YBR279W / PAF1

Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR279W / PAF1

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:4.75|P-value:1.20E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:4.49|P-value:3.40E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:3.76|P-value:4.91E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.06|P-value:1.73E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.08|P-value:3.04E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.14|P-value:9.37E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.54|P-value:2.50E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.35|P-value:4.67E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.79|P-value:4.39E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.75|P-value:5.04E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.74|P-value:1.20E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.63|P-value:7.27E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:5.89|P-value:6.52E-8 ID:SGTC_718|Compound:1130-0073|FD-Score:3.93|P-value:2.67E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.23|P-value:6.99E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.70|P-value:1.48E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:3.76|P-value:4.90E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:-3.91|P-value:6.36E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:4.28|P-value:7.76E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:3.93|P-value:2.76E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.57|P-value:2.51E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:5.63|P-value:2.35E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:6.91|P-value:2.36E-10 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:5.49|P-value:4.63E-7 ID:SGTC_1073|Compound:triclabendazole|FD-Score:5.01|P-value:4.05E-6 ID:SGTC_1112|Compound:tnp00069|FD-Score:5.93|P-value:5.36E-8 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.62|P-value:7.58E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.54|P-value:9.84E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:-3.95|P-value:5.61E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.81|P-value:9.86E-8 ID:SGTC_1540|Compound:guanosine|FD-Score:-3.23|P-value:7.02E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.40|P-value:3.92E-4 ID:SGTC_1696|Compound:st025591|FD-Score:-4.54|P-value:5.04E-6 ID:SGTC_1892|Compound:st058411|FD-Score:4.77|P-value:1.11E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.98|P-value:2.28E-4 ID:SGTC_2192|Compound:5915882|FD-Score:3.93|P-value:2.73E-4 ID:SGTC_2211|Compound:7117706|FD-Score:4.39|P-value:5.15E-5 ID:SGTC_2332|Compound:7982454|FD-Score:4.69|P-value:1.53E-5 ID:SGTC_2387|Compound:9077560|FD-Score:3.67|P-value:6.41E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.07|P-value:2.53E-8 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.26|P-value:8.38E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:4.20|P-value:1.04E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:5.84|P-value:8.17E-8 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:5.28|P-value:1.23E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:3.99|P-value:2.21E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.30|P-value:5.47E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.89|P-value:3.17E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.99|P-value:2.24E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.99|P-value:2.23E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-3.28|P-value:6.01E-4 ID:SGTC_2708|Compound:st078559|FD-Score:4.15|P-value:1.25E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:4.33|P-value:6.40E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.54|P-value:9.84E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-4.47|P-value:6.90E-6 ID:SGTC_2862|Compound:9027634|FD-Score:4.02|P-value:2.01E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.83|P-value:8.96E-8 ID:SGTC_2953|Compound:9074162|FD-Score:4.71|P-value:1.44E-5 ID:SGTC_3011|Compound:9081274|FD-Score:4.05|P-value:1.76E-4 ID:SGTC_3041|Compound:9091929|FD-Score:4.34|P-value:6.24E-5 ID:SGTC_3112|Compound:9123419|FD-Score:4.12|P-value:1.41E-4 ID:SGTC_3114|Compound:9122766|FD-Score:5.42|P-value:6.28E-7 ID:SGTC_3335|Compound:9143315|FD-Score:3.57|P-value:9.06E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:4.75|P-value:1.20E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:4.49|P-value:3.40E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:3.76|P-value:4.91E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.06|P-value:1.73E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.08|P-value:3.04E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.14|P-value:9.37E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.54|P-value:2.50E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.35|P-value:4.67E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.79|P-value:4.39E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.75|P-value:5.04E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.74|P-value:1.20E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.63|P-value:7.27E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:5.89|P-value:6.52E-8 ID:SGTC_718|Compound:1130-0073|FD-Score:3.93|P-value:2.67E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.23|P-value:6.99E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.70|P-value:1.48E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:3.76|P-value:4.90E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:-3.91|P-value:6.36E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:4.28|P-value:7.76E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:3.93|P-value:2.76E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.57|P-value:2.51E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:5.63|P-value:2.35E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:6.91|P-value:2.36E-10 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:5.49|P-value:4.63E-7 ID:SGTC_1073|Compound:triclabendazole|FD-Score:5.01|P-value:4.05E-6 ID:SGTC_1112|Compound:tnp00069|FD-Score:5.93|P-value:5.36E-8 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.62|P-value:7.58E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.54|P-value:9.84E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:-3.95|P-value:5.61E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.81|P-value:9.86E-8 ID:SGTC_1540|Compound:guanosine|FD-Score:-3.23|P-value:7.02E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.40|P-value:3.92E-4 ID:SGTC_1696|Compound:st025591|FD-Score:-4.54|P-value:5.04E-6 ID:SGTC_1892|Compound:st058411|FD-Score:4.77|P-value:1.11E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.98|P-value:2.28E-4 ID:SGTC_2192|Compound:5915882|FD-Score:3.93|P-value:2.73E-4 ID:SGTC_2211|Compound:7117706|FD-Score:4.39|P-value:5.15E-5 ID:SGTC_2332|Compound:7982454|FD-Score:4.69|P-value:1.53E-5 ID:SGTC_2387|Compound:9077560|FD-Score:3.67|P-value:6.41E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.07|P-value:2.53E-8 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.26|P-value:8.38E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:4.20|P-value:1.04E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:5.84|P-value:8.17E-8 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:5.28|P-value:1.23E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:3.99|P-value:2.21E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.30|P-value:5.47E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.89|P-value:3.17E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.99|P-value:2.24E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.99|P-value:2.23E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-3.28|P-value:6.01E-4 ID:SGTC_2708|Compound:st078559|FD-Score:4.15|P-value:1.25E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:4.33|P-value:6.40E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.54|P-value:9.84E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-4.47|P-value:6.90E-6 ID:SGTC_2862|Compound:9027634|FD-Score:4.02|P-value:2.01E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.83|P-value:8.96E-8 ID:SGTC_2953|Compound:9074162|FD-Score:4.71|P-value:1.44E-5 ID:SGTC_3011|Compound:9081274|FD-Score:4.05|P-value:1.76E-4 ID:SGTC_3041|Compound:9091929|FD-Score:4.34|P-value:6.24E-5 ID:SGTC_3112|Compound:9123419|FD-Score:4.12|P-value:1.41E-4 ID:SGTC_3114|Compound:9122766|FD-Score:5.42|P-value:6.28E-7 ID:SGTC_3335|Compound:9143315|FD-Score:3.57|P-value:9.06E-4

Top fitness defect scores for YBR279W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1039 k821-0043 6.91 94.0 µM 2.36E-10 Golgi 4 2.42E-12
2 SGTC_2408 sulbentine 6.07 18.4 µM 2.53E-8 23 6.32E-10
3 SGTC_1112 tnp00069 5.93 1.2 µM 5.36E-8 3 1.54E-9
4 SGTC_648 0375-0473 5.89 33.3 µM 6.52E-8 2 1.95E-9
5 SGTC_2546 rhodinyl acetate 5.84 100.0 µM 8.17E-8 4 2.55E-9
6 SGTC_2912 7964298 5.83 10.9 µM 8.96E-8 cell wall 49 2.85E-9
7 SGTC_1511 0906-3109 5.81 28.5 µM 9.86E-8 excess fatty acid 14 3.19E-9
8 SGTC_1021 4476-0760 5.63 85.3 µM 2.35E-7 5 9.00E-9
9 SGTC_1071 trifluoperazine 5.49 6.3 µM 4.63E-7 8 2.02E-8
10 SGTC_3114 9122766 5.42 49.5 µM 6.28E-7 5 2.92E-8
11 SGTC_2550 chrysin dimethyl ether 5.28 71.9 µM 1.23E-6 2 6.50E-8
12 SGTC_243 5hr heat shock (37°C) + splitomicin 5.08 1.0 µM 3.04E-6 heat shock/prefoldin 23 1.92E-7
13 SGTC_1073 triclabendazole 5.01 3.1 µM 4.05E-6 12 2.71E-7
14 SGTC_1892 st058411 4.77 7.4 µM 1.11E-5 10 9.04E-7
15 SGTC_47 0149-0135 4.75 24.2 µM 1.20E-5 TSC3-RPN4 10 9.95E-7
16 SGTC_2953 9074162 4.71 66.5 µM 1.44E-5 12 1.24E-6
17 SGTC_791 1348-1292 4.70 225.0 µM 1.48E-5 21 1.28E-6
18 SGTC_2332 7982454 4.69 138.9 µM 1.53E-5 32 1.34E-6
19 SGTC_1012 4112-3522 4.57 18.0 µM 2.51E-5 15 2.42E-6
20 SGTC_61 0978-8327 4.49 98.6 µM 3.40E-5 ergosterol biosynthesis 17 3.48E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 9.34E-10 YGR049W SCM4 hom Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation
0.094 5.41E-8 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.085 7.31E-7 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.085 8.36E-7 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.085 8.95E-7 YKL007W CAP1 hom Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress
0.079 4.42E-6 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.078 5.38E-6 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.076 9.73E-6 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
0.072 2.98E-5 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.071 4.34E-5 YJL011C RPC17 het RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress
0.070 4.37E-5 YJL095W BCK1 hom Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.069 6.82E-5 YDL115C IWR1 hom RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress
0.069 6.94E-5 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.067 9.91E-5 YDR293C SSD1 hom Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function
0.067 1.01E-4 YDR162C NBP2 hom Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)