YCL001W / RER1

Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL001W / RER1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:4.24|P-value:6.48E-6 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.23|P-value:4.32E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.09|P-value:7.31E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.07|P-value:7.78E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.83|P-value:3.44E-7 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.73|P-value:6.97E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:3.06|P-value:8.11E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.12|P-value:7.27E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:-4.72|P-value:6.99E-7 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.12|P-value:7.33E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.48|P-value:1.69E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.24|P-value:4.23E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-3.60|P-value:1.21E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.10|P-value:7.00E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.56|P-value:1.22E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.04|P-value:1.57E-5 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.07|P-value:7.75E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.01|P-value:3.17E-10 ID:SGTC_1609|Compound:st001574|FD-Score:3.62|P-value:9.42E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.09|P-value:8.11E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.31|P-value:4.60E-6 ID:SGTC_1930|Compound:st074634|FD-Score:3.37|P-value:2.54E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.25|P-value:4.03E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.15|P-value:6.66E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-5.40|P-value:1.72E-8 ID:SGTC_2286|Compound:7945697|FD-Score:3.68|P-value:7.64E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.56|P-value:1.34E-6 ID:SGTC_2324|Compound:6149169|FD-Score:5.28|P-value:2.84E-8 ID:SGTC_2327|Compound:6189656|FD-Score:4.71|P-value:6.44E-7 ID:SGTC_2380|Compound:9035439|FD-Score:3.27|P-value:3.75E-4 ID:SGTC_2387|Compound:9077560|FD-Score:6.53|P-value:9.46E-12 ID:SGTC_2389|Compound:9091542|FD-Score:8.16|P-value:2.63E-17 ID:SGTC_2391|Compound:6285546|FD-Score:4.25|P-value:6.00E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.47|P-value:1.77E-4 ID:SGTC_2466|Compound:5983409|FD-Score:4.79|P-value:4.21E-7 ID:SGTC_2699|Compound:st077704|FD-Score:5.22|P-value:3.85E-8 ID:SGTC_2708|Compound:st078559|FD-Score:3.21|P-value:4.65E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.41|P-value:2.57E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.54|P-value:1.32E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.72|P-value:6.01E-7 ID:SGTC_2815|Compound:7968870|FD-Score:-3.30|P-value:3.86E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-3.45|P-value:2.17E-4 ID:SGTC_3018|Compound:9082602|FD-Score:4.56|P-value:1.36E-6 ID:SGTC_3342|Compound:9147791|FD-Score:3.72|P-value:6.32E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:4.24|P-value:6.48E-6 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.23|P-value:4.32E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.09|P-value:7.31E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.07|P-value:7.78E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.83|P-value:3.44E-7 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.73|P-value:6.97E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:3.06|P-value:8.11E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.12|P-value:7.27E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:-4.72|P-value:6.99E-7 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.12|P-value:7.33E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.48|P-value:1.69E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.24|P-value:4.23E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-3.60|P-value:1.21E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.10|P-value:7.00E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.56|P-value:1.22E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.04|P-value:1.57E-5 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.07|P-value:7.75E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.01|P-value:3.17E-10 ID:SGTC_1609|Compound:st001574|FD-Score:3.62|P-value:9.42E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.09|P-value:8.11E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.31|P-value:4.60E-6 ID:SGTC_1930|Compound:st074634|FD-Score:3.37|P-value:2.54E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.25|P-value:4.03E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.15|P-value:6.66E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-5.40|P-value:1.72E-8 ID:SGTC_2286|Compound:7945697|FD-Score:3.68|P-value:7.64E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.56|P-value:1.34E-6 ID:SGTC_2324|Compound:6149169|FD-Score:5.28|P-value:2.84E-8 ID:SGTC_2327|Compound:6189656|FD-Score:4.71|P-value:6.44E-7 ID:SGTC_2380|Compound:9035439|FD-Score:3.27|P-value:3.75E-4 ID:SGTC_2387|Compound:9077560|FD-Score:6.53|P-value:9.46E-12 ID:SGTC_2389|Compound:9091542|FD-Score:8.16|P-value:2.63E-17 ID:SGTC_2391|Compound:6285546|FD-Score:4.25|P-value:6.00E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.47|P-value:1.77E-4 ID:SGTC_2466|Compound:5983409|FD-Score:4.79|P-value:4.21E-7 ID:SGTC_2699|Compound:st077704|FD-Score:5.22|P-value:3.85E-8 ID:SGTC_2708|Compound:st078559|FD-Score:3.21|P-value:4.65E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.41|P-value:2.57E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.54|P-value:1.32E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.72|P-value:6.01E-7 ID:SGTC_2815|Compound:7968870|FD-Score:-3.30|P-value:3.86E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-3.45|P-value:2.17E-4 ID:SGTC_3018|Compound:9082602|FD-Score:4.56|P-value:1.36E-6 ID:SGTC_3342|Compound:9147791|FD-Score:3.72|P-value:6.32E-5

Top fitness defect scores for YCL001W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2389 9091542 8.16 195.5 µM 2.63E-17 iron homeostasis 7 1.71E-16
2 SGTC_2387 9077560 6.53 195.1 µM 9.46E-12 3 3.25E-11
3 SGTC_1597 7-benzyloxygramine 6.01 47.5 µM 3.17E-10 calcium & mitochondrial duress 49 9.13E-10
4 SGTC_2324 6149169 5.28 200.0 µM 2.84E-8 6 6.52E-8
5 SGTC_2699 st077704 5.22 54.6 µM 3.85E-8 endomembrane recycling 28 8.71E-8
6 SGTC_444 curcumin 4.83 90.4 µM 3.44E-7 iron homeostasis 10 6.98E-7
7 SGTC_2466 5983409 4.79 37.1 µM 4.21E-7 10 8.47E-7
8 SGTC_2812 7970281 4.72 58.4 µM 6.01E-7 9 1.19E-6
9 SGTC_2327 6189656 4.71 200.0 µM 6.44E-7 10 1.27E-6
10 SGTC_2322 7413319 4.56 38.2 µM 1.34E-6 ERAD & cell cycle 122 2.54E-6
11 SGTC_3018 9082602 4.56 49.5 µM 1.36E-6 41 2.58E-6
12 SGTC_1921 5740136 4.31 50.0 µM 4.60E-6 TRP & mitochondrial translation 45 8.20E-6
13 SGTC_2391 6285546 4.25 200.0 µM 6.00E-6 8 1.06E-5
14 SGTC_16 erodoxin 4.24 22.8 µM 6.48E-6 unfolded protein response 57 1.14E-5
15 SGTC_1428 4049-0204 4.04 61.7 µM 1.57E-5 10 2.63E-5
16 SGTC_3342 9147791 3.72 14.5 µM 6.32E-5 21 9.89E-5
17 SGTC_2286 7945697 3.68 125.0 µM 7.64E-5 65 1.18E-4
18 SGTC_1609 st001574 3.62 46.4 µM 9.42E-5 18 1.44E-4
19 SGTC_1264 0783-0040 3.56 158.0 µM 1.22E-4 42 1.84E-4
20 SGTC_2810 7959871 3.54 45.5 µM 1.32E-4 copper-dependent oxidative stress 54 2.00E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.82E-10 YKL044W_p YKL044W_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.107 4.59E-10 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.102 3.18E-9 YOL127W RPL25 het Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23
0.101 4.41E-9 YPL244C HUT1 hom Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
0.100 7.54E-9 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.099 8.99E-9 YMR057C_d YMR057C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
0.098 1.12E-8 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.097 1.52E-8 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.097 1.82E-8 YGL011C SCL1 het Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.094 4.84E-8 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.092 1.05E-7 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.088 3.61E-7 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.088 3.63E-7 YDR353W TRR1 het Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication
0.087 5.16E-7 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.086 5.35E-7 YDR202C RAV2 hom Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme