HIPHOP chemogenomics database

YCL001W-A_p

Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III

Zygosity: Homozygous strain

fixedexpanded
Profile for YCL001W-A / YCL001W-A

Click on Significant Values for Screen Details

Top fitness defect scores for YCL001W-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2322	7413319	10.40	38.2 µM	7.56E-21	ERAD & cell cycle	16	8.13E-26
2	SGTC_1161	k007-0610	9.07	110.0 µM	3.40E-16	ERAD & cell cycle	18	5.90E-20
3	SGTC_2593	nobiletin	6.75	86.2 µM	9.43E-10		5	7.54E-12
4	SGTC_2390	9097792	6.47	176.6 µM	4.23E-9		2	4.96E-11
5	SGTC_1910	st062352	6.34	60.4 µM	8.34E-9		6	1.16E-10
6	SGTC_114	0364-0001	5.96	490.3 µM	5.56E-8		12	1.26E-9
7	SGTC_1360	1598-0022	5.93	39.8 µM	6.44E-8	ERG2	7	1.51E-9
8	SGTC_20	0481-0013	5.39	4.9 µM	8.01E-7		7	3.56E-8
9	SGTC_2146	5545642	5.29	200.0 µM	1.25E-6		4	6.24E-8
10	SGTC_88	0180-0332	5.15	8.7 µM	2.26E-6		5	1.31E-7
11	SGTC_2335	9018011	4.98	154.2 µM	4.60E-6		11	3.18E-7
12	SGTC_2412	st077135	4.88	33.4 µM	7.04E-6		8	5.42E-7
13	SGTC_1140	3229-1848	4.86	3.0 µM	7.40E-6		6	5.77E-7
14	SGTC_2005	4024620	4.79	188.0 µM	9.85E-6		8	8.25E-7
15	SGTC_3107	9121808	4.51	49.5 µM	2.91E-5		2	3.20E-6
16	SGTC_2409	alverine citrate	4.51	64.0 µM	2.93E-5		40	3.23E-6
17	SGTC_1194	1488-0194	4.48	225.0 µM	3.33E-5		20	3.78E-6
18	SGTC_2503	beta-caryophyllene alcohol	4.45	24.7 µM	3.73E-5		7	4.36E-6
19	SGTC_1406	3909-7906	4.23	11.9 µM	8.09E-5	60S ribosome export	6	1.15E-5
20	SGTC_2797	7859098	4.21	81.8 µM	8.73E-5		26	1.26E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.188	3.58E-28	YCR079W	PTC6	hom	Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase
0.151	1.19E-18	YDL025C	RTK1	hom	Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.151	1.73E-18	YCR049C_d	YCR049C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.147	1.28E-17	YNL179C_d	YNL179C_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.136	3.18E-15	YOR179C	SYC1	hom	Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication
0.133	1.02E-14	YDR032C	PST2	hom	Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.132	1.50E-14	YDR317W	HIM1	hom	Protein of unknown function involved in DNA repair
0.132	1.95E-14	YOL144W	NOP8	het	Nucleolar protein required for 60S ribosomal subunit biogenesis
0.130	4.80E-14	YDR186C	YDR186C	hom	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.130	5.12E-14	YOL002C	IZH2	hom	Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.128	1.25E-13	YDL148C	NOP14	het	Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.127	1.57E-13	YMR099C	YMR099C	hom	Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.123	9.95E-13	YJL086C_d	YJL086C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
0.120	2.64E-12	YNL115C_p	YNL115C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.120	3.56E-12	YBR298C	MAL31	hom	Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C