YBR275C / RIF1

Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR275C / RIF1

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.58|P-value:1.24E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.97|P-value:5.66E-10 ID:SGTC_55|Compound:0767-0285|FD-Score:4.03|P-value:1.91E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.77|P-value:5.70E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.36|P-value:4.22E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:9.04|P-value:1.88E-20 ID:SGTC_86|Compound:0417-1630|FD-Score:6.73|P-value:3.56E-12 ID:SGTC_137|Compound:0438-0332|FD-Score:3.70|P-value:7.44E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:9.71|P-value:2.56E-23 ID:SGTC_158|Compound:k038-0087|FD-Score:5.30|P-value:3.18E-8 ID:SGTC_294|Compound:k038-0071|FD-Score:3.48|P-value:1.79E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:-3.14|P-value:8.57E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:5.41|P-value:1.68E-8 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.46|P-value:2.69E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.20|P-value:5.42E-8 ID:SGTC_631|Compound:k072-0230|FD-Score:3.35|P-value:2.98E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:8.66|P-value:6.14E-19 ID:SGTC_642|Compound:0335-0876|FD-Score:5.08|P-value:1.07E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:8.25|P-value:2.18E-17 ID:SGTC_798|Compound:1287-0182|FD-Score:3.84|P-value:4.17E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:-3.77|P-value:8.08E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:3.43|P-value:2.18E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.11|P-value:7.18E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.54|P-value:1.72E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:4.55|P-value:1.68E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.69|P-value:8.02E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.15|P-value:6.08E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:-3.75|P-value:8.52E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.53|P-value:1.51E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:-3.27|P-value:5.40E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.68|P-value:1.16E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.10|P-value:9.73E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.09|P-value:7.52E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.77|P-value:5.64E-5 ID:SGTC_1946|Compound:st076057|FD-Score:3.62|P-value:1.04E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.32|P-value:4.46E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.78|P-value:5.43E-5 ID:SGTC_2266|Compound:7929956|FD-Score:-3.53|P-value:2.08E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.46|P-value:2.68E-4 ID:SGTC_2277|Compound:7947813|FD-Score:4.45|P-value:2.65E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.24|P-value:4.52E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.13|P-value:8.62E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.09|P-value:1.44E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.01|P-value:2.00E-5 ID:SGTC_2602|Compound:kawain|FD-Score:3.15|P-value:6.19E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.23|P-value:4.64E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-3.47|P-value:2.55E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.33|P-value:3.18E-4 ID:SGTC_2847|Compound:9005661|FD-Score:3.03|P-value:9.36E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.52|P-value:1.52E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.59|P-value:1.20E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.96|P-value:3.65E-5 ID:SGTC_3341|Compound:9147222|FD-Score:4.28|P-value:5.96E-6 ID:SGTC_4|Compound:0960-0234|FD-Score:3.58|P-value:1.24E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.97|P-value:5.66E-10 ID:SGTC_55|Compound:0767-0285|FD-Score:4.03|P-value:1.91E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.77|P-value:5.70E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.36|P-value:4.22E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:9.04|P-value:1.88E-20 ID:SGTC_86|Compound:0417-1630|FD-Score:6.73|P-value:3.56E-12 ID:SGTC_137|Compound:0438-0332|FD-Score:3.70|P-value:7.44E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:9.71|P-value:2.56E-23 ID:SGTC_158|Compound:k038-0087|FD-Score:5.30|P-value:3.18E-8 ID:SGTC_294|Compound:k038-0071|FD-Score:3.48|P-value:1.79E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:-3.14|P-value:8.57E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:5.41|P-value:1.68E-8 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.46|P-value:2.69E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.20|P-value:5.42E-8 ID:SGTC_631|Compound:k072-0230|FD-Score:3.35|P-value:2.98E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:8.66|P-value:6.14E-19 ID:SGTC_642|Compound:0335-0876|FD-Score:5.08|P-value:1.07E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:8.25|P-value:2.18E-17 ID:SGTC_798|Compound:1287-0182|FD-Score:3.84|P-value:4.17E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:-3.77|P-value:8.08E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:3.43|P-value:2.18E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.11|P-value:7.18E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.54|P-value:1.72E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:4.55|P-value:1.68E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.69|P-value:8.02E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.15|P-value:6.08E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:-3.75|P-value:8.52E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.53|P-value:1.51E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:-3.27|P-value:5.40E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.68|P-value:1.16E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.10|P-value:9.73E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.09|P-value:7.52E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.77|P-value:5.64E-5 ID:SGTC_1946|Compound:st076057|FD-Score:3.62|P-value:1.04E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.32|P-value:4.46E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.78|P-value:5.43E-5 ID:SGTC_2266|Compound:7929956|FD-Score:-3.53|P-value:2.08E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.46|P-value:2.68E-4 ID:SGTC_2277|Compound:7947813|FD-Score:4.45|P-value:2.65E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.24|P-value:4.52E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.13|P-value:8.62E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.09|P-value:1.44E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.01|P-value:2.00E-5 ID:SGTC_2602|Compound:kawain|FD-Score:3.15|P-value:6.19E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.23|P-value:4.64E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-3.47|P-value:2.55E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.33|P-value:3.18E-4 ID:SGTC_2847|Compound:9005661|FD-Score:3.03|P-value:9.36E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.52|P-value:1.52E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.59|P-value:1.20E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.96|P-value:3.65E-5 ID:SGTC_3341|Compound:9147222|FD-Score:4.28|P-value:5.96E-6

Top fitness defect scores for YBR275C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_142 0335-0849 9.71 62.7 µM 2.56E-23 ubiquinone biosynthesis & proteasome 33 1.34E-22
2 SGTC_67 0335-0847 9.04 266.0 µM 1.88E-20 ubiquinone biosynthesis & proteasome 30 8.11E-20
3 SGTC_635 k038-0028 8.66 24.7 µM 6.14E-19 ubiquinone biosynthesis & proteasome 7 2.38E-18
4 SGTC_794 k038-0031 8.25 316.0 µM 2.18E-17 ubiquinone biosynthesis & proteasome 29 7.63E-17
5 SGTC_86 0417-1630 6.73 471.9 µM 3.56E-12 ubiquinone biosynthesis & proteasome 76 8.66E-12
6 SGTC_36 0335-0881 5.97 14.2 µM 5.66E-10 ubiquinone biosynthesis & proteasome 65 1.18E-9
7 SGTC_340 k038-0059 5.41 454.0 µM 1.68E-8 ubiquinone biosynthesis & proteasome 24 3.14E-8
8 SGTC_158 k038-0087 5.30 26.4 µM 3.18E-8 ubiquinone biosynthesis & proteasome 86 5.84E-8
9 SGTC_367 0335-0881 5.20 7.1 µM 5.42E-8 ubiquinone biosynthesis & proteasome 37 9.79E-8
10 SGTC_642 0335-0876 5.08 158.0 µM 1.07E-7 ubiquinone biosynthesis & proteasome 20 1.89E-7
11 SGTC_1003 4049-0218 4.55 100.0 µM 1.68E-6 10 2.72E-6
12 SGTC_945 3381-0768 4.54 11.3 µM 1.72E-6 endomembrane recycling 22 2.77E-6
13 SGTC_2277 7947813 4.45 106.9 µM 2.65E-6 RSC complex & mRNA processing 16 4.22E-6
14 SGTC_64 000l-0018 4.36 272.1 µM 4.22E-6 ubiquinone biosynthesis & proteasome 129 6.62E-6
15 SGTC_3341 9147222 4.28 25.9 µM 5.96E-6 RNA processing & uracil transport 10 9.25E-6
16 SGTC_2563 tomatine 4.09 8.5 µM 1.44E-5 43 2.18E-5
17 SGTC_55 0767-0285 4.03 6.6 µM 1.91E-5 41 2.85E-5
18 SGTC_2594 a-mangostin 4.01 100.0 µM 2.00E-5 32 2.99E-5
19 SGTC_798 1287-0182 3.84 476.0 µM 4.17E-5 25 6.07E-5
20 SGTC_2125 5246583 3.78 200.0 µM 5.43E-5 tubulin folding & SWR complex 49 7.83E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.547 3.60E-261 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.526 3.10E-238 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.486 1.85E-198 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.476 4.16E-189 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.451 9.75E-168 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.448 4.20E-165 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.448 4.37E-165 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.447 3.46E-164 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.432 8.50E-153 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.431 1.95E-151 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.431 1.28E-151 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.423 9.23E-146 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.413 1.90E-138 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.402 8.33E-131 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.397 2.64E-127 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis