YBR262C / AIM5

Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR262C / AIM5

Click on Significant Values for Screen Details ID:SGTC_164|Compound:4100-3994|FD-Score:2.91|P-value:2.45E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:2.93|P-value:2.30E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.46|P-value:1.82E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.25|P-value:7.66E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:2.79|P-value:4.26E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.12|P-value:1.36E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:4.02|P-value:8.17E-7 ID:SGTC_655|Compound:k060-0012|FD-Score:3.56|P-value:1.09E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:4.76|P-value:7.31E-9 ID:SGTC_795|Compound:0685-0265|FD-Score:3.13|P-value:9.31E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:2.67|P-value:6.86E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:2.71|P-value:5.89E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.55|P-value:7.60E-15 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.63|P-value:1.14E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:-2.72|P-value:7.84E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.36|P-value:1.72E-7 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.53|P-value:1.89E-5 ID:SGTC_1563|Compound:conessine|FD-Score:2.79|P-value:4.23E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.94|P-value:3.08E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-2.69|P-value:8.65E-4 ID:SGTC_2046|Compound:4110841|FD-Score:2.84|P-value:3.39E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-2.80|P-value:5.56E-4 ID:SGTC_2255|Compound:7941087|FD-Score:2.96|P-value:2.02E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.00|P-value:9.29E-7 ID:SGTC_2329|Compound:6138490|FD-Score:3.16|P-value:7.90E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.07|P-value:6.32E-7 ID:SGTC_2602|Compound:kawain|FD-Score:4.12|P-value:4.65E-7 ID:SGTC_2628|Compound:lathosterol|FD-Score:2.76|P-value:4.83E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.40|P-value:2.43E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.82|P-value:3.73E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.38|P-value:2.77E-5 ID:SGTC_2808|Compound:7946468|FD-Score:5.39|P-value:7.43E-11 ID:SGTC_2829|Compound:7992743|FD-Score:2.65|P-value:7.62E-4 ID:SGTC_2935|Compound:9038016|FD-Score:2.86|P-value:3.15E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:2.91|P-value:2.45E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:2.93|P-value:2.30E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.46|P-value:1.82E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.25|P-value:7.66E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:2.79|P-value:4.26E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.12|P-value:1.36E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:4.02|P-value:8.17E-7 ID:SGTC_655|Compound:k060-0012|FD-Score:3.56|P-value:1.09E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:4.76|P-value:7.31E-9 ID:SGTC_795|Compound:0685-0265|FD-Score:3.13|P-value:9.31E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:2.67|P-value:6.86E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:2.71|P-value:5.89E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.55|P-value:7.60E-15 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.63|P-value:1.14E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:-2.72|P-value:7.84E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.36|P-value:1.72E-7 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.53|P-value:1.89E-5 ID:SGTC_1563|Compound:conessine|FD-Score:2.79|P-value:4.23E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.94|P-value:3.08E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-2.69|P-value:8.65E-4 ID:SGTC_2046|Compound:4110841|FD-Score:2.84|P-value:3.39E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-2.80|P-value:5.56E-4 ID:SGTC_2255|Compound:7941087|FD-Score:2.96|P-value:2.02E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.00|P-value:9.29E-7 ID:SGTC_2329|Compound:6138490|FD-Score:3.16|P-value:7.90E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.07|P-value:6.32E-7 ID:SGTC_2602|Compound:kawain|FD-Score:4.12|P-value:4.65E-7 ID:SGTC_2628|Compound:lathosterol|FD-Score:2.76|P-value:4.83E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.40|P-value:2.43E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.82|P-value:3.73E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.38|P-value:2.77E-5 ID:SGTC_2808|Compound:7946468|FD-Score:5.39|P-value:7.43E-11 ID:SGTC_2829|Compound:7992743|FD-Score:2.65|P-value:7.62E-4 ID:SGTC_2935|Compound:9038016|FD-Score:2.86|P-value:3.15E-4

Top fitness defect scores for YBR262C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2808 7946468 5.39 45.5 µM 7.43E-11 11 3.55E-8
2 SGTC_769 0302-0231 4.76 76.0 µM 7.31E-9 20 9.64E-7
3 SGTC_2602 kawain 4.12 100.0 µM 4.65E-7 20 1.92E-5
4 SGTC_2568 diosmetin 4.07 100.0 µM 6.32E-7 22 2.40E-5
5 SGTC_640 3381-0960 4.02 37.1 µM 8.17E-7 10 2.88E-5
6 SGTC_2309 7664088 4.00 163.9 µM 9.29E-7 28 3.16E-5
7 SGTC_655 k060-0012 3.56 42.0 µM 1.09E-5 24 1.88E-4
8 SGTC_456 gingerol 3.46 170.0 µM 1.82E-5 34 2.72E-4
9 SGTC_2749 bexarotene 3.40 57.4 µM 2.43E-5 43 3.34E-4
10 SGTC_2806 7952793 3.38 58.4 µM 2.77E-5 43 3.68E-4
11 SGTC_2329 6138490 3.16 200.0 µM 7.90E-5 71 7.85E-4
12 SGTC_795 0685-0265 3.13 78.0 µM 9.31E-5 excess fatty acid 60 8.84E-4
13 SGTC_2255 7941087 2.96 197.4 µM 2.02E-4 83 0.00155
14 SGTC_334 1502-1024 2.93 68.5 µM 2.30E-4 53 0.00171
15 SGTC_164 4100-3994 2.91 89.6 µM 2.45E-4 96 0.00179
16 SGTC_2935 9038016 2.86 30.0 µM 3.15E-4 73 0.00214
17 SGTC_2046 4110841 2.84 106.0 µM 3.39E-4 iron homeostasis 71 0.00226
18 SGTC_2752 diclazuril 2.82 33.1 µM 3.73E-4 219 0.00242
19 SGTC_1563 conessine 2.79 56.1 µM 4.23E-4 78 0.00265
20 SGTC_606 k015-0008 2.79 38.6 µM 4.26E-4 71 0.00267

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.328 4.84E-85 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.292 7.09E-67 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.274 6.68E-59 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.246 2.74E-47 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.236 9.44E-44 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.233 1.64E-42 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.223 5.91E-39 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.220 3.31E-38 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.219 1.11E-37 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.216 1.15E-36 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.210 7.11E-35 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.201 6.59E-32 YEL026W SNU13 het RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
0.200 9.39E-32 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.199 3.41E-31 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.193 1.45E-29 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress