YBR280C / SAF1

F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR280C / SAF1

Click on Significant Values for Screen Details ID:SGTC_172|Compound:1112-0046|FD-Score:3.77|P-value:6.84E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.82|P-value:4.79E-7 ID:SGTC_564|Compound:3555-0129|FD-Score:-4.24|P-value:7.82E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.14|P-value:6.91E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.11|P-value:8.46E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:-3.21|P-value:5.33E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:5.22|P-value:6.42E-8 ID:SGTC_949|Compound:1165-0505|FD-Score:4.34|P-value:5.59E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:-3.31|P-value:3.77E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.16|P-value:6.35E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.38|P-value:3.21E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.31|P-value:6.61E-6 ID:SGTC_1519|Compound:esterone|FD-Score:3.20|P-value:6.09E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-4.64|P-value:1.20E-6 ID:SGTC_1675|Compound:st018485|FD-Score:4.07|P-value:1.96E-5 ID:SGTC_1772|Compound:st048439|FD-Score:3.92|P-value:3.76E-5 ID:SGTC_1797|Compound:st048695|FD-Score:-3.31|P-value:3.73E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-3.06|P-value:9.17E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.63|P-value:1.20E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.12|P-value:8.27E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.56|P-value:1.60E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.37|P-value:2.99E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.06|P-value:9.92E-4 ID:SGTC_2469|Compound:5655019|FD-Score:-3.99|P-value:2.48E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.25|P-value:5.17E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.22|P-value:5.17E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:3.17|P-value:6.74E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.63|P-value:1.20E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.84|P-value:4.57E-5 ID:SGTC_3076|Compound:9116187|FD-Score:3.37|P-value:3.36E-4 ID:SGTC_3085|Compound:9117376|FD-Score:-4.06|P-value:1.83E-5 ID:SGTC_3094|Compound:9117742|FD-Score:3.75|P-value:7.58E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.16|P-value:7.00E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-3.51|P-value:1.73E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-4.13|P-value:1.30E-5 ID:SGTC_3334|Compound:9142812|FD-Score:-3.18|P-value:6.08E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.77|P-value:6.84E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.82|P-value:4.79E-7 ID:SGTC_564|Compound:3555-0129|FD-Score:-4.24|P-value:7.82E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.14|P-value:6.91E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.11|P-value:8.46E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:-3.21|P-value:5.33E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:5.22|P-value:6.42E-8 ID:SGTC_949|Compound:1165-0505|FD-Score:4.34|P-value:5.59E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:-3.31|P-value:3.77E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.16|P-value:6.35E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.38|P-value:3.21E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.31|P-value:6.61E-6 ID:SGTC_1519|Compound:esterone|FD-Score:3.20|P-value:6.09E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-4.64|P-value:1.20E-6 ID:SGTC_1675|Compound:st018485|FD-Score:4.07|P-value:1.96E-5 ID:SGTC_1772|Compound:st048439|FD-Score:3.92|P-value:3.76E-5 ID:SGTC_1797|Compound:st048695|FD-Score:-3.31|P-value:3.73E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-3.06|P-value:9.17E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.63|P-value:1.20E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.12|P-value:8.27E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.56|P-value:1.60E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.37|P-value:2.99E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.06|P-value:9.92E-4 ID:SGTC_2469|Compound:5655019|FD-Score:-3.99|P-value:2.48E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.25|P-value:5.17E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.22|P-value:5.17E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:3.17|P-value:6.74E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.63|P-value:1.20E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.84|P-value:4.57E-5 ID:SGTC_3076|Compound:9116187|FD-Score:3.37|P-value:3.36E-4 ID:SGTC_3085|Compound:9117376|FD-Score:-4.06|P-value:1.83E-5 ID:SGTC_3094|Compound:9117742|FD-Score:3.75|P-value:7.58E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.16|P-value:7.00E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-3.51|P-value:1.73E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-4.13|P-value:1.30E-5 ID:SGTC_3334|Compound:9142812|FD-Score:-3.18|P-value:6.08E-4

Top fitness defect scores for YBR280C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_947 3447-0010 5.22 211.0 µM 6.42E-8 4 8.93E-8
2 SGTC_949 1165-0505 4.34 146.0 µM 5.59E-6 12 6.97E-6
3 SGTC_1457 k015-0032 4.31 57.3 µM 6.61E-6 30 8.21E-6
4 SGTC_1675 st018485 4.07 24.5 µM 1.96E-5 60S ribosome export 24 2.37E-5
5 SGTC_1772 st048439 3.92 82.2 µM 3.76E-5 39 4.48E-5
6 SGTC_172 1112-0046 3.77 2.6 µM 6.84E-5 NEO1 39 8.03E-5
7 SGTC_3094 9117742 3.75 49.5 µM 7.58E-5 24 8.89E-5
8 SGTC_1953 st076800 3.63 12.1 µM 1.20E-4 56 1.40E-4
9 SGTC_2981 9013952 3.63 39.0 µM 1.20E-4 53 1.40E-4
10 SGTC_2405 ticlatone 3.56 3.5 µM 1.60E-4 84 1.84E-4
11 SGTC_1339 1486-1321 3.38 22.7 µM 3.21E-4 ERG2 44 3.64E-4
12 SGTC_3076 9116187 3.37 49.5 µM 3.36E-4 29 3.80E-4
13 SGTC_2540 epiandrosterone 3.25 100.0 µM 5.17E-4 96 5.80E-4
14 SGTC_1519 esterone 3.20 74.0 µM 6.09E-4 DNA intercalators 49 6.81E-4
15 SGTC_2686 alizarin 3.17 95.4 µM 6.74E-4 RPP1 & pyrimidine depletion 57 7.51E-4
16 SGTC_3197 9113331 3.16 49.5 µM 7.00E-4 74 7.79E-4
17 SGTC_2007 4011539 3.12 71.8 µM 8.27E-4 cell wall signaling 103 9.18E-4
18 SGTC_668 1682-0499 3.11 62.6 µM 8.46E-4 64 9.39E-4
19 SGTC_2455 5377712 3.06 9.8 µM 9.92E-4 55 0.00110
20 SGTC_2970 9090938 3.01 41.9 µM 0.00117 RNA processing & uracil transport 107 0.00129

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 4.13E-19 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.113 4.62E-11 YPL060W MFM1 hom Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p
0.096 2.92E-8 YDR244W PEX5 hom Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
0.088 3.29E-7 YOR218C_d YOR218C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
0.087 3.86E-7 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.082 1.87E-6 YBR133C HSL7 hom Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress
0.081 2.48E-6 YIL141W_d YIL141W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.55E-6 YKL090W CUE2 hom Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
0.076 1.12E-5 YLR299W ECM38 hom Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
0.075 1.26E-5 YFL045C SEC53 het Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
0.075 1.53E-5 YDR201W SPC19 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
0.072 3.10E-5 YOL130W ALR1 het Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
0.071 4.26E-5 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.070 5.17E-5 YPL274W SAM3 hom High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
0.069 6.69E-5 YIL108W YIL108W hom Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress