YCL005W-A / VMA9

Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL005W-A / VMA9

Click on Significant Values for Screen Details ID:SGTC_359|Compound:0081-0058|FD-Score:5.43|P-value:4.52E-7 ID:SGTC_443|Compound:clozapine|FD-Score:-3.55|P-value:5.42E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.47|P-value:9.00E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.62|P-value:5.59E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.47|P-value:6.81E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.68|P-value:4.61E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.43|P-value:9.88E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:4.55|P-value:1.98E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:3.47|P-value:8.89E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.97|P-value:3.47E-6 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.28|P-value:5.58E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.60|P-value:1.64E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.02|P-value:1.43E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.82|P-value:6.65E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.47|P-value:8.85E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.52|P-value:5.89E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.95|P-value:3.83E-6 ID:SGTC_1717|Compound:st033143|FD-Score:3.70|P-value:4.24E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.39|P-value:3.62E-5 ID:SGTC_1748|Compound:st037455|FD-Score:-3.47|P-value:6.96E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.95|P-value:1.82E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-3.57|P-value:5.02E-4 ID:SGTC_1963|Compound:st076565|FD-Score:4.00|P-value:1.52E-4 ID:SGTC_1972|Compound:st070201|FD-Score:4.78|P-value:7.79E-6 ID:SGTC_1975|Compound:st070967|FD-Score:3.86|P-value:2.48E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.64|P-value:5.21E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.61|P-value:1.58E-5 ID:SGTC_2074|Compound:5212007|FD-Score:-3.74|P-value:2.81E-4 ID:SGTC_2097|Compound:5376186|FD-Score:4.63|P-value:1.45E-5 ID:SGTC_2120|Compound:5538279|FD-Score:3.69|P-value:4.33E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.86|P-value:2.46E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-5.00|P-value:2.21E-6 ID:SGTC_2321|Compound:7390090|FD-Score:3.91|P-value:2.14E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.01|P-value:1.48E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.80|P-value:7.28E-6 ID:SGTC_2452|Compound:5863136|FD-Score:5.10|P-value:2.03E-6 ID:SGTC_2481|Compound:5478948|FD-Score:5.06|P-value:2.35E-6 ID:SGTC_2483|Compound:5729050|FD-Score:-3.48|P-value:6.69E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.67|P-value:1.21E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.58|P-value:1.76E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.48|P-value:2.59E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.55|P-value:6.90E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.61|P-value:5.74E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.87|P-value:2.40E-4 ID:SGTC_2709|Compound:st078560|FD-Score:-4.74|P-value:6.51E-6 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.95|P-value:1.81E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.33|P-value:4.67E-5 ID:SGTC_2795|Compound:7780010|FD-Score:4.19|P-value:7.85E-5 ID:SGTC_2801|Compound:7907800|FD-Score:5.02|P-value:2.81E-6 ID:SGTC_2831|Compound:7999036|FD-Score:4.78|P-value:7.88E-6 ID:SGTC_2882|Compound:9058044|FD-Score:5.23|P-value:1.11E-6 ID:SGTC_2890|Compound:9046729|FD-Score:3.72|P-value:3.98E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.88|P-value:2.34E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.90|P-value:2.15E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.67|P-value:3.61E-4 ID:SGTC_3065|Compound:9113888|FD-Score:4.30|P-value:5.18E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.53|P-value:7.24E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.63|P-value:5.30E-4 ID:SGTC_3199|Compound:9111318|FD-Score:4.79|P-value:7.60E-6 ID:SGTC_3220|Compound:9131269|FD-Score:3.90|P-value:2.16E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.40|P-value:8.52E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.55|P-value:6.93E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:5.43|P-value:4.52E-7 ID:SGTC_443|Compound:clozapine|FD-Score:-3.55|P-value:5.42E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.47|P-value:9.00E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.62|P-value:5.59E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.47|P-value:6.81E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.68|P-value:4.61E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.43|P-value:9.88E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:4.55|P-value:1.98E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:3.47|P-value:8.89E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.97|P-value:3.47E-6 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.28|P-value:5.58E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.60|P-value:1.64E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.02|P-value:1.43E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.82|P-value:6.65E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.47|P-value:8.85E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.52|P-value:5.89E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.95|P-value:3.83E-6 ID:SGTC_1717|Compound:st033143|FD-Score:3.70|P-value:4.24E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.39|P-value:3.62E-5 ID:SGTC_1748|Compound:st037455|FD-Score:-3.47|P-value:6.96E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.95|P-value:1.82E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-3.57|P-value:5.02E-4 ID:SGTC_1963|Compound:st076565|FD-Score:4.00|P-value:1.52E-4 ID:SGTC_1972|Compound:st070201|FD-Score:4.78|P-value:7.79E-6 ID:SGTC_1975|Compound:st070967|FD-Score:3.86|P-value:2.48E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.64|P-value:5.21E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.61|P-value:1.58E-5 ID:SGTC_2074|Compound:5212007|FD-Score:-3.74|P-value:2.81E-4 ID:SGTC_2097|Compound:5376186|FD-Score:4.63|P-value:1.45E-5 ID:SGTC_2120|Compound:5538279|FD-Score:3.69|P-value:4.33E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.86|P-value:2.46E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-5.00|P-value:2.21E-6 ID:SGTC_2321|Compound:7390090|FD-Score:3.91|P-value:2.14E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.01|P-value:1.48E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.80|P-value:7.28E-6 ID:SGTC_2452|Compound:5863136|FD-Score:5.10|P-value:2.03E-6 ID:SGTC_2481|Compound:5478948|FD-Score:5.06|P-value:2.35E-6 ID:SGTC_2483|Compound:5729050|FD-Score:-3.48|P-value:6.69E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.67|P-value:1.21E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.58|P-value:1.76E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.48|P-value:2.59E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.55|P-value:6.90E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.61|P-value:5.74E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.87|P-value:2.40E-4 ID:SGTC_2709|Compound:st078560|FD-Score:-4.74|P-value:6.51E-6 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.95|P-value:1.81E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.33|P-value:4.67E-5 ID:SGTC_2795|Compound:7780010|FD-Score:4.19|P-value:7.85E-5 ID:SGTC_2801|Compound:7907800|FD-Score:5.02|P-value:2.81E-6 ID:SGTC_2831|Compound:7999036|FD-Score:4.78|P-value:7.88E-6 ID:SGTC_2882|Compound:9058044|FD-Score:5.23|P-value:1.11E-6 ID:SGTC_2890|Compound:9046729|FD-Score:3.72|P-value:3.98E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.88|P-value:2.34E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.90|P-value:2.15E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.67|P-value:3.61E-4 ID:SGTC_3065|Compound:9113888|FD-Score:4.30|P-value:5.18E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.53|P-value:7.24E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.63|P-value:5.30E-4 ID:SGTC_3199|Compound:9111318|FD-Score:4.79|P-value:7.60E-6 ID:SGTC_3220|Compound:9131269|FD-Score:3.90|P-value:2.16E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.40|P-value:8.52E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.55|P-value:6.93E-4

Top fitness defect scores for YCL005W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_359 0081-0058 5.43 15.9 µM 4.52E-7 60S ribosome export 14 2.83E-8
2 SGTC_2882 9058044 5.23 58.4 µM 1.11E-6 6 8.36E-8
3 SGTC_2452 5863136 5.10 48.4 µM 2.03E-6 9 1.73E-7
4 SGTC_2481 5478948 5.06 45.2 µM 2.35E-6 PDR1 16 2.06E-7
5 SGTC_2801 7907800 5.02 81.8 µM 2.81E-6 12 2.55E-7
6 SGTC_1075 aripiprazole 4.97 15.2 µM 3.47E-6 9 3.30E-7
7 SGTC_1673 st016611 4.95 27.3 µM 3.83E-6 22 3.71E-7
8 SGTC_1447 4239-0816 4.82 81.9 µM 6.65E-6 15 7.22E-7
9 SGTC_2361 9034121 4.80 116.0 µM 7.28E-6 RSC complex & mRNA processing 9 8.05E-7
10 SGTC_3199 9111318 4.79 49.5 µM 7.60E-6 11 8.49E-7
11 SGTC_1972 st070201 4.78 17.4 µM 7.79E-6 14 8.74E-7
12 SGTC_2831 7999036 4.78 19.5 µM 7.88E-6 23 8.87E-7
13 SGTC_2488 5268135 4.67 45.7 µM 1.21E-5 31 1.49E-6
14 SGTC_2097 5376186 4.63 200.0 µM 1.45E-5 9 1.85E-6
15 SGTC_2024 5144227 4.61 134.0 µM 1.58E-5 22 2.05E-6
16 SGTC_1377 2944-0135 4.60 198.0 µM 1.64E-5 calcium & mitochondrial duress 21 2.15E-6
17 SGTC_2567 aureobasidin a 4.58 60.0 nM 1.76E-5 68 2.33E-6
18 SGTC_897 1000-0139 4.55 31.4 µM 1.98E-5 22 2.69E-6
19 SGTC_2575 plumbagin 4.48 510.0 nM 2.59E-5 superoxide 28 3.71E-6
20 SGTC_1729 st035615 4.39 46.0 µM 3.62E-5 24 5.55E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.89E-10 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.092 9.59E-8 YPR036W VMA13 hom Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
0.084 9.76E-7 YHR026W VMA16 hom Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
0.084 1.20E-6 YDL185W VMA1 hom Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
0.084 1.26E-6 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.083 1.31E-6 YKL041W VPS24 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
0.082 2.19E-6 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.080 3.22E-6 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.079 4.68E-6 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.078 5.61E-6 YOR106W VAM3 hom Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region
0.078 6.51E-6 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.077 7.79E-6 YPL033C SRL4 hom Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p
0.073 2.19E-5 YGR020C VMA7 hom Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.072 3.03E-5 YPL234C VMA11 hom Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen
0.071 4.12E-5 YBL094C_d YBL094C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W