YBR291C / CTP1

Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR291C / CTP1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.38|P-value:4.58E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.73|P-value:1.10E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:10.10|P-value:1.09E-23 ID:SGTC_138|Compound:0850-0259|FD-Score:6.56|P-value:5.72E-11 ID:SGTC_139|Compound:0099-0334|FD-Score:3.88|P-value:7.06E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.02|P-value:2.61E-12 ID:SGTC_276|Compound:colchicine|FD-Score:3.20|P-value:8.58E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.97|P-value:4.89E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.78|P-value:1.03E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:4.45|P-value:6.22E-6 ID:SGTC_408|Compound:cantharidin|FD-Score:4.21|P-value:1.81E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:3.77|P-value:1.10E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.66|P-value:1.48E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:-4.38|P-value:7.28E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:3.66|P-value:1.69E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:4.12|P-value:2.64E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:4.48|P-value:5.55E-6 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.19|P-value:7.89E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.46|P-value:3.44E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.91|P-value:6.23E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:5.47|P-value:3.85E-8 ID:SGTC_768|Compound:0384-0033|FD-Score:3.48|P-value:3.27E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.59|P-value:2.16E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:5.17|P-value:1.90E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:3.36|P-value:5.01E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.65|P-value:2.54E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.94|P-value:6.04E-7 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.35|P-value:5.09E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.31|P-value:5.96E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:-3.24|P-value:6.59E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.44|P-value:3.67E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.57|P-value:2.29E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.60|P-value:2.05E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.15|P-value:2.37E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.33|P-value:5.52E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.44|P-value:3.30E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:4.90|P-value:7.68E-7 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.86|P-value:7.76E-5 ID:SGTC_1629|Compound:st005085|FD-Score:3.40|P-value:4.30E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.28|P-value:1.34E-5 ID:SGTC_1827|Compound:berberine|FD-Score:5.54|P-value:2.65E-8 ID:SGTC_1847|Compound:st056231|FD-Score:3.21|P-value:8.38E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.38|P-value:4.67E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.18|P-value:9.09E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.90|P-value:6.47E-5 ID:SGTC_2147|Compound:5545932|FD-Score:9.01|P-value:4.00E-19 ID:SGTC_2171|Compound:5739187|FD-Score:3.16|P-value:9.84E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.55|P-value:2.23E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.18|P-value:8.22E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.23|P-value:1.69E-5 ID:SGTC_2255|Compound:7941087|FD-Score:-3.14|P-value:9.24E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.17|P-value:9.58E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.92|P-value:6.10E-5 ID:SGTC_2339|Compound:9000433|FD-Score:6.93|P-value:5.03E-12 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.94|P-value:5.63E-5 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.20|P-value:8.56E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.49|P-value:3.07E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.22|P-value:1.71E-5 ID:SGTC_2709|Compound:st078560|FD-Score:4.14|P-value:2.40E-5 ID:SGTC_2714|Compound:st079313|FD-Score:3.83|P-value:8.78E-5 ID:SGTC_2794|Compound:7785382|FD-Score:5.87|P-value:4.17E-9 ID:SGTC_2896|Compound:9052656|FD-Score:6.10|P-value:1.04E-9 ID:SGTC_2952|Compound:9073731|FD-Score:3.65|P-value:1.70E-4 ID:SGTC_3031|Compound:9088762|FD-Score:5.12|P-value:2.51E-7 ID:SGTC_3037|Compound:9091026|FD-Score:8.58|P-value:1.64E-17 ID:SGTC_3043|Compound:9092303|FD-Score:3.45|P-value:3.64E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-3.45|P-value:3.24E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.78|P-value:1.06E-4 ID:SGTC_3167|Compound:9103034|FD-Score:3.40|P-value:4.32E-4 ID:SGTC_3206|Compound:9114350|FD-Score:4.15|P-value:2.37E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.38|P-value:4.58E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.73|P-value:1.10E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:10.10|P-value:1.09E-23 ID:SGTC_138|Compound:0850-0259|FD-Score:6.56|P-value:5.72E-11 ID:SGTC_139|Compound:0099-0334|FD-Score:3.88|P-value:7.06E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.02|P-value:2.61E-12 ID:SGTC_276|Compound:colchicine|FD-Score:3.20|P-value:8.58E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.97|P-value:4.89E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.78|P-value:1.03E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:4.45|P-value:6.22E-6 ID:SGTC_408|Compound:cantharidin|FD-Score:4.21|P-value:1.81E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:3.77|P-value:1.10E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.66|P-value:1.48E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:-4.38|P-value:7.28E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:3.66|P-value:1.69E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:4.12|P-value:2.64E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:4.48|P-value:5.55E-6 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.19|P-value:7.89E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.46|P-value:3.44E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.91|P-value:6.23E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:5.47|P-value:3.85E-8 ID:SGTC_768|Compound:0384-0033|FD-Score:3.48|P-value:3.27E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.59|P-value:2.16E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:5.17|P-value:1.90E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:3.36|P-value:5.01E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.65|P-value:2.54E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.94|P-value:6.04E-7 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.35|P-value:5.09E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.31|P-value:5.96E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:-3.24|P-value:6.59E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.44|P-value:3.67E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.57|P-value:2.29E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.60|P-value:2.05E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.15|P-value:2.37E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.33|P-value:5.52E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.44|P-value:3.30E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:4.90|P-value:7.68E-7 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.86|P-value:7.76E-5 ID:SGTC_1629|Compound:st005085|FD-Score:3.40|P-value:4.30E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.28|P-value:1.34E-5 ID:SGTC_1827|Compound:berberine|FD-Score:5.54|P-value:2.65E-8 ID:SGTC_1847|Compound:st056231|FD-Score:3.21|P-value:8.38E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.38|P-value:4.67E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.18|P-value:9.09E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.90|P-value:6.47E-5 ID:SGTC_2147|Compound:5545932|FD-Score:9.01|P-value:4.00E-19 ID:SGTC_2171|Compound:5739187|FD-Score:3.16|P-value:9.84E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.55|P-value:2.23E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.18|P-value:8.22E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.23|P-value:1.69E-5 ID:SGTC_2255|Compound:7941087|FD-Score:-3.14|P-value:9.24E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.17|P-value:9.58E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.92|P-value:6.10E-5 ID:SGTC_2339|Compound:9000433|FD-Score:6.93|P-value:5.03E-12 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.94|P-value:5.63E-5 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.20|P-value:8.56E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.49|P-value:3.07E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.22|P-value:1.71E-5 ID:SGTC_2709|Compound:st078560|FD-Score:4.14|P-value:2.40E-5 ID:SGTC_2714|Compound:st079313|FD-Score:3.83|P-value:8.78E-5 ID:SGTC_2794|Compound:7785382|FD-Score:5.87|P-value:4.17E-9 ID:SGTC_2896|Compound:9052656|FD-Score:6.10|P-value:1.04E-9 ID:SGTC_2952|Compound:9073731|FD-Score:3.65|P-value:1.70E-4 ID:SGTC_3031|Compound:9088762|FD-Score:5.12|P-value:2.51E-7 ID:SGTC_3037|Compound:9091026|FD-Score:8.58|P-value:1.64E-17 ID:SGTC_3043|Compound:9092303|FD-Score:3.45|P-value:3.64E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-3.45|P-value:3.24E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.78|P-value:1.06E-4 ID:SGTC_3167|Compound:9103034|FD-Score:3.40|P-value:4.32E-4 ID:SGTC_3206|Compound:9114350|FD-Score:4.15|P-value:2.37E-5

Top fitness defect scores for YBR291C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 10.10 9.0 µM 1.09E-23 cell wall 74 1.99E-24
2 SGTC_2147 5545932 9.01 89.7 µM 4.00E-19 ergosterol biosynthesis 1 1.02E-19
3 SGTC_3037 9091026 8.58 49.5 µM 1.64E-17 NEO1-PIK1 11 4.72E-18
4 SGTC_221 trifluoperazine 7.02 10.3 µM 2.61E-12 NEO1-PIK1 102 1.10E-12
5 SGTC_2339 9000433 6.93 200.0 µM 5.03E-12 2 2.17E-12
6 SGTC_138 0850-0259 6.56 40.9 µM 5.72E-11 cell wall 88 2.67E-11
7 SGTC_2896 9052656 6.10 71.4 µM 1.04E-9 endomembrane recycling 39 5.33E-10
8 SGTC_2794 7785382 5.87 27.3 µM 4.17E-9 5 2.24E-9
9 SGTC_1827 berberine 5.54 7.2 µM 2.65E-8 60S ribosome export 5 1.51E-8
10 SGTC_742 0kpi-0133 5.47 140.0 µM 3.85E-8 ERG2 7 2.22E-8
11 SGTC_926 2268-1401 5.17 59.4 µM 1.90E-7 TSC3-RPN4 13 1.16E-7
12 SGTC_3031 9088762 5.12 49.5 µM 2.51E-7 3 1.54E-7
13 SGTC_1134 3477-0009 4.94 42.5 µM 6.04E-7 21 3.82E-7
14 SGTC_1417 3966-0327 4.90 90.4 µM 7.68E-7 6 4.89E-7
15 SGTC_1107 amlodipine 4.65 47.0 µM 2.54E-6 19 1.68E-6
16 SGTC_687 k029-0044 4.48 34.9 µM 5.55E-6 PDR1 13 3.77E-6
17 SGTC_399 oxolinic acid 4.45 75.0 µM 6.22E-6 3 4.24E-6
18 SGTC_1801 st050089 4.28 28.4 µM 1.34E-5 NEO1-PIK1 102 9.33E-6
19 SGTC_2250 alverine citrate 4.23 130.0 µM 1.69E-5 138 1.19E-5
20 SGTC_2688 kanamycin b 4.22 96.7 µM 1.71E-5 calcium & mitochondrial duress 333 1.20E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 7.01E-41 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.224 2.63E-39 YNL077W APJ1 hom Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.214 3.65E-36 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.208 4.81E-34 YOL144W NOP8 het Nucleolar protein required for 60S ribosomal subunit biogenesis
0.206 1.87E-33 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.201 5.96E-32 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.199 2.42E-31 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.197 9.88E-31 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.195 6.00E-30 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.193 1.39E-29 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.193 2.22E-29 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.192 2.96E-29 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.191 4.84E-29 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.190 8.94E-29 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
0.189 1.99E-28 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery