YCL014W / BUD3

Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL014W / BUD3

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:6.55|P-value:8.45E-12 ID:SGTC_58|Compound:0957-0393|FD-Score:6.67|P-value:3.58E-12 ID:SGTC_64|Compound:000l-0018|FD-Score:7.30|P-value:3.14E-14 ID:SGTC_67|Compound:0335-0847|FD-Score:6.40|P-value:2.41E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:16.80|P-value:1.19E-67 ID:SGTC_103|Compound:0844-0104|FD-Score:5.07|P-value:9.43E-8 ID:SGTC_107|Compound:0358-0022|FD-Score:3.78|P-value:5.09E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:7.29|P-value:3.29E-14 ID:SGTC_142|Compound:0335-0849|FD-Score:8.88|P-value:3.16E-20 ID:SGTC_158|Compound:k038-0087|FD-Score:16.20|P-value:1.11E-62 ID:SGTC_236|Compound:1509-0011|FD-Score:4.05|P-value:1.61E-5 ID:SGTC_283|Compound:0987-0079|FD-Score:3.28|P-value:3.77E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:6.49|P-value:1.21E-11 ID:SGTC_340|Compound:k038-0059|FD-Score:11.10|P-value:1.54E-30 ID:SGTC_352|Compound:k048-0007|FD-Score:3.09|P-value:7.56E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.18|P-value:5.03E-8 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.31|P-value:4.76E-6 ID:SGTC_534|Compound:k292-0788|FD-Score:3.60|P-value:1.09E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:5.83|P-value:1.02E-9 ID:SGTC_677|Compound:0929-0063|FD-Score:4.64|P-value:9.23E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:13.00|P-value:5.08E-41 ID:SGTC_846|Compound:0335-0850|FD-Score:7.83|P-value:3.96E-16 ID:SGTC_852|Compound:0418-0143|FD-Score:4.68|P-value:7.73E-7 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.07|P-value:7.52E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.71|P-value:6.89E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.17|P-value:5.71E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.57|P-value:1.24E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.78|P-value:5.17E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.69|P-value:6.95E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.69|P-value:7.16E-7 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.47|P-value:1.85E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:26.80|P-value:9.50E-168 ID:SGTC_1522|Compound:st012842|FD-Score:-3.72|P-value:6.18E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.84|P-value:3.27E-7 ID:SGTC_1694|Compound:st024011|FD-Score:-3.16|P-value:5.41E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.42|P-value:2.09E-4 ID:SGTC_1975|Compound:st070967|FD-Score:4.68|P-value:7.60E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:14.10|P-value:8.78E-48 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.01|P-value:1.94E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.78|P-value:5.24E-5 ID:SGTC_2833|Compound:9001315|FD-Score:4.30|P-value:5.06E-6 ID:SGTC_2925|Compound:9010536|FD-Score:4.02|P-value:1.85E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.09|P-value:7.67E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.84|P-value:3.72E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.97|P-value:4.18E-10 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.34|P-value:3.07E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.21|P-value:7.72E-6 ID:SGTC_3117|Compound:9124945|FD-Score:-3.29|P-value:3.34E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.68|P-value:7.43E-7 ID:SGTC_3312|Compound:9133330|FD-Score:3.66|P-value:8.52E-5 ID:SGTC_3313|Compound:9133968|FD-Score:3.07|P-value:8.07E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.19|P-value:5.34E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.04|P-value:8.50E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:6.55|P-value:8.45E-12 ID:SGTC_58|Compound:0957-0393|FD-Score:6.67|P-value:3.58E-12 ID:SGTC_64|Compound:000l-0018|FD-Score:7.30|P-value:3.14E-14 ID:SGTC_67|Compound:0335-0847|FD-Score:6.40|P-value:2.41E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:16.80|P-value:1.19E-67 ID:SGTC_103|Compound:0844-0104|FD-Score:5.07|P-value:9.43E-8 ID:SGTC_107|Compound:0358-0022|FD-Score:3.78|P-value:5.09E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:7.29|P-value:3.29E-14 ID:SGTC_142|Compound:0335-0849|FD-Score:8.88|P-value:3.16E-20 ID:SGTC_158|Compound:k038-0087|FD-Score:16.20|P-value:1.11E-62 ID:SGTC_236|Compound:1509-0011|FD-Score:4.05|P-value:1.61E-5 ID:SGTC_283|Compound:0987-0079|FD-Score:3.28|P-value:3.77E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:6.49|P-value:1.21E-11 ID:SGTC_340|Compound:k038-0059|FD-Score:11.10|P-value:1.54E-30 ID:SGTC_352|Compound:k048-0007|FD-Score:3.09|P-value:7.56E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.18|P-value:5.03E-8 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.31|P-value:4.76E-6 ID:SGTC_534|Compound:k292-0788|FD-Score:3.60|P-value:1.09E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:5.83|P-value:1.02E-9 ID:SGTC_677|Compound:0929-0063|FD-Score:4.64|P-value:9.23E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:13.00|P-value:5.08E-41 ID:SGTC_846|Compound:0335-0850|FD-Score:7.83|P-value:3.96E-16 ID:SGTC_852|Compound:0418-0143|FD-Score:4.68|P-value:7.73E-7 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.07|P-value:7.52E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.71|P-value:6.89E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.17|P-value:5.71E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.57|P-value:1.24E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.78|P-value:5.17E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.69|P-value:6.95E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.69|P-value:7.16E-7 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.47|P-value:1.85E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:26.80|P-value:9.50E-168 ID:SGTC_1522|Compound:st012842|FD-Score:-3.72|P-value:6.18E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.84|P-value:3.27E-7 ID:SGTC_1694|Compound:st024011|FD-Score:-3.16|P-value:5.41E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.42|P-value:2.09E-4 ID:SGTC_1975|Compound:st070967|FD-Score:4.68|P-value:7.60E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:14.10|P-value:8.78E-48 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.01|P-value:1.94E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.78|P-value:5.24E-5 ID:SGTC_2833|Compound:9001315|FD-Score:4.30|P-value:5.06E-6 ID:SGTC_2925|Compound:9010536|FD-Score:4.02|P-value:1.85E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.09|P-value:7.67E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.84|P-value:3.72E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.97|P-value:4.18E-10 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.34|P-value:3.07E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.21|P-value:7.72E-6 ID:SGTC_3117|Compound:9124945|FD-Score:-3.29|P-value:3.34E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.68|P-value:7.43E-7 ID:SGTC_3312|Compound:9133330|FD-Score:3.66|P-value:8.52E-5 ID:SGTC_3313|Compound:9133968|FD-Score:3.07|P-value:8.07E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.19|P-value:5.34E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.04|P-value:8.50E-4

Top fitness defect scores for YCL014W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1294 1000-1494 26.80 117.0 µM 9.50E-168 2 2.12E-158
2 SGTC_86 0417-1630 16.80 471.9 µM 1.19E-67 ubiquinone biosynthesis & proteasome 11 5.62E-64
3 SGTC_158 k038-0087 16.20 26.4 µM 1.11E-62 ubiquinone biosynthesis & proteasome 10 2.75E-59
4 SGTC_2582 agaric acid 14.10 100.0 µM 8.78E-48 redox potentiating 21 3.13E-45
5 SGTC_794 k038-0031 13.00 316.0 µM 5.08E-41 ubiquinone biosynthesis & proteasome 7 7.54E-39
6 SGTC_340 k038-0059 11.10 454.0 µM 1.54E-30 ubiquinone biosynthesis & proteasome 2 5.92E-29
7 SGTC_142 0335-0849 8.88 62.7 µM 3.16E-20 ubiquinone biosynthesis & proteasome 38 3.23E-19
8 SGTC_846 0335-0850 7.83 148.0 µM 3.96E-16 ubiquinone biosynthesis & proteasome 9 2.40E-15
9 SGTC_64 000l-0018 7.30 272.1 µM 3.14E-14 ubiquinone biosynthesis & proteasome 55 1.49E-13
10 SGTC_137 0438-0332 7.29 85.4 µM 3.29E-14 ubiquinone biosynthesis & proteasome 46 1.56E-13
11 SGTC_58 0957-0393 6.67 9.0 µM 3.58E-12 cell wall 178 1.31E-11
12 SGTC_36 0335-0881 6.55 14.2 µM 8.45E-12 ubiquinone biosynthesis & proteasome 50 2.96E-11
13 SGTC_294 k038-0071 6.49 157.0 µM 1.21E-11 ubiquinone biosynthesis & proteasome 10 4.15E-11
14 SGTC_67 0335-0847 6.40 266.0 µM 2.41E-11 ubiquinone biosynthesis & proteasome 59 7.96E-11
15 SGTC_3059 1327-0034 5.97 3.0 µM 4.18E-10 27 1.18E-9
16 SGTC_635 k038-0028 5.83 24.7 µM 1.02E-9 ubiquinone biosynthesis & proteasome 15 2.74E-9
17 SGTC_367 0335-0881 5.18 7.1 µM 5.03E-8 ubiquinone biosynthesis & proteasome 38 1.10E-7
18 SGTC_103 0844-0104 5.07 51.8 µM 9.43E-8 ERAD & cell cycle 98 1.99E-7
19 SGTC_1635 st007035 4.84 42.4 µM 3.27E-7 172 6.46E-7
20 SGTC_1161 k007-0610 4.69 110.0 µM 7.16E-7 ERAD & cell cycle 90 1.36E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.766 0 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.718 0 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.690 0 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.659 0 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.627 0 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.611 0 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.600 0 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.599 0 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.520 1.82E-231 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.511 4.84E-223 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.510 1.37E-221 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.508 1.19E-219 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.481 7.14E-194 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.475 9.51E-189 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.471 3.50E-185 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex