YBR270C_p / BIT2

Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR270C / BIT2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.56|P-value:7.51E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:3.34|P-value:1.82E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.27|P-value:2.40E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.33|P-value:1.95E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.26|P-value:2.96E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.05|P-value:7.85E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.11|P-value:6.19E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.10|P-value:1.00E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.41|P-value:2.01E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.54|P-value:7.14E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.74|P-value:3.35E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.18|P-value:3.47E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.83|P-value:2.28E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.02|P-value:8.69E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.08|P-value:6.98E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.40|P-value:1.48E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:2.92|P-value:9.12E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.14|P-value:5.45E-6 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.11|P-value:4.47E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.47|P-value:1.04E-6 ID:SGTC_1745|Compound:st081495|FD-Score:3.46|P-value:1.12E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-5.85|P-value:5.03E-10 ID:SGTC_1791|Compound:st048313|FD-Score:2.94|P-value:8.36E-4 ID:SGTC_1793|Compound:st048256|FD-Score:-3.59|P-value:9.63E-5 ID:SGTC_2067|Compound:5224629|FD-Score:-3.24|P-value:3.81E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.08|P-value:5.06E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.01|P-value:6.44E-4 ID:SGTC_2268|Compound:7933382|FD-Score:5.40|P-value:5.13E-9 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.57|P-value:1.05E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.73|P-value:5.24E-5 ID:SGTC_2671|Compound:danthron|FD-Score:3.18|P-value:3.46E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-3.44|P-value:1.73E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:2.91|P-value:9.29E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.69|P-value:4.31E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.35|P-value:2.51E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.15|P-value:4.97E-6 ID:SGTC_2810|Compound:7959871|FD-Score:-3.28|P-value:3.36E-4 ID:SGTC_2846|Compound:9008642|FD-Score:2.94|P-value:8.51E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.80|P-value:2.66E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.56|P-value:7.51E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:3.34|P-value:1.82E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.27|P-value:2.40E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.33|P-value:1.95E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.26|P-value:2.96E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.05|P-value:7.85E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.11|P-value:6.19E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.10|P-value:1.00E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.41|P-value:2.01E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.54|P-value:7.14E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.74|P-value:3.35E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.18|P-value:3.47E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.83|P-value:2.28E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.02|P-value:8.69E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.08|P-value:6.98E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.40|P-value:1.48E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:2.92|P-value:9.12E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.14|P-value:5.45E-6 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.11|P-value:4.47E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.47|P-value:1.04E-6 ID:SGTC_1745|Compound:st081495|FD-Score:3.46|P-value:1.12E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-5.85|P-value:5.03E-10 ID:SGTC_1791|Compound:st048313|FD-Score:2.94|P-value:8.36E-4 ID:SGTC_1793|Compound:st048256|FD-Score:-3.59|P-value:9.63E-5 ID:SGTC_2067|Compound:5224629|FD-Score:-3.24|P-value:3.81E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.08|P-value:5.06E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.01|P-value:6.44E-4 ID:SGTC_2268|Compound:7933382|FD-Score:5.40|P-value:5.13E-9 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.57|P-value:1.05E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.73|P-value:5.24E-5 ID:SGTC_2671|Compound:danthron|FD-Score:3.18|P-value:3.46E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-3.44|P-value:1.73E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:2.91|P-value:9.29E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.69|P-value:4.31E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.35|P-value:2.51E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.15|P-value:4.97E-6 ID:SGTC_2810|Compound:7959871|FD-Score:-3.28|P-value:3.36E-4 ID:SGTC_2846|Compound:9008642|FD-Score:2.94|P-value:8.51E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.80|P-value:2.66E-5

Top fitness defect scores for YBR270C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2268 7933382 5.40 153.8 µM 5.13E-9 13 3.39E-8
2 SGTC_967 1306-0166 4.54 352.0 µM 7.14E-7 16 2.85E-6
3 SGTC_1565 sinapyl alcohol 4.47 95.1 µM 1.04E-6 17 3.99E-6
4 SGTC_453 enantio-paf c16 4.26 10.0 µM 2.96E-6 122 1.02E-5
5 SGTC_2758 dehydroepiandrosterone 4.15 69.3 µM 4.97E-6 33 1.63E-5
6 SGTC_1159 4092-0538 4.14 61.2 µM 5.45E-6 24 1.77E-5
7 SGTC_1120 ficusin 4.08 1.8 µM 6.98E-6 21 2.21E-5
8 SGTC_1021 4476-0760 3.83 85.3 µM 2.28E-5 31 6.40E-5
9 SGTC_2943 9068529 3.80 45.3 µM 2.66E-5 21 7.36E-5
10 SGTC_1014 4130-3005 3.74 69.3 µM 3.35E-5 24 9.06E-5
11 SGTC_2750 bromebric acid 3.69 70.2 µM 4.31E-5 39 1.14E-4
12 SGTC_58 0957-0393 3.56 9.0 µM 7.51E-5 cell wall 423 1.87E-4
13 SGTC_1745 st081495 3.46 74.0 µM 1.12E-4 RNA processing & uracil transport 98 2.67E-4
14 SGTC_1126 isoteolin 3.40 1.0 µM 1.48E-4 50 3.43E-4
15 SGTC_64 000l-0018 3.34 272.1 µM 1.82E-4 ubiquinone biosynthesis & proteasome 187 4.15E-4
16 SGTC_158 k038-0087 3.33 26.4 µM 1.95E-4 ubiquinone biosynthesis & proteasome 183 4.40E-4
17 SGTC_142 0335-0849 3.27 62.7 µM 2.40E-4 ubiquinone biosynthesis & proteasome 178 5.31E-4
18 SGTC_2671 danthron 3.18 100.0 µM 3.46E-4 DNA damage response 67 7.37E-4
19 SGTC_1017 4239-0030 3.18 168.0 µM 3.47E-4 59 7.39E-4
20 SGTC_1163 k060-0048 3.11 49.9 µM 4.47E-4 60 9.28E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 5.95E-24 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.168 1.44E-22 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.167 2.60E-22 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.160 9.59E-21 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.155 1.45E-19 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.152 7.99E-19 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.150 1.82E-18 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.150 2.22E-18 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.146 1.88E-17 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.145 2.38E-17 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.141 2.03E-16 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.137 1.37E-15 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.134 5.52E-15 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.134 8.04E-15 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.131 2.34E-14 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p