YBR298C / MAL31

Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR298C / MAL31

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:-3.76|P-value:4.44E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.37|P-value:2.76E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:3.90|P-value:2.54E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.35|P-value:9.42E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.21|P-value:8.73E-5 ID:SGTC_269|Compound:exalamide|FD-Score:3.65|P-value:5.62E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.48|P-value:9.48E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:4.92|P-value:5.94E-6 ID:SGTC_300|Compound:r073-0011|FD-Score:5.52|P-value:4.43E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:3.71|P-value:4.76E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.59|P-value:6.89E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.06|P-value:4.19E-8 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.66|P-value:6.06E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.07|P-value:1.42E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.48|P-value:9.59E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.38|P-value:4.85E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.89|P-value:2.92E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.56|P-value:8.40E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.72|P-value:5.15E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:4.00|P-value:1.82E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.58|P-value:6.98E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:9.00|P-value:6.04E-16 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.69|P-value:5.01E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.68|P-value:5.21E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.89|P-value:2.64E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.64|P-value:5.89E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.52|P-value:8.44E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.71|P-value:1.35E-5 ID:SGTC_2312|Compound:7706453|FD-Score:3.89|P-value:2.63E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.24|P-value:7.99E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.04|P-value:1.59E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.25|P-value:1.47E-6 ID:SGTC_2939|Compound:9044578|FD-Score:5.82|P-value:1.12E-7 ID:SGTC_2994|Compound:9053520|FD-Score:3.86|P-value:2.92E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.96|P-value:2.08E-4 ID:SGTC_3068|Compound:9116768|FD-Score:8.09|P-value:3.18E-13 ID:SGTC_3138|Compound:9097216|FD-Score:4.00|P-value:1.84E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.48|P-value:9.45E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.76|P-value:4.44E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.37|P-value:2.76E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:3.90|P-value:2.54E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.35|P-value:9.42E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.21|P-value:8.73E-5 ID:SGTC_269|Compound:exalamide|FD-Score:3.65|P-value:5.62E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.48|P-value:9.48E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:4.92|P-value:5.94E-6 ID:SGTC_300|Compound:r073-0011|FD-Score:5.52|P-value:4.43E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:3.71|P-value:4.76E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.59|P-value:6.89E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.06|P-value:4.19E-8 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.66|P-value:6.06E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.07|P-value:1.42E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.48|P-value:9.59E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.38|P-value:4.85E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.89|P-value:2.92E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.56|P-value:8.40E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.72|P-value:5.15E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:4.00|P-value:1.82E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.58|P-value:6.98E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:9.00|P-value:6.04E-16 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.69|P-value:5.01E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.68|P-value:5.21E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.89|P-value:2.64E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.64|P-value:5.89E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.52|P-value:8.44E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.71|P-value:1.35E-5 ID:SGTC_2312|Compound:7706453|FD-Score:3.89|P-value:2.63E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.24|P-value:7.99E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.04|P-value:1.59E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.25|P-value:1.47E-6 ID:SGTC_2939|Compound:9044578|FD-Score:5.82|P-value:1.12E-7 ID:SGTC_2994|Compound:9053520|FD-Score:3.86|P-value:2.92E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.96|P-value:2.08E-4 ID:SGTC_3068|Compound:9116768|FD-Score:8.09|P-value:3.18E-13 ID:SGTC_3138|Compound:9097216|FD-Score:4.00|P-value:1.84E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.48|P-value:9.45E-4

Top fitness defect scores for YBR298C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_995 3931-2021 9.00 34.6 µM 6.04E-16 RPP1 & pyrimidine depletion 2 1.09E-19
2 SGTC_3068 9116768 8.09 49.5 µM 3.18E-13 1 3.00E-16
3 SGTC_58 0957-0393 7.37 9.0 µM 2.76E-11 cell wall 150 8.38E-14
4 SGTC_2939 9044578 5.82 71.4 µM 1.12E-7 16 2.95E-9
5 SGTC_300 r073-0011 5.52 5.0 µM 4.43E-7 4 1.67E-8
6 SGTC_173 1273-0061 5.35 2.7 µM 9.42E-7 mitochondrial stress 132 4.30E-8
7 SGTC_2912 7964298 5.25 10.9 µM 1.47E-6 cell wall 62 7.50E-8
8 SGTC_289 k017-0060 4.92 526.0 µM 5.94E-6 1 4.35E-7
9 SGTC_2249 haloperidol 4.71 116.4 µM 1.35E-5 ergosterol depletion effects on membrane 75 1.21E-6
10 SGTC_710 3448-4187 4.38 58.0 µM 4.85E-5 fatty acid desaturase (OLE1) 45 6.04E-6
11 SGTC_2322 7413319 4.24 38.2 µM 7.99E-5 ERAD & cell cycle 138 1.13E-5
12 SGTC_221 trifluoperazine 4.21 10.3 µM 8.73E-5 NEO1-PIK1 192 1.26E-5
13 SGTC_457 grayanotoxin iii 4.07 135.0 µM 1.42E-4 61 2.32E-5
14 SGTC_2558 carylophyllene oxide 4.04 100.0 µM 1.59E-4 11 2.67E-5
15 SGTC_894 0960-0238 4.00 55.9 µM 1.82E-4 10 3.15E-5
16 SGTC_3138 9097216 4.00 49.5 µM 1.84E-4 14 3.20E-5
17 SGTC_2996 9066192 3.96 71.4 µM 2.08E-4 34 3.72E-5
18 SGTC_138 0850-0259 3.90 40.9 µM 2.54E-4 cell wall 203 4.78E-5
19 SGTC_2312 7706453 3.89 155.7 µM 2.63E-4 28 5.01E-5
20 SGTC_1396 3511-0007 3.89 98.6 µM 2.64E-4 mitochondrial processes 12 5.03E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.27E-25 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.171 2.66E-23 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.171 2.97E-23 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.163 2.26E-21 YCL037C SRO9 hom Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication
0.160 1.17E-20 YBR291C CTP1 hom Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
0.160 1.32E-20 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.159 1.88E-20 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.156 9.86E-20 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.146 1.66E-17 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.146 1.73E-17 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.144 5.50E-17 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.141 2.09E-16 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.140 4.71E-16 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.138 1.02E-15 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.138 1.07E-15 YJL059W YHC3 hom Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)