YCL002C_p

Putative protein of unknown function; YCL002C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL002C / YCL002C

Click on Significant Values for Screen Details ID:SGTC_256|Compound:clotrimazole|FD-Score:3.21|P-value:6.15E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.12|P-value:8.46E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.13|P-value:1.53E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.20|P-value:5.84E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.31|P-value:3.94E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.11|P-value:1.69E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.40|P-value:4.52E-6 ID:SGTC_865|Compound:0488-0499|FD-Score:6.27|P-value:1.21E-10 ID:SGTC_872|Compound:0588-0139|FD-Score:5.69|P-value:4.63E-9 ID:SGTC_889|Compound:0919-1524|FD-Score:3.83|P-value:5.72E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.82|P-value:5.87E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:3.61|P-value:1.39E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:4.42|P-value:4.15E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:6.48|P-value:3.01E-11 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.16|P-value:7.31E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.72|P-value:8.94E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.49|P-value:2.20E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.19|P-value:6.05E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.63|P-value:1.27E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-3.77|P-value:6.55E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.10|P-value:8.88E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.15|P-value:1.42E-5 ID:SGTC_1554|Compound:st069299|FD-Score:4.35|P-value:5.61E-6 ID:SGTC_1709|Compound:st033179|FD-Score:3.26|P-value:5.07E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-6.34|P-value:6.63E-11 ID:SGTC_1748|Compound:st037455|FD-Score:4.97|P-value:2.67E-7 ID:SGTC_1749|Compound:st037932|FD-Score:-3.45|P-value:2.31E-4 ID:SGTC_1762|Compound:st045503|FD-Score:-4.47|P-value:2.95E-6 ID:SGTC_1765|Compound:st044815|FD-Score:3.31|P-value:4.28E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.47|P-value:2.36E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.27|P-value:5.00E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.15|P-value:7.60E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:3.18|P-value:6.75E-4 ID:SGTC_2260|Compound:7964312|FD-Score:5.18|P-value:8.79E-8 ID:SGTC_2312|Compound:7706453|FD-Score:3.83|P-value:5.69E-5 ID:SGTC_2350|Compound:9023895|FD-Score:3.51|P-value:2.03E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.84|P-value:5.34E-5 ID:SGTC_2385|Compound:9074692|FD-Score:4.82|P-value:5.73E-7 ID:SGTC_2388|Compound:9080168|FD-Score:3.87|P-value:4.80E-5 ID:SGTC_2393|Compound:9031399|FD-Score:4.31|P-value:6.84E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.88|P-value:4.13E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.99|P-value:2.92E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.30|P-value:4.36E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.06|P-value:9.56E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-4.15|P-value:1.28E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-4.05|P-value:1.98E-5 ID:SGTC_2952|Compound:9073731|FD-Score:3.34|P-value:3.80E-4 ID:SGTC_3003|Compound:9075612|FD-Score:4.98|P-value:2.53E-7 ID:SGTC_3234|Compound:9132280|FD-Score:3.86|P-value:4.91E-5 ID:SGTC_3244|Compound:9134489|FD-Score:4.60|P-value:1.76E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.21|P-value:6.15E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.12|P-value:8.46E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.13|P-value:1.53E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.20|P-value:5.84E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.31|P-value:3.94E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.11|P-value:1.69E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.40|P-value:4.52E-6 ID:SGTC_865|Compound:0488-0499|FD-Score:6.27|P-value:1.21E-10 ID:SGTC_872|Compound:0588-0139|FD-Score:5.69|P-value:4.63E-9 ID:SGTC_889|Compound:0919-1524|FD-Score:3.83|P-value:5.72E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.82|P-value:5.87E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:3.61|P-value:1.39E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:4.42|P-value:4.15E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:6.48|P-value:3.01E-11 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.16|P-value:7.31E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.72|P-value:8.94E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.49|P-value:2.20E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.19|P-value:6.05E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.63|P-value:1.27E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-3.77|P-value:6.55E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.10|P-value:8.88E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.15|P-value:1.42E-5 ID:SGTC_1554|Compound:st069299|FD-Score:4.35|P-value:5.61E-6 ID:SGTC_1709|Compound:st033179|FD-Score:3.26|P-value:5.07E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-6.34|P-value:6.63E-11 ID:SGTC_1748|Compound:st037455|FD-Score:4.97|P-value:2.67E-7 ID:SGTC_1749|Compound:st037932|FD-Score:-3.45|P-value:2.31E-4 ID:SGTC_1762|Compound:st045503|FD-Score:-4.47|P-value:2.95E-6 ID:SGTC_1765|Compound:st044815|FD-Score:3.31|P-value:4.28E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.47|P-value:2.36E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.27|P-value:5.00E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.15|P-value:7.60E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:3.18|P-value:6.75E-4 ID:SGTC_2260|Compound:7964312|FD-Score:5.18|P-value:8.79E-8 ID:SGTC_2312|Compound:7706453|FD-Score:3.83|P-value:5.69E-5 ID:SGTC_2350|Compound:9023895|FD-Score:3.51|P-value:2.03E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.84|P-value:5.34E-5 ID:SGTC_2385|Compound:9074692|FD-Score:4.82|P-value:5.73E-7 ID:SGTC_2388|Compound:9080168|FD-Score:3.87|P-value:4.80E-5 ID:SGTC_2393|Compound:9031399|FD-Score:4.31|P-value:6.84E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.88|P-value:4.13E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.99|P-value:2.92E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.30|P-value:4.36E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.06|P-value:9.56E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-4.15|P-value:1.28E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-4.05|P-value:1.98E-5 ID:SGTC_2952|Compound:9073731|FD-Score:3.34|P-value:3.80E-4 ID:SGTC_3003|Compound:9075612|FD-Score:4.98|P-value:2.53E-7 ID:SGTC_3234|Compound:9132280|FD-Score:3.86|P-value:4.91E-5 ID:SGTC_3244|Compound:9134489|FD-Score:4.60|P-value:1.76E-6

Top fitness defect scores for YCL002C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1124 fisetin 6.48 1.2 µM 3.01E-11 4 4.55E-11
2 SGTC_865 0488-0499 6.27 301.0 µM 1.21E-10 4 1.78E-10
3 SGTC_872 0588-0139 5.69 234.0 µM 4.63E-9 10 6.33E-9
4 SGTC_2260 7964312 5.18 200.0 µM 8.79E-8 2 1.13E-7
5 SGTC_3003 9075612 4.98 71.4 µM 2.53E-7 9 3.20E-7
6 SGTC_1748 st037455 4.97 53.6 µM 2.67E-7 10 3.36E-7
7 SGTC_2385 9074692 4.82 200.0 µM 5.73E-7 22 7.12E-7
8 SGTC_3244 9134489 4.60 49.5 µM 1.76E-6 9 2.14E-6
9 SGTC_983 1491-0821 4.42 12.2 µM 4.15E-6 8 4.96E-6
10 SGTC_423 5-fluorouracil 4.40 457.0 µM 4.52E-6 exosome 14 5.40E-6
11 SGTC_1554 st069299 4.35 38.7 µM 5.61E-6 12 6.68E-6
12 SGTC_2393 9031399 4.31 185.9 µM 6.84E-6 RNA processing & uracil transport 18 8.11E-6
13 SGTC_1551 6-bromo-3'-methylflavone 4.15 63.5 µM 1.42E-5 7 1.66E-5
14 SGTC_343 4130-2827 4.13 29.8 µM 1.53E-5 27 1.79E-5
15 SGTC_419 nsc-638432 4.11 893.0 µM 1.69E-5 DNA damage response 10 1.97E-5
16 SGTC_2583 asiatic acid 3.99 100.0 µM 2.92E-5 36 3.36E-5
17 SGTC_2388 9080168 3.87 200.0 µM 4.80E-5 3 5.48E-5
18 SGTC_3234 9132280 3.86 49.5 µM 4.91E-5 21 5.61E-5
19 SGTC_2376 9072922 3.84 81.3 µM 5.34E-5 33 6.08E-5
20 SGTC_2312 7706453 3.83 155.7 µM 5.69E-5 29 6.48E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 9.75E-19 YCL022C_d YCL022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W
0.099 9.69E-9 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.088 3.19E-7 YPL112C PEX25 hom Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
0.085 7.93E-7 YOL125W TRM13 hom 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases
0.084 9.73E-7 YCL047C POF1 hom ATPase involved in the protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; also interacts with Ubc7p
0.084 1.20E-6 YDR185C UPS3 hom Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations
0.082 1.78E-6 YNL324W_d YNL324W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.12E-6 YOL035C_d YOL035C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.078 6.38E-6 YKL064W MNR2 hom Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations
0.078 6.65E-6 YNL325C FIG4 hom Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain
0.073 2.14E-5 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.072 2.97E-5 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.071 4.38E-5 YDR124W_p YDR124W_p hom Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
0.069 6.90E-5 YGR038W ORM1 hom Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control
0.068 7.46E-5 YPL083C SEN54 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p