YBR292C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR292C / YBR292C

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.11|P-value:7.71E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:14.30|P-value:2.65E-48 ID:SGTC_168|Compound:3970-0862|FD-Score:3.14|P-value:6.77E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.48|P-value:1.95E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.63|P-value:1.09E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.17|P-value:6.19E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.98|P-value:2.47E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:3.06|P-value:9.10E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.10|P-value:7.95E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.24|P-value:4.81E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.07|P-value:8.77E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.30|P-value:3.79E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.59|P-value:1.29E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.67|P-value:9.00E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.38|P-value:3.94E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.62|P-value:1.27E-6 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.05|P-value:1.86E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.06|P-value:9.19E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.58|P-value:1.33E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.37|P-value:3.00E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.20|P-value:5.55E-4 ID:SGTC_1625|Compound:st003711|FD-Score:6.54|P-value:1.35E-11 ID:SGTC_1765|Compound:st044815|FD-Score:4.43|P-value:3.19E-6 ID:SGTC_1827|Compound:berberine|FD-Score:3.18|P-value:5.82E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.26|P-value:4.39E-4 ID:SGTC_1902|Compound:st060212|FD-Score:5.99|P-value:4.97E-10 ID:SGTC_1904|Compound:st060225|FD-Score:4.35|P-value:4.55E-6 ID:SGTC_1953|Compound:st076800|FD-Score:4.03|P-value:1.97E-5 ID:SGTC_2001|Compound:4023502|FD-Score:-5.45|P-value:1.46E-8 ID:SGTC_2005|Compound:4024620|FD-Score:-3.40|P-value:2.70E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.64|P-value:1.02E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.66|P-value:9.58E-5 ID:SGTC_2010|Compound:4012422|FD-Score:4.63|P-value:1.20E-6 ID:SGTC_2193|Compound:5925765|FD-Score:3.41|P-value:2.52E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.14|P-value:6.77E-4 ID:SGTC_2217|Compound:6934799|FD-Score:3.86|P-value:4.20E-5 ID:SGTC_2223|Compound:6903751|FD-Score:5.73|P-value:2.53E-9 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.88|P-value:3.75E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-3.26|P-value:4.44E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.32|P-value:3.57E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.29|P-value:3.99E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.87|P-value:3.91E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.37|P-value:2.95E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.99|P-value:2.34E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.40|P-value:3.55E-6 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.24|P-value:4.90E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.28|P-value:6.35E-6 ID:SGTC_2841|Compound:9004761|FD-Score:-5.13|P-value:8.67E-8 ID:SGTC_2842|Compound:9000675|FD-Score:-4.67|P-value:1.01E-6 ID:SGTC_2884|Compound:9058502|FD-Score:4.23|P-value:8.13E-6 ID:SGTC_2896|Compound:9052656|FD-Score:3.47|P-value:2.00E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.15|P-value:1.17E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.34|P-value:3.35E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-3.51|P-value:1.76E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.19|P-value:5.69E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.40|P-value:2.63E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-3.30|P-value:3.85E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-4.21|P-value:9.19E-6 ID:SGTC_39|Compound:0986-0283|FD-Score:3.11|P-value:7.71E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:14.30|P-value:2.65E-48 ID:SGTC_168|Compound:3970-0862|FD-Score:3.14|P-value:6.77E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.48|P-value:1.95E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.63|P-value:1.09E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.17|P-value:6.19E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.98|P-value:2.47E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:3.06|P-value:9.10E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.10|P-value:7.95E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.24|P-value:4.81E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.07|P-value:8.77E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.30|P-value:3.79E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.59|P-value:1.29E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.67|P-value:9.00E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.38|P-value:3.94E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.62|P-value:1.27E-6 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.05|P-value:1.86E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.06|P-value:9.19E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.58|P-value:1.33E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.37|P-value:3.00E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.20|P-value:5.55E-4 ID:SGTC_1625|Compound:st003711|FD-Score:6.54|P-value:1.35E-11 ID:SGTC_1765|Compound:st044815|FD-Score:4.43|P-value:3.19E-6 ID:SGTC_1827|Compound:berberine|FD-Score:3.18|P-value:5.82E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.26|P-value:4.39E-4 ID:SGTC_1902|Compound:st060212|FD-Score:5.99|P-value:4.97E-10 ID:SGTC_1904|Compound:st060225|FD-Score:4.35|P-value:4.55E-6 ID:SGTC_1953|Compound:st076800|FD-Score:4.03|P-value:1.97E-5 ID:SGTC_2001|Compound:4023502|FD-Score:-5.45|P-value:1.46E-8 ID:SGTC_2005|Compound:4024620|FD-Score:-3.40|P-value:2.70E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.64|P-value:1.02E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.66|P-value:9.58E-5 ID:SGTC_2010|Compound:4012422|FD-Score:4.63|P-value:1.20E-6 ID:SGTC_2193|Compound:5925765|FD-Score:3.41|P-value:2.52E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.14|P-value:6.77E-4 ID:SGTC_2217|Compound:6934799|FD-Score:3.86|P-value:4.20E-5 ID:SGTC_2223|Compound:6903751|FD-Score:5.73|P-value:2.53E-9 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.88|P-value:3.75E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-3.26|P-value:4.44E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.32|P-value:3.57E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.29|P-value:3.99E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.87|P-value:3.91E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.37|P-value:2.95E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.99|P-value:2.34E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.40|P-value:3.55E-6 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.24|P-value:4.90E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.28|P-value:6.35E-6 ID:SGTC_2841|Compound:9004761|FD-Score:-5.13|P-value:8.67E-8 ID:SGTC_2842|Compound:9000675|FD-Score:-4.67|P-value:1.01E-6 ID:SGTC_2884|Compound:9058502|FD-Score:4.23|P-value:8.13E-6 ID:SGTC_2896|Compound:9052656|FD-Score:3.47|P-value:2.00E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.15|P-value:1.17E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.34|P-value:3.35E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-3.51|P-value:1.76E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.19|P-value:5.69E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.40|P-value:2.63E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-3.30|P-value:3.85E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-4.21|P-value:9.19E-6

Top fitness defect scores for YBR292C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 14.30 9.0 µM 2.65E-48 cell wall 30 1.37E-46
2 SGTC_1625 st003711 6.54 30.1 µM 1.35E-11 calcium & mitochondrial duress 6 3.15E-11
3 SGTC_1902 st060212 5.99 70.5 µM 4.97E-10 1 1.02E-9
4 SGTC_2223 6903751 5.73 107.6 µM 2.53E-9 superoxide 5 4.89E-9
5 SGTC_2010 4012422 4.63 159.0 µM 1.20E-6 7 1.85E-6
6 SGTC_1259 0671-0132 4.62 43.0 µM 1.27E-6 10 1.96E-6
7 SGTC_1765 st044815 4.43 90.4 µM 3.19E-6 15 4.78E-6
8 SGTC_2688 kanamycin b 4.40 96.7 µM 3.55E-6 calcium & mitochondrial duress 307 5.29E-6
9 SGTC_1251 0490-5699 4.38 265.0 µM 3.94E-6 21 5.85E-6
10 SGTC_1904 st060225 4.35 78.0 µM 4.55E-6 12 6.72E-6
11 SGTC_2785 7756463 4.28 72.7 µM 6.35E-6 22 9.27E-6
12 SGTC_2884 9058502 4.23 52.0 µM 8.13E-6 23 1.18E-5
13 SGTC_2962 9082311 4.15 13.2 µM 1.17E-5 16 1.67E-5
14 SGTC_1308 1187-1617 4.05 41.4 µM 1.86E-5 fatty acid desaturase (OLE1) 37 2.61E-5
15 SGTC_1953 st076800 4.03 12.1 µM 1.97E-5 46 2.76E-5
16 SGTC_2585 alliin 3.99 100.0 µM 2.34E-5 24 3.26E-5
17 SGTC_457 grayanotoxin iii 3.98 135.0 µM 2.47E-5 63 3.43E-5
18 SGTC_2233 sulbentine 3.88 40.4 µM 3.75E-5 66 5.14E-5
19 SGTC_2507 purpurin 3.87 79.7 µM 3.91E-5 copper-dependent oxidative stress 40 5.35E-5
20 SGTC_2217 6934799 3.86 96.1 µM 4.20E-5 TSC3-RPN4 9 5.73E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.295 2.58E-68 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.284 1.89E-63 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.284 3.11E-63 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.257 1.19E-51 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.254 1.42E-50 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.252 8.00E-50 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.250 5.54E-49 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.248 2.14E-48 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.236 8.07E-44 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.234 5.82E-43 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.229 2.48E-41 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.227 1.47E-40 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.221 2.80E-38 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.220 3.91E-38 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.216 9.53E-37 YDL213C NOP6 hom rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes