YBR264C / YPT10

Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR264C / YPT10

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.40|P-value:2.90E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.36|P-value:3.41E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.89|P-value:4.17E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.45|P-value:2.45E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:5.41|P-value:2.17E-8 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.08|P-value:8.63E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.29|P-value:4.33E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.23|P-value:5.48E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.38|P-value:3.19E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.37|P-value:3.20E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.32|P-value:3.85E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:-3.05|P-value:9.86E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.27|P-value:4.79E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:5.28|P-value:4.49E-8 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.62|P-value:1.23E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.73|P-value:8.63E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.53|P-value:1.74E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:4.44|P-value:3.42E-6 ID:SGTC_1685|Compound:st024049|FD-Score:-3.21|P-value:5.54E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.13|P-value:7.86E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.64|P-value:1.16E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.16|P-value:7.06E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.32|P-value:3.90E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.51|P-value:1.93E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.28|P-value:4.33E-4 ID:SGTC_2341|Compound:7987486|FD-Score:6.42|P-value:3.88E-11 ID:SGTC_2343|Compound:7990716|FD-Score:-4.24|P-value:8.31E-6 ID:SGTC_2466|Compound:5983409|FD-Score:3.12|P-value:8.11E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.72|P-value:8.40E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.07|P-value:9.03E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.49|P-value:2.11E-4 ID:SGTC_2995|Compound:9067767|FD-Score:4.38|P-value:4.60E-6 ID:SGTC_3067|Compound:9117431|FD-Score:-3.06|P-value:9.50E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.19|P-value:6.17E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.96|P-value:2.90E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:3.40|P-value:2.90E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.36|P-value:3.41E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.89|P-value:4.17E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.45|P-value:2.45E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:5.41|P-value:2.17E-8 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.08|P-value:8.63E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.29|P-value:4.33E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.23|P-value:5.48E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.38|P-value:3.19E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.37|P-value:3.20E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.32|P-value:3.85E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:-3.05|P-value:9.86E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.27|P-value:4.79E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:5.28|P-value:4.49E-8 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.62|P-value:1.23E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.73|P-value:8.63E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.53|P-value:1.74E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:4.44|P-value:3.42E-6 ID:SGTC_1685|Compound:st024049|FD-Score:-3.21|P-value:5.54E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.13|P-value:7.86E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.64|P-value:1.16E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.16|P-value:7.06E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.32|P-value:3.90E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.51|P-value:1.93E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.28|P-value:4.33E-4 ID:SGTC_2341|Compound:7987486|FD-Score:6.42|P-value:3.88E-11 ID:SGTC_2343|Compound:7990716|FD-Score:-4.24|P-value:8.31E-6 ID:SGTC_2466|Compound:5983409|FD-Score:3.12|P-value:8.11E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.72|P-value:8.40E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.07|P-value:9.03E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.49|P-value:2.11E-4 ID:SGTC_2995|Compound:9067767|FD-Score:4.38|P-value:4.60E-6 ID:SGTC_3067|Compound:9117431|FD-Score:-3.06|P-value:9.50E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.19|P-value:6.17E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.96|P-value:2.90E-5

Top fitness defect scores for YBR264C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2341 7987486 6.42 176.7 µM 3.88E-11 3 6.64E-11
2 SGTC_361 000s-0510 5.41 1.4 µM 2.17E-8 8 3.16E-8
3 SGTC_1246 0422-0085 5.28 105.0 µM 4.49E-8 7 6.43E-8
4 SGTC_1360 1598-0022 4.73 39.8 µM 8.63E-7 ERG2 16 1.15E-6
5 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 4.44 61.8 µM 3.42E-6 ergosterol biosynthesis 2 4.41E-6
6 SGTC_2995 9067767 4.38 71.4 µM 4.60E-6 16 5.88E-6
7 SGTC_117 lucigenin 3.89 22.1 µM 4.17E-5 redox potentiating 86 5.05E-5
8 SGTC_2570 licareol 3.72 100.0 µM 8.40E-5 38 1.00E-4
9 SGTC_1936 st074407 3.64 74.3 µM 1.16E-4 DNA damage response 50 1.37E-4
10 SGTC_1350 1495-0454 3.62 146.0 µM 1.23E-4 44 1.46E-4
11 SGTC_1597 7-benzyloxygramine 3.53 47.5 µM 1.74E-4 calcium & mitochondrial duress 154 2.04E-4
12 SGTC_2108 5365811 3.51 200.0 µM 1.93E-4 30 2.25E-4
13 SGTC_2779 methotrexate 3.49 400.0 µM 2.11E-4 38 2.45E-4
14 SGTC_213 1246-0773 3.45 967.0 nM 2.45E-4 38 2.84E-4
15 SGTC_41 0478-0632 3.40 82.6 µM 2.90E-4 51 3.36E-4
16 SGTC_751 0833-0568 3.38 350.0 µM 3.19E-4 42 3.68E-4
17 SGTC_934 2950-0684 3.37 338.0 µM 3.20E-4 39 3.69E-4
18 SGTC_93 0109-0045 3.36 59.2 µM 3.41E-4 DNA damage response 70 3.93E-4
19 SGTC_1048 3161-0300 3.32 24.5 µM 3.85E-4 40 4.43E-4
20 SGTC_2092 5303694 3.32 80.7 µM 3.90E-4 TSC3-RPN4 61 4.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.76E-16 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.122 1.07E-12 YER085C_p YER085C_p hom Putative protein of unknown function
0.121 1.89E-12 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.113 5.33E-11 YHR123W EPT1 hom sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication
0.113 6.11E-11 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.109 2.57E-10 YLR093C NYV1 hom v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane
0.108 2.95E-10 YJR080C AIM24 hom Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss
0.102 3.17E-9 YKR063C LAS1 het Protein required for pre-rRNA processing at both ends of ITS2; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S transition of the cell cycle; human ortholog is Las1L; mutants require the SSD1-v allele for viability
0.090 1.59E-7 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.090 2.01E-7 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.089 2.21E-7 YCR066W RAD18 hom E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA
0.087 5.18E-7 YBL091C-A SCS22 hom Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication
0.086 5.43E-7 YFL019C_d YFL019C_d hom Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
0.086 6.19E-7 YCR043C_p YCR043C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
0.085 9.28E-7 YPR032W SRO7 hom Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication