YCL008C / STP22

Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL008C / STP22

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.74|P-value:4.75E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.64|P-value:2.09E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:-4.30|P-value:7.51E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-10.40|P-value:1.56E-20 ID:SGTC_59|Compound:0330-0160|FD-Score:-6.14|P-value:3.09E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:4.02|P-value:1.86E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:8.42|P-value:5.17E-14 ID:SGTC_117|Compound:lucigenin|FD-Score:5.42|P-value:8.36E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.82|P-value:3.83E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-4.03|P-value:1.92E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.50|P-value:3.45E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.72|P-value:1.58E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.98|P-value:2.15E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.53|P-value:3.06E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.91|P-value:8.62E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:10.70|P-value:1.09E-21 ID:SGTC_232|Compound:clozapine|FD-Score:5.17|P-value:2.44E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:4.38|P-value:5.34E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.23|P-value:1.98E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-5.21|P-value:2.15E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.71|P-value:5.09E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:7.98|P-value:8.75E-13 ID:SGTC_528|Compound:3492-0019|FD-Score:7.25|P-value:7.60E-11 ID:SGTC_576|Compound:1073-0113|FD-Score:6.54|P-value:3.68E-9 ID:SGTC_601|Compound:0986-0029|FD-Score:-5.00|P-value:5.21E-6 ID:SGTC_608|Compound:k048-0125|FD-Score:4.71|P-value:1.58E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:3.50|P-value:9.78E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.63|P-value:6.67E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:5.10|P-value:3.22E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.63|P-value:6.83E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.90|P-value:7.49E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:3.90|P-value:2.80E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.89|P-value:7.66E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:5.18|P-value:2.30E-6 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.51|P-value:3.31E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:6.47|P-value:5.50E-9 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.37|P-value:5.54E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.78|P-value:1.02E-9 ID:SGTC_1119|Compound:parthenolide|FD-Score:-7.54|P-value:1.43E-11 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.20|P-value:2.15E-8 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.52|P-value:3.39E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.92|P-value:2.70E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.45|P-value:7.38E-7 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.16|P-value:2.55E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.29|P-value:7.53E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:8.03|P-value:6.33E-13 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.45|P-value:4.20E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.19|P-value:1.05E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:5.30|P-value:1.40E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.32|P-value:4.79E-11 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.99|P-value:2.19E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:4.09|P-value:1.50E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.44|P-value:4.34E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.57|P-value:7.97E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:11.10|P-value:4.53E-23 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.47|P-value:4.03E-5 ID:SGTC_1687|Compound:st020778|FD-Score:12.70|P-value:1.30E-29 ID:SGTC_1750|Compound:st081859|FD-Score:8.57|P-value:1.84E-14 ID:SGTC_1754|Compound:st042065|FD-Score:4.36|P-value:5.81E-5 ID:SGTC_1760|Compound:st045453|FD-Score:5.19|P-value:2.26E-6 ID:SGTC_1770|Compound:st043884|FD-Score:-4.11|P-value:1.46E-4 ID:SGTC_1771|Compound:st048882|FD-Score:6.04|P-value:4.69E-8 ID:SGTC_1788|Compound:fluconazole|FD-Score:7.00|P-value:3.07E-10 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.80|P-value:1.10E-5 ID:SGTC_1797|Compound:st048695|FD-Score:5.89|P-value:9.69E-8 ID:SGTC_1801|Compound:st050089|FD-Score:5.27|P-value:1.61E-6 ID:SGTC_1803|Compound:st050068|FD-Score:8.32|P-value:9.52E-14 ID:SGTC_1804|Compound:st050076|FD-Score:4.21|P-value:9.91E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.59|P-value:7.41E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.71|P-value:5.29E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.35|P-value:5.97E-5 ID:SGTC_1884|Compound:5633444|FD-Score:9.50|P-value:2.38E-17 ID:SGTC_1962|Compound:st076595|FD-Score:3.53|P-value:9.01E-4 ID:SGTC_2006|Compound:4011487|FD-Score:5.33|P-value:1.21E-6 ID:SGTC_2016|Compound:5121758|FD-Score:5.71|P-value:2.21E-7 ID:SGTC_2050|Compound:5263056|FD-Score:3.93|P-value:2.52E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.82|P-value:3.69E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.39|P-value:5.13E-5 ID:SGTC_2141|Compound:5621638|FD-Score:4.72|P-value:1.48E-5 ID:SGTC_2164|Compound:5685496|FD-Score:-3.85|P-value:3.38E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-4.32|P-value:6.90E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.57|P-value:7.98E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.62|P-value:6.93E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.51|P-value:3.29E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.79|P-value:1.52E-7 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.88|P-value:7.88E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.60|P-value:3.74E-7 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.34|P-value:6.21E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:8.33|P-value:8.81E-14 ID:SGTC_2625|Compound:euphol|FD-Score:-3.56|P-value:8.49E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-4.54|P-value:3.06E-5 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.71|P-value:1.57E-5 ID:SGTC_2648|Compound:atorvastatin|FD-Score:7.14|P-value:1.39E-10 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.55|P-value:8.84E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.27|P-value:1.60E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.40|P-value:5.03E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.70|P-value:5.30E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.75|P-value:4.62E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.25|P-value:1.72E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:3.81|P-value:3.80E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.47|P-value:3.82E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.59|P-value:7.66E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.62|P-value:2.17E-5 ID:SGTC_2790|Compound:5423970|FD-Score:3.80|P-value:3.88E-4 ID:SGTC_2795|Compound:7780010|FD-Score:5.85|P-value:1.15E-7 ID:SGTC_2925|Compound:9010536|FD-Score:9.99|P-value:5.57E-19 ID:SGTC_2928|Compound:9011484|FD-Score:4.38|P-value:5.47E-5 ID:SGTC_2930|Compound:9013230|FD-Score:4.07|P-value:1.61E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.70|P-value:5.32E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.71|P-value:1.56E-5 ID:SGTC_2999|Compound:9069765|FD-Score:6.19|P-value:2.18E-8 ID:SGTC_3062|Compound:9077494|FD-Score:4.34|P-value:6.15E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-3.73|P-value:5.10E-4 ID:SGTC_3110|Compound:9122132|FD-Score:4.55|P-value:2.90E-5 ID:SGTC_3152|Compound:9099253|FD-Score:5.33|P-value:1.24E-6 ID:SGTC_3194|Compound:9111903|FD-Score:3.69|P-value:5.56E-4 ID:SGTC_3284|Compound:9108171|FD-Score:4.00|P-value:2.05E-4 ID:SGTC_3296|Compound:9122258|FD-Score:7.81|P-value:2.54E-12 ID:SGTC_3308|Compound:9128332|FD-Score:3.71|P-value:5.24E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.74|P-value:4.75E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.64|P-value:2.09E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:-4.30|P-value:7.51E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-10.40|P-value:1.56E-20 ID:SGTC_59|Compound:0330-0160|FD-Score:-6.14|P-value:3.09E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:4.02|P-value:1.86E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:8.42|P-value:5.17E-14 ID:SGTC_117|Compound:lucigenin|FD-Score:5.42|P-value:8.36E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.82|P-value:3.83E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-4.03|P-value:1.92E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.50|P-value:3.45E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.72|P-value:1.58E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.98|P-value:2.15E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.53|P-value:3.06E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.91|P-value:8.62E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:10.70|P-value:1.09E-21 ID:SGTC_232|Compound:clozapine|FD-Score:5.17|P-value:2.44E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:4.38|P-value:5.34E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.23|P-value:1.98E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-5.21|P-value:2.15E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.71|P-value:5.09E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:7.98|P-value:8.75E-13 ID:SGTC_528|Compound:3492-0019|FD-Score:7.25|P-value:7.60E-11 ID:SGTC_576|Compound:1073-0113|FD-Score:6.54|P-value:3.68E-9 ID:SGTC_601|Compound:0986-0029|FD-Score:-5.00|P-value:5.21E-6 ID:SGTC_608|Compound:k048-0125|FD-Score:4.71|P-value:1.58E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:3.50|P-value:9.78E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.63|P-value:6.67E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:5.10|P-value:3.22E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.63|P-value:6.83E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.90|P-value:7.49E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:3.90|P-value:2.80E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.89|P-value:7.66E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:5.18|P-value:2.30E-6 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.51|P-value:3.31E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:6.47|P-value:5.50E-9 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.37|P-value:5.54E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.78|P-value:1.02E-9 ID:SGTC_1119|Compound:parthenolide|FD-Score:-7.54|P-value:1.43E-11 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.20|P-value:2.15E-8 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.52|P-value:3.39E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.92|P-value:2.70E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.45|P-value:7.38E-7 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.16|P-value:2.55E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.29|P-value:7.53E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:8.03|P-value:6.33E-13 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.45|P-value:4.20E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.19|P-value:1.05E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:5.30|P-value:1.40E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.32|P-value:4.79E-11 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.99|P-value:2.19E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:4.09|P-value:1.50E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.44|P-value:4.34E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.57|P-value:7.97E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:11.10|P-value:4.53E-23 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.47|P-value:4.03E-5 ID:SGTC_1687|Compound:st020778|FD-Score:12.70|P-value:1.30E-29 ID:SGTC_1750|Compound:st081859|FD-Score:8.57|P-value:1.84E-14 ID:SGTC_1754|Compound:st042065|FD-Score:4.36|P-value:5.81E-5 ID:SGTC_1760|Compound:st045453|FD-Score:5.19|P-value:2.26E-6 ID:SGTC_1770|Compound:st043884|FD-Score:-4.11|P-value:1.46E-4 ID:SGTC_1771|Compound:st048882|FD-Score:6.04|P-value:4.69E-8 ID:SGTC_1788|Compound:fluconazole|FD-Score:7.00|P-value:3.07E-10 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.80|P-value:1.10E-5 ID:SGTC_1797|Compound:st048695|FD-Score:5.89|P-value:9.69E-8 ID:SGTC_1801|Compound:st050089|FD-Score:5.27|P-value:1.61E-6 ID:SGTC_1803|Compound:st050068|FD-Score:8.32|P-value:9.52E-14 ID:SGTC_1804|Compound:st050076|FD-Score:4.21|P-value:9.91E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.59|P-value:7.41E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.71|P-value:5.29E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.35|P-value:5.97E-5 ID:SGTC_1884|Compound:5633444|FD-Score:9.50|P-value:2.38E-17 ID:SGTC_1962|Compound:st076595|FD-Score:3.53|P-value:9.01E-4 ID:SGTC_2006|Compound:4011487|FD-Score:5.33|P-value:1.21E-6 ID:SGTC_2016|Compound:5121758|FD-Score:5.71|P-value:2.21E-7 ID:SGTC_2050|Compound:5263056|FD-Score:3.93|P-value:2.52E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.82|P-value:3.69E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.39|P-value:5.13E-5 ID:SGTC_2141|Compound:5621638|FD-Score:4.72|P-value:1.48E-5 ID:SGTC_2164|Compound:5685496|FD-Score:-3.85|P-value:3.38E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-4.32|P-value:6.90E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.57|P-value:7.98E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.62|P-value:6.93E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.51|P-value:3.29E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.79|P-value:1.52E-7 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.88|P-value:7.88E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.60|P-value:3.74E-7 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.34|P-value:6.21E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:8.33|P-value:8.81E-14 ID:SGTC_2625|Compound:euphol|FD-Score:-3.56|P-value:8.49E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-4.54|P-value:3.06E-5 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.71|P-value:1.57E-5 ID:SGTC_2648|Compound:atorvastatin|FD-Score:7.14|P-value:1.39E-10 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.55|P-value:8.84E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.27|P-value:1.60E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.40|P-value:5.03E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.70|P-value:5.30E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.75|P-value:4.62E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.25|P-value:1.72E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:3.81|P-value:3.80E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.47|P-value:3.82E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.59|P-value:7.66E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.62|P-value:2.17E-5 ID:SGTC_2790|Compound:5423970|FD-Score:3.80|P-value:3.88E-4 ID:SGTC_2795|Compound:7780010|FD-Score:5.85|P-value:1.15E-7 ID:SGTC_2925|Compound:9010536|FD-Score:9.99|P-value:5.57E-19 ID:SGTC_2928|Compound:9011484|FD-Score:4.38|P-value:5.47E-5 ID:SGTC_2930|Compound:9013230|FD-Score:4.07|P-value:1.61E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.70|P-value:5.32E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.71|P-value:1.56E-5 ID:SGTC_2999|Compound:9069765|FD-Score:6.19|P-value:2.18E-8 ID:SGTC_3062|Compound:9077494|FD-Score:4.34|P-value:6.15E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-3.73|P-value:5.10E-4 ID:SGTC_3110|Compound:9122132|FD-Score:4.55|P-value:2.90E-5 ID:SGTC_3152|Compound:9099253|FD-Score:5.33|P-value:1.24E-6 ID:SGTC_3194|Compound:9111903|FD-Score:3.69|P-value:5.56E-4 ID:SGTC_3284|Compound:9108171|FD-Score:4.00|P-value:2.05E-4 ID:SGTC_3296|Compound:9122258|FD-Score:7.81|P-value:2.54E-12 ID:SGTC_3308|Compound:9128332|FD-Score:3.71|P-value:5.24E-4

Top fitness defect scores for YCL008C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1687 st020778 12.70 55.4 µM 1.30E-29 33 2.24E-37
2 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 11.10 54.9 µM 4.53E-23 redox potentiating 11 5.23E-29
3 SGTC_227 fluconazole 10.70 33.5 µM 1.09E-21 azole & statin 14 3.06E-27
4 SGTC_2925 9010536 9.99 32.5 µM 5.57E-19 azole & statin 4 8.85E-24
5 SGTC_1884 5633444 9.50 25.0 µM 2.38E-17 redox potentiating 13 1.07E-21
6 SGTC_1750 st081859 8.57 2.4 µM 1.84E-14 endomembrane recycling 58 5.23E-18
7 SGTC_102 gallobenzophenone 8.42 83.6 µM 5.17E-14 redox potentiating 6 1.96E-17
8 SGTC_2619 obliquin 8.33 87.9 µM 8.81E-14 cell wall 40 3.88E-17
9 SGTC_1803 st050068 8.32 52.4 µM 9.52E-14 NEO1-PIK1 36 4.28E-17
10 SGTC_1311 1190-0148 8.03 100.0 µM 6.33E-13 azole & statin 3 4.80E-16
11 SGTC_525 k781-2675 7.98 26.7 µM 8.75E-13 redox potentiating 12 7.25E-16
12 SGTC_3296 9122258 7.81 64.0 µM 2.54E-12 redox potentiating 2 2.82E-15
13 SGTC_1495 4469-0029 7.32 237.0 µM 4.79E-11 32 1.20E-13
14 SGTC_528 3492-0019 7.25 172.0 µM 7.60E-11 calcium & mitochondrial duress 92 2.16E-13
15 SGTC_2648 atorvastatin 7.14 78.7 µM 1.39E-10 azole & statin 9 4.67E-13
16 SGTC_1788 fluconazole 7.00 20.0 µM 3.07E-10 azole & statin 24 1.28E-12
17 SGTC_1083 didemethylchlorpromazine sulfoxide 6.78 707.4 nM 1.02E-9 redox potentiating 19 5.90E-12
18 SGTC_576 1073-0113 6.54 22.7 µM 3.68E-9 redox potentiating 13 3.03E-11
19 SGTC_1036 k216-0215 6.47 33.5 µM 5.50E-9 mitochondrial response to ROS 12 5.05E-11
20 SGTC_1130 3454-2858 6.20 15.9 µM 2.15E-8 NEO1 37 2.87E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.589 7.31E-312 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.584 1.05E-306 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.551 4.51E-266 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.538 2.04E-251 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.479 1.88E-192 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.463 7.38E-178 YMR077C VPS20 hom Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
0.463 6.98E-178 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.413 4.70E-138 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.402 2.44E-130 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.387 4.00E-120 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.383 1.10E-117 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.347 2.45E-95 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.328 9.68E-85 YLR119W SRN2 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.327 2.49E-84 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.318 8.17E-80 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif