YBR293W / VBA2

Permease of basic amino acids in the vacuolar membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR293W / VBA2

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:-4.16|P-value:1.24E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.32|P-value:3.94E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.11|P-value:8.32E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.14|P-value:7.53E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:8.04|P-value:2.20E-16 ID:SGTC_171|Compound:k064-0041|FD-Score:4.20|P-value:1.09E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:3.67|P-value:1.03E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.25|P-value:5.08E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.10|P-value:8.63E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.84|P-value:5.29E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:4.93|P-value:3.04E-7 ID:SGTC_887|Compound:0885-0007|FD-Score:-3.18|P-value:6.39E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:-3.11|P-value:8.05E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:5.36|P-value:2.96E-8 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.13|P-value:1.50E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:5.08|P-value:1.44E-7 ID:SGTC_968|Compound:1309-0633|FD-Score:3.40|P-value:2.95E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:4.97|P-value:2.49E-7 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.10|P-value:1.72E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.33|P-value:3.80E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.10|P-value:8.80E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.98|P-value:2.86E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:8.22|P-value:4.48E-17 ID:SGTC_1132|Compound:3456-3614|FD-Score:5.03|P-value:1.82E-7 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.19|P-value:6.34E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.17|P-value:6.88E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.98|P-value:2.41E-7 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.50|P-value:2.02E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.77|P-value:6.85E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.55|P-value:1.64E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.88|P-value:4.49E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.93|P-value:3.58E-5 ID:SGTC_1654|Compound:st012436|FD-Score:5.00|P-value:2.15E-7 ID:SGTC_1661|Compound:st013063|FD-Score:3.32|P-value:4.05E-4 ID:SGTC_1662|Compound:st014054|FD-Score:3.97|P-value:2.98E-5 ID:SGTC_1664|Compound:st014217|FD-Score:5.90|P-value:1.20E-9 ID:SGTC_1684|Compound:st024538|FD-Score:3.27|P-value:4.71E-4 ID:SGTC_1685|Compound:st024049|FD-Score:-3.07|P-value:9.43E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.50|P-value:2.04E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.31|P-value:4.12E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.24|P-value:5.28E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.42|P-value:2.73E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.08|P-value:9.20E-4 ID:SGTC_2085|Compound:5307070|FD-Score:6.21|P-value:1.72E-10 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.53|P-value:1.79E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.22|P-value:5.64E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.40|P-value:2.95E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.41|P-value:2.87E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.24|P-value:5.33E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.07|P-value:9.56E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.22|P-value:5.70E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.10|P-value:1.72E-5 ID:SGTC_2556|Compound:citropten|FD-Score:3.47|P-value:2.27E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:5.81|P-value:2.12E-9 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.71|P-value:8.83E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.06|P-value:9.86E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-5.60|P-value:7.20E-9 ID:SGTC_2827|Compound:7993847|FD-Score:7.25|P-value:1.12E-13 ID:SGTC_2837|Compound:9008476|FD-Score:3.07|P-value:9.65E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.80|P-value:6.16E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.67|P-value:1.03E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.20|P-value:5.87E-4 ID:SGTC_3157|Compound:9099274|FD-Score:5.26|P-value:5.18E-8 ID:SGTC_3159|Compound:9100096|FD-Score:3.74|P-value:7.77E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.45|P-value:2.47E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.24|P-value:5.38E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.70|P-value:1.03E-6 ID:SGTC_25|Compound:0118-0223|FD-Score:-4.16|P-value:1.24E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.32|P-value:3.94E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.11|P-value:8.32E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.14|P-value:7.53E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:8.04|P-value:2.20E-16 ID:SGTC_171|Compound:k064-0041|FD-Score:4.20|P-value:1.09E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:3.67|P-value:1.03E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.25|P-value:5.08E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.10|P-value:8.63E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.84|P-value:5.29E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:4.93|P-value:3.04E-7 ID:SGTC_887|Compound:0885-0007|FD-Score:-3.18|P-value:6.39E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:-3.11|P-value:8.05E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:5.36|P-value:2.96E-8 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.13|P-value:1.50E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:5.08|P-value:1.44E-7 ID:SGTC_968|Compound:1309-0633|FD-Score:3.40|P-value:2.95E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:4.97|P-value:2.49E-7 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.10|P-value:1.72E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.33|P-value:3.80E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.10|P-value:8.80E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.98|P-value:2.86E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:8.22|P-value:4.48E-17 ID:SGTC_1132|Compound:3456-3614|FD-Score:5.03|P-value:1.82E-7 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.19|P-value:6.34E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.17|P-value:6.88E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.98|P-value:2.41E-7 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.50|P-value:2.02E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.77|P-value:6.85E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.55|P-value:1.64E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.88|P-value:4.49E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.93|P-value:3.58E-5 ID:SGTC_1654|Compound:st012436|FD-Score:5.00|P-value:2.15E-7 ID:SGTC_1661|Compound:st013063|FD-Score:3.32|P-value:4.05E-4 ID:SGTC_1662|Compound:st014054|FD-Score:3.97|P-value:2.98E-5 ID:SGTC_1664|Compound:st014217|FD-Score:5.90|P-value:1.20E-9 ID:SGTC_1684|Compound:st024538|FD-Score:3.27|P-value:4.71E-4 ID:SGTC_1685|Compound:st024049|FD-Score:-3.07|P-value:9.43E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.50|P-value:2.04E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.31|P-value:4.12E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.24|P-value:5.28E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.42|P-value:2.73E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.08|P-value:9.20E-4 ID:SGTC_2085|Compound:5307070|FD-Score:6.21|P-value:1.72E-10 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.53|P-value:1.79E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.22|P-value:5.64E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.40|P-value:2.95E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.41|P-value:2.87E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.24|P-value:5.33E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.07|P-value:9.56E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.22|P-value:5.70E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.10|P-value:1.72E-5 ID:SGTC_2556|Compound:citropten|FD-Score:3.47|P-value:2.27E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:5.81|P-value:2.12E-9 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.71|P-value:8.83E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.06|P-value:9.86E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-5.60|P-value:7.20E-9 ID:SGTC_2827|Compound:7993847|FD-Score:7.25|P-value:1.12E-13 ID:SGTC_2837|Compound:9008476|FD-Score:3.07|P-value:9.65E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.80|P-value:6.16E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.67|P-value:1.03E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.20|P-value:5.87E-4 ID:SGTC_3157|Compound:9099274|FD-Score:5.26|P-value:5.18E-8 ID:SGTC_3159|Compound:9100096|FD-Score:3.74|P-value:7.77E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.45|P-value:2.47E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.24|P-value:5.38E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.70|P-value:1.03E-6

Top fitness defect scores for YBR293W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1129 3453-1384 8.22 223.0 µM 4.48E-17 3 9.80E-17
2 SGTC_160 3453-0671 8.04 289.7 µM 2.20E-16 4 4.64E-16
3 SGTC_2827 7993847 7.25 71.4 µM 1.12E-13 1 2.04E-13
4 SGTC_2085 5307070 6.21 144.1 µM 1.72E-10 superoxide 5 2.67E-10
5 SGTC_1664 st014217 5.90 9.0 µM 1.20E-9 60S ribosome export 3 1.79E-9
6 SGTC_2569 tetrandrine 5.81 100.0 µM 2.12E-9 2 3.12E-9
7 SGTC_899 1083-0020 5.36 478.0 µM 2.96E-8 2 4.11E-8
8 SGTC_3157 9099274 5.26 49.5 µM 5.18E-8 6 7.10E-8
9 SGTC_906 1165-0455 5.08 526.0 µM 1.44E-7 2 1.93E-7
10 SGTC_1132 3456-3614 5.03 2.5 µM 1.82E-7 tubulin folding & SWR complex 18 2.43E-7
11 SGTC_1654 st012436 5.00 41.8 µM 2.15E-7 3 2.86E-7
12 SGTC_1179 1021-1431 4.98 9.3 µM 2.41E-7 19 3.19E-7
13 SGTC_1034 k072-0165 4.97 12.7 µM 2.49E-7 Golgi 9 3.29E-7
14 SGTC_884 0851-0618 4.93 334.0 µM 3.04E-7 4 4.01E-7
15 SGTC_3299 9121982 4.70 43.1 µM 1.03E-6 12 1.32E-6
16 SGTC_171 k064-0041 4.20 9.7 µM 1.09E-5 heme requiring 24 1.33E-5
17 SGTC_905 2-aminofluorene 4.13 215.0 µM 1.50E-5 cell wall signaling 24 1.82E-5
18 SGTC_1035 k081-0041 4.10 55.2 µM 1.72E-5 Golgi 19 2.07E-5
19 SGTC_2420 aureobasidin a 4.10 50.0 nM 1.72E-5 35 2.08E-5
20 SGTC_1119 parthenolide 3.98 318.5 nM 2.86E-5 TSC3-RPN4 37 3.42E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.31E-9 YKL153W_d YKL153W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
0.100 7.16E-9 YLR142W PUT1 hom Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
0.097 1.80E-8 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.091 1.27E-7 YLR357W RSC2 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance
0.087 4.04E-7 YNL321W VNX1 hom Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate
0.085 7.68E-7 YIL118W RHO3 het Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
0.084 1.10E-6 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.082 2.01E-6 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.077 8.55E-6 YPL090C RPS6A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication
0.077 9.30E-6 YLR131C ACE2 hom Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
0.076 1.18E-5 YLR216C CPR6 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress
0.074 1.61E-5 YDR152W GIR2 hom Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein
0.074 1.72E-5 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.074 1.88E-5 YDR083W RRP8 hom Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1
0.072 3.03E-5 YPR032W SRO7 hom Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication