YBR268W / MRPL37

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR268W / MRPL37

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.05|P-value:1.17E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:5.00|P-value:1.40E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:10.70|P-value:1.81E-19 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.74|P-value:7.87E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:6.86|P-value:4.47E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:11.40|P-value:6.87E-22 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.14|P-value:2.64E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.90|P-value:1.73E-11 ID:SGTC_314|Compound:1671-0008|FD-Score:3.98|P-value:4.28E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:-3.72|P-value:8.24E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-4.83|P-value:2.26E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.41|P-value:2.51E-6 ID:SGTC_480|Compound:am 92016|FD-Score:3.80|P-value:7.40E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:-4.48|P-value:7.67E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:5.26|P-value:5.29E-6 ID:SGTC_755|Compound:1995-0008|FD-Score:5.48|P-value:2.24E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:6.81|P-value:5.53E-9 ID:SGTC_767|Compound:0929-0023|FD-Score:6.10|P-value:1.61E-7 ID:SGTC_771|Compound:0250-0039|FD-Score:3.82|P-value:6.91E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.87|P-value:2.25E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:4.21|P-value:2.11E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.67|P-value:4.62E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.99|P-value:1.48E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:-4.26|P-value:1.59E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.18|P-value:2.35E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.93|P-value:3.41E-7 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.61|P-value:5.71E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.89|P-value:2.12E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.03|P-value:3.68E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:7.16|P-value:9.52E-10 ID:SGTC_1526|Compound:st051518|FD-Score:4.68|P-value:4.41E-5 ID:SGTC_1616|Compound:st002734|FD-Score:-4.66|P-value:4.13E-5 ID:SGTC_1621|Compound:st003705|FD-Score:4.62|P-value:5.50E-5 ID:SGTC_1622|Compound:st003707|FD-Score:4.04|P-value:3.59E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.21|P-value:2.10E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.73|P-value:9.17E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.42|P-value:3.71E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.80|P-value:6.55E-4 ID:SGTC_1833|Compound:st055984|FD-Score:5.29|P-value:4.65E-6 ID:SGTC_1896|Compound:st058441|FD-Score:4.21|P-value:2.16E-4 ID:SGTC_1905|Compound:st060207|FD-Score:5.93|P-value:3.40E-7 ID:SGTC_2120|Compound:5538279|FD-Score:4.42|P-value:1.07E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.43|P-value:2.69E-6 ID:SGTC_2304|Compound:7443016|FD-Score:4.37|P-value:1.28E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.74|P-value:7.90E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-6.37|P-value:3.80E-8 ID:SGTC_2310|Compound:7668677|FD-Score:-4.55|P-value:5.96E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.75|P-value:8.60E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.80|P-value:7.41E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.34|P-value:1.42E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-5.05|P-value:9.92E-6 ID:SGTC_2696|Compound:st077691|FD-Score:4.19|P-value:2.30E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-6.89|P-value:3.11E-9 ID:SGTC_2835|Compound:9006588|FD-Score:4.16|P-value:2.50E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.31|P-value:3.68E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-3.72|P-value:8.21E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.89|P-value:5.71E-4 ID:SGTC_3326|Compound:9140064|FD-Score:8.75|P-value:1.05E-13 ID:SGTC_3331|Compound:9141060|FD-Score:4.72|P-value:3.89E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:5.05|P-value:1.17E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:5.00|P-value:1.40E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:10.70|P-value:1.81E-19 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.74|P-value:7.87E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:6.86|P-value:4.47E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:11.40|P-value:6.87E-22 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.14|P-value:2.64E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.90|P-value:1.73E-11 ID:SGTC_314|Compound:1671-0008|FD-Score:3.98|P-value:4.28E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:-3.72|P-value:8.24E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-4.83|P-value:2.26E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.41|P-value:2.51E-6 ID:SGTC_480|Compound:am 92016|FD-Score:3.80|P-value:7.40E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:-4.48|P-value:7.67E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:5.26|P-value:5.29E-6 ID:SGTC_755|Compound:1995-0008|FD-Score:5.48|P-value:2.24E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:6.81|P-value:5.53E-9 ID:SGTC_767|Compound:0929-0023|FD-Score:6.10|P-value:1.61E-7 ID:SGTC_771|Compound:0250-0039|FD-Score:3.82|P-value:6.91E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.87|P-value:2.25E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:4.21|P-value:2.11E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.67|P-value:4.62E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.99|P-value:1.48E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:-4.26|P-value:1.59E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.18|P-value:2.35E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.93|P-value:3.41E-7 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.61|P-value:5.71E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.89|P-value:2.12E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.03|P-value:3.68E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:7.16|P-value:9.52E-10 ID:SGTC_1526|Compound:st051518|FD-Score:4.68|P-value:4.41E-5 ID:SGTC_1616|Compound:st002734|FD-Score:-4.66|P-value:4.13E-5 ID:SGTC_1621|Compound:st003705|FD-Score:4.62|P-value:5.50E-5 ID:SGTC_1622|Compound:st003707|FD-Score:4.04|P-value:3.59E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.21|P-value:2.10E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.73|P-value:9.17E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.42|P-value:3.71E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.80|P-value:6.55E-4 ID:SGTC_1833|Compound:st055984|FD-Score:5.29|P-value:4.65E-6 ID:SGTC_1896|Compound:st058441|FD-Score:4.21|P-value:2.16E-4 ID:SGTC_1905|Compound:st060207|FD-Score:5.93|P-value:3.40E-7 ID:SGTC_2120|Compound:5538279|FD-Score:4.42|P-value:1.07E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.43|P-value:2.69E-6 ID:SGTC_2304|Compound:7443016|FD-Score:4.37|P-value:1.28E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.74|P-value:7.90E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-6.37|P-value:3.80E-8 ID:SGTC_2310|Compound:7668677|FD-Score:-4.55|P-value:5.96E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.75|P-value:8.60E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.80|P-value:7.41E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.34|P-value:1.42E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-5.05|P-value:9.92E-6 ID:SGTC_2696|Compound:st077691|FD-Score:4.19|P-value:2.30E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-6.89|P-value:3.11E-9 ID:SGTC_2835|Compound:9006588|FD-Score:4.16|P-value:2.50E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.31|P-value:3.68E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-3.72|P-value:8.21E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.89|P-value:5.71E-4 ID:SGTC_3326|Compound:9140064|FD-Score:8.75|P-value:1.05E-13 ID:SGTC_3331|Compound:9141060|FD-Score:4.72|P-value:3.89E-5

Top fitness defect scores for YBR268W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 11.40 5.3 µM 6.87E-22 163 3.02E-30
2 SGTC_70 0141-0289 10.70 43.3 µM 1.81E-19 mitochondrial stress 17 7.91E-27
3 SGTC_3326 9140064 8.75 16.4 µM 1.05E-13 2 1.07E-18
4 SGTC_310 1273-0058 7.90 1.1 µM 1.73E-11 mitochondrial stress 93 1.41E-15
5 SGTC_1468 k284-1086 7.16 134.0 µM 9.52E-10 DNA intercalators 3 4.00E-13
6 SGTC_173 1273-0061 6.86 2.7 µM 4.47E-9 mitochondrial stress 91 3.52E-12
7 SGTC_761 k216-0224 6.81 480.0 µM 5.53E-9 1 4.75E-12
8 SGTC_1742 st038235 6.42 28.9 µM 3.71E-8 mitochondrial stress 39 6.90E-11
9 SGTC_767 0929-0023 6.10 86.0 µM 1.61E-7 TRP & mitochondrial translation 21 5.44E-10
10 SGTC_1905 st060207 5.93 84.5 µM 3.40E-7 1 1.55E-9
11 SGTC_1247 0448-0043 5.93 5.8 µM 3.41E-7 ERG2 10 1.56E-9
12 SGTC_755 1995-0008 5.48 37.3 µM 2.24E-6 7 2.18E-8
13 SGTC_2232 chlorophetanol 5.43 41.5 µM 2.69E-6 TRP & mitochondrial translation 58 2.83E-8
14 SGTC_1833 st055984 5.29 71.0 µM 4.65E-6 5 6.08E-8
15 SGTC_720 r052-1644 5.26 49.9 µM 5.29E-6 TSC3-RPN4 12 7.29E-8
16 SGTC_10 0279-0212 5.05 42.6 µM 1.17E-5 TRP & mitochondrial translation 58 2.23E-7
17 SGTC_63 0099-0242 5.00 26.7 µM 1.40E-5 mitochondrial stress 56 2.86E-7
18 SGTC_1057 3448-5381 4.99 134.0 µM 1.48E-5 calcium & mitochondrial duress 13 3.08E-7
19 SGTC_1353 1498-1206 4.89 8.1 µM 2.12E-5 mitochondrial response to ROS 31 5.10E-7
20 SGTC_800 3448-7362 4.87 155.0 µM 2.25E-5 translation 97 5.54E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.380 1.65E-115 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.369 4.75E-109 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.352 1.00E-98 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.349 2.78E-96 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.345 2.31E-94 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.343 1.90E-93 YIL070C MAM33 hom Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R
0.340 2.27E-91 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.339 3.59E-91 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.339 6.54E-91 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.338 3.38E-90 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.337 7.09E-90 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.336 1.85E-89 YJL063C MRPL8 hom Mitochondrial ribosomal protein of the large subunit
0.335 6.20E-89 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.335 1.74E-88 YLR439W MRPL4 hom Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
0.334 5.03E-88 YGR101W PCP1 hom Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases