YBR266C_d / SLM6

Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR266C / SLM6

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:-3.50|P-value:2.77E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.88|P-value:7.33E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.89|P-value:6.93E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.19|P-value:8.10E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.11|P-value:2.49E-5 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.39|P-value:4.49E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.20|P-value:7.98E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.53|P-value:2.74E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.30|P-value:5.53E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.21|P-value:8.37E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.58|P-value:2.01E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:4.24|P-value:1.66E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.77|P-value:1.09E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.38|P-value:7.88E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:6.13|P-value:9.04E-10 ID:SGTC_924|Compound:2046-0044|FD-Score:4.01|P-value:4.35E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:4.88|P-value:8.43E-7 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.15|P-value:9.19E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.24|P-value:7.65E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.85|P-value:8.29E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.91|P-value:7.52E-7 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.42|P-value:4.11E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.93|P-value:5.99E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.99|P-value:4.58E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:-4.82|P-value:9.86E-7 ID:SGTC_1478|Compound:0453-0656|FD-Score:3.98|P-value:4.78E-5 ID:SGTC_1775|Compound:st081588|FD-Score:4.23|P-value:1.72E-5 ID:SGTC_1815|Compound:st051655|FD-Score:-3.47|P-value:3.12E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.82|P-value:9.21E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.46|P-value:3.48E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.61|P-value:1.79E-4 ID:SGTC_2225|Compound:6654152|FD-Score:-3.23|P-value:7.18E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.50|P-value:3.01E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.06|P-value:3.52E-5 ID:SGTC_2441|Compound:5730946|FD-Score:3.27|P-value:6.75E-4 ID:SGTC_2483|Compound:5729050|FD-Score:4.02|P-value:4.08E-5 ID:SGTC_2643|Compound:anethole|FD-Score:3.59|P-value:2.21E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.55|P-value:2.56E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.34|P-value:5.42E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.24|P-value:7.57E-4 ID:SGTC_2808|Compound:7946468|FD-Score:5.80|P-value:6.51E-9 ID:SGTC_2938|Compound:9059746|FD-Score:4.63|P-value:2.83E-6 ID:SGTC_2943|Compound:9068529|FD-Score:3.44|P-value:3.83E-4 ID:SGTC_3006|Compound:9075424|FD-Score:4.35|P-value:1.01E-5 ID:SGTC_3030|Compound:9087619|FD-Score:3.41|P-value:4.22E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.32|P-value:5.84E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-3.52|P-value:2.52E-4 ID:SGTC_3354|Compound:9151612|FD-Score:4.01|P-value:4.22E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:-3.50|P-value:2.77E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.88|P-value:7.33E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.89|P-value:6.93E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.19|P-value:8.10E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.11|P-value:2.49E-5 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.39|P-value:4.49E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.20|P-value:7.98E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.53|P-value:2.74E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.30|P-value:5.53E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.21|P-value:8.37E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.58|P-value:2.01E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:4.24|P-value:1.66E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.77|P-value:1.09E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.38|P-value:7.88E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:6.13|P-value:9.04E-10 ID:SGTC_924|Compound:2046-0044|FD-Score:4.01|P-value:4.35E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:4.88|P-value:8.43E-7 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.15|P-value:9.19E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.24|P-value:7.65E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.85|P-value:8.29E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.91|P-value:7.52E-7 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.42|P-value:4.11E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.93|P-value:5.99E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.99|P-value:4.58E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:-4.82|P-value:9.86E-7 ID:SGTC_1478|Compound:0453-0656|FD-Score:3.98|P-value:4.78E-5 ID:SGTC_1775|Compound:st081588|FD-Score:4.23|P-value:1.72E-5 ID:SGTC_1815|Compound:st051655|FD-Score:-3.47|P-value:3.12E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.82|P-value:9.21E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.46|P-value:3.48E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.61|P-value:1.79E-4 ID:SGTC_2225|Compound:6654152|FD-Score:-3.23|P-value:7.18E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.50|P-value:3.01E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.06|P-value:3.52E-5 ID:SGTC_2441|Compound:5730946|FD-Score:3.27|P-value:6.75E-4 ID:SGTC_2483|Compound:5729050|FD-Score:4.02|P-value:4.08E-5 ID:SGTC_2643|Compound:anethole|FD-Score:3.59|P-value:2.21E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.55|P-value:2.56E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.34|P-value:5.42E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.24|P-value:7.57E-4 ID:SGTC_2808|Compound:7946468|FD-Score:5.80|P-value:6.51E-9 ID:SGTC_2938|Compound:9059746|FD-Score:4.63|P-value:2.83E-6 ID:SGTC_2943|Compound:9068529|FD-Score:3.44|P-value:3.83E-4 ID:SGTC_3006|Compound:9075424|FD-Score:4.35|P-value:1.01E-5 ID:SGTC_3030|Compound:9087619|FD-Score:3.41|P-value:4.22E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.32|P-value:5.84E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-3.52|P-value:2.52E-4 ID:SGTC_3354|Compound:9151612|FD-Score:4.01|P-value:4.22E-5

Top fitness defect scores for YBR266C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_911 3456-4043 6.13 236.0 µM 9.04E-10 mitochondrial processes 2 4.34E-10
2 SGTC_2808 7946468 5.80 45.5 µM 6.51E-9 8 3.36E-9
3 SGTC_1178 0988-0033 4.91 191.0 µM 7.52E-7 14 4.60E-7
4 SGTC_928 2764-0428 4.88 58.7 µM 8.43E-7 cell wall 32 5.18E-7
5 SGTC_2938 9059746 4.63 27.3 µM 2.83E-6 fatty acid desaturase (OLE1) 28 1.82E-6
6 SGTC_3006 9075424 4.35 71.4 µM 1.01E-5 8 6.78E-6
7 SGTC_851 0394-0702 4.24 453.0 µM 1.66E-5 mitochondrial processes 6 1.14E-5
8 SGTC_1775 st081588 4.23 35.2 µM 1.72E-5 60S ribosome export 19 1.18E-5
9 SGTC_2300 7976697 4.06 71.6 µM 3.52E-5 ERG2 30 2.48E-5
10 SGTC_2483 5729050 4.02 27.2 µM 4.08E-5 22 2.88E-5
11 SGTC_3354 9151612 4.01 71.4 µM 4.22E-5 7 2.99E-5
12 SGTC_924 2046-0044 4.01 21.3 µM 4.35E-5 13 3.08E-5
13 SGTC_1247 0448-0043 3.99 5.8 µM 4.58E-5 ERG2 39 3.25E-5
14 SGTC_1478 0453-0656 3.98 35.7 µM 4.78E-5 19 3.40E-5
15 SGTC_1220 1838-0075 3.93 193.0 µM 5.99E-5 11 4.30E-5
16 SGTC_118 0083-0097 3.89 135.3 µM 6.93E-5 translation 139 5.00E-5
17 SGTC_33 0986-0033 3.88 35.8 µM 7.33E-5 calcium & mitochondrial duress 23 5.30E-5
18 SGTC_973 1325-0077 3.85 65.9 µM 8.29E-5 9 6.01E-5
19 SGTC_1827 berberine 3.82 7.2 µM 9.21E-5 60S ribosome export 22 6.71E-5
20 SGTC_864 0469-0573 3.77 172.0 µM 1.09E-4 25 8.00E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 6.01E-10 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.106 8.53E-10 YPL239W YAR1 hom Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
0.094 5.25E-8 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.088 3.26E-7 YBR017C KAP104 hom Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis
0.084 1.10E-6 YBR267W REI1 hom Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
0.082 2.16E-6 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.081 2.82E-6 YLR062C_d BUD28_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.076 1.15E-5 YAL059W ECM1 hom Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
0.075 1.42E-5 YMR290W-A_d YMR290W-A_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
0.074 1.65E-5 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.074 1.68E-5 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.074 2.02E-5 YDR196C CAB5 het Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies
0.072 3.21E-5 YKR092C SRP40 hom Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
0.070 4.48E-5 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.070 5.05E-5 YOL144W NOP8 het Nucleolar protein required for 60S ribosomal subunit biogenesis