-4 ERG2 27 2.01E-4
16 SGTC_213 1246-0773 3.52 967.0 nM 1.19E-4 34 2.15E-4
17 SGTC_2008 4012253 3.50 172.0 µM 1.28E-4 38 2.31E-4
18 SGTC_1341 1486-1360 3.50 280.0 µM 1.31E-4 46 2.36E-4
19 SGTC_1239 0337-0584 3.49 35.4 µM 1.33E-4 unfolded protein response 75 2.39E-4
20 SGTC_48 0382-0018 3.45 55.0 µM 1.59E-4 21 2.81E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.183 9.45E-27 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.159 2.43E-20 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.138 1.13E-15 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.129 6.73E-14 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.124 5.51E-13 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.122 1.32E-12 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.118 9.07E-12 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.117 8.96E-12 YOR292C_p YOR292C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
0.112 8.26E-11 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.112 8.77E-11 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.110 1.50E-10 YOR324C FRT1 hom Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication
0.110 1.66E-10 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.108 4.10E-10 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.106 7.02E-10 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.106 7.85E-10 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication