YBR301W / PAU24

Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR301W / PAU24

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:2.91|P-value:8.66E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:4.46|P-value:7.13E-7 ID:SGTC_53|Compound:0973-0023|FD-Score:3.28|P-value:2.05E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.51|P-value:7.48E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.45|P-value:9.89E-5 ID:SGTC_466|Compound:geldanamycin|FD-Score:4.15|P-value:3.58E-6 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.34|P-value:1.57E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:-2.98|P-value:5.20E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:2.95|P-value:7.40E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.15|P-value:2.67E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-5.01|P-value:1.98E-8 ID:SGTC_939|Compound:1165-0479|FD-Score:3.27|P-value:2.10E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:2.88|P-value:9.47E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-4.11|P-value:3.23E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.06|P-value:3.74E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.64|P-value:4.32E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.43|P-value:1.06E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.06|P-value:4.79E-4 ID:SGTC_1701|Compound:st028638|FD-Score:4.73|P-value:1.58E-7 ID:SGTC_1706|Compound:st031321|FD-Score:3.75|P-value:2.58E-5 ID:SGTC_1710|Compound:st031758|FD-Score:2.90|P-value:9.03E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-2.95|P-value:5.79E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.60|P-value:5.11E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.94|P-value:6.13E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.60|P-value:3.79E-5 ID:SGTC_2876|Compound:9059903|FD-Score:4.04|P-value:6.32E-6 ID:SGTC_3042|Compound:9091578|FD-Score:2.91|P-value:8.71E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-2.83|P-value:9.04E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:2.91|P-value:8.66E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:4.46|P-value:7.13E-7 ID:SGTC_53|Compound:0973-0023|FD-Score:3.28|P-value:2.05E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.51|P-value:7.48E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.45|P-value:9.89E-5 ID:SGTC_466|Compound:geldanamycin|FD-Score:4.15|P-value:3.58E-6 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.34|P-value:1.57E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:-2.98|P-value:5.20E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:2.95|P-value:7.40E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.15|P-value:2.67E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-5.01|P-value:1.98E-8 ID:SGTC_939|Compound:1165-0479|FD-Score:3.27|P-value:2.10E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:2.88|P-value:9.47E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-4.11|P-value:3.23E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.06|P-value:3.74E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.64|P-value:4.32E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.43|P-value:1.06E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.06|P-value:4.79E-4 ID:SGTC_1701|Compound:st028638|FD-Score:4.73|P-value:1.58E-7 ID:SGTC_1706|Compound:st031321|FD-Score:3.75|P-value:2.58E-5 ID:SGTC_1710|Compound:st031758|FD-Score:2.90|P-value:9.03E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-2.95|P-value:5.79E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.60|P-value:5.11E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.94|P-value:6.13E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.60|P-value:3.79E-5 ID:SGTC_2876|Compound:9059903|FD-Score:4.04|P-value:6.32E-6 ID:SGTC_3042|Compound:9091578|FD-Score:2.91|P-value:8.71E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-2.83|P-value:9.04E-4

Top fitness defect scores for YBR301W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1701 st028638 4.73 40.4 µM 1.58E-7 6 1.14E-6
2 SGTC_51 1013-0126 4.46 23.4 µM 7.13E-7 24 4.11E-6
3 SGTC_466 geldanamycin 4.15 89.2 µM 3.58E-6 RPP1 & pyrimidine depletion 5 1.63E-5
4 SGTC_2876 9059903 4.04 26.0 µM 6.32E-6 10 2.66E-5
5 SGTC_1706 st031321 3.75 10.0 µM 2.58E-5 TSC3-RPN4 17 8.86E-5
6 SGTC_1686 st019653 3.64 115.5 µM 4.32E-5 mitochondrial processes 15 1.38E-4
7 SGTC_1756 st041558 3.60 35.5 µM 5.11E-5 16 1.59E-4
8 SGTC_388 3',4'-dichloroisocoumarin 3.51 16.7 µM 7.48E-5 26 2.21E-4
9 SGTC_421 streptovitacin 3.45 30.0 mM 9.89E-5 42 2.81E-4
10 SGTC_1691 st019933 3.43 84.6 µM 1.06E-4 25 2.98E-4
11 SGTC_474 dl-dihydrosphingosine 3.34 5.0 µM 1.57E-4 60 4.16E-4
12 SGTC_53 0973-0023 3.28 40.0 µM 2.05E-4 RNA processing & uracil transport 26 5.26E-4
13 SGTC_939 1165-0479 3.27 45.3 µM 2.10E-4 66 5.36E-4
14 SGTC_1699 st031318 3.06 29.1 µM 4.79E-4 53 0.00109
15 SGTC_494 Boc-Gly-Val-Val-CHO 2.95 140.0 µM 7.40E-4 36 0.00158
16 SGTC_36 0335-0881 2.91 14.2 µM 8.66E-4 ubiquinone biosynthesis & proteasome 190 0.00181
17 SGTC_3042 9091578 2.91 49.5 µM 8.71E-4 ERG2 31 0.00182
18 SGTC_1710 st031758 2.90 61.5 µM 9.03E-4 47 0.00188
19 SGTC_1275 0867-0008 2.88 21.1 µM 9.47E-4 62 0.00196
20 SGTC_452 diindolylmethane 2.86 8.0 µM 0.00102 RNA processing & uracil transport 45 0.00209

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.54E-10 YHL043W ECM34 hom Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.092 9.79E-8 YJL049W_p YJL049W_p hom Putative protein of unknown function; YJL049W is a non-essential gene
0.090 1.86E-7 YLR269C_d YLR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 9.29E-7 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.079 4.48E-6 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.079 5.16E-6 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.078 5.77E-6 YOR250C CLP1 het Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation
0.077 6.99E-6 YNL243W SLA2 hom Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo
0.076 9.67E-6 YOR079C ATX2 hom Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation
0.075 1.32E-5 YJL161W_p FMP33_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.074 1.58E-5 YKL108W SLD2 het Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress
0.074 1.72E-5 YOL083W ATG34 hom Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog
0.073 2.09E-5 YGL006W-A_p YGL006W-A_p hom Putative protein of unknown function; identified by SAGE
0.072 2.97E-5 YMR158C-A_p YMR158C-A_p hom Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene
0.072 3.37E-5 YDR262W_p YDR262W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment