YCL001W-A_p

Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL001W-A / YCL001W-A

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:5.39|P-value:8.01E-7 ID:SGTC_57|Compound:miconazole|FD-Score:-4.83|P-value:8.93E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:4.07|P-value:1.44E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:5.15|P-value:2.26E-6 ID:SGTC_114|Compound:0364-0001|FD-Score:5.96|P-value:5.56E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.62|P-value:6.63E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.57|P-value:7.31E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.96|P-value:2.13E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.14|P-value:1.14E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.07|P-value:1.53E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.86|P-value:2.89E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.53|P-value:8.26E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.55|P-value:7.72E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:4.86|P-value:7.40E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:9.07|P-value:3.40E-16 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.48|P-value:3.33E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:5.93|P-value:6.44E-8 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.49|P-value:9.37E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:4.23|P-value:8.09E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.51|P-value:8.79E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.53|P-value:8.27E-4 ID:SGTC_1910|Compound:st062352|FD-Score:6.34|P-value:8.34E-9 ID:SGTC_2005|Compound:4024620|FD-Score:4.79|P-value:9.85E-6 ID:SGTC_2006|Compound:4011487|FD-Score:3.60|P-value:6.69E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.59|P-value:7.23E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.84|P-value:3.08E-4 ID:SGTC_2146|Compound:5545642|FD-Score:5.29|P-value:1.25E-6 ID:SGTC_2167|Compound:5876490|FD-Score:3.77|P-value:3.89E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-5.04|P-value:3.77E-6 ID:SGTC_2246|Compound:7293507|FD-Score:3.94|P-value:2.23E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.51|P-value:8.68E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.70|P-value:4.96E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-4.02|P-value:1.81E-4 ID:SGTC_2322|Compound:7413319|FD-Score:10.40|P-value:7.56E-21 ID:SGTC_2335|Compound:9018011|FD-Score:4.98|P-value:4.60E-6 ID:SGTC_2390|Compound:9097792|FD-Score:6.47|P-value:4.23E-9 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.51|P-value:2.93E-5 ID:SGTC_2412|Compound:st077135|FD-Score:4.88|P-value:7.04E-6 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:4.45|P-value:3.73E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:6.75|P-value:9.43E-10 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.54|P-value:8.05E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.69|P-value:5.07E-4 ID:SGTC_2699|Compound:st077704|FD-Score:-3.73|P-value:4.65E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:3.76|P-value:3.99E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.89|P-value:2.66E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.21|P-value:8.73E-5 ID:SGTC_2972|Compound:9093619|FD-Score:3.91|P-value:2.45E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.76|P-value:4.18E-4 ID:SGTC_3107|Compound:9121808|FD-Score:4.51|P-value:2.91E-5 ID:SGTC_20|Compound:0481-0013|FD-Score:5.39|P-value:8.01E-7 ID:SGTC_57|Compound:miconazole|FD-Score:-4.83|P-value:8.93E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:4.07|P-value:1.44E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:5.15|P-value:2.26E-6 ID:SGTC_114|Compound:0364-0001|FD-Score:5.96|P-value:5.56E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.62|P-value:6.63E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.57|P-value:7.31E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.96|P-value:2.13E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.14|P-value:1.14E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.07|P-value:1.53E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.86|P-value:2.89E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.53|P-value:8.26E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.55|P-value:7.72E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:4.86|P-value:7.40E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:9.07|P-value:3.40E-16 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.48|P-value:3.33E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:5.93|P-value:6.44E-8 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.49|P-value:9.37E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:4.23|P-value:8.09E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.51|P-value:8.79E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.53|P-value:8.27E-4 ID:SGTC_1910|Compound:st062352|FD-Score:6.34|P-value:8.34E-9 ID:SGTC_2005|Compound:4024620|FD-Score:4.79|P-value:9.85E-6 ID:SGTC_2006|Compound:4011487|FD-Score:3.60|P-value:6.69E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.59|P-value:7.23E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.84|P-value:3.08E-4 ID:SGTC_2146|Compound:5545642|FD-Score:5.29|P-value:1.25E-6 ID:SGTC_2167|Compound:5876490|FD-Score:3.77|P-value:3.89E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-5.04|P-value:3.77E-6 ID:SGTC_2246|Compound:7293507|FD-Score:3.94|P-value:2.23E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.51|P-value:8.68E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.70|P-value:4.96E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-4.02|P-value:1.81E-4 ID:SGTC_2322|Compound:7413319|FD-Score:10.40|P-value:7.56E-21 ID:SGTC_2335|Compound:9018011|FD-Score:4.98|P-value:4.60E-6 ID:SGTC_2390|Compound:9097792|FD-Score:6.47|P-value:4.23E-9 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.51|P-value:2.93E-5 ID:SGTC_2412|Compound:st077135|FD-Score:4.88|P-value:7.04E-6 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:4.45|P-value:3.73E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:6.75|P-value:9.43E-10 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.54|P-value:8.05E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.69|P-value:5.07E-4 ID:SGTC_2699|Compound:st077704|FD-Score:-3.73|P-value:4.65E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:3.76|P-value:3.99E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.89|P-value:2.66E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.21|P-value:8.73E-5 ID:SGTC_2972|Compound:9093619|FD-Score:3.91|P-value:2.45E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.76|P-value:4.18E-4 ID:SGTC_3107|Compound:9121808|FD-Score:4.51|P-value:2.91E-5

Top fitness defect scores for YCL001W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2322 7413319 10.40 38.2 µM 7.56E-21 ERAD & cell cycle 16 8.13E-26
2 SGTC_1161 k007-0610 9.07 110.0 µM 3.40E-16 ERAD & cell cycle 18 5.90E-20
3 SGTC_2593 nobiletin 6.75 86.2 µM 9.43E-10 5 7.54E-12
4 SGTC_2390 9097792 6.47 176.6 µM 4.23E-9 2 4.96E-11
5 SGTC_1910 st062352 6.34 60.4 µM 8.34E-9 6 1.16E-10
6 SGTC_114 0364-0001 5.96 490.3 µM 5.56E-8 12 1.26E-9
7 SGTC_1360 1598-0022 5.93 39.8 µM 6.44E-8 ERG2 7 1.51E-9
8 SGTC_20 0481-0013 5.39 4.9 µM 8.01E-7 7 3.56E-8
9 SGTC_2146 5545642 5.29 200.0 µM 1.25E-6 4 6.24E-8
10 SGTC_88 0180-0332 5.15 8.7 µM 2.26E-6 5 1.31E-7
11 SGTC_2335 9018011 4.98 154.2 µM 4.60E-6 11 3.18E-7
12 SGTC_2412 st077135 4.88 33.4 µM 7.04E-6 8 5.42E-7
13 SGTC_1140 3229-1848 4.86 3.0 µM 7.40E-6 6 5.77E-7
14 SGTC_2005 4024620 4.79 188.0 µM 9.85E-6 8 8.25E-7
15 SGTC_3107 9121808 4.51 49.5 µM 2.91E-5 2 3.20E-6
16 SGTC_2409 alverine citrate 4.51 64.0 µM 2.93E-5 40 3.23E-6
17 SGTC_1194 1488-0194 4.48 225.0 µM 3.33E-5 20 3.78E-6
18 SGTC_2503 beta-caryophyllene alcohol 4.45 24.7 µM 3.73E-5 7 4.36E-6
19 SGTC_1406 3909-7906 4.23 11.9 µM 8.09E-5 60S ribosome export 6 1.15E-5
20 SGTC_2797 7859098 4.21 81.8 µM 8.73E-5 26 1.26E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 3.58E-28 YCR079W PTC6 hom Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase
0.151 1.19E-18 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.151 1.73E-18 YCR049C_d YCR049C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.147 1.28E-17 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.136 3.18E-15 YOR179C SYC1 hom Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication
0.133 1.02E-14 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.132 1.50E-14 YDR317W HIM1 hom Protein of unknown function involved in DNA repair
0.132 1.95E-14 YOL144W NOP8 het Nucleolar protein required for 60S ribosomal subunit biogenesis
0.130 4.80E-14 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.130 5.12E-14 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.128 1.25E-13 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.127 1.57E-13 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.123 9.95E-13 YJL086C_d YJL086C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
0.120 2.64E-12 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.120 3.56E-12 YBR298C MAL31 hom Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C