YCL004W / PGS1

Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YCL004W / PGS1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:4.77|P-value:2.48E-6 ID:SGTC_4|Compound:0960-0234|FD-Score:4.51|P-value:8.06E-6 ID:SGTC_35|Compound:0133-0054|FD-Score:4.88|P-value:1.52E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:4.39|P-value:1.31E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.53|P-value:3.65E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.55|P-value:3.42E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.87|P-value:1.07E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.17|P-value:3.24E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:3.78|P-value:1.47E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.23|P-value:9.94E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.60|P-value:5.32E-6 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.31|P-value:7.67E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.90|P-value:9.30E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-7.58|P-value:1.95E-13 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.88|P-value:1.01E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.68|P-value:2.14E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.74|P-value:1.95E-8 ID:SGTC_549|Compound:1661-1316|FD-Score:5.63|P-value:3.59E-8 ID:SGTC_577|Compound:r071-0003|FD-Score:-5.36|P-value:1.46E-7 ID:SGTC_584|Compound:0986-0246|FD-Score:3.41|P-value:5.40E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.57|P-value:3.19E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.42|P-value:1.06E-7 ID:SGTC_686|Compound:1319-0111|FD-Score:-4.46|P-value:9.89E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:4.33|P-value:1.73E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.24|P-value:2.47E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.37|P-value:6.37E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:6.22|P-value:1.31E-9 ID:SGTC_1022|Compound:4477-0945|FD-Score:5.71|P-value:2.27E-8 ID:SGTC_1023|Compound:4482-3888|FD-Score:6.25|P-value:1.13E-9 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.54|P-value:6.92E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:3.23|P-value:9.96E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.32|P-value:7.47E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.95|P-value:7.73E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:7.95|P-value:1.32E-14 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.68|P-value:3.77E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.62|P-value:2.69E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.33|P-value:1.73E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.24|P-value:9.55E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.44|P-value:9.57E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.35|P-value:6.79E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.32|P-value:7.40E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.98|P-value:7.09E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.68|P-value:2.12E-4 ID:SGTC_1765|Compound:st044815|FD-Score:-7.01|P-value:1.00E-11 ID:SGTC_1829|Compound:berberine|FD-Score:-5.91|P-value:7.76E-9 ID:SGTC_1831|Compound:st055328|FD-Score:4.16|P-value:3.36E-5 ID:SGTC_1834|Compound:st055981|FD-Score:3.40|P-value:5.75E-4 ID:SGTC_1837|Compound:st055472|FD-Score:-3.87|P-value:1.05E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.99|P-value:4.83E-9 ID:SGTC_1849|Compound:st056239|FD-Score:-3.96|P-value:7.64E-5 ID:SGTC_1893|Compound:st059353|FD-Score:4.45|P-value:1.02E-5 ID:SGTC_1903|Compound:st060211|FD-Score:-3.25|P-value:9.34E-4 ID:SGTC_1907|Compound:st060210|FD-Score:6.87|P-value:2.44E-11 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.68|P-value:2.65E-8 ID:SGTC_2202|Compound:7226349|FD-Score:-3.48|P-value:4.33E-4 ID:SGTC_2203|Compound:7227154|FD-Score:-5.18|P-value:3.49E-7 ID:SGTC_2281|Compound:7943571|FD-Score:3.67|P-value:2.21E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.98|P-value:9.54E-7 ID:SGTC_2322|Compound:7413319|FD-Score:-4.39|P-value:1.35E-5 ID:SGTC_2342|Compound:7990637|FD-Score:3.55|P-value:3.33E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.38|P-value:6.02E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.50|P-value:4.08E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.99|P-value:6.81E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.54|P-value:3.56E-4 ID:SGTC_2445|Compound:5742597|FD-Score:4.32|P-value:1.74E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.98|P-value:6.99E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.81|P-value:1.35E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.93|P-value:1.21E-6 ID:SGTC_2790|Compound:5423970|FD-Score:-4.02|P-value:5.98E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.31|P-value:7.73E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.16|P-value:3.42E-5 ID:SGTC_2846|Compound:9008642|FD-Score:3.94|P-value:7.98E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.61|P-value:2.73E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.99|P-value:6.82E-5 ID:SGTC_2968|Compound:9090663|FD-Score:4.08|P-value:4.77E-5 ID:SGTC_3016|Compound:9080866|FD-Score:4.23|P-value:2.53E-5 ID:SGTC_3103|Compound:9120822|FD-Score:4.51|P-value:7.81E-6 ID:SGTC_3142|Compound:9086498|FD-Score:3.31|P-value:7.62E-4 ID:SGTC_3275|Compound:9138069|FD-Score:-3.90|P-value:9.50E-5 ID:SGTC_3283|Compound:9109332|FD-Score:3.26|P-value:9.00E-4 ID:SGTC_3338|Compound:9144300|FD-Score:3.35|P-value:6.63E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:4.77|P-value:2.48E-6 ID:SGTC_4|Compound:0960-0234|FD-Score:4.51|P-value:8.06E-6 ID:SGTC_35|Compound:0133-0054|FD-Score:4.88|P-value:1.52E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:4.39|P-value:1.31E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.53|P-value:3.65E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.55|P-value:3.42E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.87|P-value:1.07E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.17|P-value:3.24E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:3.78|P-value:1.47E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.23|P-value:9.94E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.60|P-value:5.32E-6 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.31|P-value:7.67E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.90|P-value:9.30E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-7.58|P-value:1.95E-13 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.88|P-value:1.01E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.68|P-value:2.14E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.74|P-value:1.95E-8 ID:SGTC_549|Compound:1661-1316|FD-Score:5.63|P-value:3.59E-8 ID:SGTC_577|Compound:r071-0003|FD-Score:-5.36|P-value:1.46E-7 ID:SGTC_584|Compound:0986-0246|FD-Score:3.41|P-value:5.40E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.57|P-value:3.19E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.42|P-value:1.06E-7 ID:SGTC_686|Compound:1319-0111|FD-Score:-4.46|P-value:9.89E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:4.33|P-value:1.73E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.24|P-value:2.47E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.37|P-value:6.37E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:6.22|P-value:1.31E-9 ID:SGTC_1022|Compound:4477-0945|FD-Score:5.71|P-value:2.27E-8 ID:SGTC_1023|Compound:4482-3888|FD-Score:6.25|P-value:1.13E-9 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.54|P-value:6.92E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:3.23|P-value:9.96E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.32|P-value:7.47E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.95|P-value:7.73E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:7.95|P-value:1.32E-14 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.68|P-value:3.77E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.62|P-value:2.69E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.33|P-value:1.73E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.24|P-value:9.55E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.44|P-value:9.57E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.35|P-value:6.79E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.32|P-value:7.40E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.98|P-value:7.09E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.68|P-value:2.12E-4 ID:SGTC_1765|Compound:st044815|FD-Score:-7.01|P-value:1.00E-11 ID:SGTC_1829|Compound:berberine|FD-Score:-5.91|P-value:7.76E-9 ID:SGTC_1831|Compound:st055328|FD-Score:4.16|P-value:3.36E-5 ID:SGTC_1834|Compound:st055981|FD-Score:3.40|P-value:5.75E-4 ID:SGTC_1837|Compound:st055472|FD-Score:-3.87|P-value:1.05E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.99|P-value:4.83E-9 ID:SGTC_1849|Compound:st056239|FD-Score:-3.96|P-value:7.64E-5 ID:SGTC_1893|Compound:st059353|FD-Score:4.45|P-value:1.02E-5 ID:SGTC_1903|Compound:st060211|FD-Score:-3.25|P-value:9.34E-4 ID:SGTC_1907|Compound:st060210|FD-Score:6.87|P-value:2.44E-11 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.68|P-value:2.65E-8 ID:SGTC_2202|Compound:7226349|FD-Score:-3.48|P-value:4.33E-4 ID:SGTC_2203|Compound:7227154|FD-Score:-5.18|P-value:3.49E-7 ID:SGTC_2281|Compound:7943571|FD-Score:3.67|P-value:2.21E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.98|P-value:9.54E-7 ID:SGTC_2322|Compound:7413319|FD-Score:-4.39|P-value:1.35E-5 ID:SGTC_2342|Compound:7990637|FD-Score:3.55|P-value:3.33E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.38|P-value:6.02E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.50|P-value:4.08E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.99|P-value:6.81E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.54|P-value:3.56E-4 ID:SGTC_2445|Compound:5742597|FD-Score:4.32|P-value:1.74E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.98|P-value:6.99E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.81|P-value:1.35E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.93|P-value:1.21E-6 ID:SGTC_2790|Compound:5423970|FD-Score:-4.02|P-value:5.98E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.31|P-value:7.73E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.16|P-value:3.42E-5 ID:SGTC_2846|Compound:9008642|FD-Score:3.94|P-value:7.98E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.61|P-value:2.73E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.99|P-value:6.82E-5 ID:SGTC_2968|Compound:9090663|FD-Score:4.08|P-value:4.77E-5 ID:SGTC_3016|Compound:9080866|FD-Score:4.23|P-value:2.53E-5 ID:SGTC_3103|Compound:9120822|FD-Score:4.51|P-value:7.81E-6 ID:SGTC_3142|Compound:9086498|FD-Score:3.31|P-value:7.62E-4 ID:SGTC_3275|Compound:9138069|FD-Score:-3.90|P-value:9.50E-5 ID:SGTC_3283|Compound:9109332|FD-Score:3.26|P-value:9.00E-4 ID:SGTC_3338|Compound:9144300|FD-Score:3.35|P-value:6.63E-4

Top fitness defect scores for YCL004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1133 3473-0247 7.95 50.0 µM 1.32E-14 RSC complex & mRNA processing 14 8.96E-16 0.77
2 SGTC_1907 st060210 6.87 83.7 µM 2.44E-11 1 3.25E-12 0.90
3 SGTC_1023 4482-3888 6.25 16.0 µM 1.13E-9 TSC3-RPN4 2 2.11E-10 0.95
4 SGTC_1014 4130-3005 6.22 69.3 µM 1.31E-9 2 2.49E-10 1.65
5 SGTC_546 peri-Naphthalide 5.74 147.0 µM 1.95E-8 DNA damage response 8 4.73E-9 0.24
6 SGTC_1022 4477-0945 5.71 21.3 µM 2.27E-8 1 5.57E-9 1.51
7 SGTC_1926 methyl fluorone black 5.68 53.6 µM 2.65E-8 DNA intercalators 11 6.58E-9 0.08
8 SGTC_549 1661-1316 5.63 519.0 µM 3.59E-8 1 9.16E-9 0.51
9 SGTC_1493 4348-0038 5.44 111.0 µM 9.57E-8 RSC complex & mRNA processing 23 2.66E-8 0.20
10 SGTC_682 0kpi-0099 5.42 17.0 µM 1.06E-7 17 2.96E-8 0.32
11 SGTC_2291 7917025 4.98 104.3 µM 9.54E-7 iron homeostasis 6 3.25E-7 0.03
12 SGTC_2780 5215298 4.93 71.4 µM 1.21E-6 10 4.20E-7 0.23
13 SGTC_35 0133-0054 4.88 64.1 µM 1.52E-6 3 5.39E-7 0.72
14 SGTC_3 0833-0587 4.77 95.6 µM 2.48E-6 redox potentiating 9 9.20E-7 0.42
15 SGTC_1213 1315-0166 4.68 115.0 µM 3.77E-6 10 1.45E-6 0.15
16 SGTC_266 formosanin C 4.60 406.0 nM 5.32E-6 sphingolipid biosynthesis & PDR1 17 2.11E-6 0.05
17 SGTC_1024 4507-0395 4.54 26.0 µM 6.92E-6 TSC3-RPN4 7 2.81E-6 0.03
18 SGTC_3103 9120822 4.51 49.5 µM 7.81E-6 6 3.20E-6 0.38
19 SGTC_4 0960-0234 4.51 25.7 µM 8.06E-6 Golgi 9 3.31E-6 0.17
20 SGTC_1893 st059353 4.45 36.1 µM 1.02E-5 1 4.29E-6 0.45

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 3.23E-19 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.150 2.34E-18 YDR228C PCF11 het mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping
0.149 4.36E-18 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.140 4.78E-16 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.139 7.79E-16 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.137 1.74E-15 YJR069C HAM1 hom Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine; protein abundance increases in response to DNA replication stress
0.121 1.69E-12 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.121 2.32E-12 YDR413C_d YDR413C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing
0.120 3.32E-12 YDR404C RPB7 het RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.119 4.98E-12 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.118 6.72E-12 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.116 1.95E-11 YMR277W FCP1 het Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
0.115 2.06E-11 YIL144W TID3 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
0.110 1.96E-10 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.109 2.49E-10 YBR135W CKS1 het Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters