YCL001W-B_p

Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL001W-B / YCL001W-B

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-3.76|P-value:8.16E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:3.39|P-value:4.64E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:-4.05|P-value:2.41E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-4.63|P-value:1.79E-6 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.66|P-value:1.19E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.08|P-value:3.25E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:-3.64|P-value:1.31E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.33|P-value:1.08E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:5.50|P-value:3.20E-8 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.68|P-value:1.57E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:-3.20|P-value:6.51E-4 ID:SGTC_1924|Compound:st058459|FD-Score:-3.31|P-value:4.32E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.76|P-value:1.18E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.26|P-value:7.27E-4 ID:SGTC_2072|Compound:5231554|FD-Score:3.81|P-value:9.56E-5 ID:SGTC_2076|Compound:5212012|FD-Score:-4.37|P-value:5.92E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.25|P-value:5.46E-4 ID:SGTC_2256|Compound:7954252|FD-Score:4.15|P-value:2.38E-5 ID:SGTC_2258|Compound:7960471|FD-Score:3.79|P-value:1.06E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-4.06|P-value:2.32E-5 ID:SGTC_2380|Compound:9035439|FD-Score:-3.73|P-value:9.17E-5 ID:SGTC_2381|Compound:9035592|FD-Score:3.57|P-value:2.41E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.95|P-value:3.65E-5 ID:SGTC_2443|Compound:5493264|FD-Score:-3.19|P-value:6.75E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.89|P-value:6.90E-5 ID:SGTC_2486|Compound:5283202|FD-Score:3.81|P-value:9.59E-5 ID:SGTC_2856|Compound:9022925|FD-Score:-3.13|P-value:8.15E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.47|P-value:3.46E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.08|P-value:9.77E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.76|P-value:8.16E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:3.39|P-value:4.64E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:-4.05|P-value:2.41E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-4.63|P-value:1.79E-6 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.66|P-value:1.19E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.08|P-value:3.25E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:-3.64|P-value:1.31E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.33|P-value:1.08E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:5.50|P-value:3.20E-8 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.68|P-value:1.57E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:-3.20|P-value:6.51E-4 ID:SGTC_1924|Compound:st058459|FD-Score:-3.31|P-value:4.32E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.76|P-value:1.18E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.26|P-value:7.27E-4 ID:SGTC_2072|Compound:5231554|FD-Score:3.81|P-value:9.56E-5 ID:SGTC_2076|Compound:5212012|FD-Score:-4.37|P-value:5.92E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.25|P-value:5.46E-4 ID:SGTC_2256|Compound:7954252|FD-Score:4.15|P-value:2.38E-5 ID:SGTC_2258|Compound:7960471|FD-Score:3.79|P-value:1.06E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-4.06|P-value:2.32E-5 ID:SGTC_2380|Compound:9035439|FD-Score:-3.73|P-value:9.17E-5 ID:SGTC_2381|Compound:9035592|FD-Score:3.57|P-value:2.41E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.95|P-value:3.65E-5 ID:SGTC_2443|Compound:5493264|FD-Score:-3.19|P-value:6.75E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.89|P-value:6.90E-5 ID:SGTC_2486|Compound:5283202|FD-Score:3.81|P-value:9.59E-5 ID:SGTC_2856|Compound:9022925|FD-Score:-3.13|P-value:8.15E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.47|P-value:3.46E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.08|P-value:9.77E-4

Top fitness defect scores for YCL001W-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1260 0700-1617 5.50 7.8 µM 3.20E-8 calcium & mitochondrial duress 13 1.86E-8
2 SGTC_1253 0550-0034 4.33 176.0 µM 1.08E-5 13 7.34E-6
3 SGTC_2256 7954252 4.15 200.0 µM 2.38E-5 mitochondrial processes 5 1.65E-5
4 SGTC_996 3970-0799 4.08 1.8 µM 3.25E-5 80 2.27E-5
5 SGTC_2484 5809818 3.89 12.0 µM 6.90E-5 18 4.94E-5
6 SGTC_2072 5231554 3.81 129.0 µM 9.56E-5 10 6.91E-5
7 SGTC_2486 5283202 3.81 22.4 µM 9.59E-5 38 6.93E-5
8 SGTC_2258 7960471 3.79 200.0 µM 1.06E-4 13 7.67E-5
9 SGTC_1943 st076331 3.76 65.2 µM 1.18E-4 19 8.58E-5
10 SGTC_1485 3909-9022 3.68 254.0 µM 1.57E-4 RPP1 & pyrimidine depletion 13 1.15E-4
11 SGTC_2381 9035592 3.57 200.0 µM 2.41E-4 31 1.79E-4
12 SGTC_2974 9094440 3.47 9.7 µM 3.46E-4 ergosterol biosynthesis 61 2.60E-4
13 SGTC_171 k064-0041 3.39 9.7 µM 4.64E-4 heme requiring 36 3.51E-4
14 SGTC_2070 5230947 3.26 200.0 µM 7.27E-4 31 5.57E-4
15 SGTC_1042 0350-0096 3.13 82.0 µM 0.00113 TSC3-RPN4 54 8.75E-4
16 SGTC_2388 9080168 3.09 200.0 µM 0.00130 26 0.00101
17 SGTC_2168 5727979 3.08 200.0 µM 0.00134 49 0.00105
18 SGTC_2314 7727897 2.85 200.0 µM 0.00271 82 0.00216
19 SGTC_1016 4226-1401 2.85 38.0 µM 0.00271 RNA pol III & RNase P/MRP 65 0.00217
20 SGTC_2442 5158906 2.80 48.5 µM 0.00316 81 0.00253

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 7.54E-25 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.159 1.87E-20 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.140 3.12E-16 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.125 4.64E-13 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.122 1.36E-12 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.117 1.21E-11 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.115 2.91E-11 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.111 1.02E-10 YML060W OGG1 hom Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance
0.111 1.37E-10 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.108 3.81E-10 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.108 3.94E-10 YHR180W_d YHR180W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.101 3.95E-9 YGL261C_p PAU11_p hom Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2
0.101 3.97E-9 YNR011C PRP2 het RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16
0.101 4.79E-9 YPR037C ERV2 hom Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
0.100 7.37E-9 YPL001W HAT1 hom Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair