YBR297W / MAL33

MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR297W / MAL33

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:-3.61|P-value:1.48E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.31|P-value:1.19E-13 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.58|P-value:1.62E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.17|P-value:1.46E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:3.50|P-value:2.26E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.53|P-value:2.05E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.13|P-value:8.34E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.41|P-value:3.15E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.60|P-value:1.50E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.88|P-value:5.19E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:3.84|P-value:5.91E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:3.49|P-value:2.41E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.96|P-value:3.64E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.57|P-value:1.68E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.47|P-value:2.57E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.44|P-value:2.89E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.88|P-value:5.10E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.67|P-value:1.17E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.67|P-value:6.59E-9 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.52|P-value:2.96E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.19|P-value:7.11E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.57|P-value:1.74E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.37|P-value:5.98E-6 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.08|P-value:9.78E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.70|P-value:1.07E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.08|P-value:2.20E-5 ID:SGTC_1776|Compound:st049249|FD-Score:3.49|P-value:2.35E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.42|P-value:3.03E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.88|P-value:4.98E-7 ID:SGTC_1897|Compound:st060201|FD-Score:3.43|P-value:2.98E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.19|P-value:1.37E-5 ID:SGTC_1919|Compound:st067113|FD-Score:4.09|P-value:2.10E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.71|P-value:1.00E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.96|P-value:3.70E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.24|P-value:5.92E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.00|P-value:2.79E-7 ID:SGTC_2167|Compound:5876490|FD-Score:3.20|P-value:6.88E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.47|P-value:2.54E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.52|P-value:2.92E-6 ID:SGTC_2480|Compound:5767542|FD-Score:-4.51|P-value:3.04E-6 ID:SGTC_2482|Compound:5981709|FD-Score:-6.33|P-value:1.07E-10 ID:SGTC_2691|Compound:st077356|FD-Score:-4.38|P-value:5.52E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.16|P-value:7.82E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-3.18|P-value:6.95E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.18|P-value:7.22E-4 ID:SGTC_3069|Compound:9117009|FD-Score:5.48|P-value:2.04E-8 ID:SGTC_3071|Compound:9117417|FD-Score:3.48|P-value:2.46E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.61|P-value:1.48E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.31|P-value:1.19E-13 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.58|P-value:1.62E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.17|P-value:1.46E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:3.50|P-value:2.26E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.53|P-value:2.05E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.13|P-value:8.34E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.41|P-value:3.15E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.60|P-value:1.50E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.88|P-value:5.19E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:3.84|P-value:5.91E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:3.49|P-value:2.41E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.96|P-value:3.64E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.57|P-value:1.68E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.47|P-value:2.57E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.44|P-value:2.89E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.88|P-value:5.10E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.67|P-value:1.17E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.67|P-value:6.59E-9 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.52|P-value:2.96E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.19|P-value:7.11E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.57|P-value:1.74E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.37|P-value:5.98E-6 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.08|P-value:9.78E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.70|P-value:1.07E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.08|P-value:2.20E-5 ID:SGTC_1776|Compound:st049249|FD-Score:3.49|P-value:2.35E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.42|P-value:3.03E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.88|P-value:4.98E-7 ID:SGTC_1897|Compound:st060201|FD-Score:3.43|P-value:2.98E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.19|P-value:1.37E-5 ID:SGTC_1919|Compound:st067113|FD-Score:4.09|P-value:2.10E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.71|P-value:1.00E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.96|P-value:3.70E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.24|P-value:5.92E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.00|P-value:2.79E-7 ID:SGTC_2167|Compound:5876490|FD-Score:3.20|P-value:6.88E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.47|P-value:2.54E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.52|P-value:2.92E-6 ID:SGTC_2480|Compound:5767542|FD-Score:-4.51|P-value:3.04E-6 ID:SGTC_2482|Compound:5981709|FD-Score:-6.33|P-value:1.07E-10 ID:SGTC_2691|Compound:st077356|FD-Score:-4.38|P-value:5.52E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.16|P-value:7.82E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-3.18|P-value:6.95E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.18|P-value:7.22E-4 ID:SGTC_3069|Compound:9117009|FD-Score:5.48|P-value:2.04E-8 ID:SGTC_3071|Compound:9117417|FD-Score:3.48|P-value:2.46E-4

Top fitness defect scores for YBR297W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 7.31 9.0 µM 1.19E-13 cell wall 155 1.33E-13
2 SGTC_1026 k007-1105 5.67 30.6 µM 6.59E-9 ERAD & cell cycle 47 7.02E-9
3 SGTC_3069 9117009 5.48 49.5 µM 2.04E-8 60S ribosome export 3 2.17E-8
4 SGTC_2021 4019055 5.00 173.0 µM 2.79E-7 endomembrane recycling 64 2.92E-7
5 SGTC_1829 berberine 4.88 14.4 µM 4.98E-7 60S ribosome export 9 5.20E-7
6 SGTC_2431 5490079 4.52 200.0 µM 2.92E-6 18 3.03E-6
7 SGTC_1063 disulfiram 4.52 1.8 µM 2.96E-6 12 3.07E-6
8 SGTC_1242 0402-0103 4.37 60.1 µM 5.98E-6 20 6.18E-6
9 SGTC_1915 st067105 4.19 30.6 µM 1.37E-5 RNA pol III & RNase P/MRP 38 1.41E-5
10 SGTC_100 0086-0128 4.17 49.6 µM 1.46E-5 copper-dependent oxidative stress 43 1.50E-5
11 SGTC_1919 st067113 4.09 52.3 µM 2.10E-5 TSC3-RPN4 26 2.16E-5
12 SGTC_1771 st048882 4.08 4.2 µM 2.20E-5 RPP1 & pyrimidine depletion 16 2.26E-5
13 SGTC_756 0508-1999 3.96 28.3 µM 3.64E-5 RPP1 & pyrimidine depletion 25 3.73E-5
14 SGTC_1926 methyl fluorone black 3.96 53.6 µM 3.70E-5 DNA intercalators 61 3.80E-5
15 SGTC_899 1083-0020 3.88 478.0 µM 5.10E-5 24 5.23E-5
16 SGTC_457 grayanotoxin iii 3.88 135.0 µM 5.19E-5 72 5.32E-5
17 SGTC_568 1193-0097 3.84 7.5 µM 5.91E-5 ERAD & cell cycle 160 6.05E-5
18 SGTC_1920 st075728 3.71 45.7 µM 1.00E-4 28 1.03E-4
19 SGTC_1529 apigenin 3.70 74.0 µM 1.07E-4 40 1.10E-4
20 SGTC_975 1335-0046 3.67 28.5 µM 1.17E-4 RPP1 & pyrimidine depletion 50 1.20E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 6.01E-31 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.168 1.07E-22 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.159 2.25E-20 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.157 5.37E-20 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.155 1.43E-19 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.153 4.80E-19 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.151 1.24E-18 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.151 1.46E-18 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.150 2.11E-18 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.149 3.33E-18 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.149 4.52E-18 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.148 7.13E-18 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.147 1.26E-17 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.146 2.01E-17 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.145 3.88E-17 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1