YBR251W / MRPS5

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR251W / MRPS5

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.11|P-value:1.84E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.39|P-value:3.64E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:5.15|P-value:9.09E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:9.13|P-value:1.37E-14 ID:SGTC_173|Compound:1273-0061|FD-Score:5.30|P-value:5.22E-6 ID:SGTC_195|Compound:4234-0266|FD-Score:4.68|P-value:4.91E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:4.03|P-value:4.05E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.41|P-value:1.22E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:15.20|P-value:4.65E-37 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.85|P-value:5.89E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:7.47|P-value:2.46E-10 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.25|P-value:1.81E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.99|P-value:4.54E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.26|P-value:5.29E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.26|P-value:5.12E-6 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.64|P-value:5.76E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:5.33|P-value:4.60E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:3.98|P-value:4.71E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.73|P-value:8.83E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:4.28|P-value:1.85E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.15|P-value:2.82E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.83|P-value:7.32E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.77|P-value:8.65E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:5.06|P-value:1.27E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:5.39|P-value:3.58E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.57|P-value:7.09E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.46|P-value:1.05E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.34|P-value:1.53E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-4.14|P-value:2.54E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-6.45|P-value:3.35E-8 ID:SGTC_1251|Compound:0490-5699|FD-Score:6.41|P-value:4.69E-8 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.18|P-value:2.58E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.49|P-value:3.18E-8 ID:SGTC_1683|Compound:st010134|FD-Score:4.09|P-value:3.34E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.60|P-value:1.95E-8 ID:SGTC_1819|Compound:st053448|FD-Score:4.45|P-value:1.07E-4 ID:SGTC_1834|Compound:st055981|FD-Score:5.53|P-value:2.11E-6 ID:SGTC_1842|Compound:st055362|FD-Score:5.50|P-value:2.31E-6 ID:SGTC_1921|Compound:5740136|FD-Score:3.99|P-value:4.58E-4 ID:SGTC_2005|Compound:4024620|FD-Score:4.20|P-value:2.36E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.34|P-value:1.51E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.00|P-value:3.94E-4 ID:SGTC_2177|Compound:5811945|FD-Score:5.53|P-value:2.08E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.72|P-value:4.34E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.63|P-value:1.41E-6 ID:SGTC_2254|Compound:7938975|FD-Score:5.02|P-value:1.50E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.92|P-value:5.58E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-4.47|P-value:8.84E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-3.93|P-value:4.92E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.79|P-value:8.14E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.05|P-value:3.75E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.55|P-value:7.73E-5 ID:SGTC_2526|Compound:patulin|FD-Score:8.38|P-value:1.41E-12 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.58|P-value:6.96E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.88|P-value:4.85E-7 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.34|P-value:1.54E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.08|P-value:1.21E-5 ID:SGTC_2881|Compound:9058953|FD-Score:4.22|P-value:2.22E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.04|P-value:2.09E-7 ID:SGTC_3007|Compound:9078383|FD-Score:-4.58|P-value:6.13E-5 ID:SGTC_3010|Compound:9080089|FD-Score:-3.98|P-value:4.14E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.71|P-value:9.31E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:6.11|P-value:1.84E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.39|P-value:3.64E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:5.15|P-value:9.09E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:9.13|P-value:1.37E-14 ID:SGTC_173|Compound:1273-0061|FD-Score:5.30|P-value:5.22E-6 ID:SGTC_195|Compound:4234-0266|FD-Score:4.68|P-value:4.91E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:4.03|P-value:4.05E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.41|P-value:1.22E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:15.20|P-value:4.65E-37 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.85|P-value:5.89E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:7.47|P-value:2.46E-10 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.25|P-value:1.81E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.99|P-value:4.54E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.26|P-value:5.29E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.26|P-value:5.12E-6 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.64|P-value:5.76E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:5.33|P-value:4.60E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:3.98|P-value:4.71E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.73|P-value:8.83E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:4.28|P-value:1.85E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.15|P-value:2.82E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.83|P-value:7.32E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.77|P-value:8.65E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:5.06|P-value:1.27E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:5.39|P-value:3.58E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.57|P-value:7.09E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.46|P-value:1.05E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.34|P-value:1.53E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-4.14|P-value:2.54E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-6.45|P-value:3.35E-8 ID:SGTC_1251|Compound:0490-5699|FD-Score:6.41|P-value:4.69E-8 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.18|P-value:2.58E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.49|P-value:3.18E-8 ID:SGTC_1683|Compound:st010134|FD-Score:4.09|P-value:3.34E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.60|P-value:1.95E-8 ID:SGTC_1819|Compound:st053448|FD-Score:4.45|P-value:1.07E-4 ID:SGTC_1834|Compound:st055981|FD-Score:5.53|P-value:2.11E-6 ID:SGTC_1842|Compound:st055362|FD-Score:5.50|P-value:2.31E-6 ID:SGTC_1921|Compound:5740136|FD-Score:3.99|P-value:4.58E-4 ID:SGTC_2005|Compound:4024620|FD-Score:4.20|P-value:2.36E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.34|P-value:1.51E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.00|P-value:3.94E-4 ID:SGTC_2177|Compound:5811945|FD-Score:5.53|P-value:2.08E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.72|P-value:4.34E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.63|P-value:1.41E-6 ID:SGTC_2254|Compound:7938975|FD-Score:5.02|P-value:1.50E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.92|P-value:5.58E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-4.47|P-value:8.84E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-3.93|P-value:4.92E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.79|P-value:8.14E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.05|P-value:3.75E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.55|P-value:7.73E-5 ID:SGTC_2526|Compound:patulin|FD-Score:8.38|P-value:1.41E-12 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.58|P-value:6.96E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.88|P-value:4.85E-7 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.34|P-value:1.54E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.08|P-value:1.21E-5 ID:SGTC_2881|Compound:9058953|FD-Score:4.22|P-value:2.22E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.04|P-value:2.09E-7 ID:SGTC_3007|Compound:9078383|FD-Score:-4.58|P-value:6.13E-5 ID:SGTC_3010|Compound:9080089|FD-Score:-3.98|P-value:4.14E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.71|P-value:9.31E-4

Top fitness defect scores for YBR251W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 15.20 5.3 µM 4.65E-37 98 2.29E-52
2 SGTC_70 0141-0289 9.13 43.3 µM 1.37E-14 mitochondrial stress 23 3.41E-20
3 SGTC_2526 patulin 8.38 37.6 µM 1.41E-12 14 2.56E-17
4 SGTC_310 1273-0058 7.47 1.1 µM 2.46E-10 mitochondrial stress 104 4.06E-14
5 SGTC_275 trichlorophene 6.85 5.7 µM 5.89E-9 mitochondrial stress 95 3.77E-12
6 SGTC_1742 st038235 6.60 28.9 µM 1.95E-8 mitochondrial stress 31 2.08E-11
7 SGTC_1597 7-benzyloxygramine 6.49 47.5 µM 3.18E-8 calcium & mitochondrial duress 46 4.16E-11
8 SGTC_1251 0490-5699 6.41 265.0 µM 4.69E-8 6 7.24E-11
9 SGTC_10 0279-0212 6.11 42.6 µM 1.84E-7 TRP & mitochondrial translation 27 5.07E-10
10 SGTC_2603 homopterocarpin 5.88 100.0 µM 4.85E-7 4 2.02E-9
11 SGTC_2250 alverine citrate 5.63 130.0 µM 1.41E-6 68 9.23E-9
12 SGTC_2177 5811945 5.53 192.0 µM 2.08E-6 9 1.60E-8
13 SGTC_1834 st055981 5.53 52.8 µM 2.11E-6 RPP1 & pyrimidine depletion 9 1.62E-8
14 SGTC_1842 st055362 5.50 61.2 µM 2.31E-6 2 1.85E-8
15 SGTC_1150 3909-7983 5.39 10.9 µM 3.58E-6 5 3.45E-8
16 SGTC_28 pentachloropyridine N-oxide 5.39 1.6 µM 3.64E-6 TSC3-RPN4 27 3.54E-8
17 SGTC_596 1155-0152 5.33 116.0 µM 4.60E-6 TRP & mitochondrial translation 13 4.93E-8
18 SGTC_173 1273-0061 5.30 2.7 µM 5.22E-6 mitochondrial stress 135 5.90E-8
19 SGTC_63 0099-0242 5.15 26.7 µM 9.09E-6 mitochondrial stress 51 1.30E-7
20 SGTC_2633 5,7-dihydroxyisoflavone 5.08 100.0 µM 1.21E-5 16 1.94E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.458 6.19E-173 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.456 8.03E-172 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.452 1.54E-168 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.446 4.26E-164 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.420 8.72E-144 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.419 1.18E-142 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.419 1.59E-142 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.413 2.60E-138 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.413 3.28E-138 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.409 2.64E-135 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.408 9.86E-135 YGR165W MRPS35 hom Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.406 6.03E-133 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.405 7.12E-133 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.401 3.69E-130 YNR037C RSM19 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
0.399 1.45E-128 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation