YCL016C / DCC1

Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL016C / DCC1

Click on Significant Values for Screen Details ID:SGTC_138|Compound:0850-0259|FD-Score:5.19|P-value:3.00E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:4.65|P-value:2.42E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.51|P-value:5.23E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.37|P-value:1.38E-6 ID:SGTC_459|Compound:nigericin|FD-Score:5.46|P-value:9.55E-7 ID:SGTC_565|Compound:1418-0001|FD-Score:4.97|P-value:7.28E-6 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.90|P-value:4.10E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.96|P-value:2.66E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.69|P-value:6.14E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:4.58|P-value:3.11E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.84|P-value:3.93E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.53|P-value:9.87E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.23|P-value:1.10E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-4.43|P-value:7.13E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.91|P-value:3.11E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:5.42|P-value:1.13E-6 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.77|P-value:1.55E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:-5.97|P-value:1.34E-7 ID:SGTC_1193|Compound:1488-0126|FD-Score:-5.81|P-value:2.81E-7 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.85|P-value:3.81E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.42|P-value:5.61E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.85|P-value:3.79E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.98|P-value:2.49E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.90|P-value:3.19E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.79|P-value:4.59E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.61|P-value:7.97E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.86|P-value:3.62E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.77|P-value:1.53E-5 ID:SGTC_1707|Compound:st032323|FD-Score:5.37|P-value:1.42E-6 ID:SGTC_1734|Compound:st037168|FD-Score:8.12|P-value:7.63E-13 ID:SGTC_1765|Compound:st044815|FD-Score:4.22|P-value:1.13E-4 ID:SGTC_1790|Compound:st045711|FD-Score:4.28|P-value:9.19E-5 ID:SGTC_1791|Compound:st048313|FD-Score:-3.99|P-value:3.05E-4 ID:SGTC_1792|Compound:st045773|FD-Score:5.51|P-value:7.54E-7 ID:SGTC_1815|Compound:st051655|FD-Score:-4.57|P-value:4.28E-5 ID:SGTC_2243|Compound:6634756|FD-Score:4.42|P-value:5.66E-5 ID:SGTC_2258|Compound:7960471|FD-Score:4.99|P-value:6.62E-6 ID:SGTC_2403|Compound:6032726|FD-Score:-3.76|P-value:6.23E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.13|P-value:1.54E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.48|P-value:4.57E-5 ID:SGTC_2446|Compound:5162541|FD-Score:3.72|P-value:5.71E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:6.80|P-value:1.56E-9 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.80|P-value:4.41E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.75|P-value:5.13E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:4.26|P-value:9.85E-5 ID:SGTC_2803|Compound:7707263|FD-Score:3.65|P-value:6.92E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.04|P-value:2.02E-4 ID:SGTC_3122|Compound:9126309|FD-Score:3.99|P-value:2.40E-4 ID:SGTC_3128|Compound:9127691|FD-Score:5.68|P-value:3.71E-7 ID:SGTC_3130|Compound:9127414|FD-Score:6.98|P-value:5.93E-10 ID:SGTC_3140|Compound:9094243|FD-Score:3.99|P-value:2.44E-4 ID:SGTC_3340|Compound:9146634|FD-Score:5.43|P-value:1.07E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:5.19|P-value:3.00E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:4.65|P-value:2.42E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.51|P-value:5.23E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.37|P-value:1.38E-6 ID:SGTC_459|Compound:nigericin|FD-Score:5.46|P-value:9.55E-7 ID:SGTC_565|Compound:1418-0001|FD-Score:4.97|P-value:7.28E-6 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.90|P-value:4.10E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.96|P-value:2.66E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.69|P-value:6.14E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:4.58|P-value:3.11E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.84|P-value:3.93E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.53|P-value:9.87E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.23|P-value:1.10E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-4.43|P-value:7.13E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.91|P-value:3.11E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:5.42|P-value:1.13E-6 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.77|P-value:1.55E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:-5.97|P-value:1.34E-7 ID:SGTC_1193|Compound:1488-0126|FD-Score:-5.81|P-value:2.81E-7 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.85|P-value:3.81E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.42|P-value:5.61E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.85|P-value:3.79E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.98|P-value:2.49E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.90|P-value:3.19E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.79|P-value:4.59E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.61|P-value:7.97E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.86|P-value:3.62E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.77|P-value:1.53E-5 ID:SGTC_1707|Compound:st032323|FD-Score:5.37|P-value:1.42E-6 ID:SGTC_1734|Compound:st037168|FD-Score:8.12|P-value:7.63E-13 ID:SGTC_1765|Compound:st044815|FD-Score:4.22|P-value:1.13E-4 ID:SGTC_1790|Compound:st045711|FD-Score:4.28|P-value:9.19E-5 ID:SGTC_1791|Compound:st048313|FD-Score:-3.99|P-value:3.05E-4 ID:SGTC_1792|Compound:st045773|FD-Score:5.51|P-value:7.54E-7 ID:SGTC_1815|Compound:st051655|FD-Score:-4.57|P-value:4.28E-5 ID:SGTC_2243|Compound:6634756|FD-Score:4.42|P-value:5.66E-5 ID:SGTC_2258|Compound:7960471|FD-Score:4.99|P-value:6.62E-6 ID:SGTC_2403|Compound:6032726|FD-Score:-3.76|P-value:6.23E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.13|P-value:1.54E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.48|P-value:4.57E-5 ID:SGTC_2446|Compound:5162541|FD-Score:3.72|P-value:5.71E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:6.80|P-value:1.56E-9 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.80|P-value:4.41E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.75|P-value:5.13E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:4.26|P-value:9.85E-5 ID:SGTC_2803|Compound:7707263|FD-Score:3.65|P-value:6.92E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.04|P-value:2.02E-4 ID:SGTC_3122|Compound:9126309|FD-Score:3.99|P-value:2.40E-4 ID:SGTC_3128|Compound:9127691|FD-Score:5.68|P-value:3.71E-7 ID:SGTC_3130|Compound:9127414|FD-Score:6.98|P-value:5.93E-10 ID:SGTC_3140|Compound:9094243|FD-Score:3.99|P-value:2.44E-4 ID:SGTC_3340|Compound:9146634|FD-Score:5.43|P-value:1.07E-6

Top fitness defect scores for YCL016C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1734 st037168 8.12 69.4 µM 7.63E-13 1 2.26E-16
2 SGTC_3130 9127414 6.98 49.5 µM 5.93E-10 2 1.46E-12
3 SGTC_2575 plumbagin 6.80 510.0 nM 1.56E-9 superoxide 13 5.22E-12
4 SGTC_3128 9127691 5.68 49.5 µM 3.71E-7 3 6.92E-9
5 SGTC_1792 st045773 5.51 43.6 µM 7.54E-7 7 1.76E-8
6 SGTC_459 nigericin 5.46 15.3 µM 9.55E-7 39 2.39E-8
7 SGTC_3340 9146634 5.43 11.1 µM 1.07E-6 3 2.78E-8
8 SGTC_1168 k815-0004 5.42 80.5 µM 1.13E-6 DNA damage response 1 3.00E-8
9 SGTC_453 enantio-paf c16 5.37 10.0 µM 1.38E-6 74 3.89E-8
10 SGTC_1707 st032323 5.37 6.3 µM 1.42E-6 DNA damage response 29 4.03E-8
11 SGTC_138 0850-0259 5.19 40.9 µM 3.00E-6 cell wall 139 1.07E-7
12 SGTC_2258 7960471 4.99 200.0 µM 6.62E-6 3 3.02E-7
13 SGTC_565 1418-0001 4.97 44.5 µM 7.28E-6 4 3.42E-7
14 SGTC_1633 st005664 4.77 67.9 µM 1.53E-5 15 8.99E-7
15 SGTC_1186 1319-0216 4.77 26.0 µM 1.55E-5 7 9.16E-7
16 SGTC_301 4119-0100 4.65 24.5 µM 2.42E-5 NEO1 64 1.64E-6
17 SGTC_870 0573-2213 4.58 57.6 µM 3.11E-5 ERG2 10 2.28E-6
18 SGTC_2438 5259590 4.48 200.0 µM 4.57E-5 12 3.77E-6
19 SGTC_1313 1220-0047 4.42 237.0 µM 5.61E-5 25 4.93E-6
20 SGTC_2243 6634756 4.42 200.0 µM 5.66E-5 14 4.98E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.087 5.05E-7 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.086 5.52E-7 YBR235W VHC1 hom Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family
0.085 7.15E-7 YGR239C PEX21 hom Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress
0.083 1.30E-6 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.083 1.36E-6 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.082 2.27E-6 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.080 3.15E-6 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.17E-6 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.079 5.16E-6 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.075 1.44E-5 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.074 1.81E-5 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.071 3.99E-5 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.070 5.03E-5 YGR199W PMT6 hom Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases
0.070 5.04E-5 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.067 9.13E-5 YER119C AVT6 hom Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication