YBR296C-A_p

Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR296C-A / YBR296C-A

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:4.06|P-value:6.18E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.11|P-value:6.88E-7 ID:SGTC_113|Compound:0099-0221|FD-Score:-4.28|P-value:2.49E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:6.37|P-value:8.59E-10 ID:SGTC_125|Compound:0133-0007|FD-Score:3.78|P-value:1.76E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.92|P-value:1.05E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.51|P-value:1.01E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.38|P-value:7.00E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-4.22|P-value:3.17E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.85|P-value:2.30E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:4.25|P-value:3.03E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:3.52|P-value:4.37E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.58|P-value:3.66E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.67|P-value:2.49E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.50|P-value:4.71E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.32|P-value:8.55E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.63|P-value:6.07E-6 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.07|P-value:5.95E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:3.42|P-value:6.30E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-4.53|P-value:8.86E-6 ID:SGTC_1725|Compound:st036284|FD-Score:3.55|P-value:3.95E-4 ID:SGTC_1727|Compound:st034309|FD-Score:6.11|P-value:3.87E-9 ID:SGTC_1774|Compound:st048371|FD-Score:3.37|P-value:7.22E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-4.22|P-value:3.17E-5 ID:SGTC_1958|Compound:st076513|FD-Score:8.06|P-value:1.29E-14 ID:SGTC_1980|Compound:st071811|FD-Score:4.88|P-value:2.01E-6 ID:SGTC_2082|Compound:5219693|FD-Score:3.56|P-value:3.87E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.00|P-value:8.03E-5 ID:SGTC_2342|Compound:7990637|FD-Score:4.38|P-value:1.74E-5 ID:SGTC_2351|Compound:9026858|FD-Score:3.60|P-value:3.37E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.07|P-value:6.00E-5 ID:SGTC_2475|Compound:5812728|FD-Score:4.30|P-value:2.40E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.30|P-value:9.23E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.51|P-value:4.53E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.91|P-value:1.11E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.56|P-value:3.93E-4 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.31|P-value:8.96E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.20|P-value:3.58E-5 ID:SGTC_2963|Compound:9082507|FD-Score:-3.54|P-value:4.01E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-4.95|P-value:1.38E-6 ID:SGTC_2985|Compound:9022375|FD-Score:-3.48|P-value:4.89E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.27|P-value:2.71E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.33|P-value:8.44E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.75|P-value:2.01E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.94|P-value:9.75E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.96|P-value:9.18E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-4.85|P-value:2.20E-6 ID:SGTC_3209|Compound:9113616|FD-Score:4.23|P-value:3.27E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.93|P-value:1.03E-4 ID:SGTC_13|Compound:0199-0087|FD-Score:4.06|P-value:6.18E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.11|P-value:6.88E-7 ID:SGTC_113|Compound:0099-0221|FD-Score:-4.28|P-value:2.49E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:6.37|P-value:8.59E-10 ID:SGTC_125|Compound:0133-0007|FD-Score:3.78|P-value:1.76E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.92|P-value:1.05E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.51|P-value:1.01E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.38|P-value:7.00E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-4.22|P-value:3.17E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.85|P-value:2.30E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:4.25|P-value:3.03E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:3.52|P-value:4.37E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.58|P-value:3.66E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.67|P-value:2.49E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.50|P-value:4.71E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.32|P-value:8.55E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.63|P-value:6.07E-6 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.07|P-value:5.95E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:3.42|P-value:6.30E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-4.53|P-value:8.86E-6 ID:SGTC_1725|Compound:st036284|FD-Score:3.55|P-value:3.95E-4 ID:SGTC_1727|Compound:st034309|FD-Score:6.11|P-value:3.87E-9 ID:SGTC_1774|Compound:st048371|FD-Score:3.37|P-value:7.22E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-4.22|P-value:3.17E-5 ID:SGTC_1958|Compound:st076513|FD-Score:8.06|P-value:1.29E-14 ID:SGTC_1980|Compound:st071811|FD-Score:4.88|P-value:2.01E-6 ID:SGTC_2082|Compound:5219693|FD-Score:3.56|P-value:3.87E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.00|P-value:8.03E-5 ID:SGTC_2342|Compound:7990637|FD-Score:4.38|P-value:1.74E-5 ID:SGTC_2351|Compound:9026858|FD-Score:3.60|P-value:3.37E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.07|P-value:6.00E-5 ID:SGTC_2475|Compound:5812728|FD-Score:4.30|P-value:2.40E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.30|P-value:9.23E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.51|P-value:4.53E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.91|P-value:1.11E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.56|P-value:3.93E-4 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.31|P-value:8.96E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.20|P-value:3.58E-5 ID:SGTC_2963|Compound:9082507|FD-Score:-3.54|P-value:4.01E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-4.95|P-value:1.38E-6 ID:SGTC_2985|Compound:9022375|FD-Score:-3.48|P-value:4.89E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.27|P-value:2.71E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.33|P-value:8.44E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.75|P-value:2.01E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.94|P-value:9.75E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.96|P-value:9.18E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-4.85|P-value:2.20E-6 ID:SGTC_3209|Compound:9113616|FD-Score:4.23|P-value:3.27E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.93|P-value:1.03E-4

Top fitness defect scores for YBR296C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1958 st076513 8.06 41.9 µM 1.29E-14 60S ribosome export 5 3.85E-16
2 SGTC_121 0557-0495 6.37 61.3 µM 8.59E-10 calcium & mitochondrial duress 15 9.29E-11
3 SGTC_1727 st034309 6.11 9.9 µM 3.87E-9 6 4.98E-10
4 SGTC_58 0957-0393 5.11 9.0 µM 6.88E-7 cell wall 272 1.61E-7
5 SGTC_1980 st071811 4.88 45.7 µM 2.01E-6 RPP1 & pyrimidine depletion 7 5.29E-7
6 SGTC_453 enantio-paf c16 4.85 10.0 µM 2.30E-6 92 6.17E-7
7 SGTC_1203 3992-3522 4.63 103.0 µM 6.07E-6 14 1.82E-6
8 SGTC_236 1509-0011 4.51 5.3 µM 1.01E-5 359 3.21E-6
9 SGTC_2342 7990637 4.38 118.9 µM 1.74E-5 RNA processing & uracil transport 22 5.88E-6
10 SGTC_2475 5812728 4.30 15.0 µM 2.40E-5 mitochondrial processes 16 8.38E-6
11 SGTC_2997 9067075 4.27 71.4 µM 2.71E-5 unfolded protein response 46 9.60E-6
12 SGTC_539 4859-0462 4.25 2.5 µM 3.03E-5 RNA pol III & RNase P/MRP 16 1.09E-5
13 SGTC_3209 9113616 4.23 49.5 µM 3.27E-5 19 1.18E-5
14 SGTC_2845 9003024 4.20 43.0 µM 3.58E-5 amide catabolism 36 1.31E-5
15 SGTC_1283 0922-0125 4.07 16.4 µM 5.95E-5 18 2.30E-5
16 SGTC_2467 5474540 4.07 200.0 µM 6.00E-5 15 2.33E-5
17 SGTC_13 0199-0087 4.06 65.0 µM 6.18E-5 ERG2 9 2.41E-5
18 SGTC_2239 6685329 4.00 187.6 µM 8.03E-5 29 3.22E-5
19 SGTC_3200 9114385 3.96 49.5 µM 9.18E-5 36 3.74E-5
20 SGTC_3198 9112019 3.94 49.5 µM 9.75E-5 mitochondrial processes 15 4.00E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 3.03E-16 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.120 2.77E-12 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.117 9.78E-12 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.117 1.28E-11 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.116 1.69E-11 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.115 2.86E-11 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.114 4.01E-11 YJL192C SOP4 hom ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER
0.110 1.56E-10 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.106 7.18E-10 YLR120C YPS1 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.106 8.06E-10 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.106 8.36E-10 YNL289W PCL1 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth
0.104 1.46E-9 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.103 1.84E-9 YBR208C DUR1,2 hom Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress
0.102 2.85E-9 YMR135C GID8 hom Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START
0.102 3.55E-9 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly