YCL011C / GBP2

Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL011C / GBP2

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:-3.28|P-value:9.84E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.59|P-value:4.43E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.29|P-value:3.42E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.85|P-value:1.78E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.92|P-value:1.11E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.94|P-value:1.29E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.57|P-value:4.75E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:4.12|P-value:6.50E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.61|P-value:4.13E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.06|P-value:8.30E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.35|P-value:2.72E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.72|P-value:2.28E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.73|P-value:2.67E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.53|P-value:4.36E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:4.15|P-value:5.86E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.51|P-value:5.66E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.73|P-value:2.69E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.60|P-value:4.20E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.63|P-value:3.80E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.38|P-value:8.75E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.68|P-value:3.24E-4 ID:SGTC_1841|Compound:st054148|FD-Score:4.16|P-value:5.63E-5 ID:SGTC_1898|Compound:st060199|FD-Score:4.03|P-value:9.35E-5 ID:SGTC_1901|Compound:st060216|FD-Score:5.56|P-value:1.17E-7 ID:SGTC_1903|Compound:st060211|FD-Score:3.89|P-value:1.51E-4 ID:SGTC_1914|Compound:st062367|FD-Score:4.48|P-value:1.62E-5 ID:SGTC_2036|Compound:5160441|FD-Score:3.43|P-value:7.48E-4 ID:SGTC_2082|Compound:5219693|FD-Score:4.74|P-value:5.32E-6 ID:SGTC_2111|Compound:5486399|FD-Score:3.77|P-value:2.37E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-3.64|P-value:3.02E-4 ID:SGTC_2192|Compound:5915882|FD-Score:6.72|P-value:1.99E-10 ID:SGTC_2218|Compound:6965428|FD-Score:-3.70|P-value:2.46E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.81|P-value:3.02E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-4.64|P-value:6.50E-6 ID:SGTC_2339|Compound:9000433|FD-Score:4.79|P-value:4.22E-6 ID:SGTC_2345|Compound:9052315|FD-Score:3.56|P-value:4.85E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.69|P-value:3.15E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.00|P-value:1.72E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.70|P-value:3.04E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.48|P-value:1.24E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.35|P-value:2.72E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.29|P-value:2.69E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-3.53|P-value:4.37E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.71|P-value:2.91E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.66|P-value:3.49E-4 ID:SGTC_2917|Compound:7979103|FD-Score:7.25|P-value:7.53E-12 ID:SGTC_2925|Compound:9010536|FD-Score:3.41|P-value:7.80E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-4.86|P-value:2.47E-6 ID:SGTC_2953|Compound:9074162|FD-Score:-3.71|P-value:2.41E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.60|P-value:4.22E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-4.03|P-value:7.36E-5 ID:SGTC_3107|Compound:9121808|FD-Score:-3.97|P-value:9.17E-5 ID:SGTC_3147|Compound:9097027|FD-Score:4.00|P-value:1.03E-4 ID:SGTC_3167|Compound:9103034|FD-Score:3.35|P-value:9.52E-4 ID:SGTC_3169|Compound:9102970|FD-Score:3.83|P-value:1.94E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.37|P-value:7.41E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-5.17|P-value:5.77E-7 ID:SGTC_3231|Compound:9132313|FD-Score:-3.40|P-value:6.72E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.44|P-value:7.25E-4 ID:SGTC_5|Compound:0352-0601|FD-Score:-3.28|P-value:9.84E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.59|P-value:4.43E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.29|P-value:3.42E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.85|P-value:1.78E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.92|P-value:1.11E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.94|P-value:1.29E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.57|P-value:4.75E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:4.12|P-value:6.50E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.61|P-value:4.13E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.06|P-value:8.30E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.35|P-value:2.72E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.72|P-value:2.28E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.73|P-value:2.67E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.53|P-value:4.36E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:4.15|P-value:5.86E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.51|P-value:5.66E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.73|P-value:2.69E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.60|P-value:4.20E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.63|P-value:3.80E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.38|P-value:8.75E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.68|P-value:3.24E-4 ID:SGTC_1841|Compound:st054148|FD-Score:4.16|P-value:5.63E-5 ID:SGTC_1898|Compound:st060199|FD-Score:4.03|P-value:9.35E-5 ID:SGTC_1901|Compound:st060216|FD-Score:5.56|P-value:1.17E-7 ID:SGTC_1903|Compound:st060211|FD-Score:3.89|P-value:1.51E-4 ID:SGTC_1914|Compound:st062367|FD-Score:4.48|P-value:1.62E-5 ID:SGTC_2036|Compound:5160441|FD-Score:3.43|P-value:7.48E-4 ID:SGTC_2082|Compound:5219693|FD-Score:4.74|P-value:5.32E-6 ID:SGTC_2111|Compound:5486399|FD-Score:3.77|P-value:2.37E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-3.64|P-value:3.02E-4 ID:SGTC_2192|Compound:5915882|FD-Score:6.72|P-value:1.99E-10 ID:SGTC_2218|Compound:6965428|FD-Score:-3.70|P-value:2.46E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.81|P-value:3.02E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-4.64|P-value:6.50E-6 ID:SGTC_2339|Compound:9000433|FD-Score:4.79|P-value:4.22E-6 ID:SGTC_2345|Compound:9052315|FD-Score:3.56|P-value:4.85E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.69|P-value:3.15E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.00|P-value:1.72E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.70|P-value:3.04E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.48|P-value:1.24E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.35|P-value:2.72E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.29|P-value:2.69E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-3.53|P-value:4.37E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.71|P-value:2.91E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.66|P-value:3.49E-4 ID:SGTC_2917|Compound:7979103|FD-Score:7.25|P-value:7.53E-12 ID:SGTC_2925|Compound:9010536|FD-Score:3.41|P-value:7.80E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-4.86|P-value:2.47E-6 ID:SGTC_2953|Compound:9074162|FD-Score:-3.71|P-value:2.41E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.60|P-value:4.22E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-4.03|P-value:7.36E-5 ID:SGTC_3107|Compound:9121808|FD-Score:-3.97|P-value:9.17E-5 ID:SGTC_3147|Compound:9097027|FD-Score:4.00|P-value:1.03E-4 ID:SGTC_3167|Compound:9103034|FD-Score:3.35|P-value:9.52E-4 ID:SGTC_3169|Compound:9102970|FD-Score:3.83|P-value:1.94E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.37|P-value:7.41E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-5.17|P-value:5.77E-7 ID:SGTC_3231|Compound:9132313|FD-Score:-3.40|P-value:6.72E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.44|P-value:7.25E-4

Top fitness defect scores for YCL011C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2917 7979103 7.25 53.8 µM 7.53E-12 1 2.11E-13
2 SGTC_2192 5915882 6.72 198.5 µM 1.99E-10 RNA processing & uracil transport 8 9.00E-12
3 SGTC_1901 st060216 5.56 58.6 µM 1.17E-7 8 1.35E-8
4 SGTC_2405 ticlatone 5.00 3.5 µM 1.72E-6 39 2.92E-7
5 SGTC_2339 9000433 4.79 200.0 µM 4.22E-6 16 8.15E-7
6 SGTC_2082 5219693 4.74 150.0 µM 5.32E-6 RNA processing & uracil transport 13 1.06E-6
7 SGTC_1914 st062367 4.48 72.6 µM 1.62E-5 15 3.80E-6
8 SGTC_437 s-farnesyl-l-cysteine methyl ester 4.35 6.7 µM 2.72E-5 8 6.89E-6
9 SGTC_2569 tetrandrine 4.35 100.0 µM 2.72E-5 13 6.89E-6
10 SGTC_60 0986-0278 4.29 202.0 µM 3.42E-5 8 8.97E-6
11 SGTC_1841 st054148 4.16 70.0 µM 5.63E-5 8 1.58E-5
12 SGTC_1006 4099-6547 4.15 255.0 µM 5.86E-5 15 1.66E-5
13 SGTC_178 4092-0806 4.12 87.5 µM 6.50E-5 ergosterol depletion effects on membrane 87 1.87E-5
14 SGTC_430 0958-0115 4.06 16.4 µM 8.30E-5 28 2.47E-5
15 SGTC_1898 st060199 4.03 18.6 µM 9.35E-5 15 2.83E-5
16 SGTC_3147 9097027 4.00 49.5 µM 1.03E-4 22 3.18E-5
17 SGTC_158 k038-0087 3.94 26.4 µM 1.29E-4 ubiquinone biosynthesis & proteasome 142 4.09E-5
18 SGTC_1903 st060211 3.89 78.3 µM 1.51E-4 30 4.92E-5
19 SGTC_142 0335-0849 3.85 62.7 µM 1.78E-4 ubiquinone biosynthesis & proteasome 131 5.92E-5
20 SGTC_3169 9102970 3.83 49.5 µM 1.94E-4 RPP1 & pyrimidine depletion 5 6.52E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 5.97E-15 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.112 6.86E-11 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.108 3.82E-10 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.104 1.51E-9 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.101 4.37E-9 YML003W_p YML003W_p hom Putative protein of unknown function
0.101 5.06E-9 YPL138C SPP1 hom Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein
0.097 1.80E-8 YDL074C BRE1 hom E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control
0.095 3.28E-8 YDL024C DIA3 hom Protein of unknown function, involved in invasive and pseudohyphal growth
0.095 3.77E-8 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090 1.98E-7 YOR025W HST3 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.087 4.12E-7 YMR241W YHM2 hom Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome
0.083 1.35E-6 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.081 3.06E-6 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.080 3.66E-6 YPL031C PHO85 hom Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle
0.079 4.39E-6 YLR316C TAD3 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs