YBR290W / BSD2

Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR290W / BSD2

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:3.96|P-value:4.90E-5 ID:SGTC_79|Compound:0052-0007|FD-Score:-4.60|P-value:2.46E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:3.33|P-value:5.46E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.62|P-value:1.92E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.67|P-value:1.30E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.25|P-value:7.20E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.80|P-value:1.15E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:11.20|P-value:1.22E-28 ID:SGTC_176|Compound:1486-1328|FD-Score:3.39|P-value:4.33E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.59|P-value:2.11E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.32|P-value:5.50E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.68|P-value:1.50E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.33|P-value:5.41E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.29|P-value:9.45E-8 ID:SGTC_577|Compound:r071-0003|FD-Score:6.81|P-value:9.51E-12 ID:SGTC_587|Compound:k089-0003|FD-Score:-4.17|P-value:1.69E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:4.18|P-value:1.94E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.46|P-value:3.39E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.41|P-value:4.13E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.21|P-value:8.08E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.68|P-value:1.52E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:6.15|P-value:6.97E-10 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.55|P-value:2.05E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.04|P-value:3.64E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.74|P-value:1.17E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.98|P-value:4.50E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:5.08|P-value:2.90E-7 ID:SGTC_956|Compound:1185-0240|FD-Score:3.18|P-value:8.89E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.83|P-value:8.29E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.25|P-value:1.46E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.76|P-value:1.11E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.62|P-value:1.87E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.67|P-value:1.58E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.37|P-value:4.76E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.23|P-value:7.54E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.67|P-value:2.17E-6 ID:SGTC_1801|Compound:st050089|FD-Score:3.19|P-value:8.74E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.55|P-value:2.43E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.89|P-value:6.54E-5 ID:SGTC_2217|Compound:6934799|FD-Score:-3.21|P-value:6.92E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.40|P-value:4.18E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.01|P-value:1.65E-9 ID:SGTC_2311|Compound:7694451|FD-Score:3.75|P-value:1.14E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.73|P-value:1.24E-4 ID:SGTC_2394|Compound:5221648|FD-Score:15.80|P-value:2.25E-55 ID:SGTC_2395|Compound:5646831|FD-Score:6.98|P-value:3.04E-12 ID:SGTC_2400|Compound:5203494|FD-Score:9.76|P-value:3.05E-22 ID:SGTC_2401|Compound:5128683|FD-Score:-19.40|P-value:8.19E-83 ID:SGTC_2402|Compound:5553605|FD-Score:-3.37|P-value:3.94E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.40|P-value:4.20E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.59|P-value:2.10E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.71|P-value:9.52E-9 ID:SGTC_2678|Compound:equilin|FD-Score:3.24|P-value:7.25E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.14|P-value:7.19E-10 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-4.33|P-value:8.48E-6 ID:SGTC_2695|Compound:st077686|FD-Score:-5.14|P-value:1.63E-7 ID:SGTC_2809|Compound:7964133|FD-Score:7.91|P-value:3.24E-15 ID:SGTC_2810|Compound:7959871|FD-Score:-3.65|P-value:1.44E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-4.77|P-value:1.08E-6 ID:SGTC_2936|Compound:9038235|FD-Score:3.74|P-value:1.21E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.26|P-value:6.87E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.66|P-value:1.35E-4 ID:SGTC_3270|Compound:9137563|FD-Score:3.56|P-value:2.34E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.26|P-value:6.81E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.96|P-value:4.90E-5 ID:SGTC_79|Compound:0052-0007|FD-Score:-4.60|P-value:2.46E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:3.33|P-value:5.46E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.62|P-value:1.92E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.67|P-value:1.30E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.25|P-value:7.20E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.80|P-value:1.15E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:11.20|P-value:1.22E-28 ID:SGTC_176|Compound:1486-1328|FD-Score:3.39|P-value:4.33E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.59|P-value:2.11E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.32|P-value:5.50E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.68|P-value:1.50E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.33|P-value:5.41E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.29|P-value:9.45E-8 ID:SGTC_577|Compound:r071-0003|FD-Score:6.81|P-value:9.51E-12 ID:SGTC_587|Compound:k089-0003|FD-Score:-4.17|P-value:1.69E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:4.18|P-value:1.94E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.46|P-value:3.39E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.41|P-value:4.13E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.21|P-value:8.08E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.68|P-value:1.52E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:6.15|P-value:6.97E-10 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.55|P-value:2.05E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.04|P-value:3.64E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.74|P-value:1.17E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.98|P-value:4.50E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:5.08|P-value:2.90E-7 ID:SGTC_956|Compound:1185-0240|FD-Score:3.18|P-value:8.89E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.83|P-value:8.29E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.25|P-value:1.46E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.76|P-value:1.11E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.62|P-value:1.87E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.67|P-value:1.58E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.37|P-value:4.76E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.23|P-value:7.54E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.67|P-value:2.17E-6 ID:SGTC_1801|Compound:st050089|FD-Score:3.19|P-value:8.74E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.55|P-value:2.43E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.89|P-value:6.54E-5 ID:SGTC_2217|Compound:6934799|FD-Score:-3.21|P-value:6.92E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.40|P-value:4.18E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.01|P-value:1.65E-9 ID:SGTC_2311|Compound:7694451|FD-Score:3.75|P-value:1.14E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.73|P-value:1.24E-4 ID:SGTC_2394|Compound:5221648|FD-Score:15.80|P-value:2.25E-55 ID:SGTC_2395|Compound:5646831|FD-Score:6.98|P-value:3.04E-12 ID:SGTC_2400|Compound:5203494|FD-Score:9.76|P-value:3.05E-22 ID:SGTC_2401|Compound:5128683|FD-Score:-19.40|P-value:8.19E-83 ID:SGTC_2402|Compound:5553605|FD-Score:-3.37|P-value:3.94E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.40|P-value:4.20E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.59|P-value:2.10E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.71|P-value:9.52E-9 ID:SGTC_2678|Compound:equilin|FD-Score:3.24|P-value:7.25E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.14|P-value:7.19E-10 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-4.33|P-value:8.48E-6 ID:SGTC_2695|Compound:st077686|FD-Score:-5.14|P-value:1.63E-7 ID:SGTC_2809|Compound:7964133|FD-Score:7.91|P-value:3.24E-15 ID:SGTC_2810|Compound:7959871|FD-Score:-3.65|P-value:1.44E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-4.77|P-value:1.08E-6 ID:SGTC_2936|Compound:9038235|FD-Score:3.74|P-value:1.21E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.26|P-value:6.87E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.66|P-value:1.35E-4 ID:SGTC_3270|Compound:9137563|FD-Score:3.56|P-value:2.34E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.26|P-value:6.81E-4

Top fitness defect scores for YBR290W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2394 5221648 15.80 200.0 µM 2.25E-55 1 8.96E-57
2 SGTC_168 3970-0862 11.20 530.5 µM 1.22E-28 8 2.25E-29
3 SGTC_2400 5203494 9.76 178.7 µM 3.05E-22 RSC complex & mRNA processing 1 8.18E-23
4 SGTC_2809 7964133 7.91 13.0 µM 3.24E-15 60S ribosome export 2 1.31E-15
5 SGTC_2395 5646831 6.98 180.2 µM 3.04E-12 3 1.47E-12
6 SGTC_577 r071-0003 6.81 38.6 µM 9.51E-12 fatty acid desaturase (OLE1) 9 4.74E-12
7 SGTC_752 1896-0090 6.15 130.0 µM 6.97E-10 TSC3-RPN4 2 3.89E-10
8 SGTC_2688 kanamycin b 6.14 96.7 µM 7.19E-10 calcium & mitochondrial duress 150 4.02E-10
9 SGTC_2249 haloperidol 6.01 116.4 µM 1.65E-9 ergosterol depletion effects on membrane 47 9.44E-10
10 SGTC_2639 lactacystin 5.71 53.0 µM 9.52E-9 5 5.70E-9
11 SGTC_576 1073-0113 5.29 22.7 µM 9.45E-8 redox potentiating 30 6.01E-8
12 SGTC_951 1171-0579 5.08 82.7 µM 2.90E-7 cell wall 43 1.90E-7
13 SGTC_146 3448-8650 4.80 53.1 µM 1.15E-6 NEO1-PIK1 92 7.85E-7
14 SGTC_1707 st032323 4.67 6.3 µM 2.17E-6 DNA damage response 40 1.50E-6
15 SGTC_1278 0874-0585 4.25 172.0 µM 1.46E-5 10 1.06E-5
16 SGTC_608 k048-0125 4.18 159.0 µM 1.94E-5 25 1.43E-5
17 SGTC_908 3448-7491 4.04 47.7 µM 3.64E-5 mitochondrial stress 120 2.72E-5
18 SGTC_941 3237-0776 3.98 460.0 µM 4.50E-5 15 3.38E-5
19 SGTC_21 0849-0113 3.96 23.0 µM 4.90E-5 29 3.70E-5
20 SGTC_2021 4019055 3.89 173.0 µM 6.54E-5 endomembrane recycling 126 4.97E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 3.50E-22 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.147 1.30E-17 YGL089C MF(ALPHA)2 hom Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
0.137 1.44E-15 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.135 3.75E-15 YOL081W IRA2 hom GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication
0.129 7.57E-14 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.126 2.22E-13 YDR052C DBF4 het Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress
0.125 4.32E-13 YNL001W DOM34 hom Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
0.124 6.74E-13 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.123 8.32E-13 YDL234C GYP7 hom GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
0.117 8.96E-12 YGR066C_p YGR066C_p hom Putative protein of unknown function
0.117 9.21E-12 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.112 9.71E-11 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.110 1.72E-10 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.107 4.98E-10 YNL070W TOM7 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.106 7.51E-10 YDR189W SLY1 het Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex