YBR269C_p / FMP21

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR269C / FMP21

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.16|P-value:1.90E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.67|P-value:1.95E-6 ID:SGTC_99|Compound:0109-0120|FD-Score:4.59|P-value:2.72E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:3.59|P-value:1.89E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.17|P-value:8.61E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.13|P-value:9.62E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.29|P-value:1.06E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.21|P-value:7.39E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.83|P-value:7.58E-5 ID:SGTC_904|Compound:1141-0088|FD-Score:3.30|P-value:5.43E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.22|P-value:7.36E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.56|P-value:3.14E-6 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.47|P-value:4.76E-6 ID:SGTC_1456|Compound:k015-0012|FD-Score:-3.39|P-value:3.98E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.80|P-value:8.57E-5 ID:SGTC_1521|Compound:st012942|FD-Score:7.35|P-value:1.73E-13 ID:SGTC_1523|Compound:st012844|FD-Score:3.52|P-value:2.43E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.83|P-value:7.40E-5 ID:SGTC_1676|Compound:st018489|FD-Score:-3.14|P-value:9.41E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.29|P-value:5.58E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.17|P-value:8.52E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.16|P-value:8.83E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.88|P-value:6.17E-5 ID:SGTC_1995|Compound:st072814|FD-Score:5.15|P-value:1.76E-7 ID:SGTC_1996|Compound:st072960|FD-Score:3.26|P-value:6.34E-4 ID:SGTC_1997|Compound:st073024|FD-Score:7.49|P-value:6.35E-14 ID:SGTC_2044|Compound:5102272|FD-Score:3.31|P-value:5.24E-4 ID:SGTC_2256|Compound:7954252|FD-Score:-3.87|P-value:6.60E-5 ID:SGTC_2291|Compound:7917025|FD-Score:-3.80|P-value:8.51E-5 ID:SGTC_2294|Compound:7971431|FD-Score:3.28|P-value:5.87E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.21|P-value:7.42E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.37|P-value:4.25E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.74|P-value:1.06E-4 ID:SGTC_2472|Compound:5377652|FD-Score:-3.70|P-value:1.27E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.24|P-value:6.62E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.30|P-value:5.56E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.95|P-value:4.56E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.56|P-value:2.13E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.17|P-value:8.37E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.32|P-value:5.05E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.16|P-value:8.83E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.54|P-value:2.25E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.70|P-value:1.28E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.28|P-value:5.84E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.19|P-value:7.97E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.16|P-value:1.90E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.67|P-value:1.95E-6 ID:SGTC_99|Compound:0109-0120|FD-Score:4.59|P-value:2.72E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:3.59|P-value:1.89E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.17|P-value:8.61E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.13|P-value:9.62E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.29|P-value:1.06E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.21|P-value:7.39E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.83|P-value:7.58E-5 ID:SGTC_904|Compound:1141-0088|FD-Score:3.30|P-value:5.43E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.22|P-value:7.36E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.56|P-value:3.14E-6 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.47|P-value:4.76E-6 ID:SGTC_1456|Compound:k015-0012|FD-Score:-3.39|P-value:3.98E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.80|P-value:8.57E-5 ID:SGTC_1521|Compound:st012942|FD-Score:7.35|P-value:1.73E-13 ID:SGTC_1523|Compound:st012844|FD-Score:3.52|P-value:2.43E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.83|P-value:7.40E-5 ID:SGTC_1676|Compound:st018489|FD-Score:-3.14|P-value:9.41E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.29|P-value:5.58E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.17|P-value:8.52E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.16|P-value:8.83E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.88|P-value:6.17E-5 ID:SGTC_1995|Compound:st072814|FD-Score:5.15|P-value:1.76E-7 ID:SGTC_1996|Compound:st072960|FD-Score:3.26|P-value:6.34E-4 ID:SGTC_1997|Compound:st073024|FD-Score:7.49|P-value:6.35E-14 ID:SGTC_2044|Compound:5102272|FD-Score:3.31|P-value:5.24E-4 ID:SGTC_2256|Compound:7954252|FD-Score:-3.87|P-value:6.60E-5 ID:SGTC_2291|Compound:7917025|FD-Score:-3.80|P-value:8.51E-5 ID:SGTC_2294|Compound:7971431|FD-Score:3.28|P-value:5.87E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.21|P-value:7.42E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.37|P-value:4.25E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.74|P-value:1.06E-4 ID:SGTC_2472|Compound:5377652|FD-Score:-3.70|P-value:1.27E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.24|P-value:6.62E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.30|P-value:5.56E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.95|P-value:4.56E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.56|P-value:2.13E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.17|P-value:8.37E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.32|P-value:5.05E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.16|P-value:8.83E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.54|P-value:2.25E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.70|P-value:1.28E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.28|P-value:5.84E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.19|P-value:7.97E-4

Top fitness defect scores for YBR269C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1997 st073024 7.49 93.8 µM 6.35E-14 1 3.52E-14
2 SGTC_1521 st012942 7.35 49.4 µM 1.73E-13 3 9.82E-14
3 SGTC_1995 st072814 5.15 61.1 µM 1.76E-7 2 1.33E-7
4 SGTC_99 0109-0120 4.59 622.8 µM 2.72E-6 6 2.18E-6
5 SGTC_1037 k284-1091 4.56 78.7 µM 3.14E-6 6 2.52E-6
6 SGTC_1446 4239-0190 4.47 62.0 µM 4.76E-6 23 3.85E-6
7 SGTC_710 3448-4187 4.29 58.0 µM 1.06E-5 fatty acid desaturase (OLE1) 47 8.75E-6
8 SGTC_58 0957-0393 4.16 9.0 µM 1.90E-5 cell wall 359 1.58E-5
9 SGTC_2532 xanthone 3.95 78.9 µM 4.56E-5 27 3.86E-5
10 SGTC_1990 st072050 3.88 59.8 µM 6.17E-5 14 5.26E-5
11 SGTC_1534 6-azauridine 3.83 81.6 µM 7.40E-5 RNA pol III & RNase P/MRP 25 6.33E-5
12 SGTC_848 0368-0089 3.83 85.6 µM 7.58E-5 iron homeostasis 16 6.49E-5
13 SGTC_2466 5983409 3.74 37.1 µM 1.06E-4 23 9.14E-5
14 SGTC_145 3737-0113 3.59 38.4 µM 1.89E-4 DNA intercalators 93 1.65E-4
15 SGTC_2560 caryophyllene 3.56 100.0 µM 2.13E-4 26 1.86E-4
16 SGTC_3191 9110352 3.54 49.5 µM 2.25E-4 22 1.97E-4
17 SGTC_1523 st012844 3.52 44.7 µM 2.43E-4 60S ribosome export 38 2.13E-4
18 SGTC_2307 7538926 3.37 6.3 µM 4.25E-4 62 3.77E-4
19 SGTC_2787 5284540 3.32 71.4 µM 5.05E-4 48 4.49E-4
20 SGTC_2044 5102272 3.31 200.0 µM 5.24E-4 26 4.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 4.93E-14 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.112 7.79E-11 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.108 3.00E-10 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.105 9.43E-10 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.102 3.25E-9 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.100 5.62E-9 YOR106W VAM3 hom Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region
0.099 9.69E-9 YMR047C NUP116 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p)
0.098 1.19E-8 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.097 1.56E-8 YCR087W_d YCR087W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene
0.094 5.15E-8 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.094 5.36E-8 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.093 7.28E-8 YLR392C ART10 hom Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene
0.092 1.04E-7 YBR286W APE3 hom Vacuolar aminopeptidase Y, processed to mature form by Prb1p
0.091 1.15E-7 YDL213C NOP6 hom rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
0.090 1.93E-7 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids