Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YCL017C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.277 | 3.55E-60 | YPL252C | YAH1 | het | Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin |
0.262 | 9.75E-54 | YPL251W_d | YPL251W_d | het | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C |
0.198 | 4.35E-31 | YDR376W | ARH1 | het | Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability |
0.163 | 1.76E-21 | YDR431W_d | YDR431W_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.130 | 4.82E-14 | YHR042W | NCP1 | het | NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p |
0.129 | 5.86E-14 | YIL068C | SEC6 | het | Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p |
0.121 | 1.77E-12 | YMR211W | DML1 | het | Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family |
0.117 | 9.34E-12 | YDR224C | HTB1 | het | Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation |
0.113 | 5.50E-11 | YJR102C | VPS25 | hom | Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome |
0.110 | 1.74E-10 | YPL135W | ISU1 | hom | Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable |
0.110 | 1.81E-10 | YDR478W | SNM1 | het | Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP |
0.109 | 2.68E-10 | YMR218C | TRS130 | het | One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy |
0.109 | 2.71E-10 | YOR275C | RIM20 | hom | Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation |
0.105 | 9.88E-10 | YJL081C | ARP4 | het | Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes |
0.103 | 2.28E-9 | YMR043W | MCM1 | het | Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes |