YBR287W_p

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR287W / YBR287W

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:4.31|P-value:9.96E-7 ID:SGTC_133|Compound:0724-0033|FD-Score:2.85|P-value:8.23E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-2.85|P-value:9.73E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.22|P-value:1.92E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.03|P-value:4.88E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:2.86|P-value:7.85E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:2.88|P-value:7.30E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.13|P-value:2.77E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:-3.00|P-value:5.45E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.37|P-value:1.02E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:2.90|P-value:6.83E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.92|P-value:7.27E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.41|P-value:8.56E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.57|P-value:4.05E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.74|P-value:1.14E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.84|P-value:1.41E-5 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.05|P-value:3.81E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.08|P-value:3.33E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:2.92|P-value:6.35E-4 ID:SGTC_1629|Compound:st005085|FD-Score:2.81|P-value:9.45E-4 ID:SGTC_1713|Compound:st033146|FD-Score:2.95|P-value:5.55E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.38|P-value:9.73E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-3.49|P-value:7.02E-5 ID:SGTC_1803|Compound:st050068|FD-Score:-3.60|P-value:4.27E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.18|P-value:2.50E-6 ID:SGTC_1829|Compound:berberine|FD-Score:3.07|P-value:3.42E-4 ID:SGTC_1832|Compound:st054113|FD-Score:2.93|P-value:6.06E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.57|P-value:4.05E-5 ID:SGTC_2316|Compound:5844804|FD-Score:2.88|P-value:7.34E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.49|P-value:5.79E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.12|P-value:2.87E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.92|P-value:5.20E-23 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.15|P-value:2.49E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.77|P-value:1.97E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.99|P-value:5.40E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.69|P-value:2.32E-5 ID:SGTC_2791|Compound:5663188|FD-Score:4.52|P-value:3.23E-7 ID:SGTC_2922|Compound:7999257|FD-Score:-3.06|P-value:4.38E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-2.92|P-value:7.44E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-4.62|P-value:2.25E-7 ID:SGTC_2964|Compound:9083345|FD-Score:-3.54|P-value:5.83E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.03|P-value:4.01E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:4.31|P-value:9.96E-7 ID:SGTC_133|Compound:0724-0033|FD-Score:2.85|P-value:8.23E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-2.85|P-value:9.73E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.22|P-value:1.92E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.03|P-value:4.88E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:2.86|P-value:7.85E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:2.88|P-value:7.30E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.13|P-value:2.77E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:-3.00|P-value:5.45E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.37|P-value:1.02E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:2.90|P-value:6.83E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.92|P-value:7.27E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.41|P-value:8.56E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.57|P-value:4.05E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.74|P-value:1.14E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.84|P-value:1.41E-5 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.05|P-value:3.81E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.08|P-value:3.33E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:2.92|P-value:6.35E-4 ID:SGTC_1629|Compound:st005085|FD-Score:2.81|P-value:9.45E-4 ID:SGTC_1713|Compound:st033146|FD-Score:2.95|P-value:5.55E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.38|P-value:9.73E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-3.49|P-value:7.02E-5 ID:SGTC_1803|Compound:st050068|FD-Score:-3.60|P-value:4.27E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.18|P-value:2.50E-6 ID:SGTC_1829|Compound:berberine|FD-Score:3.07|P-value:3.42E-4 ID:SGTC_1832|Compound:st054113|FD-Score:2.93|P-value:6.06E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.57|P-value:4.05E-5 ID:SGTC_2316|Compound:5844804|FD-Score:2.88|P-value:7.34E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.49|P-value:5.79E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.12|P-value:2.87E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.92|P-value:5.20E-23 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.15|P-value:2.49E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.77|P-value:1.97E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.99|P-value:5.40E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.69|P-value:2.32E-5 ID:SGTC_2791|Compound:5663188|FD-Score:4.52|P-value:3.23E-7 ID:SGTC_2922|Compound:7999257|FD-Score:-3.06|P-value:4.38E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-2.92|P-value:7.44E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-4.62|P-value:2.25E-7 ID:SGTC_2964|Compound:9083345|FD-Score:-3.54|P-value:5.83E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.03|P-value:4.01E-4

Top fitness defect scores for YBR287W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 8.92 96.7 µM 5.20E-23 calcium & mitochondrial duress 44 2.30E-19
2 SGTC_2791 5663188 4.52 71.4 µM 3.23E-7 RPP1 & pyrimidine depletion 12 3.14E-6
3 SGTC_71 0417-1750 4.31 47.8 µM 9.96E-7 Golgi 34 8.04E-6
4 SGTC_2777 climbazole 3.99 1.5 µM 5.40E-6 iron homeostasis 50 3.29E-5
5 SGTC_2778 tioconazole 3.69 65.1 nM 2.32E-5 ergosterol depletion effects on membrane 75 1.11E-4
6 SGTC_1327 1436-0082 3.57 2.2 µM 4.05E-5 31 1.77E-4
7 SGTC_1903 st060211 3.57 78.3 µM 4.05E-5 41 1.77E-4
8 SGTC_2327 6189656 3.49 200.0 µM 5.79E-5 32 2.39E-4
9 SGTC_1200 1643-0193 3.41 18.4 µM 8.56E-5 30 3.31E-4
10 SGTC_1723 st034307 3.38 2.5 µM 9.73E-5 mitochondrial processes 48 3.68E-4
11 SGTC_846 0335-0850 3.37 148.0 µM 1.02E-4 ubiquinone biosynthesis & proteasome 50 3.82E-4
12 SGTC_156 3474-0145 3.22 5.6 µM 1.92E-4 endomembrane recycling 85 6.50E-4
13 SGTC_2750 bromebric acid 3.15 70.2 µM 2.49E-4 76 8.07E-4
14 SGTC_568 1193-0097 3.13 7.5 µM 2.77E-4 ERAD & cell cycle 202 8.83E-4
15 SGTC_2630 antimycin a 3.12 100.0 µM 2.87E-4 mitochondrial processes 76 9.11E-4
16 SGTC_1491 4138-0063 3.08 26.5 µM 3.33E-4 25 0.00103
17 SGTC_1829 berberine 3.07 14.4 µM 3.42E-4 60S ribosome export 47 0.00105
18 SGTC_1489 4065-0444 3.05 182.0 µM 3.81E-4 51 0.00115
19 SGTC_3309 9129340 3.03 25.8 µM 4.01E-4 52 0.00120
20 SGTC_1713 st033146 2.95 12.8 µM 5.55E-4 83 0.00158

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.236 8.38E-44 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.231 7.22E-42 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.220 7.12E-38 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.213 1.26E-35 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.210 6.97E-35 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.201 8.08E-32 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.198 7.37E-31 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.197 1.03E-30 YOR377W ATF1 hom Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism
0.192 3.16E-29 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.191 5.61E-29 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.187 1.00E-27 YNL339C YRF1-6 hom Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
0.183 1.54E-26 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.182 1.65E-26 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.181 2.98E-26 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.180 6.12E-26 YEL005C VAB2 hom Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter