YBR282W / MRPL27

Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR282W / MRPL27

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.83|P-value:5.51E-7 ID:SGTC_12|Compound:0849-0099|FD-Score:-3.47|P-value:2.30E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.53|P-value:1.85E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.08|P-value:1.94E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.49|P-value:2.11E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.83|P-value:5.60E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:3.29|P-value:4.50E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.53|P-value:1.85E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.46|P-value:2.42E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.18|P-value:6.69E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.61|P-value:1.39E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.51|P-value:2.54E-11 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.48|P-value:2.22E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.66|P-value:1.12E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.24|P-value:1.47E-13 ID:SGTC_314|Compound:1671-0008|FD-Score:4.83|P-value:5.57E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.47|P-value:2.27E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.24|P-value:5.48E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.92|P-value:3.49E-7 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.01|P-value:2.66E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.53|P-value:1.89E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.30|P-value:4.27E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.21|P-value:1.08E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.17|P-value:6.97E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.70|P-value:9.43E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.13|P-value:7.95E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:-3.15|P-value:7.26E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.27|P-value:4.85E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.18|P-value:1.28E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.29|P-value:4.46E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-4.20|P-value:1.13E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.36|P-value:3.52E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.15|P-value:1.40E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:4.15|P-value:1.46E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.83|P-value:5.65E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:5.32|P-value:3.98E-8 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.29|P-value:4.62E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.18|P-value:6.65E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.83|P-value:5.65E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.01|P-value:2.68E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.25|P-value:5.35E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.76|P-value:7.53E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:4.02|P-value:2.52E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.09|P-value:9.19E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.83|P-value:5.59E-7 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.43|P-value:2.74E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.14|P-value:7.71E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.09|P-value:9.20E-4 ID:SGTC_1624|Compound:st003710|FD-Score:5.92|P-value:1.21E-9 ID:SGTC_1627|Compound:st003713|FD-Score:4.37|P-value:5.16E-6 ID:SGTC_1641|Compound:st009299|FD-Score:3.32|P-value:4.02E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.12|P-value:8.22E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.28|P-value:4.68E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.20|P-value:1.14E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.07|P-value:9.96E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.39|P-value:2.59E-8 ID:SGTC_1834|Compound:st055981|FD-Score:3.18|P-value:6.70E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.10|P-value:8.83E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.78|P-value:6.89E-5 ID:SGTC_2028|Compound:5153890|FD-Score:3.83|P-value:5.52E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.10|P-value:8.87E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.05|P-value:5.18E-10 ID:SGTC_2318|Compound:6029776|FD-Score:-3.14|P-value:7.52E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.00|P-value:2.80E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-3.63|P-value:1.23E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.17|P-value:1.30E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.47|P-value:2.32E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.08|P-value:9.26E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.58|P-value:1.51E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:4.05|P-value:2.18E-5 ID:SGTC_2804|Compound:7954240|FD-Score:-3.60|P-value:1.38E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.81|P-value:5.96E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.46|P-value:2.41E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.07|P-value:9.84E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.83|P-value:5.51E-7 ID:SGTC_12|Compound:0849-0099|FD-Score:-3.47|P-value:2.30E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.53|P-value:1.85E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.08|P-value:1.94E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.49|P-value:2.11E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.83|P-value:5.60E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:3.29|P-value:4.50E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.53|P-value:1.85E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.46|P-value:2.42E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.18|P-value:6.69E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.61|P-value:1.39E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.51|P-value:2.54E-11 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.48|P-value:2.22E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.66|P-value:1.12E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.24|P-value:1.47E-13 ID:SGTC_314|Compound:1671-0008|FD-Score:4.83|P-value:5.57E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.47|P-value:2.27E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.24|P-value:5.48E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.92|P-value:3.49E-7 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.01|P-value:2.66E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.53|P-value:1.89E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.30|P-value:4.27E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.21|P-value:1.08E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.17|P-value:6.97E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.70|P-value:9.43E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.13|P-value:7.95E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:-3.15|P-value:7.26E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.27|P-value:4.85E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.18|P-value:1.28E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.29|P-value:4.46E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-4.20|P-value:1.13E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.36|P-value:3.52E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.15|P-value:1.40E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:4.15|P-value:1.46E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.83|P-value:5.65E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:5.32|P-value:3.98E-8 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.29|P-value:4.62E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.18|P-value:6.65E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.83|P-value:5.65E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.01|P-value:2.68E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.25|P-value:5.35E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.76|P-value:7.53E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:4.02|P-value:2.52E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.09|P-value:9.19E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.83|P-value:5.59E-7 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.43|P-value:2.74E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.14|P-value:7.71E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.09|P-value:9.20E-4 ID:SGTC_1624|Compound:st003710|FD-Score:5.92|P-value:1.21E-9 ID:SGTC_1627|Compound:st003713|FD-Score:4.37|P-value:5.16E-6 ID:SGTC_1641|Compound:st009299|FD-Score:3.32|P-value:4.02E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.12|P-value:8.22E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.28|P-value:4.68E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.20|P-value:1.14E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.07|P-value:9.96E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.39|P-value:2.59E-8 ID:SGTC_1834|Compound:st055981|FD-Score:3.18|P-value:6.70E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.10|P-value:8.83E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.78|P-value:6.89E-5 ID:SGTC_2028|Compound:5153890|FD-Score:3.83|P-value:5.52E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.10|P-value:8.87E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.05|P-value:5.18E-10 ID:SGTC_2318|Compound:6029776|FD-Score:-3.14|P-value:7.52E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.00|P-value:2.80E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-3.63|P-value:1.23E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.17|P-value:1.30E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.47|P-value:2.32E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.08|P-value:9.26E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.58|P-value:1.51E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:4.05|P-value:2.18E-5 ID:SGTC_2804|Compound:7954240|FD-Score:-3.60|P-value:1.38E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.81|P-value:5.96E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.46|P-value:2.41E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.07|P-value:9.84E-4

Top fitness defect scores for YBR282W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 7.24 1.1 µM 1.47E-13 mitochondrial stress 112 2.32E-13
2 SGTC_236 1509-0011 6.51 5.3 µM 2.54E-11 276 3.67E-11
3 SGTC_2250 alverine citrate 6.05 130.0 µM 5.18E-10 52 7.12E-10
4 SGTC_1624 st003710 5.92 6.2 µM 1.21E-9 calcium & mitochondrial duress 13 1.64E-9
5 SGTC_1144 3486-0183 5.32 12.5 µM 3.98E-8 7 5.10E-8
6 SGTC_386 1509-0011 4.92 3.1 µM 3.49E-7 110 4.31E-7
7 SGTC_10 0279-0212 4.83 42.6 µM 5.51E-7 TRP & mitochondrial translation 71 6.75E-7
8 SGTC_314 1671-0008 4.83 2.7 µM 5.57E-7 25 6.82E-7
9 SGTC_1447 4239-0816 4.83 81.9 µM 5.59E-7 14 6.86E-7
10 SGTC_58 0957-0393 4.83 9.0 µM 5.60E-7 cell wall 302 6.87E-7
11 SGTC_1627 st003713 4.37 25.6 µM 5.16E-6 calcium & mitochondrial duress 57 6.10E-6
12 SGTC_1723 st034307 4.20 2.5 µM 1.14E-5 mitochondrial processes 23 1.33E-5
13 SGTC_908 3448-7491 4.18 47.7 µM 1.28E-5 mitochondrial stress 111 1.49E-5
14 SGTC_2454 5-benzylidenerhodanine 4.17 10.4 µM 1.30E-5 TRP & mitochondrial translation 30 1.52E-5
15 SGTC_1091 telmisartan 4.15 47.6 µM 1.40E-5 8 1.63E-5
16 SGTC_1096 rimcazole 4.15 32.2 µM 1.46E-5 6 1.70E-5
17 SGTC_28 pentachloropyridine N-oxide 4.08 1.6 µM 1.94E-5 TSC3-RPN4 67 2.24E-5
18 SGTC_2664 lyso-paf C-16 4.05 73.5 µM 2.18E-5 11 2.52E-5
19 SGTC_1384 3089-0840 4.02 101.0 µM 2.52E-5 15 2.90E-5
20 SGTC_387 norethindrone acetate 4.01 66.7 µM 2.66E-5 13 3.06E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.331 1.68E-86 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.317 6.12E-79 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.315 5.52E-78 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.312 1.06E-76 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.307 3.28E-74 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.303 3.20E-72 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.300 1.21E-70 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.299 3.61E-70 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.299 4.77E-70 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.298 9.00E-70 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.296 1.08E-68 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.295 1.89E-68 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.295 2.14E-68 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.294 1.40E-67 YCR071C IMG2 hom Mitochondrial ribosomal protein of the large subunit
0.292 6.77E-67 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme