YBR294W / SUL1

High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR294W / SUL1

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.09|P-value:2.13E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:2.90|P-value:4.64E-4 ID:SGTC_57|Compound:miconazole|FD-Score:2.80|P-value:6.98E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.74|P-value:8.40E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.53|P-value:2.79E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.27|P-value:9.04E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:2.71|P-value:9.81E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.25|P-value:1.05E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.16|P-value:1.46E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.11|P-value:1.80E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.75|P-value:9.04E-6 ID:SGTC_991|Compound:3996-0057|FD-Score:3.06|P-value:2.36E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-2.97|P-value:3.31E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-2.97|P-value:3.35E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.11|P-value:1.80E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:-2.88|P-value:4.77E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:-3.04|P-value:2.49E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.34|P-value:6.81E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:-4.28|P-value:4.65E-7 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.91|P-value:3.70E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.83|P-value:6.21E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.01|P-value:2.98E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.95|P-value:3.21E-6 ID:SGTC_1751|Compound:st044839|FD-Score:2.85|P-value:5.69E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.67|P-value:1.38E-5 ID:SGTC_1999|Compound:st074831|FD-Score:3.12|P-value:1.83E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:2.93|P-value:4.20E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.90|P-value:3.98E-6 ID:SGTC_2276|Compound:7947513|FD-Score:-3.91|P-value:3.74E-6 ID:SGTC_2278|Compound:7948257|FD-Score:3.69|P-value:1.23E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-5.49|P-value:1.70E-10 ID:SGTC_2418|Compound:pentamidine|FD-Score:-12.10|P-value:1.47E-43 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.04|P-value:1.98E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:8.89|P-value:1.56E-24 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.15|P-value:1.52E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.65|P-value:1.53E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.59|P-value:1.98E-5 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.02|P-value:2.71E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:2.73|P-value:9.18E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.11|P-value:1.88E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.58|P-value:8.01E-8 ID:SGTC_2833|Compound:9001315|FD-Score:-4.43|P-value:1.97E-7 ID:SGTC_2839|Compound:9003951|FD-Score:3.81|P-value:6.92E-6 ID:SGTC_2865|Compound:9030313|FD-Score:-2.97|P-value:3.37E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-3.40|P-value:5.03E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-2.77|P-value:7.59E-4 ID:SGTC_3139|Compound:9095020|FD-Score:2.85|P-value:5.81E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-2.72|P-value:9.22E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.09|P-value:2.13E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:2.90|P-value:4.64E-4 ID:SGTC_57|Compound:miconazole|FD-Score:2.80|P-value:6.98E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.74|P-value:8.40E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.53|P-value:2.79E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.27|P-value:9.04E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:2.71|P-value:9.81E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.25|P-value:1.05E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.16|P-value:1.46E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.11|P-value:1.80E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.75|P-value:9.04E-6 ID:SGTC_991|Compound:3996-0057|FD-Score:3.06|P-value:2.36E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-2.97|P-value:3.31E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-2.97|P-value:3.35E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.11|P-value:1.80E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:-2.88|P-value:4.77E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:-3.04|P-value:2.49E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.34|P-value:6.81E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:-4.28|P-value:4.65E-7 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.91|P-value:3.70E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.83|P-value:6.21E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.01|P-value:2.98E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.95|P-value:3.21E-6 ID:SGTC_1751|Compound:st044839|FD-Score:2.85|P-value:5.69E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.67|P-value:1.38E-5 ID:SGTC_1999|Compound:st074831|FD-Score:3.12|P-value:1.83E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:2.93|P-value:4.20E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.90|P-value:3.98E-6 ID:SGTC_2276|Compound:7947513|FD-Score:-3.91|P-value:3.74E-6 ID:SGTC_2278|Compound:7948257|FD-Score:3.69|P-value:1.23E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-5.49|P-value:1.70E-10 ID:SGTC_2418|Compound:pentamidine|FD-Score:-12.10|P-value:1.47E-43 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.04|P-value:1.98E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:8.89|P-value:1.56E-24 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.15|P-value:1.52E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.65|P-value:1.53E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.59|P-value:1.98E-5 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.02|P-value:2.71E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:2.73|P-value:9.18E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.11|P-value:1.88E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.58|P-value:8.01E-8 ID:SGTC_2833|Compound:9001315|FD-Score:-4.43|P-value:1.97E-7 ID:SGTC_2839|Compound:9003951|FD-Score:3.81|P-value:6.92E-6 ID:SGTC_2865|Compound:9030313|FD-Score:-2.97|P-value:3.37E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-3.40|P-value:5.03E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-2.77|P-value:7.59E-4 ID:SGTC_3139|Compound:9095020|FD-Score:2.85|P-value:5.81E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-2.72|P-value:9.22E-4

Top fitness defect scores for YBR294W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2420 aureobasidin a 8.89 50.0 nM 1.56E-24 5 3.15E-19
2 SGTC_2419 paclitaxel 4.04 166.5 µM 1.98E-6 36 2.68E-5
3 SGTC_1727 st034309 3.95 9.9 µM 3.21E-6 39 3.89E-5
4 SGTC_2839 9003951 3.81 26.0 µM 6.92E-6 12 7.06E-5
5 SGTC_938 3126-1755 3.75 342.0 µM 9.04E-6 15 8.68E-5
6 SGTC_2278 7948257 3.69 134.3 µM 1.23E-5 28 1.11E-4
7 SGTC_1994 st072947 3.67 40.9 µM 1.38E-5 25 1.21E-4
8 SGTC_2426 5582046 3.65 32.2 µM 1.53E-5 41 1.30E-4
9 SGTC_359 0081-0058 3.53 15.9 µM 2.79E-5 60S ribosome export 63 2.08E-4
10 SGTC_1342 1486-1464 3.34 234.0 µM 6.81E-5 35 4.17E-4
11 SGTC_611 3453-1652 3.25 23.7 µM 1.05E-4 49 5.84E-4
12 SGTC_1999 st074831 3.12 12.5 µM 1.83E-4 plasma membrane duress 71 9.01E-4
13 SGTC_2763 lisinopril 3.11 49.3 µM 1.88E-4 30 9.20E-4
14 SGTC_41 0478-0632 3.09 82.6 µM 2.13E-4 70 0.00101
15 SGTC_991 3996-0057 3.06 64.7 µM 2.36E-4 48 0.00110
16 SGTC_1627 st003713 3.01 25.6 µM 2.98E-4 calcium & mitochondrial duress 149 0.00132
17 SGTC_2042 p-Dimethylaminoacetophenone 2.93 200.0 µM 4.20E-4 67 0.00172
18 SGTC_56 0957-0365 2.90 83.2 µM 4.64E-4 Golgi 110 0.00186
19 SGTC_1751 st044839 2.85 27.2 µM 5.69E-4 Golgi 40 0.00218
20 SGTC_3139 9095020 2.85 49.5 µM 5.81E-4 41 0.00222

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.217 3.80E-37 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.193 1.74E-29 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.161 8.02E-21 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.151 1.53E-18 YLR344W RPL26A hom Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication
0.150 2.11E-18 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.144 5.60E-17 YKL105C SEG2 hom Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes
0.140 3.77E-16 YKR059W TIF1 hom Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication
0.136 2.73E-15 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.135 4.87E-15 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.131 2.19E-14 YML011C RAD33 hom Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.130 3.67E-14 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.115 2.41E-11 YDL057W_p YDL057W_p hom Putative protein of unknown function; YDL057W is not an essential gene
0.114 4.12E-11 YMR280C CAT8 hom Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress
0.112 6.93E-11 YLL053C_p YLL053C_p hom Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
0.109 2.31E-10 YAL003W EFB1 het Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site