YBR284W_p

Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR284W / YBR284W

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:-4.88|P-value:6.12E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.52|P-value:2.40E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.14|P-value:9.35E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.89|P-value:5.78E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:3.25|P-value:6.40E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:4.74|P-value:1.27E-6 ID:SGTC_681|Compound:1642-0006|FD-Score:3.25|P-value:6.29E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-3.33|P-value:4.58E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.34|P-value:4.62E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.47|P-value:4.70E-6 ID:SGTC_753|Compound:1322-0200|FD-Score:4.63|P-value:2.24E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:3.12|P-value:9.85E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.19|P-value:7.82E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.95|P-value:4.43E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.49|P-value:2.76E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.37|P-value:4.21E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.08|P-value:2.63E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.21|P-value:7.38E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.86|P-value:6.54E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:6.32|P-value:1.78E-10 ID:SGTC_1387|Compound:3342-1166|FD-Score:5.40|P-value:4.35E-8 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.45|P-value:5.03E-6 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.86|P-value:6.42E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-3.79|P-value:8.26E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-3.32|P-value:4.75E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.58|P-value:1.95E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.61|P-value:1.74E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:4.21|P-value:1.50E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.37|P-value:3.96E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.74|P-value:1.04E-4 ID:SGTC_1702|Compound:st027038|FD-Score:7.27|P-value:2.83E-13 ID:SGTC_1747|Compound:st037496|FD-Score:4.04|P-value:3.06E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.11|P-value:2.34E-5 ID:SGTC_1759|Compound:st043059|FD-Score:-3.95|P-value:4.31E-5 ID:SGTC_1786|Compound:berberine|FD-Score:3.30|P-value:5.35E-4 ID:SGTC_1796|Compound:st049173|FD-Score:-3.12|P-value:9.58E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.20|P-value:7.70E-4 ID:SGTC_1841|Compound:st054148|FD-Score:-3.39|P-value:3.69E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.46|P-value:3.02E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.78|P-value:1.06E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.46|P-value:3.08E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.49|P-value:2.66E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.48|P-value:2.70E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.32|P-value:5.00E-4 ID:SGTC_1981|Compound:st071826|FD-Score:4.29|P-value:1.05E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.26|P-value:6.27E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.18|P-value:8.24E-4 ID:SGTC_1990|Compound:st072050|FD-Score:4.24|P-value:1.31E-5 ID:SGTC_1995|Compound:st072814|FD-Score:3.33|P-value:4.77E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.58|P-value:1.97E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-5.03|P-value:2.78E-7 ID:SGTC_2266|Compound:7929956|FD-Score:3.13|P-value:9.75E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.42|P-value:3.45E-4 ID:SGTC_2294|Compound:7971431|FD-Score:5.29|P-value:7.83E-8 ID:SGTC_2428|Compound:5615643|FD-Score:-3.44|P-value:3.05E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.62|P-value:2.28E-6 ID:SGTC_2464|Compound:5717415|FD-Score:4.62|P-value:2.35E-6 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.21|P-value:7.33E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.62|P-value:1.59E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:6.03|P-value:1.14E-9 ID:SGTC_2831|Compound:7999036|FD-Score:-4.45|P-value:4.72E-6 ID:SGTC_2835|Compound:9006588|FD-Score:-3.61|P-value:1.66E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.20|P-value:7.18E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.48|P-value:2.65E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.73|P-value:1.08E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.24|P-value:6.39E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.92|P-value:5.15E-5 ID:SGTC_3027|Compound:9089541|FD-Score:3.23|P-value:6.95E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.18|P-value:8.17E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.33|P-value:4.80E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.27|P-value:5.87E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-4.88|P-value:6.12E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.52|P-value:2.40E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.14|P-value:9.35E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.89|P-value:5.78E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:3.25|P-value:6.40E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:4.74|P-value:1.27E-6 ID:SGTC_681|Compound:1642-0006|FD-Score:3.25|P-value:6.29E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-3.33|P-value:4.58E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.34|P-value:4.62E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.47|P-value:4.70E-6 ID:SGTC_753|Compound:1322-0200|FD-Score:4.63|P-value:2.24E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:3.12|P-value:9.85E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.19|P-value:7.82E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.95|P-value:4.43E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.49|P-value:2.76E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.37|P-value:4.21E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.08|P-value:2.63E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.21|P-value:7.38E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.86|P-value:6.54E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:6.32|P-value:1.78E-10 ID:SGTC_1387|Compound:3342-1166|FD-Score:5.40|P-value:4.35E-8 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.45|P-value:5.03E-6 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.86|P-value:6.42E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-3.79|P-value:8.26E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-3.32|P-value:4.75E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.58|P-value:1.95E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.61|P-value:1.74E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:4.21|P-value:1.50E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.37|P-value:3.96E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.74|P-value:1.04E-4 ID:SGTC_1702|Compound:st027038|FD-Score:7.27|P-value:2.83E-13 ID:SGTC_1747|Compound:st037496|FD-Score:4.04|P-value:3.06E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.11|P-value:2.34E-5 ID:SGTC_1759|Compound:st043059|FD-Score:-3.95|P-value:4.31E-5 ID:SGTC_1786|Compound:berberine|FD-Score:3.30|P-value:5.35E-4 ID:SGTC_1796|Compound:st049173|FD-Score:-3.12|P-value:9.58E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.20|P-value:7.70E-4 ID:SGTC_1841|Compound:st054148|FD-Score:-3.39|P-value:3.69E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.46|P-value:3.02E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.78|P-value:1.06E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.46|P-value:3.08E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.49|P-value:2.66E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.48|P-value:2.70E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.32|P-value:5.00E-4 ID:SGTC_1981|Compound:st071826|FD-Score:4.29|P-value:1.05E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.26|P-value:6.27E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.18|P-value:8.24E-4 ID:SGTC_1990|Compound:st072050|FD-Score:4.24|P-value:1.31E-5 ID:SGTC_1995|Compound:st072814|FD-Score:3.33|P-value:4.77E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.58|P-value:1.97E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-5.03|P-value:2.78E-7 ID:SGTC_2266|Compound:7929956|FD-Score:3.13|P-value:9.75E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.42|P-value:3.45E-4 ID:SGTC_2294|Compound:7971431|FD-Score:5.29|P-value:7.83E-8 ID:SGTC_2428|Compound:5615643|FD-Score:-3.44|P-value:3.05E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.62|P-value:2.28E-6 ID:SGTC_2464|Compound:5717415|FD-Score:4.62|P-value:2.35E-6 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.21|P-value:7.33E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.62|P-value:1.59E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:6.03|P-value:1.14E-9 ID:SGTC_2831|Compound:7999036|FD-Score:-4.45|P-value:4.72E-6 ID:SGTC_2835|Compound:9006588|FD-Score:-3.61|P-value:1.66E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.20|P-value:7.18E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.48|P-value:2.65E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.73|P-value:1.08E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.24|P-value:6.39E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.92|P-value:5.15E-5 ID:SGTC_3027|Compound:9089541|FD-Score:3.23|P-value:6.95E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.18|P-value:8.17E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.33|P-value:4.80E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.27|P-value:5.87E-4

Top fitness defect scores for YBR284W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1702 st027038 7.27 51.0 µM 2.83E-13 1 1.86E-13
2 SGTC_1249 0481-0015 6.32 10.2 µM 1.78E-10 7 1.28E-10
3 SGTC_2653 dihydrofissinolide 6.03 100.0 µM 1.14E-9 1 8.44E-10
4 SGTC_1387 3342-1166 5.40 1.8 µM 4.35E-8 mitochondrial processes 3 3.40E-8
5 SGTC_2294 7971431 5.29 200.0 µM 7.83E-8 4 6.18E-8
6 SGTC_1856 st057054 4.78 55.7 µM 1.06E-6 15 8.66E-7
7 SGTC_626 0214-0009 4.74 33.0 µM 1.27E-6 copper-dependent oxidative stress 10 1.04E-6
8 SGTC_753 1322-0200 4.63 289.0 µM 2.24E-6 5 1.86E-6
9 SGTC_2431 5490079 4.62 200.0 µM 2.28E-6 17 1.89E-6
10 SGTC_2464 5717415 4.62 7.7 µM 2.35E-6 5 1.95E-6
11 SGTC_748 0136-0228 4.47 77.9 µM 4.70E-6 redox potentiating 62 3.94E-6
12 SGTC_1401 3807-4679 4.45 7.6 µM 5.03E-6 tubulin folding & SWR complex 13 4.23E-6
13 SGTC_1981 st071826 4.29 47.0 µM 1.05E-5 10 8.92E-6
14 SGTC_1990 st072050 4.24 59.8 µM 1.31E-5 11 1.11E-5
15 SGTC_1583 clindamycin 4.21 39.6 µM 1.50E-5 mitochondrial processes 8 1.28E-5
16 SGTC_1754 st042065 4.11 16.1 µM 2.34E-5 NEO1-PIK1 167 2.01E-5
17 SGTC_1108 betulinic acid 4.08 729.1 nM 2.63E-5 13 2.26E-5
18 SGTC_1747 st037496 4.04 66.6 µM 3.06E-5 17 2.64E-5
19 SGTC_1021 4476-0760 3.95 85.3 µM 4.43E-5 24 3.84E-5
20 SGTC_2989 9073649 3.92 71.4 µM 5.15E-5 41 4.48E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 1.92E-8 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.086 6.41E-7 YLR137W RKM5 hom Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species
0.085 8.79E-7 YPR118W MRI1 hom 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway
0.079 4.34E-6 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.077 8.49E-6 YDR223W CRF1 hom Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain
0.072 2.98E-5 YNL206C RTT106 hom Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition
0.070 5.04E-5 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.069 6.69E-5 YHL034C SBP1 hom Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
0.068 8.39E-5 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.068 8.60E-5 YKR072C SIS2 hom Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
0.067 1.09E-4 YDL220C CDC13 het Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation
0.067 1.13E-4 YNL295W_p YNL295W_p hom Putative protein of unknown function
0.066 1.23E-4 YMR222C FSH2 hom Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2
0.066 1.31E-4 YLR172C DPH5 hom Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm
0.066 1.40E-4 YPL168W_p YPL168W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated