YBR286W / APE3

Vacuolar aminopeptidase Y, processed to mature form by Prb1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR286W / APE3

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:14.20|P-value:1.02E-42 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.60|P-value:2.77E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.55|P-value:3.29E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.37|P-value:6.13E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.44|P-value:9.93E-6 ID:SGTC_230|Compound:MPP+|FD-Score:3.60|P-value:2.71E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.96|P-value:7.25E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-3.63|P-value:2.48E-4 ID:SGTC_271|Compound:rotenone|FD-Score:4.70|P-value:3.23E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.45|P-value:4.74E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.64|P-value:2.41E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.92|P-value:8.34E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:3.82|P-value:1.23E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-4.11|P-value:4.13E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:4.26|P-value:2.16E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:3.46|P-value:4.51E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:5.84|P-value:1.03E-8 ID:SGTC_670|Compound:4204-0025|FD-Score:3.34|P-value:6.63E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.52|P-value:3.64E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.84|P-value:1.71E-6 ID:SGTC_887|Compound:0885-0007|FD-Score:3.61|P-value:2.64E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.62|P-value:2.49E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.45|P-value:4.82E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:4.08|P-value:4.49E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.92|P-value:8.18E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.35|P-value:6.35E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.66|P-value:2.20E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:5.06|P-value:5.99E-7 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.53|P-value:3.51E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.50|P-value:3.81E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:4.44|P-value:9.99E-6 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.74|P-value:1.63E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.43|P-value:4.99E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.67|P-value:2.11E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.95|P-value:1.01E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.24|P-value:9.38E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.25|P-value:9.08E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.48|P-value:4.30E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.76|P-value:1.52E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-3.98|P-value:6.96E-5 ID:SGTC_2088|Compound:5278280|FD-Score:4.24|P-value:2.36E-5 ID:SGTC_2142|Compound:5622915|FD-Score:-3.57|P-value:3.15E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.75|P-value:1.57E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.61|P-value:2.67E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.32|P-value:7.23E-4 ID:SGTC_2517|Compound:totarol|FD-Score:4.62|P-value:4.65E-6 ID:SGTC_2532|Compound:xanthone|FD-Score:3.92|P-value:8.30E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.59|P-value:2.79E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.48|P-value:4.09E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.85|P-value:1.09E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.10|P-value:4.19E-5 ID:SGTC_2696|Compound:st077691|FD-Score:3.89|P-value:9.49E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.69|P-value:1.97E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.95|P-value:7.50E-5 ID:SGTC_2810|Compound:7959871|FD-Score:5.76|P-value:1.62E-8 ID:SGTC_2908|Compound:7930301|FD-Score:3.30|P-value:7.60E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.63|P-value:2.40E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.54|P-value:3.35E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.55|P-value:3.20E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.77|P-value:1.52E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.51|P-value:3.79E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.39|P-value:5.56E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:14.20|P-value:1.02E-42 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.60|P-value:2.77E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.55|P-value:3.29E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.37|P-value:6.13E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.44|P-value:9.93E-6 ID:SGTC_230|Compound:MPP+|FD-Score:3.60|P-value:2.71E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.96|P-value:7.25E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-3.63|P-value:2.48E-4 ID:SGTC_271|Compound:rotenone|FD-Score:4.70|P-value:3.23E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.45|P-value:4.74E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.64|P-value:2.41E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.92|P-value:8.34E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:3.82|P-value:1.23E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-4.11|P-value:4.13E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:4.26|P-value:2.16E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:3.46|P-value:4.51E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:5.84|P-value:1.03E-8 ID:SGTC_670|Compound:4204-0025|FD-Score:3.34|P-value:6.63E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.52|P-value:3.64E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.84|P-value:1.71E-6 ID:SGTC_887|Compound:0885-0007|FD-Score:3.61|P-value:2.64E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.62|P-value:2.49E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.45|P-value:4.82E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:4.08|P-value:4.49E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.92|P-value:8.18E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.35|P-value:6.35E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.66|P-value:2.20E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:5.06|P-value:5.99E-7 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.53|P-value:3.51E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.50|P-value:3.81E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:4.44|P-value:9.99E-6 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.74|P-value:1.63E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.43|P-value:4.99E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.67|P-value:2.11E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.95|P-value:1.01E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.24|P-value:9.38E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.25|P-value:9.08E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.48|P-value:4.30E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.76|P-value:1.52E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-3.98|P-value:6.96E-5 ID:SGTC_2088|Compound:5278280|FD-Score:4.24|P-value:2.36E-5 ID:SGTC_2142|Compound:5622915|FD-Score:-3.57|P-value:3.15E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.75|P-value:1.57E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.61|P-value:2.67E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.32|P-value:7.23E-4 ID:SGTC_2517|Compound:totarol|FD-Score:4.62|P-value:4.65E-6 ID:SGTC_2532|Compound:xanthone|FD-Score:3.92|P-value:8.30E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.59|P-value:2.79E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.48|P-value:4.09E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.85|P-value:1.09E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.10|P-value:4.19E-5 ID:SGTC_2696|Compound:st077691|FD-Score:3.89|P-value:9.49E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.69|P-value:1.97E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.95|P-value:7.50E-5 ID:SGTC_2810|Compound:7959871|FD-Score:5.76|P-value:1.62E-8 ID:SGTC_2908|Compound:7930301|FD-Score:3.30|P-value:7.60E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.63|P-value:2.40E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.54|P-value:3.35E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.55|P-value:3.20E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.77|P-value:1.52E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.51|P-value:3.79E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.39|P-value:5.56E-4

Top fitness defect scores for YBR286W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 14.20 9.0 µM 1.02E-42 cell wall 31 3.35E-46
2 SGTC_634 1611-4317 5.84 11.2 µM 1.03E-8 ERG2 7 2.62E-9
3 SGTC_2810 7959871 5.76 45.5 µM 1.62E-8 copper-dependent oxidative stress 12 4.26E-9
4 SGTC_1204 4049-0315 5.06 18.3 µM 5.99E-7 6 2.13E-7
5 SGTC_1836 st055642 4.95 81.0 µM 1.01E-6 8 3.75E-7
6 SGTC_676 falcarinol 4.84 140.0 µM 1.71E-6 37 6.65E-7
7 SGTC_271 rotenone 4.70 740.0 µM 3.23E-6 11 1.32E-6
8 SGTC_2517 totarol 4.62 10.0 µM 4.65E-6 11 1.96E-6
9 SGTC_221 trifluoperazine 4.44 10.3 µM 9.93E-6 NEO1-PIK1 184 4.45E-6
10 SGTC_1345 1488-0192 4.44 31.4 µM 9.99E-6 10 4.48E-6
11 SGTC_540 1187-0821 4.26 17.3 µM 2.16E-5 11 1.03E-5
12 SGTC_2088 5278280 4.24 127.4 µM 2.36E-5 16 1.14E-5
13 SGTC_2688 kanamycin b 4.10 96.7 µM 4.19E-5 calcium & mitochondrial duress 348 2.11E-5
14 SGTC_954 1189-0853 4.08 2.9 µM 4.49E-5 endomembrane recycling 38 2.27E-5
15 SGTC_250 brefeldin a 3.96 552.2 µM 7.25E-5 PDR1 13 3.82E-5
16 SGTC_2772 vinpocetine 3.95 57.1 µM 7.50E-5 25 3.96E-5
17 SGTC_1021 4476-0760 3.92 85.3 µM 8.18E-5 28 4.34E-5
18 SGTC_2532 xanthone 3.92 78.9 µM 8.30E-5 30 4.42E-5
19 SGTC_457 grayanotoxin iii 3.92 135.0 µM 8.34E-5 68 4.44E-5
20 SGTC_2696 st077691 3.89 74.3 µM 9.49E-5 33 5.11E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.303 6.23E-72 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.273 3.01E-58 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.261 2.33E-53 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.236 1.52E-43 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.232 2.18E-42 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.230 2.07E-41 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.225 6.99E-40 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.225 1.31E-39 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.216 1.03E-36 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.214 3.40E-36 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.212 2.52E-35 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.207 7.63E-34 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.205 3.29E-33 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.200 1.31E-31 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.199 1.94E-31 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi