YBR273C / UBX7

UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR273C / UBX7

Click on Significant Values for Screen Details ID:SGTC_179|Compound:1273-0063|FD-Score:2.94|P-value:5.13E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:2.77|P-value:9.67E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.23|P-value:1.52E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.17|P-value:1.93E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-3.08|P-value:2.43E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.12|P-value:2.09E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:2.93|P-value:5.31E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.25|P-value:1.21E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:5.55|P-value:2.49E-10 ID:SGTC_949|Compound:1165-0505|FD-Score:-2.83|P-value:6.80E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:2.91|P-value:5.79E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:4.06|P-value:2.73E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:-2.85|P-value:6.36E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.04|P-value:3.38E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.03|P-value:3.47E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.20|P-value:1.75E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.25|P-value:9.67E-7 ID:SGTC_1195|Compound:1502-0147|FD-Score:-2.88|P-value:5.63E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.07|P-value:3.00E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.06|P-value:3.12E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.85|P-value:7.20E-4 ID:SGTC_1516|Compound:st013856|FD-Score:-3.27|P-value:1.10E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:2.80|P-value:8.65E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.20|P-value:1.74E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.28|P-value:1.24E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.50|P-value:4.40E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-2.76|P-value:8.91E-4 ID:SGTC_1977|Compound:st070720|FD-Score:2.94|P-value:5.14E-4 ID:SGTC_1978|Compound:st071761|FD-Score:-2.80|P-value:7.74E-4 ID:SGTC_1988|Compound:st071872|FD-Score:2.94|P-value:5.03E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.04|P-value:2.96E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.81|P-value:8.55E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.75|P-value:1.38E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:2.78|P-value:9.43E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.14|P-value:1.92E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-3.01|P-value:3.25E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-4.33|P-value:5.17E-7 ID:SGTC_2957|Compound:9076800|FD-Score:-2.80|P-value:7.53E-4 ID:SGTC_2959|Compound:9079155|FD-Score:4.36|P-value:5.27E-7 ID:SGTC_3044|Compound:9093193|FD-Score:3.62|P-value:2.56E-5 ID:SGTC_3158|Compound:9100007|FD-Score:-3.41|P-value:5.85E-5 ID:SGTC_3218|Compound:9131285|FD-Score:4.00|P-value:3.67E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:2.94|P-value:5.13E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:2.77|P-value:9.67E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.23|P-value:1.52E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.17|P-value:1.93E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-3.08|P-value:2.43E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.12|P-value:2.09E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:2.93|P-value:5.31E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.25|P-value:1.21E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:5.55|P-value:2.49E-10 ID:SGTC_949|Compound:1165-0505|FD-Score:-2.83|P-value:6.80E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:2.91|P-value:5.79E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:4.06|P-value:2.73E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:-2.85|P-value:6.36E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.04|P-value:3.38E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.03|P-value:3.47E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.20|P-value:1.75E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.25|P-value:9.67E-7 ID:SGTC_1195|Compound:1502-0147|FD-Score:-2.88|P-value:5.63E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.07|P-value:3.00E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.06|P-value:3.12E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.85|P-value:7.20E-4 ID:SGTC_1516|Compound:st013856|FD-Score:-3.27|P-value:1.10E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:2.80|P-value:8.65E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.20|P-value:1.74E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.28|P-value:1.24E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.50|P-value:4.40E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-2.76|P-value:8.91E-4 ID:SGTC_1977|Compound:st070720|FD-Score:2.94|P-value:5.14E-4 ID:SGTC_1978|Compound:st071761|FD-Score:-2.80|P-value:7.74E-4 ID:SGTC_1988|Compound:st071872|FD-Score:2.94|P-value:5.03E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.04|P-value:2.96E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.81|P-value:8.55E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.75|P-value:1.38E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:2.78|P-value:9.43E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.14|P-value:1.92E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-3.01|P-value:3.25E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-4.33|P-value:5.17E-7 ID:SGTC_2957|Compound:9076800|FD-Score:-2.80|P-value:7.53E-4 ID:SGTC_2959|Compound:9079155|FD-Score:4.36|P-value:5.27E-7 ID:SGTC_3044|Compound:9093193|FD-Score:3.62|P-value:2.56E-5 ID:SGTC_3158|Compound:9100007|FD-Score:-3.41|P-value:5.85E-5 ID:SGTC_3218|Compound:9131285|FD-Score:4.00|P-value:3.67E-6

Top fitness defect scores for YBR273C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_941 3237-0776 5.55 460.0 µM 2.49E-10 3 1.45E-8
2 SGTC_2959 9079155 4.36 11.0 µM 5.27E-7 19 6.59E-6
3 SGTC_1155 4088-0394 4.25 48.2 µM 9.67E-7 20 1.07E-5
4 SGTC_963 1269-2853 4.06 151.0 µM 2.73E-6 21 2.46E-5
5 SGTC_3218 9131285 4.00 49.5 µM 3.67E-6 endomembrane recycling 41 3.12E-5
6 SGTC_2522 biochanin a 3.75 4.9 µM 1.38E-5 RNA pol III & RNase P/MRP 15 9.02E-5
7 SGTC_3044 9093193 3.62 49.5 µM 2.56E-5 38 1.48E-4
8 SGTC_1805 st050013 3.50 60.3 µM 4.40E-5 13 2.30E-4
9 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 3.28 19.1 µM 1.24E-4 50 5.27E-4
10 SGTC_296 1222-0039 3.23 74.9 µM 1.52E-4 35 6.22E-4
11 SGTC_1533 dihydroergotamine mesylate 3.20 29.4 µM 1.74E-4 DNA intercalators 33 6.92E-4
12 SGTC_1153 4055-0057 3.20 267.0 µM 1.75E-4 66 6.97E-4
13 SGTC_445 e6 berbamine 3.17 66.0 µM 1.93E-4 NEO1-PIK1 169 7.55E-4
14 SGTC_1219 1469-0211 3.07 33.1 µM 3.00E-4 43 0.00108
15 SGTC_1255 0566-0045 3.06 221.0 µM 3.12E-4 excess fatty acid 70 0.00111
16 SGTC_1059 3448-6867 3.04 171.0 µM 3.38E-4 40 0.00119
17 SGTC_1087 pterostilbene 3.03 9.1 µM 3.47E-4 76 0.00121
18 SGTC_1988 st071872 2.94 53.4 µM 5.03E-4 47 0.00163
19 SGTC_179 1273-0063 2.94 6.8 µM 5.13E-4 57 0.00166
20 SGTC_1977 st070720 2.94 65.3 µM 5.14E-4 51 0.00166

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.83E-13 YDR075W PPH3 hom Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
0.125 3.08E-13 YPL070W MUK1 hom Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation
0.112 8.01E-11 YJR004C SAG1 hom Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
0.101 4.49E-9 YJR038C_d YJR038C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.01E-8 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.095 4.07E-8 YMR194W RPL36A hom Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication
0.092 9.22E-8 YGL151W NUT1 hom Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
0.091 1.49E-7 YDR111C_p ALT2_p hom Catalytically inactive paralog of ALT1, an alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p
0.085 8.54E-7 YNR046W TRM112 het Protein involved in methylation of tRNA, rRNA, and translation factors; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; relative distribution to the nucleus increases upon DNA replication stress
0.082 1.74E-6 YMR013W-A_d YMR013W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73
0.078 5.49E-6 YLL018C DPS1 het Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation
0.075 1.46E-5 YPR148C YPR148C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.074 1.77E-5 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.074 1.78E-5 YGL010W_p YGL010W_p hom Putative protein of unknown function; YGL010W is not an essential gene
0.074 1.86E-5 YHR097C_p YHR097C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus